• Title, Summary, Keyword: phloroglucinol

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Identification of phenolic antioxidative components in Terminalia Chebula Retz (가자 항산화성 물질의 분리 및 확인)

  • Kim, Jeong-Sook;Lee, Gee-Dong;Kwon, Joong-Ho;Yoon, Hyung-Sik
    • Applied Biological Chemistry
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    • v.36 no.4
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    • pp.239-243
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    • 1993
  • Chemical structures of phenolic antioxidative components of defatted Terminalia chebula R. were elucidated by used MS and H-NMR. The results showed that the phenolic antioxidative components were identified as ferulic acid, vanillic acid, p-coumaric acid in free-acid extracts, and caffecic acid, vanillic acid and p-coumaric acid in soluble-acid extracts, and caffeic acid, phloroglucinol and pyrogallol in insoluble-bound extracts, respectively.

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The Phenolic Constituents of Phyllanthus ussuriensis Leaves(I) (여우주머니 잎의 Phenol성 성분(I))

  • Whang, Wan-Kyunn;Oh, In-Se;Ham, In-Hye;Hahn, Dug-Ryong
    • Korean Journal of Pharmacognosy
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    • v.25 no.2
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    • pp.113-116
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    • 1994
  • For the investigation of medicinal resource in Phyllanthus ussuriensis, the studies were conducted to evaluate the pharmaco-constituents in Phyllanthus ussuriensis, which is used as folk medicine in China. From the hot water extract of leaves, three phenolic compounds were isolated and identified as phloroglucinol, gallic acid and rutin by physico-chemical properties and spectroscopic evidences$(IR,{\;}^1H-NMR,{\;}^{13}C-NMR{\;}and{\;}Mass,{\;}etc.)$.

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Antioxidants ofnew compounds from marine Algae prevent celldeath of endothelial cells

  • Lee, Ji Yoen;Lee, Mi Hwa;Park, Hae-Ryoun;Choi, Jae Soo;Seo, Hong Suk;An, Won Gun;Choi, Won Chul
    • Journal of fish pathology
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    • v.16 no.1
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    • pp.39-49
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    • 2003
  • Cytosolic oxidation by 4-hydroxy-2-nonenal (4HNE) and tert-butyl hydroperoxide (t-BHP) results in cell death of bovine aortic endothelial cells (BAEC). In this study, we have investigated the roles of antioxidants such as 2,3,6-tribromo-4,5-dihydroxy benzyl methyl ether (TDB) and phloroglucinol in preventing cell death. After treatment with oxidants for 6h, cells became compact and showed nuclear condensation, which were characteristics of early apoptosis. After l2h treatment, morphologic features including severe cytoplasm condensation, membrane blebbing, and apoptotic bodies were prominent and these findings were interpreted as characteristics of late-apoptosis. When the apoptotic cells were treated with antioxidants for 12h, both early and late apoptotic cells did show no significant change. After oxidant treated cells were incubated with antioxidant for 24h, the characteristics of early-apoptosis were eliminated but cells in lateapoptosis could not return to normal cells. These results suggest that TDB and phloroglucinol prevent the cells from dying through apoptosis induced by 4HNE and t-BHP in early stage.

Quinone Reductase Induction Activity of Phlorotannins Derived from Eisenia bicyclis in Hepa1c1c7 Cells

  • Yoon, Na Young;Lee, Sang-Hoon;Shim, Kil Bo;Lim, Chi-Won;Lee, Moon-Hee;Cho, Hyun-Ah;Xie, Chengliang
    • Fisheries and aquatic sciences
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    • v.16 no.1
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    • pp.1-5
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    • 2013
  • To assess the feasibility of phlorotannins from Eisenia bicyclis as cancer chemopreventative agents, we tested whether they induced quinone reductase (QR) in Hepa1c1c7 cells. The ethyl acetate (EtOAc) soluble fraction obtained from E. bicyclis exhibited a QR induction activity in Hepa1c1c7 cells. Successive column chromatography of the active EtOAc fraction resulted in the isolation of four phlorotannins. Their structures were elucidated using one- and two-dimensional nuclear magnetic resonance spectroscopic techniques and characterized as phloroglucinol (1), dioxinodehydroeckol (2), dieckol (3), and fucofuroeckol-A (4). Among these compounds, fucofuroeckol-A (4) showed moderate QR induction activity, and dioxinodehydroeckol (2) exhibited potent QR induction potency with $2.05{\pm}0.04$ fold induction at a concentration of $50{\mu}M$ compared to the dimethyl sulfoxide solvent-treated control cells. However, phloroglucinol (1) and dieckol (3) exerted no detectable QR induction activity in Hepa1c1c7 cells. These results suggest that dioxinodehydroeckol could serve as a useful cancer chemopreventive chemical.

