• Title, Summary, Keyword: modifications

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Post-translational Modifications and Their Biological Functions: Proteomic Analysis and Systematic Approaches

  • Seo, Ja-Won;Lee, Kong-Joo
    • BMB Reports
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    • v.37 no.1
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    • pp.35-44
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    • 2004
  • Recently produced information on post-translational modifications makes it possible to interpret their biological regulation with new insights. Various protein modifications finely tune the cellular functions of each protein. Understanding the relationship between post-translational modifications and functional changes ("post-translatomics") is another enormous project, not unlike the human genome project. Proteomics, combined with separation technology and mass spectrometry, makes it possible to dissect and characterize the individual parts of post-translational modifications and provide a systemic analysis. Systemic analysis of post-translational modifications in various signaling pathways has been applied to illustrate the kinetics of modifications. Availability will advance new technologies that improve sensitivity and peptide coverage. The progress of "post-translatomics", novel analytical technologies that are rapidly emerging, offer a great potential for determining the details of the modification sites.

A Comparison of School Uniform Image Preferences and Modifications of School Uniform in Male and Female High School Students (남녀 고등학생의 교복이미지 선호와 교복 변형행동의 비교 연구)

  • Hwang, Jin-Sook;Ahn, Myung-Hwa;Yong, Yu-Jin;Yu, Seung-Yeon
    • Fashion & Textile Research Journal
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    • v.4 no.3
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    • pp.243-247
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    • 2002
  • The purposes of this study were 1) to investigate school uniform image preferences and the uniform modifications of male and female high school students, and 2) to find the differences between male and female students in the uniform image preferences and uniform modifications. The subjects used for the study were 195 male and 201 female high school students. The uniform image preferences consisted of three factors: comfortable & simple, unique & individual, and intelligent & classic. The uniform modifications were measured by the modifications in jacket width, sleeve length, shoulder width, slacks(skirt) length, slacks(skirt) width, and slacks(skirt) waist length. The results showed that male and female students were different in regard to uniform image preference; male students preferred unique image than did female students in their school uniforms. In addition, male and female students differed concerning uniform modifications. Generally, female students modified uniforms more than did male students. Finally, the study compared male and female students in regard to the relationships between uniform image preferences and the uniform modifications. For male and female students, the unique image preference was significantly related to the modifications in different parts of uniform.

FE model updating method incorporating damping matrices for structural dynamic modifications

  • Arora, Vikas
    • Structural Engineering and Mechanics
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    • v.52 no.2
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    • pp.261-274
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    • 2014
  • An accurate finite element (FE) model of a structure is essential for predicting reliably its dynamic characteristics. Such a model is used to predict the effects of structural modifications for dynamic design of the structure. These modifications may be imposed by design alterations for operating reasons. Most of the model updating techniques neglect damping and so these updated models can't be used for accurate prediction of vibration amplitudes. This paper deals with the basic formulation of damped finite element model updating method and its use for structural dynamic modifications. In this damped damped finite element model updating method, damping matrices are updated along with mass and stiffness matrices. The damping matrices are updated by updating the damping coefficients. A case involving actual measured data for the case of F-shaped test structure, which resembles the skeleton of a drilling machine is used to evaluate the effectiveness of damped FE model updating method for accurate prediction of the vibration levels and thus its use for structural dynamic modifications. It can be concluded from the study that damped updated FE model updating can be used for structural dynamic modifications with confidence.

Polymorphism of Q-35 (Balofloxacin) (Q-35(발오플록사신)의 결정다형)

  • Sohn, Young-Taek;Chun, He-Ryun
    • Journal of Pharmaceutical Investigation
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    • v.31 no.2
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    • pp.119-123
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    • 2001
  • Six polymorphic modifications of Balofloxacin (Q-35) were obtained by the recrystallization from different organic solvents and characterized by differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD). The dissolution patterns of these six modifications were also checked in distilled water at $37{\pm}0.5^{\circ}C$, 50 rpm for 60 minutes. The polymorphic modifications showed significant differences in the dissolution rate. The dissolution rate of Mod. 1 was faster than that of other polymorphic modifications. The transformation during storage was also studied.

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Crystal form of SKP1080 (SKP1080의 결정형)

  • Sohn, Young-Taek;Lee, Kyoung-Ee
    • Journal of Pharmaceutical Investigation
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    • v.30 no.4
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    • pp.289-293
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    • 2000
  • Three polymorphic modifications and one amorphous form were prepared by recrystallization under various conditions and characterized by DSC and X-ray crystallography. At $37{\pm}0.5^{\circ}C$, the polymorphic modifications showed significant differences in the dissolution rate. The dissolution rate of Mod. 4, amorphous form, was faster than that of other polymorphic modifications. When all modifications were stored at 52% RH, 95% RH, and in silica gel desiccator, amorphous form was transformed at 95% humidity condition.

