• Title, Summary, Keyword: regulatory

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The Effect of the Medical Service Quality and Emotion on Perceived Value - Focused on Moderating Effect of Regulatory Focus Theory- (의료서비스 품질요인이 감정과 지각된 가치에 미치는 영향에 관한 연구 -자아규제초점의 조절효과를 중심으로-)

  • Seol, Sang-Cheol;Park, Jong-Hwan;Jang, Tae-Yong
    • Korea Journal of Hospital Management
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    • v.16 no.3
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    • pp.115-132
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    • 2011
  • Prior research in medical service field have mainly focused on service quality, satisfaction, and choice attributes of hospital. However, a little research has been done on "Which service quality attributes are more preferred by customer motivation(customer regulatory focus)". This study examines how regulatory focus affects the structural impact relationships of service quality and emotion(quiescence) on perceived value in medical service context. Especially, this research draws the moderating effects of regulatory focus between medical service quality, emotion, and perceived value. The Results were summarized as follows: The relative impacts of medical service quality on customer emotion are different depending upon the regulatory focus. Hospital reputation is shown to be more important factors in prevention-oriented customer, while physical environment is the case in promotion-oriented customer. The relative impacts of medical service quality and emotion on perceived value are different depending upon the regulatory focus. Hospital reputation, convenience, and accessibility are shown to be more important factors in promotion-oriented customer, while physical environment is more important in prevention-oriented customer. Also, emotion has a positive influence on perceived value in prevention-oriented customer, whereas the effect of emotion is not significant in promotion-oriented customer.

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Characterization of Chromatin Structure-associated Histone Modifications in Breast Cancer Cells

  • Hong, Chang-Pyo;Choe, Moon-Kyung;Roh, Tae-Young
    • Genomics & Informatics
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    • v.10 no.3
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    • pp.145-152
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    • 2012
  • Chromatin structure and dynamics that are influenced by epigenetic marks, such as histone modification and DNA methylation, play a crucial role in modulating gene transcription. To understand the relationship between histone modifications and regulatory elements in breast cancer cells, we compared our chromatin immunoprecipitation sequencing (ChIP-Seq) histone modification patterns for histone H3K4me1, H3K4me3, H3K9/16ac, and H3K27me3 in MCF-7 cells with publicly available formaldehyde-assisted isolation of regulatory elements (FAIRE)-chip signals in human chromosomes 8, 11, and 12, identified by a method called FAIRE. Active regulatory elements defined by FAIRE were highly associated with active histone modifications, like H3K4me3 and H3K9/16ac, especially near transcription start sites. The H3K9/16ac-enriched genes that overlapped with FAIRE signals (FAIRE-H3K9/14ac) were moderately correlated with gene expression levels. We also identified functional sequence motifs at H3K4me1-enriched FAIRE sites upstream of putative promoters, suggesting that regulatory elements could be associated with H3K4me1 to be regarded as distal regulatory elements. Our results might provide an insight into epigenetic regulatory mechanisms explaining the association of histone modifications with open chromatin structure in breast cancer cells.

Mutual Recognition of National Military Airworthiness Authorities: A Streamlined Assessment Process

  • Purton, Leon;Kourousis, Kyriakos I.;Clothier, Reece;Massey, Kevin
    • International Journal of Aeronautical and Space Sciences
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    • v.15 no.1
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    • pp.54-62
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    • 2014
  • The Air and Space Interoperability Council (ASIC) has adopted the European Defence Agency (EDA) process for inter-regulatory military airworthiness authority recognition. However, there are gaps in the application of this process to nations outside of the European Union. This paper proposes a model that can effectively map diverse technical airworthiness regulatory frameworks. This model, referred to as the Product-Behaviour-Process (PBP) Bow-Tie model, provides the systematic structure needed to represent and compare regulatory frameworks. The PBP Bow-Tie model identifies key points of difference that need to be addressed, during inter-agency recognition between the two regulatory authorities. With the intention to adopt global use of the EDA process, the proposed PBP Bow-Tie model can be used as a basis for the successful recognition of regulatory frameworks outside of the European Union. Iris plots produced from the implementation of this model are presented, and proposed as a suitable means of illustrating the outcome of an assessment, and of supporting the comparisons of results. A comparative analysis of the Australian Defence Force and New Zealand Defence Force airworthiness regulatory frameworks is used as a case study. The case study clearly illustrates the effectiveness of the model in discerning regulatory framework differences; moreover, it has offered an opportunity to explore the limitations of the Iris plot.

