• Title, Summary, Keyword: the Weight of Role

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Parental Role Stress and Perception of the Newborn in Mothers of Preform Babies (미숙아 어머니의 부모 역할 스트레스와 신생아 지각)

  • 문영임;구현영
    • Journal of Korean Academy of Nursing
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    • v.29 no.1
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    • pp.174-182
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    • 1999
  • The purpose of this study was to contribute to neonatal nursing and maternal nursing to reduce parental role stress in mothers of preform babies and to improve perception of the newborn to by the parents. Data were collected through self-report questionnaires which were consisted of a parental role stress scale and a neonatal perception inventory. The subjects were 100 mothers of fullterm babies and 50 mothers of preform babies, all in the early postpartum stage and admitted to three hospitals in the Kyoung-In area between November 8, 1997 and May 30, 1998. The data were analyzed by a SPSS program and the results are as follows ; 1. There were no significantly differences in the means for parental role stress between mothers of fullterm babies and preform babies. The mean for perception of the newborn was significantly lower in mothers of preform babies than in mothers of fullterm babies. 2. In mothers of preform babies, the level of parental role stress was correlated to the one minute Apgar score. The level of perception of the newborn was correlated to gestational age and birth weight. 3. The mothers of preform babies whose education level was above graduation from college had lower parental role stress than those who had a lowes level of education. The mothers who had experienced cesarean section hd higher parental role stress than those who gave birth to their baby prematurely. The above findings indicate that mothers of preform babies had lower perception of the newborn than mothers of fullterm babies. Therefore, nursing intervention should be provided for mothers of preform babies to manage parental role stress and improve perception of the newborn.

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Nutritional Management in Patients with Chronic Obstructive Pulmonary Disease (만성폐쇄성폐질환 환자의 영양관리)

  • Lee, Kwan-Ho
    • Yeungnam University Journal of Medicine
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    • v.21 no.2
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    • pp.133-142
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    • 2004
  • Chronic obstructive pulmonary disease(COPD) is characterized by a not entirely reversible limitation in the airflow. An airflow limitation is progressive and associated with an abnormal inflammatory response of the lung to gases and harmful particles. In COPD, the weight loss is commonly observed and there is a negative impact on the respiratory as well as skeletal muscle function. The pathophysiological mechanisms that result in weight loss in COPD are not fully understood. However, the mechanisms of weight loss in COPD may be the result of an increased energy expenditure unbalanced by an adequate dietary intake. The commonly occurring weight loss and muscle wasting in COPD patients adversely affect the respiratory and peripheral muscle function, the exercise capacity, the health status, and even the survival rates. Therefore, it is very valuable to include management strategies that the increase energy balance in order to increase the weight and fat free mass. A Better understanding of the molecular and cellular pathological mechanisms of COPD can improve the many new directions for both the basic and clinical investigations. The Nutritional supply is an important components of a multidisciplinary pulmonary rehabilitation program. Future studies combining an exercise program, the role of anabolic steroids, nutritional individualization, a more targeted nutritional therapy, and the development of new drugs including anti-cytokines is needed for the effective management of COPD.

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Effect of Low Molecular Weight Species on the Interfacial Tension of PC/SAN Blend (PC/SAN 블렌드의 계면장력에 미치는 저분자량 성분의 영향)

  • Yang, Dongjin;Son, Younggon
    • Polymer Korea
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    • v.39 no.3
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    • pp.388-393
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    • 2015
  • Low molecular weight species were extracted from PC and SAN by a solvent extraction method in order to investigate the effect of low molecular weight species on interfacial tension and affinity between PC and SAN. From the analysis of molecular weight distribution by the GPC, it was confirmed that the low molecular weight species were effectively eliminated by the solvent extraction. Interfacial tension measurements and morphological observation were carried out with the PC and SAN of which the low molecular weight species were extracted. Interfacial tension was increased and the infinity was decreased for the extracted PC and SAN pair. This result implied that the low molecular weight species play a role as a compatibilizer between two polymers. Among two polymers, low molecular weight SAN contributes more in the compatibilization. Thus, it is favorable to use SAN containing a larger amount of low molecular weight species in fabrication of PC/ABS blend.

