• Title, Summary, Keyword: phytochemical

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Estimation of Phytochemical Intakes and Its Association with Chronic Diseases in Korean Elderly

  • Lee, Hae-Jeung;Park, Seon-Joo;Park, Haymie
    • Proceedings of the KSCN Conference
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    • pp.394.1-394
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    • 2004
  • This study was conducted to investigate the dietary phytochemical intakes and its relationship with chronic diseases in the Korean elderly. Dietary assessment was performed using a semiquantitative food frequency questionnaire (FFQ), which included 98 commonly consumed foods with actual size pictures. For estimating phytochemical intakes, we made the phytochemical database using the Korean published data and USDA references. Dietary phytochemicals studied included five carotenoids, five flavonoids, and five isoflavones.(omitted)

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Determination of Phytochemical Contents and Biological Activities from the Fruits of Elaeagnus multiflora

  • Lee, Jin-Hwan;Seo, Weon-Taek;Cho, Kye-Man
    • Preventive Nutrition and Food Science
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    • v.16 no.1
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    • pp.29-36
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    • 2011
  • The purpose of this study was to investigate the phytochemical contents and biological activities, including $\alpha$-glucosidase inhibitory activity and antioxidant activity, from the fruits of Elaeagnus multiflora using different solvent systems. The 50% ethanol extract of this species showed the most potent $\alpha$-glucosidase inibitory activity (88.5%) at a concentration of 1 mg/mL. Moreover, this extract also displayed the strongest antioxidant activity in each assay, showing 96.3% in DPPH scavenging activity, 98.2% in ABTS scavenging activity, and 2.5% in reducing power. The highest total phytochemical contents, including flavan-3-ols, phenolic acids, and flavonoids, were observed in the 50% ethanol extract. Interestingly, flavan-3-ols (3.150 mg/g) were detected at a significantly higher total content than those of phenolic acids (0.380 mg/g) and flavonoids (not detected). Additionally, the contents of individual phytochemicals showed remarkable differences, especially the epicatechin gallate (2.008 mg/g) and gallic acid (0.099 mg/g), which were the predominant constituents of each phytochemical type. Therefore, our results suggest that the 50% ethanol extract of E. multiflora fruits has strong biological activities, which are correlated with high phytochemical contents.

Phytochemical and biological investigations of Polygonum lanatum

  • Chowdhury, Sadia A.;Sohrab, Mohammad H.;Haque, Mohammad R.;Hasan, Choudhury M.;Rashid, Mohammad A.
    • Oriental Pharmacy and Experimental Medicine
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    • v.8 no.1
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    • pp.97-102
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    • 2008
  • A total of five compounds namely, 2-methylanthracene-9, 10-dione (1), 1-hydroxy-6-methylanthracene-9,10-dione (2), $\beta$-sitosterol (3), stigmasterol (4) and sitosterone (5) were isolated from the stem extracts of Polygonum lanatum for the first time. The structures of the isolated compounds (1-5) were established by extensive spectroscopic studies, including 2D NMR such as $^{1}H-^{1}H$ COSY, HSQC and HMBC studies. The crude extracts and purified compound (1) were screened for antimicrobial activity against a wide range of Gram-positive and Gram-negative bacteria and fungi by the disc diffusion method. The n-hexane and dichloromethane soluble partitionates of the methanolic extract revealed mild to moderate inhibition of growth of the test organisms. The cytotoxic potential of the extractives and compound 1 was also determined by using brine shrimp lethality bioassay, where the extractives demonstrated significant cytotoxic activities.

Dietary Phytochemical Index and the Risk of Breast Cancer: A Case Control Study in a Population of Iranian Women

  • Bahadoran, Zahra;Karimi, Zeinab;Houshiar-Rad, Anahita;Mirzayi, Hamid-Reza;Rashidkhani, Bahram
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.5
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    • pp.2747-2751
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    • 2013
  • In this study we assessed the dietary phytochemical index in relation to the risk of breast cancer in women. This case-control study was conducted on 100 incident breast cancer cases and 175 healthy controls. Data regarding socio-demographic factors, medical history, medications, and anthropometric measurements were collected. Dietary data were obtained using a validated food frequency questionnaire and a energy-adjusted dietary phytochemical index (PI) was calculated. The odds ratios of breast cancer were assessed across energyadjusted PI quartile categories. The mean age of participants was $46.2{\pm}8.9$ and $45.9{\pm}9.4$ years in cases and controls, respectively. The mean PI across quartile categories was $13.9{\pm}2.6$, $21.1{\pm}1.8$, $26.7{\pm}2.1$, $41.6{\pm}10.2$ in the first, second, third and fourth quartiles, respectively. After adjustment for all potential confounders, the risk of breast cancer in the forth quartile of dietary PI was significantly decreased (OR=0.08, 95%CI=0.01-0.84). Higher intake of phytochemical-rich foods is associated with lower risk of breast cancer.

