• Title, Summary, Keyword: liver cirrhosis

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Diagnosis of liver cirrhosis (간경변의 진단)

  • Seo, Yeon Seok
    • Journal of the Korean Medical Association
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    • v.60 no.7
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    • pp.561-567
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    • 2017
  • Liver cirrhosis results from chronic liver injury that leads to necroinflammation and fibrosis. The development of liver cirrhosis is significantly associated with increased morbidity and mortality. Liver biopsy has been considered to be the gold standard for the diagnosis of liver cirrhosis, which is characterized by diffuse fibrosis and the development of regenerating nodules. However, liver biopsy is invasive and has some drawbacks, such as sampling error and intraobserver and interobserver variability in the assessment of fibrosis stages. Recently, various non-invasive tests such as serum markers, radiologic tests, and elastography have been investigated to overcome the limitations of liver biopsy. This review will focus on the use of these non-invasive tests for diagnosing liver cirrhosis.

The Clinical Study on 33 Cases of Liver Cirrhosis (간경변으로 입원한 환자 33례에 대한 분석)

  • Choi, Seo-Hyoung;Sim, Min;Kim, Tae-Soo;Min, Ji-Yeon;Choi, Young-Gyoo
    • The Journal of Internal Korean Medicine
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    • v.26 no.4
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    • pp.836-843
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    • 2005
  • Objective : Liver cirrhosis is a disease of the liver in which normal cells are replated by scar tissue. Chronic liver disease and liver cirrhosis are the foutth ranked causes of death in Korea. However, clinical data on liver cirrhosis is not accumulated in oriental medicine. Therefore, clinical characteristics of 33 liver patients admitted to Hana Oriental Hospital from May 2004 to May 2005 were studied. Methods : Clinical characteristics of liver cirrhosis, such sex, age, causes, Child-Pugh class, chief complain, abdomen ultrasonography, disease duration, past history, blood test and urinalysis were reviewed. Results : The results of this study were as follows: 1 The distribution of sex and age in our study is similar to already reported statistics. 2. Hepatitis B and alcohol are the major factors to cause the liver cirrhosis. Diabetes and hypertention contribute more to cause than they have in previous histories. 3. Major symptoms are following: fatigue 87.9%, ascites 84.8%, jaundice 78.8%, leg edema 72.7%, dyspepsia 45.5%. 4. Most liver cirrhosis patients have pancytopenia. Standard Deviation accentuates the big differences between total bilirubin and serum amonia. 5. In urinalysis, Urobilinogen 19 patients (57.6%), bilirubin 12 patients (36.4%), blood 15 patients (45.5%) are positive. 11 cases of 15 in blood positive results scored $3{\sim}4+$. Contusions : In oriental medicine, it will be necessary to research and develop oriental medical therapies for liver disease including liver cirrhosis.

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Dynamic Hepatic Blood Flow Scan of Liver Cirrhosis by Arterialization Index (동맥혈화지표 (Arterialization Index)를 이용한 간경화증의 혈류측정)

  • Kim, I.Y.;Yoo, H.S.;Lee, J.T.;Park, C.Y.
    • The Korean Journal of Nuclear Medicine
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    • v.17 no.2
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    • pp.19-24
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    • 1983
  • The purpose of this study was to develop a method by which the sensitivity of radionuclide liver imaging for detection of liver cirrhosis could be enhanced. Dynamic blood flow scan were performed 21 cases of liver cirrhosis patients by using computerized gamma camera named arterialization index. The results were as follows: 1) Arterialization index were higher in liver cirrhosis comparing to normal value 0.33 and its mean is 2. 02. 2) Comparing to static liver scan, higher sensitivity in dynamic hepatic blood flow scan for detection of liver cirrhosis. Sensitivity for detection of liver cirrhosis is over 90%. 3) There are no correlation between arterialization index and serum albumin level. The use of hepatic dynamic blood flow scan proved effective in detection of liver cirrhosis. However, the test may be used as an aid in distinguishing between normal and pathologic livers.

