• Title, Summary, Keyword: isoflavone

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The Effect of Soy Isoflavone Supplementation on Urinary Isoflavone Excretion in Korean Postmenopausal Women (폐경 후 여성에서 이소플라본 공급에 따른 소변 중 이소플라본 배설량 변화에 관한 연구)

  • 승정자
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.31 no.6
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    • pp.1043-1047
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    • 2002
  • It is well known that soy isoflavones play beneficial roles in the prevention of chronic diseases such as breast cancer, cardiovascular disease and osteoporosis. However current data are not sufficient for estimating the level of isoflavone intake. To use the urinary isoflavone excretion as a maker of isoflavone intake,26 participants consumed the isoflavone extract capsule (90 mg soy isoplavones/capsule) daily for 3 months. The study compared effects of pre- and post-isoflavone supplement in the following parameters; physical examination, dietary recalls, and urinary isoflavon excretion. The average age, height and weight were 65.7 years, 149.4 cm, and 57.3 kg. Subjects maintained regular diet pattern, and average daily nutrient intakes between pre- and post- supplementation were not significantly different except vitamin A, carotene and vitamin C. There was no significant difference between pre- and post- supplementation in terms of daily isoflavone intake. The basal urinary isoflavone excretion was 8.37 mg/day (daidzein 6.23 mu genistein 2.14 mg), and average daily excretion rate was IS.8%. Urinary isoflavone excretion was significantly increased, after isoflavone supplementation for 3 months as compared the basal level (p<0.01). Our data suggest that urinary isoflavone level, especially daidzein and genistein, may be a useful maker to estimate isoflavone intake.

Effect of Nitrogen Fertilization levels on Growth and Isoflavone Content in Soybean (질소시비수준이 콩의 생육 및 isoflavone 함량에 미치는 영향)

  • Lee Mi-Ja;Park Jong-Chul;Oh Young-Jin;Kim Kyong-Ho;Kim Hyung-Soon;Lee Sang-Bok;Kim Jung-Gon
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.51 no.5
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    • pp.445-450
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    • 2006
  • The nitrogen fertilization effect on growth characteristics and isoflavone content was investigated in this study, and isoflavone analyzed by HPLC with photodiode array (PDA) detector and reverse-phase $C_{18}$ column. Fertilization levels were no-fertilization, no nitrogen, 50% decreased in nitrogen, standard and 50% increased in nitrogen fertilization. The 50% increased nitrogen fertilization showed the highest growth characteristics then other fertilization level and the number of pod and seed showed maximum value 31.9 and 72.3, respectively, and seed yield was 2,460 kg/ha. During growth stages, isoflavone content in leaf, stem and root of soybean plants decreased to R5 stage then increased to R7 stage. Isoflavone content according to various nitrogen fertilization condition, in case of none fertilization, no nitrogen, 50% decreased nitrogen fertilization showed higher value than those of standard and 50% increased nitrogen fertilization levels. Aglycon content among the isoflavone isomers showed much higher in plant than in seed. The highest isoflavone content was found in the root of soybean plant parts. Isoflavone content of seed was higher in none, no nitrogen, 50% decreased nitrogen than those of standard and 50% increased nitrogen fertilization.

Yields and Isoflavone Contents of Soybean Cultivar in Highland Area (국내 육성 콩 품종의 고랭지 재배 시 수랑 및 Isoflavone 함량)

  • Ok, Hyun-Choong;Yoon, Young-Ho;Jeong, Jin-Cheol;Hur, On-Sook;Lee, Choon-Woo;Kim, Chung-Guk;Cho, Hyun-Mook
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.53 no.1
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    • pp.102-109
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    • 2008
  • This study was performed to obtain fundamental information on growth adaptability and isoflavone contents of soybean cultivars in highland area of Korea. For this study, we cultivated nineteen cultivars and investigated yield and isoflavone contents. In Jinbu-myeon located at altitude of 600 m, most of cultivars showed more than 2.5 t/ha seed yield except three cultivars, and the range of isoflavone contents among nineteen cultivars was 715 to $2,545\;{\mu}g/g$. Cultivars with both high seed yield and isoflavone contents were Manrikong, Sinpaldalkong2, Cheongjakong, and Cheongjakong2 in this area. In Daegwallyeong-myeon located at altitude of 800 m, the range of seed yield and isoflavone contents was 1.4 to 2.4 t/ha and 437 to $2,370\;{\mu}g/g$, respectively. Cultivars with both high seed yield and isoflavone contents were Ilpumgeomjeongkong and Dooyookong in this area. Cultivars selected on the basis of seed yield and isoflavone contents in 2004 and 2005 showed also similar results for yield and isoflavone contents at farmer's field in highland area in 2006. In conclusion, it could be expected to produce soybeans having both higher yield and better quality if the selected soybean cultivars are cultivated in highland area.

