• Title/Summary/Keyword: liver damage

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A Psoriasis Case Report on Liver Damage Related to Scutellaria Radix (황금(黃芩)으로 인한 간손상으로 판단되는 건선 환자 1례 보고)

  • Lee, Ki-Hoon;Yang, Ji-Eun;Chang, Gyu-Tae
    • The Journal of Korean Medicine
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    • v.32 no.4
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    • pp.149-158
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    • 2011
  • Object: Any medication can have the risk of liver damage. To prevent this risk, liver function tests should be monitored carefully during every course of medication. This paper is a psoriasis case report on liver damage related to Scutellaria Radix medication. Shown by this case, herbal medicine has the possibility of liver damage, too. Therefore it should be carefully used under the direction of Oriental Medical Doctors who specialize in it. The purpose of this case report is to suggest this, and that more cases of liver damage related to herbal medicine should be reported. Methods: To monitor the medication's effect on the liver, liver function was evaluated during medications. Reflotron plus was used to evaluate AST and ALT by analyzing peripheral blood. Results: By this test, a case was identified as liver damage caused by a medication including Scutellaria Radix. Conclusion: This case suggests that Scutellaria Radix medication caused liver damage in a certain patient. Therefore, to prevent liver damage related to Scutellaria Radix, doctors should monitor patient's liver function regularly.

Effect of Cyclohexane Treatment on the Liver Damage in CCl4-Pretreated Rats (CCl4전처치한 흰쥐에 Cyclohexane 투여가 간손상에 미치는 영향)

  • 윤종국;김현희
    • Toxicological Research
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    • v.19 no.2
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    • pp.105-114
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    • 2003
  • TO evaluate an effect of cyclohexane treatment on the degree of liver damage, rats were induced liver damage with 10 or 17 times $CCl_4$ injection (0.1 m1/100 g body wt., 50% $CCl_4$ dis-solved in olive oil) at intervals of every other day. Cyclohexane (1.56 g/kg body wt., i.p.) was administrated to the animals at 48 hours after the last pretreatment of $CCl_4$ . Rats were sacrificed at 4 hours after injection of cyclohexane. On the basis of histopathological findings, liver weight/body weight (LW/ BW, %), activities of serum alanine aminotransferase (ALT), xanthine oxidase (XO) and akaline phosphatase (ALP), and contents of liver protein and manlondialdehyde (MDA), $CCl_4$ -pretreatment induced liver damage. And $CCl_4$ 17 times treated group showed more severe liver damage than $CCl_4$ 10 times treated group. Administration of one dose of cyclohexane to $CCl_4$ 10 times treated animals resulted in the enhanced liver damage; liver necrosis with proliferation of fibroblast and bile duct abnormality, and increase in hepatic MDA content and the activities of serum ALP and ALT, But the enhanced liver damage was not found in $CCl_4$ 17 times treated animals. Serum cyclohexanone concentrations at 4 or 8 hours after injection of cyclohexane were higher in all liver damaged groups than normal group and were somewhat higher In $CCl_4$ 17 times treated animals than $CCl_4$ 10 times treated ones. Among the oxygen free radical metabolizing enzymes, hepatic cytochrome P45O dependent aniline hydroxylase (CYPdAH) activity in cyclohexane metabolizing enzyme system was meaningfully increased by the injection of cyclohexane to the liver damaged rats, with increased Vmax and high affinity to aniline. LW/BW (%) and activities of serum XO and ALT were more significantly increased in liver damaged groups than normal group by administration of cyclohexanone. In conclusion, it is assumed that an enhancement of liver damage by injection of one dose of cyclohexane to liver damaged animals might be caused by oxygen free radicals and cyclohexanone.

Hepatoprotective Effects of Andrographis paniculata against Carbon Tetrachloride-Induced Liver Damage

  • Rana, A.C.;Avadhoot, Y.
    • Archives of Pharmacal Research
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    • v.14 no.1
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    • pp.93-95
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    • 1991
  • Alcoholic extract of the leaves of Andrographis paniculata Ness (=AAP) was obtained by cold maceration. A dose of 300 mg/kg $(1/6of\;LD_{50})$ of the extract was selected to study hepatoprotective action against carbon tetrachloride-induced liver damage. The extract was found to be effective in preventing liver damage which was evident by morphological, biochemical and functional parameters.