Robustness to Impulsive Noise of Algorithms based on Cross-Information Potential and Delta Functions (상호 정보 에너지와 델타함수를 이용한 알고리즘의 충격성 잡음에 대한 강인성)

  • Kim, Namyong
    • Journal of Internet Computing and Services
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    • v.17 no.2
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    • pp.11-17
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    • 2016
  • In this paper, the optimum weight of the algorithm based on the cross information-potential with the delta functions (CIPD) is derived and its robustness against impulsive noise is studied. From the analysis of the behavior of optimum weight, it is revealed that the magnitude controlling operation for input plays the main role of keeping optimum weight of CIPD stable from the impulsive noise. The simulation results show that the steady state weight of CIPD is equivalent to that of MSE criterion. Also in the simulation environment of impulsive noise, unlike the LMS algorithm based on MSE, the steady state weight of CIPD is shown to be kept stable.

Placental Superoxide Dismutase, Genetic Polymorphism, and Neonatal Birth Weight

  • Hong, Yun-Chul;Lee, Kwan-Hee;Im, Moon-Hwan;Kim, Young-Ju;Ha, Eun-Hee
    • Journal of Preventive Medicine and Public Health
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    • v.37 no.4
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    • pp.306-311
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    • 2004
  • Background : The roles of antioxidants in the placenta and genetic susceptibility to oxidant chemicals in relation to neonatal birth weight have not been elucidated. We determined whether the level of placental manganese superoxide dismutase (MnSOD) and its genetic polymorphism plays any role in oxidative stress and neonatal birth weight. Methods : We measured placental MnSOD and determined MnSOD genetic polymorphism among 108 pregnant women who were hospitalized for delivery and their singleton live births in Korea. Main outcome measurements are maternal urinary malondialdehyde (MDA) and birth weight. Results : Maternal urinary concentrations of MDA were significantly associated with neonatal birth weight (P=0.04). The enzyme level of placental MnSOD was also significantly associated with MDA concentration (P=0.04) and neonatal birth weight (p<0.01). We observed dose-response relationships between placental MnSOD and maternal urinary MDA, and neonatal birth weight after adjusting for maternal weight, height, age, and neonatal sex. After controlling for covariates, MnSOD variant genotype increased maternal urinary MDA concentrations (p<0.01) and reduced birth weight by 149 gm (P=0.08). Conclusions : This study demonstrates that the placental level of MnSOD during pregnancy significantly affects fetal growth by reducing oxidative stress, and that genetic polymorphism of MnSOD probably modulate the effects of oxidants on fetal growth.

Effect of paternal folate deficiency on placental folate content and folate receptor ${\alpha}$ expression in rats

  • Kim, Hye-Won;Choi, Yun-Jung;Kim, Ki-Nam;Tamura, Tsunenobu;Chang, Nam-Soo
    • Nutrition Research and Practice
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    • v.5 no.2
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    • pp.112-116
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    • 2011
  • We investigated the effect of paternal folate status on folate content and expression of the folate transporter folate receptor ${\alpha}$ ($FR{\alpha}$) in rat placental tissues. Rats were mated after males were fed a diet containing 0 mg of folic acid/kg of diet (paternal folate-deficient, PD) or 8 mg folic acid/kg of diet (paternal folate-supplemented, PS) for 4 weeks. At 20 days of gestation, the litter size, placental weight, and fetal weight were measured, and placental folate content (n=8/group) and expression of $FR{\alpha}$ (n=10/group) were analyzed by microbiological assay and Western blot analysis, respectively. Although there was no difference observed in litter size or fetal weight, but significant reduction (10%) in the weight of the placenta was observed in the PD group compared to that in the PS group. In the PD group, placental folate content was significantly lower (by 35%), whereas $FR{\alpha}$ expression was higher (by 130%) compared to the PS group. Our results suggest that paternal folate status plays a critical role in regulating placental folate metabolism and transport.

Effects of $\alpha$-Tocopherol and Perilla oil on the Toxicity of Polychlorinated biphenyl in Rat (랏트에 대한 Polychlorinated Biphenyl의 독성에 미치는 $\alpha$-Tocopherol과 Perilla oil의 효과)

