• Title, Summary, Keyword: lung neoplasms

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Metastatic Adenoid Cystic Carcinoma of the Lung Diagnosed by Fine Needle Aspiration Biopsy (세침 흡인 생검으로 진단된 폐의 전이성 선양 낭포암종 1예 보고)

  • Park, So-Yeon;Lee, Kwang-Gil
    • The Korean Journal of Cytopathology
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    • v.1 no.2
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    • pp.175-178
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    • 1990
  • A case of metastatic adenoid cystic carcinoma of the lung, originated from the trachea, was diagnosed by fine needle aspiration. Although the cytologic features of adenoid cystic carcinoma have been well described, it is easy to confuse adenoid cystic carcinoma with more common primary small cell neoplasms of the lung, i.e., small cell carcinoma, well differentiated adenocarcinoma, and carcinoid tumor of the lung. The features distinguishing adenoid cystic carcinoma from these neoplasms include 1) tight, globular, honeycomb pattern of cells, 2) acellualr basement membrane material in the lumen, and 3) cells lacking true nuclear melding and having bland chromatin pattern. The morphologic feature of metastatic adenoid cystic carcinoma in this case was so distinctive as to permit a definite diagnosis by aspiration cytology.

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Are Bladder Neoplasms More Aggresive in Patients with a Smoking-related Second Malignancy?

  • Otunctemur, Alper;Koklu, Ismail;Ozbek, Emin;Dursun, Murat;Sahin, Suleyman;Besiroglu, Huseyin;Erkoc, Mustafa;Danis, Eyyup;Bozkurt, Muammer;Gurbuz, Ahmet
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.9
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    • pp.4025-4028
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    • 2014
  • Background: Relationships between smoking and bladder neoplasms, one of the common malignancies, are well-known. Different smoking-related malignancies may occur together. In this study, we evaluated the stage and grade of bladder neoplasms in patients also featuring lung or larynx cancer. Materials and Methods: From January 2006 to February 2012, patients who underwent surgery for bladder neoplasms in our clinic were screened retrospectively. In the evaluation, 5 patients had larynx cancer and 20 patients have lung cancer in addition, all having been smoking for a long time. The bladder tumor stage and grade were investigated in these 25 cases. Results: Mean age of patients was 66.8 (49-78). In the evaulation, all of 5 patients who had larnyx cancer also had high grade urothelial cancer. One had T2 urothelial, and 3 T1 urothelial cancer. In the same way, all of the 20 patients with lung cancer also have high grade urothelial cancer, three T2, and 13 T1. Bladder cancer stage and grade were determined to be significantly increased in patients with concomitant bladder and lung or larynx cancer. Conclusions: In the patients who have smoking releated second malignancy, bladder cancer prognosis appears more aggressive. We now need a larger series and multi-center studies for understanding relevant pathophysiology.

Surgical Treatment of Synchronous Double Cancer of the Lung and Esophagus - A case report- (폐와 식도에서 동시에 발견된 중복암의 수술적 치료 -1예 보고-)

  • 이재익;우종수;이길수;노미숙;박미경
    • The Korean Journal of Thoracic and Cardiovascular Surgery
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    • v.36 no.11
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    • pp.866-869
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    • 2003
  • Less than 2% of patients with primary esophageal cancers have synchronous primary lung cancers and many patients with these synchronous tumors are deemed ineligible for radical resection by surgeons due to the poor prognoses of both the diseases. However, we believe that carefully selected patients could benefit from one stage curative resection for these synchronous tumors. We experienced a case of synchronous double cancer of the lung and esophagus and performed bilobectomy and Ivor Lewis operation simultaneously. To the best of our knowledge, this is the first report on the good result of one stage curative resection for these synchronous serious tumors in Korea.

Synchronous Multiple Primary Cancers of the Esophagus, Stomach, Lung and Oral Cavity (식도, 위, 폐 그리고 구강에 동시 발생한 다발성 원발암)

  • Shin, Su-Min;Shim, Young-Mog
    • The Korean Journal of Thoracic and Cardiovascular Surgery
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    • v.42 no.5
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    • pp.662-665
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    • 2009
  • A 65-year-old-male had a mass in the oral cavity, and this was ultimately determined to be squamous cell carcinoma and he underwent wide excision for it. Postoperatively, he underwent the staging work up; this showed that he had other cancers in the esophagus, stomach and lung. We performed a curative resection of all the lesions simultaneously. We report here on a case of synchronous multiple cancers of the esophagus, stomach, lung and oral cavity.

Influencing Factors on Uncertainty of Patients Undergoing Chemotherapy for Lung Neoplasms (항암화학요법을 받는 폐암환자의 불확실성 영향요인)

  • Mo, Moon-Hee;Chung, Bok-Yae
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.18 no.4
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    • pp.248-259
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    • 2017
  • This descriptive correlational study was conducted to identify the factors influencing the uncertainty of patients undergoing chemotherapy for lung neoplasms. One hundred and eleven patients were recruited from the chemotherapy clinic of a university hospital. Data were collected from July 25 to December 31, 2014, and analyzed by descriptive statistics, the t-test, ANOVA, the Scheffe test, Pearson's product moment correlation coefficients and multiple regression analysis with SPSS for Windows Version 18.0. The mean score of the uncertainty of the patients undergoing chemotherapy for lung neoplasms was 2.61(${\pm}0.46$), which was higher than that of the patients with other diseases. The uncertainty was positively correlated with the seriousness of the illness (r=.74, p<.01) and consistency of the symptoms (r=.27, p<.01). Multiple regression analysis showed that the (main) factor influencing the uncertainty was the seriousness of the illness, which explained 54% of the uncertainty of the patients undergoing chemotherapy for lung neoplasms. As a result, nursing interventions are needed to reduce the uncertainty of lung neoplasm patients who are receiving chemotherapy. The seriousness of the illness should be considered when developing nursing interventions to reduce the uncertainty of lung neoplasm patients.