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Saenggangeonbi-tang's Effect on Alcoholic Liver Cirrhosis - 1 Case (생간건비탕가감을 투여한 알콜성 간경변증 환자 치험 1례)

  • 이은;고흥
    • The Journal of Korean Medicine
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    • v.21 no.3
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    • pp.213-219
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    • 2000
  • We treated a 53 year-old male patient. He had alcoholic liver cirrhosis and diabetes. The main symptoms were fatigue, ascites, edema, anorexia, indigestion, constipation, and abdominal pain. We diagnosed him as 'the retention of pathogenic damp-heat in the liver and gall bladder’ and adminstered Saenggangeonbi-tang three times a day. We observed clinical symptoms, liver function test(AST, ALT, ${\gamma}-GT$, ALP, total bilirubin), nutritional state(total protein, albumin) and capillary blood glucose. After treatment, all the main symptoms disappeared and the patient's nutritional state has improved. Child's grade using the improvement index in liver cirrhosis has changed from B to A. Although the very mechanism of Saenggangeonbi-tang was not proven, we could suggest that Saenggangeonbi-tang is not toxic to the liver and has a good effect on alcoholic liver cirrhosis with diabetes mellitus.

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The Experience of Patients with Liver Cirrhosis (간경변증 환자의 경험)

  • Kim, Boon-Han;Kim, Yoon-Sook;Kim, Hye-Ran;Cho, Mi-Sun;Kwon, Mi-Hyoung
    • Korean Journal of Adult Nursing
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    • v.16 no.4
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    • pp.608-616
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    • 2004
  • Purpose: The aim of this study was to identify the experience of patients with liver cirrhosis. Method: This study was performed from march 2003 to June 2003. The participators were five men. Data collected through in-depth personal interviews, which were recorded and analysed according to the Colazzi's method. Result: Liver cirrhosis was classified into 20 themes, 70 formulated meaning, and 10 categories. The Result confirmed that the experience of liver cirrhosis patients were classified into 10 categories; unexpected change, limited daily living and role, difficult compliance with therapeutic regimen, unbelief so untreated with apathy, negative emotional change, lack of cause perception, self control, perceived family support, expectations for recovery and healing. Conclusion: We, cooperative researchers, realized that to reduce not only the days of hospital treatment and the economic loss, as well as the expenditure of insurance the importance of managing liver cirrhosis from early diagnosis and the physical, spiritual, social role in studying the patients who experience liver cirrhosis.

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Construction of Model for Health-related Quality of Life of Liver Cirrhosis Patients (간경변증 환자의 건강관련 삶의 질 모형구축)

  • Kim, Ji Suk;Hong, Hae Sook
    • Journal of Korean Biological Nursing Science
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    • v.16 no.4
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    • pp.292-299
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    • 2014
  • Purpose: This is a study on the structural model that aims to build a path model of multivariates affecting the quality of health-related living for liver cirrhosis patients and specify causal relations affecting the quality of health-related living for liver cirrhosis patients. Methods: The research was conducted on 244 patients diagnosed with liver cirrhosis and the data were collected from July 2013 to January 2014. The collected data were analyzed using IBM SPSS 19.0 and AMOS 21.0 statistical programs. Results: All the fit indexes of the path model properly met the assessment criteria. Anxiety, depression, functional status, and perceived health directly affected the quality of health-related living for liver cirrhosis patients and anxiety, depression, and functional status directly affected perceived health. Social support, anxiety, and depression directly affected the functional status. Conclusion: It is necessary to segment the severity of liver cirrhosis in testing its direct and indirect effects on the quality of health-related living for patients with the condition.

Pilot Study: Effects of Acupuncture on the Muscle Cramps of Liver Cirrhosis Patients

  • Kim, Seung-mo;Kwak, Min-ah;Joo, Jeong-hyun;Kim, Kyung-soon;Shin, Im-hee;Lee, Chang-hyeong
    • The Journal of Internal Korean Medicine
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    • v.39 no.3
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    • pp.293-301
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    • 2018
  • Objective: The purpose of this clinical trial is to examine the efficacy and safety of electroacupuncture on liver cirrhosis patients suffering from muscle cramps. Methods: A total of 14 liver cirrhosis patients with muscle cramps were treated by electroacupuncture three times a week for four weeks (12 times total). The electrical stimulation was a frequency of 100 Hz. Evaluation of the muscle cramps was measured by a questionnaire of subjective symptoms. The patients' condition was evaluated four times over a period of eight weeks. We also assessed the deterioration of liver disease using the Child-Pugh score and blood tests. Results: This study proves that four weeks of electroacupuncture treatment is effective in reducing the frequency of muscle cramps and that the effects of electroacupuncture treatment lasted during another four-week follow-up period after treatment. Conclusions: This study suggests that electroacupuncture treatment is beneficial for improving muscle cramps in liver cirrhosis patients (p=0.000). Electroacupuncture is thought to be a safe treatment for liver cirrhosis patients with muscle cramps without contributing to the worsening of liver function. Further study with a larger sample size is needed to confirm our findings.