Allelopathic Effects of Extracts of Trifolium repens on the Seed Germination and Seedling Growth of Zoysia japonica (토끼풀(Trifolium repens) 추출액이 잔디(Zoysia japonica)의 발아와 생장에 미치는 알레로파시 효과)

  • Lee, Ji-Hun;Kim, In-Taek;Lee, Ho-Jun;Kim, Yong-Ok
    • The Korean Journal of Ecology
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    • v.24 no.3
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    • pp.125-130
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    • 2001
  • The allelopathic effects of aqueous extracts from Trifolium repens were studied. Aqueous extracts of leaves, stems, roots and flowers of T. repens strongly inhibited the seed germination and seedling growth of Zoysia japonica. In general, the higher concentration of the extracts showed the more great inhibition effect. The phenolic compounds extracted from T repens were analysed and identified using gas chromatography. 14 phenolic compounds were isolated from the leaves, stems, roots and flowers: caffeic acid, p-hydroxy benzoic acid, ferulic acid, gallic acid, p-coumaric acid, vanillic acid, trans-cinnamic acid, 2,5 dihydroxy benzoic acid, syringic acid, 2-hydroxy cinnamic acid, benzoic acid, salicylic acid, phloroglucinol and phanylacetic acid. The seed germination and relative growth ratio of Z. japonica by 14 phenolic compounds were inhibited in whole treatment. Stronger growth inhibitor were benzoic acid, salicylic acid and trans-cinnamic acid. From these results it is suggested that the phenolic compounds from T. repens seemed to be responsible for the allelopathic potential.

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Preparation and Properties of UV Curable Phlorogulcinol Based Acrylate for PET Film (PET 필름용 UV 경화 플로로글루시놀계 아크릴레이트 제조 및 물성)

  • Choi, Jeon-Mo;Lee, Eun-Young;Kim, Sangyong;Cho, Jin-Ku;Kim, Baekjin;Lee, Sang-Hyeup;Kim, Hyun Joong
    • Journal of Adhesion and Interface
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    • v.11 no.2
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    • pp.50-56
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    • 2010
  • Polyethyleneterephthalate (PET) film is widely used in various industrial fields such as mobile phone, display pannel, notebook etc. Recently PET film attached on indium tin oxide (ITO) surface has a role of high pencil hardness, high refractive index etc. So we synthesized two types of multi-functional monomer which are epoxy modifed acrylate and unmodified acrylate type using recyclable resource like phloroglucinol, derived from trinitrotoluene. We studied the effect of multi-functional monomer's chemical structure on the various properties such as refractive index, optical transmittance, and pencil hardness. We characterized synthesized multi-functional monomer by qualitative analysis through H NMR. We observed that pencil hardness of 1,3,5-triepoxide benzene and 1,3,5-triacrylate benzene they have the range of 2~3 H at high UV dosage of 300 mW. Refractive index appeared the value of 1.54~1.57. Transmittance of all multi-functional monomers has more than 93%.

Studies on the Chemical Components of Korean Ginseng (I)-GLC/MS Analysis of Free Phenolic Fraction- (고려삼의 페놀성 분획의 성분연구( I ) -유리 페놀성 분획의 GLC/MS분석-)

  • 김만욱;위재준
    • Journal of Ginseng Research
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    • v.9 no.1
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    • pp.54-63
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    • 1985
  • The free phenolic fraction from Korean white ginseng (Panax ginseng C.A. Meyer) was studied by GLC/MS as trimethylsilyl and methyl derivative. Five phenolic compounds such as 2,6-ditert butyl p-crestal, phloroglucinol, protocatechuic acid, isoferulic acid, quinic acid were identified newly. And additionally 13 organic acids and hydrocarbons were also identified in the fraction.

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Antioxidative Effectiveness of Phenolics on Linoleic Acid With Phenolics (페놀물질을 첨가한 Linoleic Acid의 항산화 효과측정)

  • 김정숙
    • Journal of the East Asian Society of Dietary Life
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    • v.3 no.2
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    • pp.147-153
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    • 1993
  • Phenolics as antioxidant were added to linoleic acid to prevent lipid oxidation. Antioxidative effectiveness of them was measured by peroxie value at each 24hour interval in order to compare with 0.02% protocatechuic acid(PRL) and phloroglucinol(PHL) in linloleic acid, contrast tube at 37$^{\circ}C$for 96 hours blowing oxygen into specimen. Perocide values of oxidized linoleic acid, PRL, PHL for 96 hours were 78, 42, 30, From that the effect is more clearly demonstrated by NMR rather than UV and that the effect was dependent on the functional group and geometric molecular structure of phenolics.

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