Primary Epithelial Myoepithelial Lung Carcinoma

  • Cho, Seong Ho;Park, Sung Dal;Ko, Taek Yong;Lee, Hae Young;Kim, Jong In
    • The Korean Journal of Thoracic and Cardiovascular Surgery
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    • v.47 no.1
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    • pp.59-62
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    • 2014
  • Primary epithelial-myoepithelial carcinoma (EMC) of the lung is an extremely rare neoplasm that originates from submucosal bronchial glands and has been found in the salivary glands, breast tissue, and sweat glands. However, only a few cases in the respiratory tract have been identified. In the literature, most pulmonary EMCs have been reported to have developed endobronchially although a few EMC cases have been presented as intraparenchymatous tumors. We have identified a case of primary EMC that developed in the peripheral lung parenchyma.

Serum CEA Level Change and Its Significance Before and after Gefitinib Therapy on Patients with Advanced Non-small Cell Lung Cancer

  • Qin, Hai-Feng;Qu, Li-Li;Liu, Hui;Wang, Sha-Sha;Gao, Hong-Jun
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.7
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    • pp.4205-4208
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    • 2013
  • Objective: The aim of this study was to explore change and significance of serum carcino-embryonic antigen (CEA) before and after gefitinib therapy in patients with advanced non-small-cell lung cancer (NSCLC). Methods: Forty patients with advanced NSCLCs in III~IV stages were selected as study objects given gefitinib therapy combined with routine local radiotherapy until tumor progression or intolerable toxicity. After treatment, all patients were divided into control and non-control groups according to the results of evaluation based on RECIST 1.1 (Response Evaluation Criteria in Solid Tumors in 2009). Peripheral fasting blood from all patients was collected in the early morning and serum CEA was assessed by electro-chemiluminescence immunoassay (ECLIA) before and after treatment. Before treatment, patients were divided into high CEA group (CEA level > 50 ng/mL) and low CEA group (CEA level ${\leq}$ 50 ng/mL). Adverse reactions were noted and progression-free survival (PFS) in both groups was recorded after long-term follow-up that ended in December, 2012. Results: There was no difference between control and non-control groups in CEA level before treatment (P>0.05), whereas serum CEA decreased more markedly lower in the control group after treatment (P<0.01). All patients were divided into high CEA group (26) and low CEA group (14) according to serum CEA level. There was no statistically significant difference between two groups in adverse reactions (P>0.05) but the rate in former group was lower. Additionally, survival rates at 9 and 12 months in high CEA group were clearly higher than in the low CEA group (P<0.01). Conclusions: Serum CEA level can serve as a biochemical index to evaluate the prognosis with gefitinib treatment for NSCLC.

Clinical Evaluation of Flexible Fiberoptic Bronchoscopy in The Diagnosis of the Lung Cancer (폐암진단에 있어서 Flexible fiberoptic bronchoscopy의 임상적 의의)

  • 이종태
    • The Korean Journal of Thoracic and Cardiovascular Surgery
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    • v.13 no.3
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    • pp.206-211
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    • 1980
  • One hundred and thirteen patients underwent diagnostic fiberoptic bronchoscopy to exclude the presence of the lung cancer at the Department of Thoracic and Cardiovascular Surgery, Kyungpook National University Hospital from January 1979, to July 1980. Sixty five cases of these patients were studied for passible lung cancer by bronchoscopic examination. Patients varied in age from 24 to 75 years, with the highest concentration lying in the sixth decade (49%). male was predominated with sex ratio of 6.3 : 1. Forth three (75.4%) of 57 cases impressed as definitive, and 8(14.5%) of 55 cases impressed as negatibe lung cancer were subsequently proved to have had lung cancer. Positive bronchoscopic biopsy was found in 10 of 14 lung cancers which were situated in the left main bronchus and in 11 of 13 neoplasms involving the right upper lobe bronchus. epidermoid cell carcinomas were most frequent(82.4%). Bronchial biopsy detected 34(79%) of 43 hilar cancers and 1.3(59%) 22 periphera neoplasms, in those patients who had fiberoptic bronchoscopic examinations. In the present series of 65 cases, the lesion was so far advanced when first seen that it was considered inoperable in 31 (47.7%) and operable 34(52.3%), 19(55.9%) of these refusing surgery. fifteen were explored of whom 12(80%) were resectable.

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Year-in-Review of Lung Cancer

  • Son, Ji Woong
    • Tuberculosis and Respiratory Diseases
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    • v.73 no.3
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    • pp.137-142
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    • 2012
  • In the last several years, we have made slow but steady progress in understanding molecular biology of lung cancer. This review is focused on advances in understanding the biology of lung cancer that have led to proof of concept studies on new therapeutic approaches. The three selected topics include genetics, epigenetics and non-coding RNA. This new information represents progress in the integration of molecular mechanisms that to identify more effective ways to target lung cancer.

Druggable Targets of Squamous Cell Lung Cancer

  • Kim, Cheol Hyeon
    • Tuberculosis and Respiratory Diseases
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    • v.75 no.6
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    • pp.231-235
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    • 2013
  • Knowledge of molecular pathogenesis of non-small cell lung cancer has increased remarkably and changed the principles of treatment, especially during the past decade. These advancements have been limited mainly to adenocarcinoma of the lung. Recently, genetic alterations in squamous cell lung cancer (SQCLC) have been detailed and positive results of clinical trials using agents targeting these changes have indicated the potential for improved treatment outcomes for SQCLC.