• Title/Summary/Keyword: liver damage

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Effect of CCl4-induced liver damage on the metabolism of toluene in rats (흰쥐에 있어서 사염화탄소에 의한 간 손상이 toluene 대사에 미치는 영향)

  • Choi, Woo-Chang;Cha, Sang-Eun;Yoon, Chong-Guk
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.7 no.1
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    • pp.61-69
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    • 1997
  • To evaluate an effect of pathological liver damage on the toluene metabolism, the rate were induced acute liver damage with 3 times $CCl_4$ injection (0.1 ml of 50 % in olive oil/100 g body wt.) three days. In the present animal molel, the injection of toluene(0.3 ml of 50 % in olive oil) showed the more decreased urine hippuric acid throughout 24 hr in the liver damage induced animals($CCl_4$-pretreated rats) than normal group. The activities of hepatic aniline hydroxylase, benzylalcohol dehydrogenase and benzaldehyde dehydrogenase were significantly decreased in $CCl_4$-pretreated rats than the normal group at 24 hr after injection of toluene. Furthermore, the benzaldehyde dehydrogenase in pooled liver of $CCl_4$-pretreated rats showed similiar $K_m$ value, but showed the more decreased $V_{max}$ value compared with the normal group by the injection of toluene. These results suggest that the rats induced liver damage with $CCl_4$ may reduce the toluene metabolism.

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Protective Effects of Gami Yugan-tang on Liver Damage in Rats (흰쥐의 간손상(肝損傷)에 대한 가미유간탕(加味愈肝湯)의 간(肝) 보호효과(保護效果))

  • Jung, Hee;Go, Ho-Yeon;Hsia, Yu-Chun;Yeo, Hyun-Soo;Baik, Jong-Woo;Ko, Seung-Gyu;Park, Jong-Hyung;Jun, Chan-Yong;Kang, Jea-Chun
    • The Journal of Internal Korean Medicine
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    • v.29 no.1
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    • pp.265-277
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    • 2008
  • In order to investigate the protective effects of Gami Yugan-tang on liver damage in rats induced by $CCl_{4}$ and d-galactosamine, the serum transaminase(ALT & AST), alkaline phosphatase(ALP), lactic dehydrogenase(LDH), superoxide dismutase(SOD), catalase, glutathione S-transferase(GST), glutathione peroxidase(GPX) for enzyme activities, and lipid peroxidation were measured. All animals were divided into 4 groups: normal group (untreated), control group (treated with 0.9% saline solution), sample I group (treated with 740mg/kg Gami Yugan-tang), and sample II group (treated with 1,480mg/kg Gami Yugan-tang). The results were as follows : 1. The results of liver damage in rats induced by $CCl_4$ : The protective effects of ALT were displayed in sample I and sample II, and AST, ALP, LDH, SOD, catalase, GST, GPX, and lipid peroxidation were noted in sample II group. It showed slight necrosis of hepatic cell and pathologic changes, for example, inflammatory cells infiltration were improved in sample II group compared to the control group. 2. The results of liver damage in rats induced by d-galactosamine : The inhibitory effects of AST, ALT, LDH, and ALP activities were noted in both sample I and sample II groups. The findings from this experiment suggests that Gami Yugan-tang has protective effects against liver damage in rats induced by $CCl_{4}$ and d-galactosamine.

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The Flavonoid Morin Inhibits Dimethylnitrosamine-Induced Liver Damage in Rats

  • Shin, Dong-Soo;Lee, Hye-Eun;Lee, Hee-Woo;Shin, Ji-Young;Yoon, Sik;Chung, Hae-Young;Moon, Jeon-Ok
    • Proceedings of the PSK Conference
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    • pp.122.1-122
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    • 2003
  • Morin, one of the major natural flavonoids has been reported to exhibit a wide range of pharmacological properties. In this study, we investigated the hepatoprotective effect of morin on the dimethylnitrosamine (DMN)-induced liver damage in rats. Oral administration of morin (10, 20mg/kg daily for 4 weeks) into the DMN-treated rats remarkably prevented the elevation of serum alanine transaminase, aspartate transaminase and alkaline phospatase, and bilirubin levels. Morin also increased serum protein level and reduced the hepatic level of malondialdehyde in DMN-treated rats. (omitted)