The Impact of Transformational Leadership, Servant Leadership, and Followers' Regulatory Focus on Individual Creativity: The Mediation Effect of Intrinsic Motivation (변혁적 리더십 및 서번트 리더십과 조직 구성원의 조절 초점 성향이 개인 창의성에 미치는 영향: 내재적 동기의 매개효과)

  • Kwon, Sang-Jib
    • Knowledge Management Research
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    • v.17 no.3
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    • pp.137-159
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    • 2016
  • Although prior studies suggest that transformational leadership and servant leadership fuel followers' creativity, there is a few study on leadership style and followers' personality interaction. Based on regulatory focus theory, this study believe that interaction impacts of leadership styles and followers' regulatory focus differed in promotion focus and prevention focus employees' creativity. To strengthen causal process and rule out alternative results, this study conducted an experimental study using field employees. Participant were randomly assigned to four conditions (transformational leadership ${\times}$ promotion focus), (transformational leadership ${\times}$ prevention focus), (servant leadership ${\times}$ promotion focus), (servant leadership ${\times}$ prevention focus). The major results of this study suggest that (1) transformational leadership was positively related to promotion focus followers' intrinsic motivation and creativity, and was negatively related to prevention focus followers' intrinsic motivation and creativity. (2) Servant leadership, on the other hand, was positively related to promotion focus and prevention focus followers' motivation and creativity. (3) Intrinsic motivation mediated the relationship between interaction effects of leadership style and follower's regulatory focus style and individual creativity. The results of this study demonstrated a remarkable differential impact based on a simple manipulation inducing feeling or thinking of a responsive situation. This research, measuring interaction impact of leadership and followers' regulatory focus in an experimental context, expands the leadership style and regulatory focus literature and provides future directions on leadership role in personality-related research domains.

A Systematic Analysis of Drosophila Regulatory Peptide Expression in Enteroendocrine Cells

  • Chen, Ji;Kim, Seol-min;Kwon, Jae Young
    • Molecules and Cells
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    • v.39 no.4
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    • pp.358-366
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    • 2016
  • The digestive system is gaining interest as a major regulator of various functions including immune defense, nutrient accumulation, and regulation of feeding behavior, aside from its conventional function as a digestive organ. The Drosophila midgut epithelium is completely renewed every 1-2 weeks due to differentiation of pluripotent intestinal stem cells in the midgut. Intestinal stem cells constantly divide and differentiate into enterocytes that secrete digestive enzymes and absorb nutrients, or enteroendocrine cells that secrete regulatory peptides. Regulatory peptides have important roles in development and metabolism, but study has mainly focused on expression and functions in the nervous system, and not much is known about the roles in endocrine functions of enteroendocrine cells. We systemically examined the expression of 45 regulatory peptide genes in the Drosophila midgut, and verified that at least 10 genes are expressed in the midgut enteroendocrine cells through RT-PCR, in situ hybridization, antisera, and 25 regulatory peptide-GAL transgenes. The Drosophila midgut is highly compartmentalized, and individual peptides in enteroendocrine cells were observed to express in specific regions of the midgut. We also confirmed that some peptides expressed in the same region of the midgut are expressed in mutually exclusive enteroendocrine cells. These results indicate that the midgut enteroendocrine cells are functionally differentiated into different subgroups. Through this study, we have established a basis to study regulatory peptide functions in enteroendocrine cells as well as the complex organization of enteroendocrine cells in the Drosophila midgut.

