• Title, Summary, Keyword: nutraceutical

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Isolation and Characterization of Steroids of Nutraceutical Value in Physalis minima

  • Misra Laxmi N.;Lal Pyare;Kumar Devinder
    • Preventive Nutrition and Food Science
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    • v.11 no.2
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    • pp.133-139
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    • 2006
  • There is great demand of nutraceutical secondary metabolites in the world so as to feed the population by improving agricultural production with new varieties of food crops but what is still more important is to add nutrition into the food. Physalis minima, plant of Solanaceae family, contain certain secondary metabolites which enhance the over all metabolic functions of the body. Withasteroids are one of such phytochemicals that are generally regarded as safe. These chemicals are almost monopoly of the plants of Solanaceae. The leaves, stem and roots of P. minima have been examined to yield several steroids, identification of which has been discussed in this paper. These withasteroids contribute to the potential nutraceutical and health function value since incorporation of withanolides in the diet may prevent or decrease the growth of tumors in humans.

Nutraceutical Properties of Dioscorea opposita Thunb. (Yam) Fermented by Lactobacillus bulgaricus and Streptococcus thermophilus

  • Jeon, Byung Ju;Ko, Eun Jung;Kwak, Hae-Soo
    • Journal of Dairy Science and Biotechnology
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    • v.30 no.2
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    • pp.69-74
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    • 2012
  • This study was performed to determine by the ability of the mixed culture of Lactobacillus bulgaricus and Streptococcus thermophilus to ferment Dioscorea opposita Thunb. (yam) and to evaluate the nutraceutical value of fermented yam. The titratable acidity (TA) value increased from 2 to 6% with increased concentrations in both raw yam and extracted lactic acid bacteria (LAB) fermented yam (LFY). The viable cell counts and the allantoin and diosgenin contents were higher in raw LFY at large concentrations (6%) than in extracted LFY samples at all fermentation periods up to 32 h. Based on these data, it confirmed that raw yam fermented by the combination culture of L. bulgaricus and S. thermophilus for various fermentation periods favors the symbiotic growth of LAB and results in higher nutraceutical content.

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Effect of fermented soybean curd residue (FSCR; SCR-meju) by aspergillus oryzae on the anti-obesity and lipids improvement (Aspergillus Oryzae로 발효시킨 비지메주의 항비만 및 지질개선 효과)

  • Lee, Sang-Il;Lee, Ye-Kyung;Kim, Soon-Dong;Lee, Ji-Ean;Choi, Jongkeu;Bak, Jong-Phil;Lim, Jong-Hwan;Suh, Joo-Won;Lee, In-Ae
    • Journal of Nutrition and Health
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    • v.46 no.6
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    • pp.493-502
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    • 2013
  • In this study, we designed to confirm the dietary effect of anti-obesity of fermented soybean curd residue (FSCR; SCR-Meju; Biji-meju) by A. oryzae, which is well known as a Korean traditional meju microbe. We observed that body weight gain, serum and hepatic lipid profile, as well as the activity of ROS generating enzyme and ROS scavenging enzyme in high-fat diet induced obese mice fed experimental diet (SCR and SCR-meju). Body weight gain and epididymal fat weight of HC (high-fat diet control) was markedly higher than that of NC (Normal control). Conversely, body weight gain and epididymal fat weight of the SCR (Biji) and SCR-meju (Biji-meju) group was significantly lower than that of HC; these of the SCR-meju group was lower than that of the SCR group. Furthermore, serum TG and total-cholesterol and LDL-cholesterol contents of SCR and SCR-meju groups were lower than that of HC, and HDL-cholesterol level of the SCR-meju group was significantly higher than that of HC. In conclusion, although precise mechanisms of the antiobese effects of SCR-meju in this study are unknown, the present study provides an experimental evidence that SCR-meju may prevent obesity and obesity related metabolic syndromes, such as hyperlipidemia, hypertension and diabetes, and liver disease by high-fat diet. Nevertheless, further study in this filed will be needed.

