• Title, Summary, Keyword: pharmacological efficacy

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Study of Literature on RADIX STEMONAE(Investigation of efficacy and pharmacological action on RADIX STEMONAE) (백부근(百部根)에 관(關)한 문헌적(文獻的) 고찰(考察) (효능(效能) 및 약리작용(藥理作用)을 중심(中心)으로))

  • Choi Hae-Yun;Kim Jong-Dae
    • Herbal Formula Science
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    • v.7 no.1
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    • pp.65-76
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    • 1999
  • According to the study of literature on RADIX STEMONAE about its efficacy, pharmacological action, and clinical adaptive disease, the results are as follows; 1. About the efficacy of RADIX STEMONAE, it is known as moistening the lungs to arrest cough, and intestinal parasites from ancient to now, and dispelling phlegm is also known. 2. The clinical adaptation of RADIX STEMONAE is chronic bronchitis, pertussis, pulmonary tuberculosis in respiratory disease, and ascaricide for Ascaris, Enterobius vermicularis or eczema, pruritus, destroy louse for endermic liniment. 3. The pharmacological action of RADIX STEMONAE are antitussive, tuberculostatic, anthelmintic, antibacterial, antivirus, antifungal. 4. The antitussive mechanism of RADIX STEMONAE is central inhibitor for cough center of medulla oblongata, and the mechanisms of bronchial smooth muscle relax, and expectorant is also known.

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Pharmacological Treatment of Major Depressive Episodes with Mixed Features: A Systematic Review

  • Shim, In Hee;Bahk, Won-Myong;Woo, Young Sup;Yoon, Bo-Hyun
    • Clinical Psychopharmacology and Neuroscience
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    • v.16 no.4
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    • pp.376-382
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    • 2018
  • We reviewed clinical studies investigating the pharmacological treatment of major depressive episodes (MDEs) with mixed features diagnosed according to the dimensional criteria (more than two or three [hypo]manic symptoms+principle depressive symptoms). We systematically reviewed published randomized controlled trials on the pharmacological treatment of MDEs with mixed features associated with mood disorders, including major depressive disorder (MDD) and bipolar disorder (BD). We searched the PubMed, Cochrane Library, and ClinicalTrials.gov databases through December 2017 with the following key word combinations linked with the word OR: (a) mixed or mixed state, mixed features, DMX, mixed depression; (b) depressive, major depressive, MDE, MDD, bipolar, bipolar depression; and (c) antidepressant, antipsychotic, mood stabilizer, anticonvulsant, treatment, medication, algorithm, guideline, pharmacological. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We found few randomized trials on pharmacological treatments for MDEs with mixed features. Of the 36 articles assessed for eligibility, 11 investigated MDEs with mixed features in mood disorders: six assessed the efficacy of antipsychotic drugs (lurasidone and ziprasidone) in the acute phase of MDD with mixed features, although four of these were post hoc analyses based on large randomized controlled trials. Four studies compared antipsychotic drugs (olanzapine, lurasidone, and ziprasidone) with placebo, and one study assessed the efficacy of combination therapy (olanzapine+fluoxetine) in the acute phase of BD with mixed features. Pharmacological treatments for MDEs with mixed features have focused on antipsychotics, although evidence of their efficacy is lacking. Additional well-designed clinical trials are needed.

Physiologically Functional Foods (기능성 식품에 관하여)

  • 이종임
    • Culinary science and hospitality research
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    • v.5 no.2
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    • pp.401-418
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    • 1999
  • Many plants and animal have long been known to have medicinal effects and therefore have been used as medicines. There are many substances that show various pharmacologic efficacy such as anti-tumor efficacy, anti-inflammatory efficacy, cholesterol-lowering efficacy, anti-coagulant of blood efficacy and anti-bacterial efficacy. I summarized the recent advances in research on physiologically functional foods. The pharmacological efficacy of dietary fiber, chitin & chitosan, DHA(docosahexaenoic acid), mushroom, alginic acid and herbs have selected as topices for discussion. I was examining the anti-coagulant activity of herbs, I discovered that Eugenia caryophyllata T. (clove) had a relatively high anti-coagulant activity.