Effect of Biotic Substances on Isoflavone Content in Soybean Germination (Biotic 물질이 콩 발아 중 Isoflavone 함량에 미치는 영향)

  • Kim, Seo-Young;Song, Young-Ho;Yi, Yoo-Jung;Kim, Hong-Sik;Kim, Yong-Ho
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.65 no.2
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    • pp.84-92
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    • 2020
  • For humans, soybean and soybean products are the main dietary sources of isoflvones, which are polyphenolic compounds that represent one of the most common categories of phytoestrogens. The objective of this study was to determine isoflavone concentrations in soybean cultivars during germination when treated with some biotic substances. Three soybean cultivars were germinated in replicated trials in 2018/2019 and their individual and total isoflavone concentrations were determined using HPLC (High-Performance Liquid Chromatography). Significant differences were observed in total isoflavone content were observed among cultivars regardless of years and treatments. 'Daepung2-ho' and 'Uram' had significantly higher total isoflavones than 'Pungsannaul-kong'. Differences among treatments were also significant for total isoflavone content. In 2018, with chitosan treatment, total isoflavone concentration ranged from 551.15 to 7584.07 ㎍ g-1, with an average of 2972.64 ㎍ g-1 across cultivars. In 2019, there was no significant difference among treatments in total isoflavone content. Regarding individual isoflavone concentrations, the malonyl-glucoside groups accounted for over 85% of the total isoflavone content, which is indicated that these groups play an important role with regard to isoflavone components in soybean seeds. The individual proportions in the total concentrations of isoflavones varied according to germination period and seed tissues. Glucosides and malonyl-glucosides showed differences in concentrations among seed tissues, aglycones were further accumulated as germination period was progressed. This study suggests that biotic substances have an impact on seed isoflavone content during germination. However, cultivars with consistently high or low isoflavone concentrations across biotic substance treatments were identified desspite differences in germination period and seed tissues, demonstrating that the genetic factor plays the most important role in isoflavone accumulation.

Isoflavone Content and its Relationship with Other Seed Quality Traits of Soybean Cultivars Collected in South Korea

  • Kim, Sun-Lim;Chi, Hee-Youn;Kim, Jung-Tae;Lee, Yeong-Ho;Park, Nam-Kyu;Son, Jong-Rok;Kim, Si-Ju
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.51 no.1
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    • pp.81-88
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    • 2006
  • The 117 soybean cultivars were collected from nine provinces in Korea, and various seed quality traits along with isoflavone contents were evaluated to elucidate their relationship. The 100-seed weight of the black soybean (31.2 g) was significantly higher (p<0.05) than yellow soybeans (28.6 g). The composition of genistein, daidzein, and glycitein accounted for 75.8, 22.8, and 1.4 % of total isoflavone in yellow soybean cultivars, while their compositions in black soybeans were 58.5, 39.7, and 1.8%, respectively. The mean contents of total isoflavone in yellow and black soybean were $l,561.6{\mu}g\;g^{-1}\;and\;l,018.3{\mu}g\;g^{-1}$. The isofalvone content showed significant variation among cultivars when classified by the seed size. In the yellow soybeans, total isoflavone content was higher in small size soybean cultivars $(1,776.0{\mu}g\;g^{-1})$ and medium size soybean cultivars $(1,714.3{\mu}g\;g^{-1})$ compared to large size ones $(1,518.5{\mu}g\;g^{-1})$. Genistein content was proved as the major factor determining the relationship between isoflavone content and 100-seed weights (r =-0.206*). Daidzein and glycitein, however, showed no significant relationship with the 100-seed weights. Isoflavone content was not significantly correlated with color parameters L (lightness) and a (redness) values, but color parameter b (yellowness) was positively correlated with glycitein (r=0.264*) in the yellow soybeans, while its negative correlation between daidzein (r=-0.245*) and total isoflavone (r=-0.256*) were observed in black soybeans. However, these findings suggested that the seed color value may not serve as an effective parameter for estimating the isoflavone intensity of the soybeans. Variation of protein and lipid contents between yellow soybeans (n=58) and black soybeans (n=59) was relatively stable, however, protein and lipid contents have no significant relationship with isoflavone content.