Anti-inflammatory Effects of Chitosan-phytochemical Conjugates against Propionibacterium acnes-induced Inflammation (Propionibacterium acnes에 의해 유도된 염증에 대한 Chitosan-phytochemical Conjugates의 항염증 효과)

  • Kim, Ji-Hoon;Je, Jae-Young;Kim, Young-Mog
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.49 no.5
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    • pp.589-593
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    • 2016
  • Propionibacterium acnes infection in skin tissue often causes acne vulgaris, commonly characterized by inflammatory papules, pustules, and nodules. Chitosan and its derivatives possess strong anti-inflammatory effects. In this study, the anti-inflammatory activity of chitosan-phytochemical conjugates on P. acnes-infected human skin keratinocytes (HaCaT) was evaluated. We designed a model of P. acnes-induced inflammation in viable HaCaT cells. Nitric oxide (NO), an inflammatory marker, was successfully elevated by P. acnes infection in HaCaT cells in a dose-dependent manner. Furthermore, the levels of NO were reduced by treatment with chitosan-phytochemical conjugates (chitosan-caffeic acid, -ferulic acid and -sinapic acid) in a dose-dependent manner. Among these conjugates, chitosan-caffeic acid exhibited the strongest NO suppression in HaCaT cells infected with P. acnes. The results obtained in this study suggest that chitosan-phytochemical conjugates could be used as a potential therapeutic agent against acne vulgaris.

Influence of phytochemical composition on in vitro antioxidant and reducing activities of Indian ginseng [Withania somnifera (L.) Dunal] root extracts

  • Ganguly, Bhaskar;Kumar, Nirbhay;Ahmad, Abul H.;Rastogi, Sunil K.
    • Journal of Ginseng Research
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    • v.42 no.4
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    • pp.463-469
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    • 2018
  • Background: Roots of Withania somnifera (WS) are a celebrated medicinal ingredient in Ayurvedic and many other indigenous systems of medicine. The present study investigates the effect of the phytochemical composition of the extracts on their antioxidant and reducing activities. Methods: WS roots were extracted with water, acetone, aqueous methanol (1:1), and methanol:-chloroform:water (1:1:1) to obtain aqueous, acetone, hydro-methanolic, and methanol-chloroform-water extracts. Thereafter, phytochemical constitution and antioxidant and reducing activities of the extracts were compared using different qualitative and quantitative tests. Results: Maximum extraction recovery was obtained with 50% aqueous methanol whereas extraction with acetone yielded the poorest recovery. Methanol-chloroform-water extract had the highest content of phytochemical constituents, except tannins, and also exhibited the highest antioxidant and reducing activities. Conclusion: Phytochemical composition and antioxidant and reducing activities of the extracts were positively associated with the use of organic solvents during the extraction process. Alkaloids and flavonoids were the most important contributors in the antioxidant and reducing activities of the extracts.

Fatty Acids and Phytochemical Components of Ipomoea spp. Seeds

  • Das, Saubhik;Ganguly, Subhendu Narayan;Mukherjee, Kalyan Kumar
    • Natural Product Sciences
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    • v.5 no.3
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    • pp.121-123
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    • 1999
  • Twelve species of Ipomoea were investigated for allelopathic behavior. Seed extracts of I. quamoclit, I. nil and I. pes-tigridis showed significant allelopathy over germination of other seeds. Investigation on seed extracts of I. quamoclit, revealed the presence of several phytochemical components viz., n-triacontanol, sitosterol, stigmasterol, ${\alpha}-amyrin$, taraxerone, taraxerol, erythrodiol, cucurbitacin-G. Seed fat of twelve species were also analyzed.

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Antinociceptive activity of the ethanolic extract of Ficus racemosa Lin. (Moraceae)

  • Ferdous, Muhshina;Rouf, Razina;Shilpi, Jamil Ahmad;Uddin, Shaikh Jamal
    • Oriental Pharmacy and Experimental Medicine
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    • v.8 no.1
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    • pp.93-96
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    • 2008
  • The ethanolic extract of Ficus racemosa Lin. (Moraceae) bark and fruit were tested for its possible antinociceptive activity study on acetic acid induced writhing method in mice. Both the bark and fruit extracts at a dose of 500 mg/kg body weight showed significant antinociceptive activity on the experimental animals. The fruit extract showed most potent inhibition of acetic acid induced writhing in mice (61.38%, P < 0.001) where as the bark extract showed inhibition only 42.6% (P < 0.001) and all the result were statistically significant.

Phytochemical Survey of Saudi Arabian Plants

  • Woo, Won-Sick;Chi, Hyung-Joon;Jado, Ahmad
    • Korean Journal of Pharmacognosy
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    • v.7 no.4
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    • pp.247-250
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    • 1976
  • Phytochemical survey has been made of the occurrence of alkaloids, saponins, terpenoids and flavonoids in 43 Saudi Arabian plants. The result is presented in Table I.

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