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Study on Bromobenzene Metabolism in Rats with Liver Damage (흰쥐에 있어서 간손상 정도에 따른 Bromobenzene 대사)

  • 신중규
    • Toxicological Research
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    • v.13 no.4
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    • pp.371-376
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    • 1997
  • To compare the severe liver damage with the slight one on the bromobeazene metabolism in rats, the animal group described as B7 group was induced the stage of slight liver damage with 7 times bromobenzene injection every other day (400 mg/Kg body wt. i.p.), whereas B40 group was induced that of more severe liver damage with bromobeazene 40 times injection as identified with determination of serum levels of alanine aminotransferase(ALT) activity and the histopathological findings. In the present experimental animal model, the decreasing rate of glutathione(GSH) and the increasing rate of glutathione S-transferase activity to the control group were higher in B7 group than B40 group. Furthermore the single dose of bromobenzene was injected to the two groups and sacrificed at 8hr and the hepatic aniline hydroxylase(AH) activity, GSH content and GST activity were determined. The increasing rate of AH activity to the control was lower in B40 group than B7 group and the decreasing rate of GSH to the control was also lower in B40 than B7 group. Moreover, B7 group showed the increased activity of hepatic GST to the control whereas B40 group showed the decrease activity of the enzyme. And Vmax value in GST was more decreased in B40 group than B7 group.

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Preventive effects of water extracts from Artemisiae Iwayomogi Herba on hyperlipiderma and liver damage induced by alcohol (한인진(韓茵蔯)이 알콜 투여로 유발된 흰쥐의 고지혈증과 간 손상의 예방에 미치는 영향)

  • Seo, Bu-Il
    • The Korea Journal of Herbology
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    • v.22 no.1
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    • pp.103-110
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    • 2007
  • Objectives : This study was performed to prove the preventive effect of water extracts from Artemisiae Iwayomogi Herba on hyperlipiderma and liver damage induced alcohol. Methods : Except for the normal group, we fed rat on 25% alcohol for 55 days. And Artemisiae Iwayomogi Herba extract was administrated for the same period. We measured the serum component in rat's blood. body weight and weight of liver. Result : At first, we observed preventive effects of Artemisiae Iwayomogi Herba on hyperlipiderma induced by alcohol. Artemisiae Iwayomogi Herba group showed significant decrease of total cholesterol and triglyceride in comparison with those of the control group. Artemisiae Iwayomogi Herba group showed significant increase of body weight in comparison with those of the control group in 4weeks and 8weeks. At second, we observed preventive effects of Artemisiae Iwayomogi Herba on liver damage induced by alcohol. Artemisiae Iwayomogi Herba group showed significant decrease of GOT, ALP and LDH in comparison with those of the control group. Artemisiae Iwayomogi Herba group showed significant increase of liver weight in comparison with those of the control group. Conclusion : Reviewing these experimental results, it appears that water extracts from Artemisiae Iwayomogi Herba have pharmaceutical preventive efficacy on hyperlipiderma and liver damage induced by alcohol. Therefore further additional study should be conducted to elucidate in depth the pharmaceutical efficacy of Artemisiae Iwayomogi Herba.

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Effect of Cyclohexane and Xylene Mixture Treatment on the Liver Damage in Rats

  • Shin, Joong-Kyu
    • Biomedical Science Letters
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    • v.9 no.2
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    • pp.93-98
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    • 2003
  • To investigate the cyclohexane and xylene mixture treatment on the liver damage, the rats were treated by the mixture of cyclohexane and xylene (CH+X) and then, liver damage was demonstrated by liver function findings based on liver weight/body weight, serum level of alanine aminotransferase (ALT), xanthine oxidase (XO) and then compared with cyclohexane treated group (CH group) and xylene-treated group (X). The CH+X group showed merely severer liver damge than CH or X group. On the other hand, CH+X group showed lower activity of hepatic cytochrome P-450 dependent aniline hydroxylase (CYPdAH) than CH or X group, but no statical differences were demonstrated among three experimental groups. Especially the hepatic GSH content was merely declined than CH or X group and the activity of hepatic GST was higher in CH+X group than CH or X group. In conclusion, cyclohexane and xylene mixture treated animals showed merely severer liver damage than cyclohexane or xylene treated group and such a fact may be caused by inhibition of cyclohexane or xylene metabolism and oxygen free radical.

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Preventive Effect of Sarcodon aspratus Extract on the Liver Damage in B(a)P-Treated Mice (벤조피렌을 투여한 마우스에서 향버섯 추출물의 간 손상 예방 효과)