Effect of Soy Isoflavone Supplementation and Exercise on Serum Lipids in Postmenopausal Women (이소플라본 보충과 운동이 폐경 후 여성의 혈중 지질 수준에 미치는 영향)

  • Choi In-Sun;Bae Yun-Jung;Jang Sul;Lee Da-Hong;Yun Mi-Eun;Lee Haeng-Shin;Kim Mi-Hyun;Lee Sang-Ho;Sung Chung-Ja
    • Journal of Nutrition and Health
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    • v.38 no.6
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    • pp.411-418
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    • 2005
  • To elucidate the effect of soy isoflavone supplementation and exercise on serum lipids in normolipidemic and mildly hyperlipidemic postmenopausal period, 54 women residing in Seoul area were recruited. The subjects were divided into 4 groups: control group (n=13), isoflavone group (n=14), exercise group (n=14), isoflavone + exercise group (n=13). The control group was given placebo capsules, isoflavone group was given soy isoflavone supplements (90 mg/day), exercise group was given placebo capsules and exercised 3 times/week, over 30 min/time, and isoflavone + exercise group took soy isoflavone supplement and exercised. The duration of study were 8 weeks. The average age of the subjects was 57.0 years, 56.0 years, 54.4 years, and 55.2 years, respectively. There were no significant differences among the four groups in terms of height, weight, and body mass index. There were no significant differences among the four groups in terms of serum, total cholesterol, HDL-cholesterol. But the subjects indicated a significant difference in serum LDL-cholesterol (110.5 mg/day in before versus 74.6 mg/day in after) in the isoflavone + exercise group at the levels of p<0.05. In conclusion, the isoflavone supplementation and exercise may be helpful to decrease serum lipids of normolipidemic and mildly hyperlipidemic postmenopausal women.

이소플라본의 첨가가 난소절제쥐에서 골밀도 및 골함량에 미치는 영향

  • 최미자;강유정;전효선
    • Proceedings of the KSCN Conference
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    • pp.439.1-439
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    • 2004
  • 콩단백질에 풍부한 isoflavones는 약한 estrogenic한 효과를 가진다고 보고 되면서 폐경 여성이나 난소절제쥐를 대상으로 골 대사에 미치는 효과에 대한 연구가 많이 이루어졌다. 그러나 isoflavones가 골대사에 미치는 효과는 isoflavones의 량, 섭취기간, 생리상태, 칼슘의 섭취량 등 여러 가지의 변수에 따라 다르게 나타났다. 일반적으로 isoflavones의 섭취가 너무 작거나 너무 많아도 그 효과 미미하여 isoflavones의 적당량에 대한 연구가 계속 요망되고 있다.(중략)

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Quantitative Variation of Total Seed Isoflavone and its Compositions in Korean Soybean Cultivars (Glycine max (L.) Merr.)

  • Kim, Hong-Sik;Kang, Beom-Kyu;Seo, Jeong-Hyun;Ha, Tae-Joung;Kim, Hyun-Tae;Shin, Sang-Ouk;Park, Chang-Hwan;Kwak, Do-Yeon
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.64 no.2
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    • pp.89-101
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    • 2019
  • The variation of content of 12 soybean seed isoflavone components was determined in the aglycone, glucoside, malonylglucoside and acetylglucoside groups of 44 Korean soybean cultivars grown in 2016 as well as in 2017. The total isoflavone content of the 44 cultivars averaged at $2935.4{\mu}g/g$ and was in the range of 950.6 to $5226.3{\mu}g/g$ for two years. Malonylglucoside group averaged at $2437.2{\mu}g/g$ with the highest proportion of isoflavone composition (83.0%). Significant differences were observed between cultivars, years and their interactions for both the total isoflavone and each composition group contents (P < 0.0001); however, no year-wise differences were observed for daidzein and genistin. The broad-sense heritability ($h^2$) within the set of 44 Korean soybean cultivars was as high as 0.93 for the total isoflavone content and was in the range of 0.8-0.92 for each composition group of isoflavone except for acetylglucoside. The total isoflavone content in cultivar group for soy-sprout was higher ($3850.4{\mu}g/g$) than that for the other cultivar groups of soy-paste and tofu ($3082.8{\mu}g/g$), black or green soybean cooked with rice ($2345.8{\mu}g/g$), and early maturity group ($1298.6{\mu}g/g$). The total isoflavone content of 'Sowonkong', a soybean cultivar for soy-sprout, was the highest ($5226.3{\mu}g/g$). In the cultivar group for soy-paste and tofu, the average isoflavone contents of 'Daepung', 'Daepung2ho', 'Saegeum', 'Uram', and 'Jinpung' were higher than $4000{\mu}g/g$. With the exception of small seeded cultivars with low isoflavone contents such as 'Sohwang' and 'Socheongja', the seed size and total isoflavone content were significantly negatively correlated in 2016 and 2017, respectively ($r=-0.47^{**}$ and $-0.49^{**}$). The number of days of growth from flowering to maturity did not affect the variations observed in isoflavone content.

