• Title/Summary/Keyword: natural product

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A Pyridyl Alkaloid and Benzoic Acid Derivatives from the Rhizomes of Anemarrhena asphodeloides

  • Youn, Ui-Joung;Lee, Yoo-Jin;Jeon, Ha-Rim;Shin, Hyun-Ji;Son, Young-Min;Nam, Joo-Won;Han, Ah-Reum;Seo, Eun-Kyoung
    • Natural Product Sciences
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    • v.16 no.4
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    • pp.203-206
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    • 2010
  • A pyridyl alkaloid, 3-pyridylcarbinol (1) and benzoic acid derivatives, 4-hydroxy benzoic acid (2), 4-hydroxyactophenone (3), vanilic acid (4), and benzoic acid (5) were isolated from the rhizomes of Anemarrhena asphodeloides on the basis of spectroscopic and physicochemical analyses including 1D- and 2D- NMR techniques as well as by comparison of their data with the published values. Compounds 1 - 5 were isolated for the first time from this plant source.

Quantitative Analysis and Validation of Hirsutenone and Muricarpone B from Fermented Alnus sibirica

  • YIN, Jun;YOON, Ki Hoon;YOON, Seong Hye;AHN, Hye Shin;LEE, Min Won
    • Natural Product Sciences
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    • v.23 no.2
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    • pp.146-150
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    • 2017
  • Alnus sibirica (AS) geographically distributes in Korea, Japan, Northeast China and Russia. The bark of this plant had been used for antipyretic, expectorant, anti-phlogistic, antitussive, anti-asthmatic and as a health tea for alcoholism. Recently, we studied various biological activities of AS and the isolated diarylheptanoid. In present study, we conducted fermentation of AS (FAS) and isolated two diarylheptanoid (hirsutenone and muricarpone B). Moreover, we established the validation and contents determinations of the two compounds by HPLC on FAS.

Cancer Chemopreventive Effects of Korean Seaweed Extracts

  • Lee, Saet-Byoul;Lee, Joo-Young;Song, Dae-Geun;Pan, Cheol-Ho;Nho, Chu-Won;Kim, Min-Cheol;Lee, Eun-Ha;Jung, Sang-Hoon;Kim, Hyung-Seop;Kim, Yeong-Shik;Um, Byung-Hun
    • Food Science and Biotechnology
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    • v.17 no.3
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    • pp.613-622
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    • 2008
  • Cancer chemopreventive effects can be exerted through the induction of phase II detoxification enzymes and the inhibition of inflammatory responses. In this study, the cancer chemopreventive effects and anti-inflammatory responses of 30 seaweed extracts were examined. The extracts of Dictyota coriacea and Cutleria cylindrica exhibited the high chemoprevention index, having 4.36 and 4.66, respectively. They also activated antioxidant response element at $100\;{\mu}g/mL$ by about 3-fold while did not activate xenobiotic response element. Seven seaweed extracts, Ishige okamurae, Desmarestia ligulata, Desmarestia viridis, Dictyopteris divaricata, D. coriacea, Sargassum horneri, and Sargassum yezoense, showed significant inhibition on nitric oxide (NO) and prostaglandin $E_2$ ($PGE_2$) production in a dose-dependant manner in $5-20\;{\mu}g/mL$. These seaweed extracts could be used as food materials for cancer chemoprevention. D. coriacea could contain potential chemopreventive agents not only that regulate genes via an ARE-dependent mechanism but also prevent the inflammation through inhibition of NO and $PGE_2$ production.

Chinoketides A and B, Two New Antimicrobial Polyketides from the Endophytes of Distylium chinense with the "Black-Box" Co-culture Method

  • Lv, Meng-Meng;Tan, Ming-Hui;Lu, Li-Wen;Zhang, Rong-Hua;Guo, Zhi-Yong;Liu, Cheng-Xiong;Yang, Jin;Zou, Kun;Proksch, Peter
    • Natural Product Sciences
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    • v.24 no.3
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    • pp.159-163
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    • 2018
  • Two new polyketides, chinoketides A and B (1 - 2) with a known compound xylarphthalide A (3), were isolated from the solid medium of the endophytes from the leaves of the relic plant Distylium chinense with the "black-box" co-culture method, and the structures of two new compounds were elucidated by NMR, MS and CD spectra. And the absolute configurations of chinoketides A (1) and B (2) were determined as 2R,3R,8S and 5R,6S by calculating their ECD spectra to compare with the experimental CD spectra. Finally, the antimicrobial activities were evaluated to Erwinia carotovora sub sp. Carotovora (Jones) Bersey et al, and the results showed that compounds 1 - 3 displayed the antimicrobial activities with MIC value at 20.5, 30.4 and $10.2{\mu}g/mL$.

Chemical Constituents from the Stony Coral Alveopora japonica

  • Youn, Ui-Joung;Lee, Yoo-Jin;Jeon, Ha-Rim;Shin, Hyun-Ji;Son, Young-Min;Nam, Joo-Won;Han, Ah-Reum;Song, Jun-Im;Won, Yong-Jin;Seo, Eun-Kyoung
    • Natural Product Sciences
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    • v.17 no.1
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    • pp.1-4
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    • 2011
  • Chemical investigations of the stony coral Alveopora japonica Eguchi (Poritidae) resulted in the isolation of four known compounds (1 - 4). The structures of 1 - 4 were identified as a sterol, ergosta-5,24(28)-dien-$3{\beta}$-ol (1), a mixture of monoacyl glycrols (2), eicosanoic acid and tetracosanoic acid, and two nucleosides, thymine (3) and 2'-deoxythymidine (4), respectively, on the basis of spectroscopic and physicochemical analyses including 1D- and 2D- NMR techniques as well as by comparison of their data with the published values. Compounds 1 - 4 were isolated from this species for the first time. Moreover, these compounds (1 - 4) were found in the genus Alveopora and the family Poritidae for the first time.

Minor Phenolic Constituents of the Anemarrhenae Rhizoma

  • Youn, Ui-Joung;Lee, Ye-Seul;Jeong, Ha-Na;Nam, Joo-Won;Lee, Yoo-Jin;Son, Young-Min;Hwang, Eun-Sook;Seo, Eun-Kyoung
    • Natural Product Sciences
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    • v.15 no.4
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    • pp.203-207
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    • 2009
  • A homoisoflavanone, 7,4'-dihydroxyhomoisoflavanone (1) and a flavanone, (2S)-7,4'-dihydroxy-5-methoxyflavanone (2), were isolated from the rhizomes of Anemarrhena asphodeloides, together with 4,4'-dihydroxychalcon (3), 2'-O-methylphlorethin (4), 1,3-bis-di-p-hydroxyphenyl-4-penten-1-one (5), and 2,4'-dihydroxy-4-methoxybenzophenone (6) on the basis of spectroscopic and physicochemical analyses including 1Dand 2D- NMR techniques as well as by comparison of their data with the published values. Compounds 1 - 4 were isolated for the first time from this plant source. Among isolates, compound 2 exhibited moderate inhibitory effect on the differentiation of pre-adipocyte 3T3-L1 cells.