  • 이갑랑;배준태;장종선;박준홍;박선희;김지영;오은정;김현정;김옥미
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.30 no.2
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    • pp.320-324
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    • 2001
  • To investigate the effect of Sarcodon aspratus methanol extract on liver damage in benzo(a)pyrene (B(a)P)-treated mice, mice were divided into 4 groups of control, B(a)P, Sarcodon aspratus methanol extract and Sarcodon aspratus methanol extract-B(a)P. The activities of serum aminotransferase, cytochrome P-450 and hepatic content of lipid peroxide after B(a)P-treatment were increased than control, but those levels were significantly decreased by the treatment of Sarcodon aspratus methanol extract. On the other hand, the hepatic glutathione content and glutathione S-transferase activity were increased by the treatment of Sarcodon aspratus methanol extract. Also the activities of superoxide dismutase, catalase and glutathione peroxidase were decreased by the treatment of Sarcodon aspratus methanol extract. In addition cytochrome P-450 1A1 isozyme protein level, which was remarkably increased by B(a)P treatment from results of immuno blotting, was decreased by the treatment with methanol extract of Sarcodon aspratus. These results suggest that Sarcodon aspratus methanol extract have protective effect on liver damage by decreasing lipid peroxide and activities of free radical generating enzymes.

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Inhibitory Effect of Coprinus comatus Ethanol Extract on the Liver damage in Benzo(a)pyrene-treated Mice (먹물버섯 에탄올추출물이 Benzo(a) pyrene 투여에 의한 마우스의 간 손상에 미치는 영향)

  • 이갑랑;이병훈;김현정;장종선;배준태;박선희;이승언;김옥미;이별나
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.28 no.6
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    • pp.1364-1368
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    • 1999
  • This study was carried out to investigate the inhibiton effects of Coprinus comatus ethanol extract of edible mushroom on liver damage in benzo(a)pyrene (B(a)P) treated mice. The activities of serum aminotransferase, cytochrome P 450 and hepatic content of lipid peroxide after B(a)P treatment were increased than those of control, but those levels were significantly decreased by the treatment of Coprinus comatus ethanol extract. Whereas, the hepatic glutathione content and glutathione S transferase activity were decreased by B(a)P treatment than those of control, but those were increased by the treatment of Coprinus comatus ethanol extract. Also the activities of superoxide dismutase, catalase and glutathione peroxidase after B(a)P treatment were markedly increased than those of control, but those levels were decreased by the treatment of Coprinus comatus ethanol extract. These results suggest that Coprinus comatus ethanol extract have a protective effect on liver damage by benzo(a)pyrene through the mechanisms of decreasing lipid peroxide and activities of free radical generating enzymes.

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Effects of G009 on Chemical-Induced Liver Damage in Rats (G009의 간 보호작용에 관한 연구)

  • Lee, Joo-Young;Park, Ki-Sook;Chung, Jin-Ho;Cho, Mee-Jung;Ko, Kwang-Ho;Lee, Jun-Woo;Jeong, Hoon;Lee, Seung-Yong
    • Biomolecules & Therapeutics
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    • v.2 no.2
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    • pp.206-212
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    • 1994
  • The present study was performed to determine the protective effect of G009 on liver damage induced bv ethanol $CCl_4$ and thioacetamide in rats. In acute fatty liver animal model induced by ethanol, triglyceride accumulation was markedly decreased to the normal control level by 25 mg/kg G009 treatment. In addition, G009 significantly reduced serum ALT and AST levels in $CCl_4$-induced acute hepatitis animals. Treatment of G009 to the acute hepatitis rats induced by thioacetamide resulted in a dose dependent reduction of serum ALT level as well as AST level up to the normal control level. These protective effects of G009 were confirmed by histological examinations of the liver. These results suggested that G009 could be effective for the protection from the liver damage induced by ethanol, $CCl_4$and thioacetamide.

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An Effect of Bromobenzene Treatment on the Liver Damage of Rats Previously Fed Low or High Protein Diet (단백식이 조건을 달리하여 성장시킨 흰쥐에 Bromobenzene 투여가 간손상에 미치는 영향)

  • 신중규;채순님;윤종국
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.23 no.6
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    • pp.894-898
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    • 1994
  • To evaluate an effect of dietary protein on the liver damage, the bromobenzene was intraperitoneally injected to the rats fed a low or high protein diet and then the liver weight per body weight and serum levels of alanine aminotransferase (ALT) activities were determined to demonstrate the differences in liver damage between the groups fed low or high protein diet. Hepatic aniline hydroxylase (AH), glutthione (GSH) content and glutathione s-transferase(GST) activity were also determined to clarify causes of liver damage between the two groups. Increases of liver weight per body weight and serum ALT activities were higher in brombenzene treated rats fed low protein diet than those fed high protein diet. The increasing rate of hepatic AH activity was higher in bromobenzne-treated rats fed low protein diet than that in those fed high protein diet. Furthermore , hepatic glutathione contents and GST activities in bromobenzene-treated rats were higher in rats fed high protein diet than those fed low protein diet. In case of control group, the heaptic glutathione content and GST activity were also higher in rats fed high protein diet than those fed low protein diet.

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