Antifibrotic Effects of Oriental Herbs Extraction on Liver Cirrhosis (한약재(자하거, 백출, 차전자) 추출물의 간경화 억제효능에 관한 연구)

  • Yu, Byung-Soo;Lee, Jong-Hyung;Cho, Syung-Eun;Baek, Seung-Hwa
    • YAKHAK HOEJI
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    • v.51 no.1
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    • pp.7-12
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    • 2007
  • Hepatic cirrhosis is an important feature of chronic liver disease. Liver cirrhosis is characterized by hyperaccumulation of fibrous tissue components and is commonly observed in latter or terminal states of chronic hepatic disease. The antifibrotic effects on liver cirrhosis by oriental herbs extraction material were examined in bile duct ligated rats. Oriental herbs extraction (0.99 mg/kg rat weight/day) was administrated to cirrohotic rats for 4 weeks. Liver collagen content of bile duct ligated rats was significantly increased. And liver histology showed collagen fiber deposition was increased as well as the normal architecture was lost with large zone of necrosis being observed. Herbs extraction administrated rats showed significantly decreased liver collagen content, accumulation of collagen fiber in histological analysis, and biochemical markers of hepatic diseases. Those results demonstrate the usefulness of herbs extraction materials as an antifibrotic agent for liver cirrhosis.

Alcohol and Liver disease (알코올과 간질환)

  • 박병채
    • Journal of Life Science
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    • v.5 no.3
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    • pp.145-150
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    • 1995
  • Alcoholic liver disease is defined by the development of three types of liver damage following chronic heavy alcohol consumption, namely, alcoholic fatty liver, alcoholic hepatitis, and alcoholic cirrhosis, The clinical features and laboratory tests often do not distinguish among these types of liver injuries. In addition, a considerable number of the patients who have clinical and laboratory features compatible with alcoholic liver disease are diagnosed on liver biopsy to have chronic viral hepatitis or other lesion. Because of these factors, liver biopsy is frequently needed to arrive a definite diagnosis of the disease, its activity, and its chronicity. Fatty liver is usually a benign and reverible condition that disappears on abstinence from alcohol. However, alcoholic hepatitis is usually regarded as a precursor of cirrhosis. The principle factors in the development of alcoholic hepatitis and cirrhosis are the quantity and length of ingestion of alcohol. women are much more susceptible than men to hepatic injuries. Since only 10 - 20% of alcoholics develop cirrhosis, however, it is conceivable that other factors, either genetic, environmental, or nutritional may contribute in the genesis of liver injuries. The most important factor in the treatment of alcoholic liver disease is prolonzed abstinence from alcohol, since abstinence by itself improves clinical status and survival, Nutritional support in patients with nutritional deficiency, and specific drug therapies such as corticosteroid or anabolic steroids for hospitaliged patients with severe alcoholic hepatitis also play an important role in devreasing morbidity and improving survival. Liver transplantation is a newer treatment modality in the patients with advanced cirrhosis, not responsible to medical treatment.

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Experimental Hepatic Cirrhosis in Rats (실험적 간경화 동물모델 비교)

  • Park, Eun-Jeon;Kim, Jae-Baek;Sohn, Dong-Hwan;Ko, Geon-Il
    • YAKHAK HOEJI
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    • v.41 no.5
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    • pp.622-628
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    • 1997
  • Hepatic cirrhosis is a common response to chronic liver injury from many causes and is one of the most common cause of all deaths. This study was carried out to compare experimental hepatic cirrhosis in rats to understand this disease and to apply for the pharmacokinetics in disease state. Following three kinds of experimental models were induced; 1) Bile duct ligation/scission (BDL/S), 2) N, N-dimethylnitrosamine(DMN), 3) Carbon tetrachloride. The hepatic cirrhosis was characterized by examing the liver/body weight ratio, serum biochemical values, hydroxyproline content in liver and histopathological lesions in cirrhotic rat liver. The results are as follows : (1) In BDL/S, the liver was enlarged to 250% of normal liver. In contrast the liver was shrinked to 48% and 78% of the normal liver in DMN and carbon tetrachloride, respectively. (2) In carbon tetrachloride and BDL/S, the serum ALT, AST, ALP and total bilirubin levels were significantly increased to 200~300% of normal level, while ALT and total bilirubin levels were significantly increased in DMN group. (3) Hydroxyproline content in cirrhotic rat liver was significantly 200~500% higher than that of normal liver. (4) Nodular formation with fibrosis was observed in BDL/S, DMN, carbon tetrachloride induced cirrhotic rat liver.

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