Inferring candidate regulatory networks in human breast cancer cells

  • Jung, Ju-Hyun;Lee, Do-Heon
    • Bioinformatics and Biosystems
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    • v.2 no.1
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    • pp.24-27
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    • 2007
  • Human cell regulatory mechanism is one of suspicious problems among biologists. Here we tried to uncover the human breast cancer cell regulatory mechanism from gene expression data (Marc J. Van de vijver, et. al., 2002) using a module network algorithm which is suggested by Segal, et. al.(2003) Finally, we derived a module network which consists of 50 modules and 10 tree depths. Moreover, to validate this candidate network, we applied a GO enrichment test and known transcription factor-target relationships from Transfac(R) (V. Matys, et. al, 2006) and HPRD database (Peri, S. et al., 2003).

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Inference of Genetic Regulatory Modules Using ChIP-on-chip and mRNA Expression Data

  • Cho, Hye-Young;Lee, Do-Heon
    • Bioinformatics and Biosystems
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    • v.2 no.2
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    • pp.62-65
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    • 2007
  • We present here the strategy of data integration for inference of genetic regulatory modules. First, we construct all possible combinations of regulators of genes using chromatin-immunoprecipitation(ChIP)-chip data. Second, hierarchical clustering method is employed to analyze mRNA expression profiles. Third, integration method is applied to both of the data. Finally, we construct a genetic regulatory module which is involved in the function of ribosomal protein synthesis.

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Legal Research on FinTech Regulatory Sandbox Fostering Financial Innovations in Korea (핀테크 활성화를 위한 규제 샌드박스의 도입 방안 연구)

  • Ko, Young-Mi
    • Journal of Legislation Research
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    • no.53
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    • pp.213-267
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    • 2017
  • Regulatory barrier is considered most challenging out of all FinTech barriers, which many technology innovators have always experienced. Even though technological solutions promise customers accessibility to more cost-effective and secured financial services, it is quite challenging to create regulatory environment that enables innovation FinTech industry. Especially, a common challenge FinTech innovators and business face is regulatory uncertainty and confusion rather than any particular regulation. Since many FinTech models are continuously introducing new innovative ways in providing financial services, significant confusion could be raised in applying principles of existing law and regulations. In addition, it is uncertain whether or not applying complex regulatory compliance model intended for large financial institutions to small start-ups is appropriate since most existing regulations and rules are established and introduced without considering innovative tools such as mobile instruments, e-trade, and internet. Therefore, new mechanism to access to regulatory information in a more cost-effective, quick and immediate way should be created. Regulators, technological innovators, and financial customers should cooperate each other to find out appropriate solutions for those issues. Many regulators are introducing regulatory sandbox which provides service providers with opportunities to test their innovations, during the test, providing regulators with enough time to understand risks of innovations. However, regulatory sandbox is not a panacea for all challenges to FinTech innovations. Therefore, regulators should make comprehensive and multidimensional efforts including regulatory sandbox in supporting FinTech ecosystem.

The Influence of Self-Regulatory Group Counseling on Self- regulation and Satisfaction with School Life of the Higher grade Students in Elementary School (자기조절 집단상담이 초등학교 고학년 학생의 자기조절능력과 학교생활 만족도에 미치는 영향)