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Aspirin Inhibits Dimethylnitrosamine-Induced Liver Damage in Rats

  • Lee, Dong-Soo;Lee, Hye-Eun;Shin, Ji-Young;Lee, Hee-Woo;Chung, Hae-Young;Yoon, Sik;Moon, Jeon-Ok
    • Proceedings of the PSK Conference
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    • pp.116.2-116
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    • 2003
  • Aspirin and aspirin-like nonsteroidal antiinflammatory drug have been the mainstay of therapy for rheumatoid arthritis. In this study, we investigated the hepatoprotective effect of aspirin on the dimethylnitrosamine (DMN)-induced liver damage in rats. Oral administration of aspirin (7.5, 15mg/kg daily for 4 weeks) into the DMN-treated rats remarkably prevented the elevation of serum alanine transaminase, aspartate transaminase and alkaline phosphatase, and bilirubin levels. Aspirin also increased serum protein level and reduced the hepatic level of malondialdehyde in DMN-treated rats. (omitted)

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Hepatoprotective activity of Indigofera aspalathoides extract against CCl4-induced liver damage

  • Gupta, M.;Mazumder, U.K.;Haldar, P.K.;Manikandan, L.;Senthilkumar, G.P.;Kander, C.C.
    • Advances in Traditional Medicine
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    • v.4 no.2
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    • pp.100-103
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    • 2004
  • The plant Indigofera aspalathoides are used by a large number of tribes in India for the treatment of various hepatic disorder. The methanol extract of Indigofera aspalathoides (MEIA) was evaluated for its effect on carbontetrachloride $(CCl_{4})$ induced liver damage. Biochemical parameters such as serum glutamine oxaloacetate trasaminase (SGOT), serum glutamine pyruvate transaminase (SGPT), serum alkaline phosphatase (ALP), total serum protein (TP), thiobarbituric acid reactive substances (TBRS) and glutathione content of the liver were estimated to assess liver function and metabolism. Biochemical observations suggest that methanol extract of Indigofera aspalathoides (MEIA) significantly restored the liver function and metabolism towards normal condition in $CCl_{4}$-induced hepatic damage.

The Effect of Mushroom Extracts on Carbon Tetrachloride-Induced Hepatotoxicity in Rats (버섯 추출물이 사염화탄소 유발 간손상에 미치는 영향)

  • 김건희;한혜경
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.27 no.2
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    • pp.326-332
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    • 1998
  • The effect of mushroom extracts from Pleurotus ostreatus and Lentinus edodes on carbon tetrachloride(CCl4)-induced hepatotoxicity was investigated. Rats were administered orally each mushroom extract at the dose of 150mg/kg, foolwed by treatment with CCl4. Liver damage was produced in male Sprague-Dawley rats, after 21hrs from dosing with CCl4(0.25ml/kg) which were given intraperitoneally. Liver damage without renal injury was confirmed by measuring plasma enzyme, creatinine and blood analysis and liver analysis. Plasma aminotransferase activity, and levels of cholesterol and triglyceride were analyzed. Plasma alanine aminotransferase and aspartate aminotransferase activities were decreased by 34% and 61.5% in pretreatment group of Lentinus edodes compared with CCl4 treated group, respectively. The adminstration of all mushroom extracts led the plasma cholesterol and triglyceride levels decrease more than the CCl4-treated rats. These results suggest that Lentinus edodes extract protect liver from damage induced by CCl4.