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Interactional Modifications in Text-based Chats between Korean and Japanese Students

  • Chu, He-Ra
    • English Language & Literature Teaching
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    • v.12 no.2
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    • pp.1-18
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    • 2006
  • This study investigates the types of interactional modifications employed by Japanese and Korean university students during text-based chats. In particular, this study focuses on the role of a network-based medium on the use of interactional modifications, which have been claimed to facilitate interlanguage development. The results show that students use a variety of features of interactional modifications. The most used strategies were the use of paralinguistic features, framing, overt indication of understanding/agreement, and clarification checks, which reveals inconsistent results with findings from research on the negotiation of meaning in face-to-face interaction. Results suggest that the computer-mediated communication (CMC) environment requires the above mentioned strategies and students are able to adapt to this new context by employing alternative strategies. The majority of negotiations were generated by content and lexical items either to resolve communication problems or to better manage interactions, and very few negotiations occurred in terms of grammar. The findings suggest that text-based synchronous chats can be an effective tool for promoting interactive competence, but their effectiveness on grammatical development is uncertain.

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Crystal Form of A Camptothecin Derivative (Camptothecin 유도체의 결정형)

  • Sohn, Young-Taek;Moon, Hyun-Young
    • Journal of Pharmaceutical Investigation
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    • v.32 no.2
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    • pp.81-85
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    • 2002
  • Three polymorphic modifications of CKD-602, water soluble derivative of camptothecin, were obtained by the recrystallization from different organic solvents and characterized by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and X-ray powder diffraction (XRPD). The major endothermic peaks of the DSC curve of Form 1, Form 2 and Form 3 was shown at $268.71^{\circ}C$, $247.83^{\circ}C$, $244.76^{\circ}C$, respectively. Form 2 was elucidated to be an acetic acid solvate and Form 3 was elucidated to be a methanol solvate. The dissolution patterns of these three modifications were also checked in distilled water at $37{\pm}0.5^{\circ}C$, for 30 minutes. The polymorphic modifications showed differences in the dissolution rate. The dissolution rate of Form 1 was faster than that of other polymorphic modifications. When stored at different relative humidity over the period of 3 months, all of the polymorphic modifications did not undergo transformation.

Histone Modifications and It's Relation with Functional Aspects (히스톤의 변이와 이와 관련된 기능적 측면)

  • Kang, Han-Chul;Kim, Jong-Bum;Roh, Kyung Hee;Kim, Hyun-UK;Lee, Kyung-Ryeol;Kim, Sun Hee
    • Journal of Applied Biological Chemistry
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    • v.57 no.4
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    • pp.379-386
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    • 2014
  • Chromatin is an instructive DNA structure that can widely respond to external signals. An important change of chromatin is the modifications of histone for this regulation. There are accumulating lists of these modifications and the complexity of their action is gradually understood. It is evident that histone modifications play important roles in most biological processes that are involved in the expression or repression of DNA. The surface of nucleosomes is susceptible to multiplicity of modifications. Chromatin modifications can play either by eliminating chromatin contacts or by recruiting non-histone proteins to chromatin. Many of these regulations seem to be epigenetically inherited. Thus, histone modifications are closely correlated with many fundamental biological processes in animal, plant and microbial kingdoms. Failures of histone modification lead, in general, to defective chromosome condensation or decondensation, impeding many biological functions including development, maturation, and protection against various diseases.

Sequence-based 5-mers highly correlated to epigenetic modifications in genes interactions

  • Salimi, Dariush;Moeini, Ali;Masoudi?Nejad, Ali
    • Genes and Genomics
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    • v.40 no.12
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    • pp.1363-1371
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    • 2018
  • One of the main concerns in biology is extracting sophisticated features from DNA sequence for gene interaction determination, receiving a great deal of researchers' attention. The epigenetic modifications along with their patterns have been intensely recognized as dominant features affecting on gene expression. However, studying sequenced-based features highly correlated to this key element has remained limited. The main objective in this research was to propose a new feature highly correlated to epigenetic modifications capable of classification of genes. In this paper, classification of 34 genes in PPAR signaling pathway associated with muscle fat tissue in human was performed. Using different statistical outlier detection methods, we proposed that 5-mers highly correlated to epigenetic modifications can correctly categorize the genes involved in the same biological pathway or process. Thirty-four genes in PPAR signaling pathway were classified via applying a proposed feature, 5-mers strongly associated to 17 different epigenetic modifications. For this, diverse statistical outlier detection methods were applied to specify the group of thoroughly correlated genes. The results indicated that these 5-mers can appropriately identify correlated genes. In addition, our results corresponded to GeneMania interaction information, leading to support the suggested method. The appealing findings imply that not only epigenetic modifications but also their highly correlated 5-mers can be applied for reconstructing gene regulatory networks as supplementary data as well as other applications like physical interaction, genes prioritization, indicating some sort of data fusion in this analysis.

Crystal Forms of Cefaclor (세파클러의 결정형)

  • Sohn, Young-Taek;Jeon, Im-Jak
    • Journal of Pharmaceutical Investigation
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    • v.30 no.3
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    • pp.201-205
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    • 2000
  • Three new polymorphic modifications were prepared by recrystallization under various conditions and characterized by DSC and X-ray crystallography. In pH 4.0 buffer at $37{\pm}0.5^{\circ}C$, the polymorphic modifications showed significant differences in the dissolution rate. The dissolution rate of Mod. 4, amorphous form, was faster than that of marketed cefaclor (Mod. 1). When all modifications were stored at 52% RH, 95% RH and in silica gel desiccator, any polymorphic transformation was not observed.

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