Effects of Isoflavone Supplementation on Serum Lipids in Hyperlipidemic Postmenopausal Women (일부 고지혈증 폐경 여성의 Isoflavone 공급에 따른 혈중지질 변화에 관한 연구)

  • 이다홍;승정자;이행신;김미현;서유리
    • Korean Journal of Community Nutrition
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    • v.6 no.1
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    • pp.69-75
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    • 2001
  • Intake of soy protein the fisk factors associated with cardiovascular disease in postmenopausal women. This study was designed to effects of isoflavone supplementation on serum lipids in 16 hyperlipidemic postmenopausal women . For this purpose, an intervention study was conducted for 12 weeks. Subjects were healthy, free-living women consuming habitual diets with 0.3g/d of isoflavone. Food and nutrient intake was obtained by 24-hr recall method and anthropometric measurement were made. Systolic and diastolic blood pressure, total serum cholesterol. HDL-cholesterol and LDL-cholesterol were determined before and after the isoflavone supplementation. The results were summarized as follows. The average age, hight, weight and BMI of the subject were 65.3 years, 151.4 cm, 62.2 kg and 27.1, respectively. The systolic blood pressure and diastolic blood pressure were not reduced significantly with isoflavone supplementation. Total cholesterol (p<0.001), HDL-C(p<0.05), and LDL-C(p<0.01) were significantly increased after isoflavone concentration. In conclusion, isoflavone supplementation was not effective to modify risk factors for cardiovascular disease.

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A Study on Dietary Isoflavone Intake from Soy Food and Urinary Isoflavone Excretion and, Menopausal Symptoms in Korean Women in Rural Areas (농촌지역 일부 폐경기 여성의 일상 식이 중 대두식품을 통한 이소플라본의 섭취 및 소변 중 배설량과 갱년기 증상에 관한 연구)

  • 승정자;최선혜;김미현;박민혜;고병섭;김호경
    • Korean Journal of Community Nutrition
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    • v.5 no.1
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    • pp.120-129
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    • 2000
  • Very little is known about the relation between isoflavone intake and menopausal symptoms in Korean woman To find the effects and correlations between these factors, questionnaires(maternal factors, menopausal symptoms) anthropometric measurement, 24hr dietary recalls, and urinary isoflavones analysis were conducted in 100 postmenopausal women residing in the Kyunggi-do rural area. The average age hight and weight of the subject were 61.5 years, 153.6 cm and 56.2kg. The average age at menarche, menopause, and menstrual cycle were 16.7 years, 47.2 years, 29.8 years, respectively. Most of the postmenopausal women experienced mildly menopausal symptoms. The mean calorie, protein and calcium intake were 1417.6 kcal(74.7% of the Korean RDA) 53.2 g(88.6% of the Korean RDA) and 454.0mg(65.6% of the Korean RDA) respectively. The ration of energy from carbohydrate, protein, and fat was 68: 15: 17 The average isoflavone intake from soy foods was 27.27 mg. The major food source of the isoflavone were soybeans and soybean curd. The average urinary isoflavone excretion was 2. 78nmol/mg Cr and showed significant positive correlation with isoflavone intake. Isoflavone intake from soy foods had a negative correlation with the severity of menopausal symptoms. Therefore, soy foods which contain isoflavone may have a protective effect on menopausal symptoms of women in Korea.

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