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Effect of Cuscutae extract on experimentally induced liver damage in rabbits (토사자 추출물이 실험적으로 유발된 가토의 간장기능장애에 미치는 영향)

  • Lee, Myung-Yul;Jun, Sung-Joo
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.18 no.3
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    • pp.333-337
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    • 1989
  • This study was carried out to investigate effects of Cuscutae semen extract(C. S. E) on $CCI_4$-induced liver damage in rabbits and acute toxicity in mice. $LD_{50}(mg/kg)$ of C. S. E. was 7.83g/kg by intraperitoneal administration in mice. C. S. E. groups were showed more rapid recuperation than the control group intoxicated by $CCI_4$ only. SGPT activity was lowered significantly in 800mg/kg after 6 days. The levels of total cholesterol and total bilirubin and alkaline phosphatase were decreased apparently in 800mg/kg from 6 days. It is suggested that C. S. E. can be administered not only as a therapeutic agent(such as liver tonics) but also a healthy food to shorten the recovery time in liver diseases.

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A Study for New Hepatotropic Agents from Natural Resources -The Effect of Azalea Pollen on Aromatic Toxicants Induced Hepatotoxicity- (천연자원을 이용한 간기능 증진제 개발 연구-Aromatic toxicants 에 의해 유도된 간기능 장해에 미치는 진달래 화분립의 영향)

  • 윤수홍;박은주
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.21 no.4
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    • pp.341-347
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    • 1992
  • In search for new drugs and methods of pharmacotherapy of liver damage , the pollen extracts was administrated to the experimental animals and ivnestigated its biochemical effects in the serum and liver when aromatic hepatotoxicants-phenybutazone, aniline and benzo(a) pyrene-was administered. As the results are the pretretment of azalea pollen was prevented the leakage of asartate aminotransaminase (AST), alanine aminotransfease(ALT), alkaline phosphatase (ALP) activity and bilirubin level to serum and liver, except serum lactate dehydrogenase (LDH) activity.

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Alterations of Glutathione and Glutathione-Dependent Enzyme Activities by Monosodium-L-Glutamate in Rats with Carbon Tetrachloride-Induced Liver Damage (사염화탄소와 Monosodium-L-Glutamate 병용투여에 의한 간조직의 환원형글루타치온 함량 및 그의 관련효소활성의 변화)

  • 김형춘;이왕섭;전완주;김수희;주왕기
    • YAKHAK HOEJI
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    • v.35 no.5
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    • pp.384-388
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    • 1991
  • To explore the effect of monosodium-L-glutamate(MSG) on CCI$_{4}$-damaged liver in Wister male rat, 5% MSG solution as drink water were administered after S.C. injection of 0.1 mg/kg CC1$_{4}$ twice a week for 4 weeks. After last administration of MSG, heptic glutathione(GSH) dependent system was assayed. It showed that MSG increased significanly hepatic glutathione(GSH) and glutathione peroxidase(GSH$_{px}$), but decreased glutathione-S-transferase(GST) acivity in normal rats. MSG increased significantly the GSH$_{px}$ and GST activities in rats with CCI$_{4}$-induced liver damage. These results indicate that decrease of GSH dependent systems in CC1$_{4}$ liver injury might be partially elevated by coadministration of MSG.

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Critical Review on an Effect of Dietary Protein Content on the Xenobiotics Metabolism in Rats (식이성 단백질 함량이 Xenobiotics 대사에 미치는 영향)

  • 윤종국
    • Journal of the East Asian Society of Dietary Life
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    • v.5 no.3
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    • pp.385-394
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    • 1995
  • Our previous reports on the effect of dietary protein on methanethiol, ethacrynic acid, bromobenzene and carbon tetrachloride metabolism were overall reviewed. The methanethiol, ethacrynicacid and bromobenzene treated rats showed the more severe liver damage in those fed a low protein diet than those fed a standard protein diet. These xenobiotics treated rats showed the lower content of hepatic glutathione and its conjugated enzyme, glutathione S-transferase activities in those fed a low protein diet than those fed a standard protein diet. In case of carbon tetrachloride treated rats, the liver damage was more reduced in rats fed a low protein diet than those fed a standard protein diet. Concomitantly the hepatic cytochrome P-450 content, and its decreasing rate to the control were lower in rats fed a low protein diet than those fed a standard protein diet.

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