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Study on the Comparison of Effects by Extraction Methods of Roast and Raw Semen Zizyphi Spinosae (생산조인(生酸棗仁)과 초산조인(炒酸棗仁)의 추출방법에 따른 효능비교연구)

  • Lee, Eun-Kyoung;Hong, Hak-Gi;Chong, Myong-Soo
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.23 no.6
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    • pp.1416-1422
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    • 2009
  • To observe the difference and change of the efficacy and ingredient appearing according to whether semen zizyphi spinosae has been roasted and its extraction method, locomotor activity, anticonvulsant activity, sleeping effect of each hot water and UMPM low temperature extracts of roast and raw semen zizyphi spinosae were measured through animal tests. Roast semen zizyphi spinosae showed superior pharmacological efficacy than raw semen zizyphi spinosae. Also, hot water extraction method showed superior pharmacological efficacy than low temperature extraction method(UMPM) that uses ultrasonic waves and microwaves. In short, it was shown that herbal medicine's extraction method needs to maximize medicinal effects by trying optimum extraction methods according to efficacy by considering characteristics of each herbal medicine. Together, there's also the need for in-depth studies on water-soluble ingredients of semen zizyphi spinosae that may be extracted through full hot water extraction method.

Systematic Studies on Galgeun-tang(gegen-tang, kakkon-to) for Establishment of Evidence Based Medicine (표준한방처방의 EBM 구축을 위한 갈근탕(葛根湯) 문헌 분석 연구)

  • Lee, Jun-Kyoung;Kim, Jung-Hoon;Shin, Hyeun-Kyoo
    • Herbal Formula Science
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    • v.19 no.1
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    • pp.103-111
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    • 2011
  • Objectives : The purpose of this report was to provide the information of activity and safety of galgeun-tang by analyzing domestic/international papers and theses about galgeun-tang. Methods : Domestic/international papers and theses related to galgeun-tang were reviewed and analyzed. These papers were then classified by efficacy, or clinical trials. Results : The basic pharmacological experiment showed antipyretic, analgesic and anti-virus and anti-oxidant efficacy of galgeun-tang. In the case report of galgeun-tang, it showed therapeutic effect for patient with chronic rhinitis. But administration of galgeun-tang induced pruritic eruption in the two case report as a side effects of galgeun-tang. Conclutions : galgeun-tang showed tantipyretic, analgesic and anti-virus and anti-oxidant efficacy in the basic pharmacological experiment. Also, galgeun-tang showed therapeutic effect for patient with chronic rhinitis. But it was reported that galgeun-tang induced pruritic eruption in two case report, so physicians should be aware of the potential side effects.

Chemical and Biochemical Studies on Non-saponin Constituents of Korean Ginseng (고려인삼의 비사포닌 성분에 대한 화학적 및 생화학적 연구)

  • Han, Byung-Hoon;Park, Myung-Hwan;Han, Yong-Nam
    • Journal of Ginseng Research
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    • v.16 no.3
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    • pp.228-234
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    • 1992
  • There has been general tendency to explain the traditional ginseng efficacy through the pharmacological and biochemical activities of ginsenosides. However, when we analyze the pharmacological and biological data on ginseng reported yet, we can easily arrive at the conclsion that most of the data on pharmacological and biological activities must have been obtained using impure ginsenoside samples, which should contain some non-saponin constituents as impurities. Based on the above back-ground, the non-saponin constituents of ginseng were studied in our laboratory. Phenolic substances including Maltol, Vanillic Acid, Salicylic Acid, Ferrulic Acid and Caffeic acid and impure ginsenoside samples were found to show strong antioxidant and anti-fatigue activities, while pure ginsenosides were devoid of the activities. Maltol, one of antioxidant components In Korean red ginseng drew a special interest due to its very low pro-oxidant activity. The antioxidant activity of ginseng may be considered as scientific basis for the antiageing activity which was described in traditional medicinal material book as "long-term medication of ginseng will improve bio-efficiency and extend life-span" The lignin components, another non-saponin consitutents, isolated from ginseng extract In our laboratory may eplain the hepato-protective activity of ginseng which has been repeatedly rtaimed as one of the efficacies of ginsenosides. The P-carboline alkaloids isolated in our laboratory as one of the non-saponin constituents of ginseng may play some pharmacological activities which should also be investigated. Present paper will include chemistry and biochemical aspects of the non-saponin constituents of ginseng with special interests for the explanation of traditional ginseng efficacy on modern scientific basis.fic basis.