  • 최경현;김문석;황두환;문재규;김성오
    • Environmental health and toxicology
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    • v.3 no.3_4
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    • pp.39-51
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    • 1988
  • Effects of ${\alpha}$-tocopherol and perilla oil on the toxicity of polychlorinated biphenyls (PCB) in male rat were studied. Rats were fed ad libitum for 6 weeks with the animal diet which contains PCB 30 ppm and 100 ppm. Perilla oil (0.5 g/kg body weight) and ${\alpha}$-tocopherol (30 mg/kg body weight) were administered intraperitoneally twice a week for 6 weeks. Rats fed with PCB showed enlargement of liver and spleen, increase in aspartate aminotransferase, alkaline phosphatase, sereum lipid and cytochrome P 450 and decrease in body weight and glutathione. When perilla oil was administered to rats fed with PCB increase in aspartate aminotransferase, alkaline phosphatase, serum lipid and cytochrome P45O and decrease in body weight and glutathione were significantly augmented, compared to rats fed with PCB alone. This means that perilla oil potentiates the toxicity of PCB. On the other hand when ${\alpha}$-tocopherol was administered to rats fed with PCB increase in aspartate aminotransferase, alkaline phosphatase, serum lipid and cytochrome P45O and decrease in body weight and glutathione were signigicantly reduced, compared to rats fed with PCB alone. This means that u-tocopherol reduces the toxicity of PCB. From the above results, it may be concluded that PCB is metabolized by microsomal mixed function oxidase and the metabolite causes the toxicity and microsomal glutathione plays a role of protection on the toxicity of PCB.

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FABP3 and FABP4 Genes Are the Potential Candidates for Body Weights in Korean Native Chicken

  • Cahyadi, Muhammad;Seo, Dongwon;Choi, Nuri;Jin, Shil;Maharani, Dyah;Heo, Kang Nyeong;Kang, Bo Seok;Jo, Cheorun;Lee, Jun Heon
    • Korean Journal of Poultry Science
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    • v.40 no.2
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    • pp.91-96
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    • 2013
  • FABPs, 15 kDa organic substances, are small intracellular proteins which have a primary role to regulate fatty acid uptake and intracellular transport. This study was conducted to identify SNPs in the two FABP family genes and their associations with the body weight traits in Korean native chicken (KNC). Two SNPs, namely g.508C>T of FABP3 gene and g.285C>T of FABP4 gene, have been genotyped by using PCR-RFLP method. The results showed that FABP3 was significantly associated with body weight at birth, body weights at 12 to 20 weeks, and also slaughter weight. Moreover, the g.285C>T SNP of FABP4 gene was not associated with any body weight traits. These results suggested that the g.508C>T SNP of FABP3 genes can be used as molecular markers to select KNC having desirable body weights.

Soluble isocitrate dehydrogenase plays a key role in obesity and hyperlipidemia

  • Koh, Ho-Jin;Lee, Su-Min;Huh, Tae-Lin
    • Proceedings of the Korean Society of Applied Pharmacology
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    • pp.5-7
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    • 2003
  • NADPH is an essential co-factor for fat and cholesterol biosynthesis. However, the role of cytosolic NADP$\^$+/-dependent isocitrate dehydrogenase (IDPc), a putative NADPH producer, in the control of the fat and cholesterol metabolism has not been assessed. Here we report that increased or decreased IDPc expression in 3T3-Ll fat cells promoted or retarded adipogenesis, respectively. Furthermore, overexpression of IDPc in transgenic mice exhibited fatty liver, hypertriglyceridemia, hypercholesterolemia and obesity by increasing NADPH production leading to subsequent stimulation of acetyl-coenzyme A and malonyl-coenzyme A consumption. In contrast, administrations of a synthetic IDPc inhibitor, DAl1004, to ob/ob mice effectively reduced body weight with lowering cholesterol and triglyceride levels. In addition, a positive relationship (${\gamma}$ = 0.69, $\rho$<0.0l) between plasma IDPc activity and body mass indexes was observed in 98 randomly-selected human volunteers. Our findings strongly indicate that NADPH produced by IDPc plays an important role in controlling body fat and lipid biosynthesis.

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Effects of Protein-Bound Polysacharide Isolated from Acanthopananx senticosus in Reducing the Toxic Effects of Cisplatin (가시오가피 추출물의 독성경감 및 면역증강효과)

  • Lee, Keyong-Ho;Yoon, Won-Ho
    • Korean Journal of Pharmacognosy
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    • v.38 no.2
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    • pp.152-156
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    • 2007
  • Protein-bound polysaccharide is derived from Acanthopananx senticosus by the cold water extraction. The aim of the study was to evaluate the effects of PS against weight loss and hematological change as a indication of toxicity produced by the treatment of cisplatin. PS protected the weight loss caused by cisplatin (6 mg/kg) and significantly recovered hematological change. Treatment of PS showed the recovery on the weight loss and hematological change as indicators of toxicity of cisplatin treatment. By increasing lymphocyte proliferation and cytokine production, PS may be highly effective in protecting against cisplatin-induced toxicity. The results suggest PS might have a role in reducing toxicity or permitting larger dose of cisplatin to be given.