  • Tak, Hyo-Jin
    • The Korean Journal of Elementary Counseling
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    • v.6 no.1
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    • pp.247-268
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    • 2007
  • This thesis aims to examine the influences of self-regulatory group counseling on self-regulation and school life satisfaction of the higher grade students in Elementary school. To achieve this aim, the following research questions were posed: First, What kind of influence does the self-regulatory group counseling have on the self- regulation of the higher grade students in Elementary school. Second, What kind of influence does the self-regulatory group counseling have on school life satisfaction scale of the higher grade students in Elementary school. In order to verify these research questions, the self-regulation test and school life satisfaction scale were conducted to both the experimental group and control group in pre-test, next, self-regulatory group counseling was practiced to the experimental group. And finally, a post-test was given to both the experimental group and control group. For this study, 200 students from 6th-grader of S Elementary school located in Incheon were given the self-regulation test and chosen 50 students who received low marks. Then, 50 students were researched into the school life satisfaction scale and chosen 16 students who got average-below score again. It was two matching groups through consideration of their score of the school life satisfaction scale, 8 students were arranged to the experimental group and the rest to the control group. The Self-Regulatory Group Counseling program developed by Eun Hyuck-gi(1999). The program was based on the following three programs: "The development. of the Cognitive-Behavioral Counseling therapy and their reports" by Kim HyeSuk(1996), Group counseling" by Brigman and Early(1991) and the study on the improving program in human relation" by Park KyeongAe(1998). The Self-Regulatory Group Counseling program activity was conducted during 6 weeks. Each session was 60 minutes and it continued for 8 sessions. The data collected to find out a difference in self-regulation and the degree of school life satisfaction between the experimental and control groups were processed by means of SPSSWIN program, and the post-test between both the groups were comparatively analyzed through t-test, a mean difference test. The following conclusions were drawn from the results of this study. First, the self-regulatory group counseling program has obvious effect of improving the self-regulation of the higher grade students in Elementary school. Second, the self-regulatory group counseling program has obvious effect of improving the school life satisfaction of the higher grade students in Elementary school. Particularly, this study shows statistical significance in cognitive facts of the self-regulation and the degrees of satisfaction with general school life, teacher, friend and facilities. Since the self-regulatory group counseling program has positive effects on self-regulation and satisfaction with their school life, It is required to utilize the structured self-regulatory group counseling program in school more widely to help students.

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Establishment Method of the Regulatory Framework for Communications Reflecting the Ecosystem Elements (생태계 요소를 반영한 방송통신 규제체계의 정립 방안)

  • Hong, Dae-Sik;Choe, Dong-Uk
    • Journal of Legislation Research
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    • no.41
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    • pp.401-434
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    • 2011
  • The discussion on the adoption of the horizontal regulatory framework is underway to overcome the problems regarding the vertical regulatory framework resulting from a convergence of broadcasting and telecommunications services. Recently, however, the horizontal regulatory framework shows its limitation to regulate the ecosystem established mainly by Google and Apple. The existing horizontal regulatory framework does not fully reflect the characteristics of the two-sided market and the change in the competition structure in the broadcasting and telecommunications sector. What is important to note is that if the existing horizontal regulatory framework is simply applied to the ecosystem, a regulatory imbalance can be caused among ecosystems. The existing horizontal regulatory framework, which is subject to a value chain structure, categorizes business entities into either contents layer or transmission layer and applies the same regulation to all business entities in the same category. However, in the ecosystem, a keystone-player can be categorized into different layers depending on its strategy. Therefore, if the existing horizontal regulatory framework is applied as it is, the regulatory imbalance between keystone-players located in less regulated areas and keystone-players located in more regulated areas occurs resulting in a distortion of competition. There are two possible ways to establish a new regulatory framework to prevent the distortion of competition likely to be caused by the adoption of a horizontal regulatory system. First, a new ecosystem regulatory framework different from the existing one can be established. Second, the horizontal regulatory framework can be modified to reflect the ecosystem elements. The first approach is hard to adopt given the current situation as the approach requires the analysis of all broadcasting and telecommunications ecosystems including mobile and wired services; currently research and study on the competition conditions in the ecosystems is not enough. Therefore, this paper supports the second approach proposing a modified horizontal regulatory framework through the improvement of institutions and remedies suitable for accommodating the ecosystem elements. This paper intends to propose a way to regulate broadcasting and telecommunications ecosystems taking into consideration the ecosystem elements on top of the Telecommunications Business Act, Broadcasting Act, IPTV Act, the competition condition evaluation system of the Basic Act on Broadcasting and Telecommunications Development, and regulation on common carriers under the Telecommunications Business Act.