Comparison of Biological Activities of Ethanol Extracts of Unripe Fruit of Bitter Melon (Momordica charantia L.) Cultivated in Hamyang, Korea (함양에서 재배된 여주의 추출조건에 따른 생리활성)

  • Moon, Jeong-Han;Choi, Dong-Won;Kim, Seong-Eun;Seomoon, Ji-Hoon;Hong, Su-Young;Kim, Hyun-Kyu;Cho, Kye-Man;Song, Jin;Kang, Sang-Soo;Kim, Kang-Hwa;Kwon, Oh-Kyung
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.44 no.11
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    • pp.1637-1644
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    • 2015
  • To develop health-functional food ingredients for improvement of diabetes, we examined biological activities, including total contents of polyphenols and flavonoids, antioxidant activity, and inhibition of ${\alpha}$-glucosidase and pancreatic lipase activities of ethanol extracts from unripe fruit of Momordica charantia L. cultivated in Hamyang, Korea. Ethanol extracts were tested using different ethanol concentrations (0%, 30%, 50%, and 70%) and temperatures ($50^{\circ}C$ and $70^{\circ}C$). Experimental results showed that total polyphenol and flavonoid contents were achieved concentrations of 7.77 mg/g (tannic acid), 7.66 mg/g (gallic acid), and 10.66 mg/g (rutin). The hydroxyl radical scavenging, ABTS cation radical scavenging, and FRAP activities were 82.19%, 42.82%, and 0.19 under the same conditions, respectively. The highest inhibitory activities of ${\alpha}$-glucosidase and pancreatic lipase were achieved in the 70% ethanol extract at $70^{\circ}C$. These results will be useful for development of health functional foods for anti-diabetes using 70% ethanol extract from unripe fruit of bitter melon.

Anti-obesity Effect of Soybean Curd Residue Fermented by Genus Aspergillus (Aspergillus 속 미생물에 의한 발효비지의 항비만 효과)

  • Lee, Sang-Il;Lee, Ye-Kyung;Kim, Soon-Dong;Lim, Jong-Hwan;Suh, Ju-Won;Lee, In-Ae
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.14 no.11
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    • pp.5800-5808
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    • 2013
  • The anti-obesity effect of soybean curd residues (biji) fermented by seven Aspergillus spp. was investigated with obese ICR mice fed a high-fat diet. After inducing obesity by feeding high-fat diet for 5 weeks, animals were fed with a high fat diet supplemented with 2% fermented soybean curd residues for 6 weeks. Total cholesterol, triglyceride, Alanine transaminase, high-density lipoprotein cholesterol, hepatic content of glutathione and lipid peroxide were determined. In the case of body weight, AE4 group showed most prominent decrease (31.33%, P<0.05) and increase of hepatic GSH and ALT demonstrated hyperlipidemia inhibition. From the results, it is concluded that soybean curd residues fermented by Aspergillus spp. has anti-obesity effect and it is thought that fermented soybean curd resides can reduce obesity in human significantly.

Papaya: A gifted nutraceutical plant - a critical review of recent human health research

  • Karunamoorthi, Kaliyaperumal;Kim, Hyung-Min;Jegajeevanram, Kaliyaperumal;Xavier, Jerome;Vijayalakshmi, Jayaraman
    • CELLMED
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    • v.4 no.1
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    • pp.2.1-2.17
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    • 2014
  • The plant kingdom is considered to be a repository of modern medicine, attributable to their rich source of bio-active molecules and secondary metabolites. It is indeed the Nutraceuticals that enhance immunity and ensure a healthier life because of their prophylactic and therapeutic values. Over centuries, papaya [Caricaceae; (Carica papaya Linn.)] is a renowned nutritious and medicinal plant. Each part of the papaya like root, stem, leaf, flower, fruit, seed, rinds, and latex has its own nutraceutical properties. It serves as food, cooking aid, and Ethnomedicine to prevent and treat wide-range of diseases and disorders. It has also been traditionally used as appetite enhancer, meat tenderizer, purgative, medicinal acne, abortifacient and vermifuge. Over decades, a series of scientific attempts were made to authenticate the nutraceutical properties of papaya. These studies validated that the papaya has antiplasmodial, antitrichochramal, antitrichomonal, antidengue, and anti-cancer activities. They have also exhibited that papaya possesses antiseptic, antiparasitic, anti-inflammatory, antidiabetic, and contraceptive features, and it helps in the management of sickle-cell anaemia, HIV, heart diseases and digestional disorders too. Nevertheless, the responsible bio-active molecules and their mode of actions remain indistinct and imprecise, and this calls for further pharmacological and clinical research on them. Conclusively, papaya is one of the naturally gifted plants; though its nutraceutical properties as a food or as a quasi-drug are poorly understood or undervalued by people. Accordingly, this scrutiny, demand for instigation of public health awareness campaigns to promote papaya consumption, so that the society shall acquire optimal benefits of papaya and in turn prevent and alleviate various diseases and illness.

