• Title/Summary/Keyword: ointment bases

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Percutaneous Absorption of Ascorbic acid Dipalmitate in Various Ointment Bases (아스코르빈산 디팔미테이트의 경피흡수에 미치는 연고기제의 영향)

  • Moon, Yong-Koo;Lee, Wan-Ha
    • Journal of Pharmaceutical Investigation
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    • v.21 no.2
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    • pp.97-101
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    • 1991
  • Six different O/W cream bases containing 4% ascorbic acid dipalmitate and two different O/W cream bases containing 1% ascorbic acid were prepared. Percutanceous absorption of ascorbic acid as well as safety were determined using rabbits. The stability of the creams was also tested at room temperature. Ascorbic acid concentrations in urines varied depending on the characteristics of cream bases used. The absorption of ascorbic acid was increased and sustained with the cream bases containing branched chain esters of fatty acid instead of natural oils used currently. The excretion level of ascorbic acid in urine was high with the cream base including nonionic surfactants and a small quantity of natural oils. The creams containing nonionic surfactants showed excellent stability, while those containing anionic surfactants were not stable in terms of pH, odor and coloring test at room temperature during six months. But, the two creams containing ascorbic acid were unstable. All the cream bases tested showed good safety.

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Wall slip of vaseline in steady shear rheometry

  • Song, Ki-Won;Chang, Gap-Shik;Koo, Ja-Seung
    • Korea-Australia Rheology Journal
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    • v.15 no.2
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    • pp.55-61
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    • 2003
  • The steady shear flow properties of vaseline generally used as a base of the pharmaceutical dosage forms were studied in the consideration of wall slip phenomenon. The purpose of this study was to show that how slip may affect the experimental steady-state flow curves of semisolid ointment bases and to discuss the ways to eliminate (or minimize) wall slip effect in a rotational rheometer. Using both a strain-controlled ARES rheometer and a stress-controlled AR1000 rheometer, the steady shear flow behavior was investigated with various experimental conditions ; the surface roughness, sample preparation, plate diameter, gap size, shearing time, and loading methods were varied. A stress-controlled rheometer was suitable for investigating the flow behavior of semisolid ointment bases which show severe wall slip effects. In the conditions of parallel plates attached with sand paper, treated sample, smaller diameter fixture, larger gap size, shorter shearing time, and normal force control loading method, the wall slip effects could be minimized. A critical shear stress for the onset of slip was extended to above 10,000 dyne/$\textrm{cm}^2$. The wall slip effects could not be perfectly eliminated by any experimental conditions. However, the slip was delayed to higher value of shear stress by selecting proper fixture properties and experimental conditions.

Influence of Ointment Base on In Vitro Release Characteristics of Oregonin (오레고닌의 in vitro 방출 특성에 미치는 연고기제의 영향)

  • Im, Tae-Jong;Oh, Il-Young;Park, Young-Mi;Park, Jong-Hyeok;Lee, Min-Won;Cho, Jae-Youl;Lee, Jae-Hwi;Choi, Young-Wook
    • Journal of Pharmaceutical Investigation
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    • v.37 no.4
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    • pp.211-216
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    • 2007
  • The bark of Alnus japonica has been used for the treatment of fever, hemorrhage and diarrehea in oriental traditional medicine. Recently, it was revealed that the diarylheptanoids from the bark of Alnus japonica possess anti-inflammatory activity and are expected to be applicable for atopic dermatitis. In this study, oregonin, one of major active components in the bark of Alnus japonica, was developed in the form of semisolid formulations for topical delivery. Oregonin was incorporated into four ointment bases: O/W cream, W/O cream, hydrophilic ointment and lipophilic ointment. Oregonin release from all formulation prepared was evaluated. Franz cell method and immersion method were employed to characterize the release patterns of drug from each formulation based on solvent availability. O/W cream showed a better release profile than the other formulations when evaluated with Franz cell method with an order of O/W cream, hydrophilic ointment, W/O cream and lipophilic ointment. In the immersion method, hydrophilic ointment showed the greatest release rate at times 1 hour exceeding compared to other bases with an order of hydrophilic ointment, O/W cream, W/O cream and lipophilic ointment. Hydrophilicity and solvent availability of formulation seems to significantly influence the release rate of oregonin from ointment bases. In this study, we successfully characterized the oregon in ointment and found that o/w cream is a promising formulation for the topical delivery of oregonin.

Transdermal Permeation of Riboflavin in Ointment Bases Using Gums & Enhancers (Gum류의 연고제제와 흡수촉진제가 Riboflavin의 경피흡수에 미치는 영향)

  • 오세영;황성규;김판기
    • Journal of Environmental Health Sciences
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    • v.26 no.2
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    • pp.91-96
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    • 2000
  • We investigated characters of transdermal therapeutic system(TTS) and the skin permeability of that with applying drug delivery system(DDS). Natural gums were selected as material of TTS. The permeation of natural gums ointment containing drug in rat skin using diffusion cell model. Permeation properties of materials were investigated for water soluble drug such as riboflavin in vitro. We used glycerin, PEG 600 and oleic acid as enhancers. Since dermis has more hydration than the stratum corneum, skin permeation rate at steady state was highly influenced when glycerin was used in riboflavin. The permeation rate of content enhancer and drug was found to be faster than that of content riboflavin only. These results showed that skin permeation rate of drug across the composite was mainly dependent on the property of ointment base and drug. All the gum ointment tested showed good safety. Proper selection of the materials which resemble and enhance properties of the delivering drug was found to be important in controlling the skin permeation rate.

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The Study on the Hardness of Ointment(IV) -Influences of Temperature on the Apparent Logarithmic Hardness of Ointments- (연고제(軟膏劑)의 경도(硬度)에 관한 연구(硏究)(IV) -온도(溫度)의 변화(變化)가 연고제(軟膏劑)의 대수경도(對數硬度) 미치는 영향(影響)-)

  • Lee, Sook-Kyung
    • Journal of Pharmaceutical Investigation
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    • v.8 no.3
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    • pp.24-31
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    • 1978
  • The relationship between temperature and apparent logarithmic hardness of ointments were clearly demonstrated. The followings were obtained as the results: 1. When the ointment base was mixed with additives and heated or cooled at various temperatures, the apparent logarithmic hardness in the first trend before reaching the critical point is subject to change mainly by the contents of the additive while in the secondary trend after reaching the critical point is subject to change mainly by the temperature. 2. No Change in the critical point was observed at different temperatures. It is assumed that the crittical point of such ointment bases has no relationship with temperatures and that the critical point itself should rather depend on the physicochemical properties of the additives.

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