• Title, Summary, Keyword: multidrug-resistant microbes

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The Function and Application of Antibiotic Peptides (항생펩타이드의 기능과 적용분야)

  • Lee, Jong-Kook;Gopal, Ramamourthy;Park, Yoonkyung
    • Applied Chemistry for Engineering
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    • v.22 no.2
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    • pp.119-124
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    • 2011
  • Currently, people are exposed to many harmful diseases. Therefore, there are many schemes, such as automation of productive facilities, development of information and communication technology, enhanced the quality of human life and wealth. However, these processes lead to weakened immune system. Thus, people are more vulnerable to infections from pathogens and environmental stress. Misuse and abuse of drugs resulted in the rapid emergence of multidrug-resistant microbes and tumors, therefore, to find new antibiotics are urgently needed. One of them is a peptide-antibiotic, that is not or less occurred a drug-resistance, comparing to conventional drugs. Peptides with various antibiotic activities have been identified from life organisms. The present review provides an overview of activities and application of peptide antibiotics.

Isolation of Multidrug-Resistant Salmonella typhimurium DT104 from Swine in Korea

  • Lee, Ki-Eun;Lee, Yeon-Hee
    • Journal of Microbiology
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    • v.45 no.6
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    • pp.590-592
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    • 2007
  • We report the isolation of Salmonella enterica serotype Typhimurium phage type DT104 (CCARM 8104) from swine in Korea. The CCARM 8104 isolate was resistant to nalidixic acid and showed reduced susceptibility to quinolones. The CCARM 8104 isolate had a missense mutation, Asp87Asn, in the quinolone resistance-determining region in gyrA and produced PSE-1. The CCARM 8104 isolate carried two different class 1 integrons, and the PSE-1 ${\beta}$-lactamase gene was inserted into a 1,200 bp class 1 integron. The presence of DT104 with pse-1 in an integron located in a plasmid and reduced susceptibility to quinolone in swine pose a significant threat of possible horizontal spread between swine and humans.

Antimicrobial Effects of Essential Oils for Multidrug-Resistant Acinetobacter baumanii (다제내성 아시네토박터 바우마니의 에센셜 오일에 대한 항균효과)

  • Park, Chang-Eun;Kwon, Pil Seung
    • Korean Journal of Clinical Laboratory Science
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    • v.50 no.4
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    • pp.431-437
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    • 2018
  • Acinetobacter baumannii is categorized as a red alert pathogen that is increasingly associated with a high mortality rate in infected patients because of its resistance to extensive antibiotics. This study evaluated the antibacterial activities of some essential oils (tee tree, rosemary, and lavender oils) against 18 clinical isolates of multidrug-resistant A. baumannii (MRAB). The carbapenemase screening Hodge test showed that all 20 strains of A. baumannii were resistant to imipenem. The identification of multidrug-resistant microbes was carried out using the VITEK system. The antimicrobial activity of essential oils was tested by a disk diffusion method against MRAB. In the disk diffusion method, tea tree showed the largest increase in inhibition size compared to lavender oil, and rosemary had no antibacterial effect. These results proved the antimicrobial effect of multidrug resistance A. baumannii. Tee tree oil would be a useful alternative natural product for the treatment and prevention of most common human pathogens and MRAB infections. This is expected to be used as an antimicrobial agent, such as hand disinfectant using natural essential oil in the future.