Anti-multi drug resistant pathogen activity of siderochelin A, produced by a novel Amycolatopsis sp. KCTC 29142 (Amycolatopsis sp. KCTC 29142로부터 유래된 siderochelin A의 다제 내성 균주에 대한 항균활성)

  • Lee, Dong-Ryung;Cheng, Jinhua;Lee, Sung-Kwon;Hong, Hee-Jeon;Song, Jaekyeong;Yang, Seung Hwan;Suh, Joo-Won
    • Korean Journal of Microbiology
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    • v.52 no.3
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    • pp.327-335
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    • 2016
  • A novel Amycolatopsis strain KCTC 29142 was isolated and characterized based on the polyphasic taxonomic analysis including morphological observation, phylogenetic analysis, physiological and chemotaxonomic characteristics. The ethyl acetate extract of strain KCTC 29142 culture broth showed strong antibacterial activity and the active compound was identified as siderochelin A, a ferrous-ion chelating compound. In this study, siderochelin A showed good activity against multi-drug resistant pathogens, including Acinetobacter baumanii, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Staphylococcus aureus (VRSA), and Escherichia coli (E. coli). The minimum inhibitory activity against clinical isolates was also determined.

The effect of nutraceutical containing PRF-K2 on periodontal condition during maintenance phase (치주 유지관리기 환자에게 PRF-K2를 함유한 nutraceutical의 효과)

  • Kim, Yu-Kang;Chung, Hyun-Ju;Kim, Se-Won;Baek, Dong-Heon
    • Journal of Periodontal and Implant Science
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    • v.37 no.1
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    • pp.91-102
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    • 2007
  • The long term success of periodontal treatment is dependent upon the effectiveness of the main-tenance care program after active treatment. The purpose of this study was to evaluate whether nutraceutical containing PRF-K2 as natural product from plant and seaweed has beneficial effects on clinical parameters, gingival crevicular fluid (GCF) volume and GCF cytokine levels during main- tenance phase after periodontal treatment. Among the generally healthy and non-smoking. moderate to severe chronic periodontitis patients during maintenance phase in Department of Periodontics, Chonnam National University Hospital, twenty eight patients took nutraceutical containing PRF-K2 (Oscotec Inc. Cheonan, Korea) for 3 months as experimental group and sixteen patients received only maintenance care as control group. Clinical examination and GCF collection were performed at baseline, 1, 2 and 3 months of experiment. Total amounts and concentrations of GCF IL-1{\beta}, IL-1ra and $PGE_2$ were evaluated using ELISA kit. In probing pocket depth, experimental group showed the tendency of more reduction than control group after 3 months of experiment. Sulcus bleeding index (SBI) and GCF volume were significantly decreased in experimental group(p<0.05), whereas they were increased in control group. GCF IL-1{\beta} level tended to decrease in both experimental and control group and IL-1ra concentration tended to increase in experimental group and to decrease in control group. IL-1ra/IL-1{\beta} ratio tended to increase in experimental group and to decrease in control group during experimental period. GCF $PGE_2$ amount did not show any change in experimental group and tended to increase in control group. These results suggest that nutraceutical supplement which contain PRF-K2 could improve perio-dontal condition during maintenance phase after periodontal therapy.

Comparison of Linarin Content and Biological Activity in Ethanol Extraction of Chrysanthemum zawadskii (구절초의 추출조건에 따른 Linarin 함량과 In Vitro 생리활성 변화)

  • Kim, Yang-Ji;Kim, Seong-Eun;Lee, Hak Sung;Hong, Su-Young;Kim, Sung-Eun;Kim, Young Jun;Lee, Jin Hyup;Park, Sung Jin;Kim, Jun Ho;Park, Youn-Je;Kim, Hyun-Kyu
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.45 no.10
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    • pp.1414-1421
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    • 2016
  • This study was designed to determine optimal extraction conditions of Chrysanthemum zawadskii (CZ) with high yield of bioactive compounds (linarin, polyphenols, and flavonoids) and improved in vitro activities. Ethanol extracts were examined at different concentrations (0, 30, 50, 70, and 95%) and temperatures (50 and $70^{\circ}C$). The recommended extraction conditions were 50% ethanol at $70^{\circ}C$ for 4 h, which gave the highest yield of linarin, polyphenols, and flavonoids. This extract appeared to have the greatest ABTS and DPPH radical scavenging activities (87.81% and 51.42% at $500{\mu}g/mL$, respectively) and ${\alpha}$-glucosidase (74.59%) and pancreatic lipase inhibitory activities (90.44%). As contents of linarin increased, antioxidative activity, inhibitory effects of carbohydrates and lipid absorption of CZ extracts increased as well. From these results, CZ extracts can be used in functional food industries.