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A Survey on Ancient Literature Records on Woohwangchungsim-won and its potential clincial application (우황청심원의 고문헌기록 및 실험적 연구결과 분석을 통한 임상응용 확대의 필요성 고찰)

  • Oh, Young-Taeck;Oh, Hyeon-Muk;Kim, Seo-Woo;Kim, Won-Yong;Son, Chang-Gue;Cho, Jung-Hyo
    • Journal of Haehwa Medicine
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    • v.26 no.1
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    • pp.1-10
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    • 2017
  • Objectives: The aim of this study is (1) to investigate the historic changes and pharmacological efficacies of Woohwangchungsim-won and (2) to discuss the necessities for Woohwangchungsim-won's clinical applications. Methods: This study was performed through (1) investigating the ancient literature records related with Woohwangchungsim-won and analyzing Woohwangchungsim-won's composition, dosage and indications, (2) searching articles about Woohwangchungsim-won on 10 major Korean web and 3 major foreign web article search engines and analyzing Woohwangchungsim-won's pharmacological efficacies and indications. Results: Woohwangchungsim-wom has been used for cerebrovascular diseases such as stroke and palpitation. Also, there are some ancient literature records of Woohwangchungsim-won's clinical applications in neuropsychiatric disorders such as depression and bipolar disorder. In addition, there have been a number of experimental studies which demonstrate Woohwangchungsim-won's neuroprotective effect on cerebral cortex and hippocampus injury. So, it is possible to infer that Woohwangchungsim-won can be used for the treatments of neuropsychiatric disorders associated with neuronal cell death in cerebral cortex and hippocampus. But there have been no or less experimental studies which demonstrate the pharmacological efficacy of Woohwangchungsim-won on such disease. Conclusion: It is necessary that further experimental studies which demonstrate Woohwangchungsim-won's pharmacological efficacy on neuropsychiatric disorders should be done and Woohwangchungsim-won's clinical applications should be expanded on the basis of those related experimental results.

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Ginseng as a Complementary and Alternative Medicine for Postmenopausal Symptoms

  • Shim, Myeong-Kuk;Lee, Young-Joo
    • Journal of Ginseng Research
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    • v.33 no.2
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    • pp.89-92
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    • 2009
  • Ginseng is a popular herbal medicine that has been used for thousands of years. A number of its components have been isolated and characterized, including ginsenosides, polysaccharides, peptides, polyacetylenic alcohols, and fatty acids. The lipophilic characteristics of ginsenosides have raised the possibility of their efficacy as steroid hormones. Several in-vitro studies have reported their pharmacological function as steroid hormones, especially estrogen, but no human study to date has confirmed their efficacy as alternatives to synthetic estrogen.

Herbal and Pharmacological effects of Ginseng Radix and Strategy for Future Research (인삼의 본초 및 약리 효능과 향후 연구방향)

  • Kim Sung-Hoon;Kim Dong-Hee;Lee Tae-Hyung
    • Journal of Ginseng Research
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    • v.23 no.1
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    • pp.21-37
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    • 1999
  • For the purpose of wide application of Korea Ginseng Radix (KGR) as a tonic and medicinal drug, bibliographical study on Ginseng Radix (GR) was done about its herbal and pharmacological effects known so far. Herbal effect of GR was studied in 28 classical books including Shennongbencaojing(신농본초경), the oldest herbal book in oriental medicine and also its pharmacological effects was compared with its herbal effect. In bibliographical study 38 kinds of efficacies of GR were referred in those books, for example, in fields of gastrointestinal tract, heart, psychology, body fluid, hormone and respiratory tract in order from statistical analysis. GR was chiefly used for supplementing Qi, vital energy in oriental medicine. However, experimental study on respiratory diseases was not reported except lung cancer yet, while GR was used for the treatment of asthma mostly mixed with other herb in oriental medicine. So far research with GR was performed chiefly for isolation of constituents as saponins and evaluation of its efficacy experimentally by KGTR (Korea Ginseng Tobacco Research Institute). From the above studies, to make KGR used widely than before, I suggest study with KGR should be done according to oriental principles such as Qi and tasters and combination theory between herbs excepting typical analytical research with saponins.

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An Integrative Review of Non-pharmacological Intervention in Elderly Patients with Mild Cognitive Impairment (국내 경도인지장애 노인의 비약물적 중재에 대한 통합적 문헌고찰)

  • Kim, Doo Ree
    • Journal of the Korea Convergence Society
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    • v.8 no.5
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    • pp.243-253
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    • 2017
  • The purpose of this study is to provide evidences for developing non-pharmacological intervention program in elderly patients with mild cognitive impairment by integrative review and analyze. An integrative review concept analysis method was used. According to the study result, relevant studies were 11, which are related to non-pharmacological intervention program in elderly patients with mild cognitive impairment. The quality of stduies were two groups nonrandomized studies were 9, and one group nonrandomized studies were 2. Non-pharmacological intervention program studies for elderly patients with mild cognitive impairment were 4 in cognitive training program, 6 in exercise program, and 1 in music program. The efficacy of non-pharmacological intervention in elderly patients with mild cognitive impairment was different by studies, and we need further studies based on these study results.