• Title, Summary, Keyword: history of medicine

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Family History and Survival of Patients with Gastric Cancer: A Meta-Analysis

  • Oh, Myueng Guen;Kim, Jin Hwa;Han, Mi Ah;Park, Jong;Ryu, So Yeon;Choi, Seong Woo
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.8
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    • pp.3465-3470
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    • 2014
  • Background: Previous studies have generated conflicting evidence regarding associations between family history and survival after gastric cancer surgery. In this study, we investigated this question using a meta-analysis. Materials and Methods: To identify relevant studies, PubMed and Embase databases were searched up to June 2013. Two reviewers independently assessed search results and data extraction of included studies. Hazard ratios (HRs) and 95% confidence intervals (CIs) for overall survival (OS) were calculated based on fixed- or random-effects models. Homogeneity of effects across studies was assessed using $x^2$ test statistics and quantified by $I^2$. Results: A total of five studies were selected according to the inclusion criteria. The total number of patients included was 2,030, which ranged from 145 to 598 per study. There was no significant difference in OS by family history of cancer (HR=0.83, 95%CIs=0.50-1.38), but subgroup analysis of patients with a first-degree family history of cancer (HR=0.74, 95%CIs=0.60-0.93) and gastric cancer family history (HR=0.56, 95%CIs=0.41-0.76) tended to show better OS in these patients. Conclusions: This meta-analysis suggests that a first-degree family history of cancer or gastric cancer family history is associated with better survival of gastric cancer patients after surgery, after a systematic review of five previous studies. These results can be applied by clinicians when counselling patients regarding their risk of death from gastric cancer. Further study is needed to investigate the underlying mechanism between family history and survival in gastric cancer patients.

Reliability of Covariates in Baseline Survey of a Cohort Study: Epidemiological Investigation on Cancer Risk Among Residents Who Reside Near the Nuclear Power Plants in Korea (코호트 기반 조사 공변수 자료의 신뢰도 평가 연구: 원전주변지역주민 역학조사연구)

  • Bae, Sang-Hyuk;Park, Bo-Young;Li, Zhong-Min;Ahn, Yoon-Ok
    • Journal of Preventive Medicine and Public Health
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    • v.43 no.2
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    • pp.159-165
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    • 2010
  • Objectives: We evaluated the reliability of the possible covariates of the baseline survey data collected for the Epidemiological Investigation on Cancer Risk Among Residents Who Reside Near the Nuclear Power Plants in Korea. Methods: Follow-up surveys were conducted for 477 participants of the cohort at less than 1 year after the initial survey. The mean interval between the initial and follow-up surveys was 282.5 days. Possible covariates were identified by analyzing the correlations with the exposure variable and associations with the outcome variables for all the variables. Logistic regression analysis with stepwise selection was further conducted among the possible covariates to select variables that have covariance with other variables. We considered that these variables can be representing other variables. Seven variables for the males and 3 variables for the females, which had covariance with other possible covariates, were selected as representative variables. The Kappa index of each variable was calculated. Results: For the males, the Kappa indexes were as follow; family history of cancer was 0.64, family history of liver diseases in parents and siblings was 0.56, family history of hypertension in parents and siblings was 0.51, family history of liver diseases was 0.50, family history of hypertension was 0.44, a history of chronic liver diseases was 0.53 and history of pulmonary tuberculosis was 0.36. For females, the Kappa indexes were as follow; family history of cancer was 0.58, family history of hypertension in parents and siblings was 0.56 and family history of hypertension was 0.47. Conclusions: Most of the possible covariates showed good to moderate agreement.

Association of Prescribed Drug intoxication and Neuropsychiatric history (약물 음독과 정신과 과거력의 연관성)

  • Kim, Hyeon-Jung;Kim, Hye-Mi;Kim, Ho-Jung;Cho, Young-Soon;Lee, Myung-Gab;Jun, Duck-Ho;Go, Chan-Young
    • Journal of The Korean Society of Clinical Toxicology
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    • v.9 no.2
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    • pp.77-80
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    • 2011
  • Purpose: The purpose of this study was to investigate the relationship between patients with a neuropsychiatric history and features of their suicide attempt, in order to analyze the risk associated with psychiatrist prescribed drugs Methods: We retrospectively investigated cases of intentional overdose drug ingestion in patients greater than 14 years of age who visited OO emergency medical center between January 1, 2008 and July 31, 2010. We evaluated patient medical records to ascertain their age, sex, neuropsychiatric history, and components of ingested intoxicant. Information regarding any suicide reattempt was obtained after discharge through follow up telephone survey. SPSS version 13.0 was used for statistical analysis. Fisher's exact test was performed with p<0.05 considered statistically significant. Results: Ninety-six of 209 patients (46%) had a past history of psychological problems. Among those 96 patients with a history of psychological problems, 46(48%) used an overdose of the medicine prescribed by their psychologist in order to attempt suicide. However, for patients without a history of psychological problems, intoxication by neuropsychiatric drugs was insignificant. Neuropsychiatric patients required greater follow up care after discharge and exhibited significantly more suicide reattempts. Conclusion: This study revealed that patients sometimes use the medicine prescribed by their psychologist to attempt suicide. Therefore, an exhaustive plan to control the medicines prescribed to psychiatric patients should be established.

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Hereditary protein S deficiency presenting acute pulmonary embolism

  • Kim, Jiwan;Kim, Sung Hea;Jung, Sang Man;Park, Sooyoun;Yu, HyungMin;An, Sanghee;Kang, Seonghui;Kim, Hyun-Joong
    • Yeungnam University Journal of Medicine
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    • v.31 no.1
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    • pp.52-55
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    • 2014
  • Protein S deficiency is one of the several risk factors for thrombophilia and can cause blood clotting disorders such as deep vein thrombosis and pulmonary embolism. A 54-year-old man was admitted with the complaint of dyspnea and was diagnosed with pulmonary embolism. The patient had very low level of free protein S, total protein S antigen, and protein S activity (type I protein S deficiency). In history taking, we found that his mother, 78 year old, had a history of same disease 10 years ago, and confirmed the pronounced low level of protein S. The patient's son also had very low level of protein S, however there had not been any history of pulmonary embolism yet. This case study suggests that asymptomatic persons with a family history of protein S deficiency and pulmonary embolism should be checked regularly for early detection of the disease, as protein S deficiency can be suspected.

Activity of confucian doctors' in Korea (한국(韓國)에서의 유의(儒醫)들의 활동(活動) - 의서(醫書)의 편찬(編纂), 치료활동(治療活動)을 중심(中心)으로)

  • Kim, Nam Il
    • The Journal of Korean Medical History
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    • v.20 no.2
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    • pp.42-49
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    • 2007
  • 'confucian doctor' are typically people who study the principles of medicine based on Confusional concepts. In Korea, studying both medicine and Confucianism became a common practice since Confucianism became popular and the class of intellectuals were formed around Confucianism. This study is a research on the activity of confucian doctors in Korea. Many confucian doctors that were discovered in documents are organized according to their activity and books they wrote.

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Review on History of Local Medicinal Herb Festival (한방지역축제의 역사성 고찰)

  • Song, Jae-Min;Do, Mi-ja;Ahn, Sang-Woo;Jung, Ji-Ho;Kim, Namil
    • The Journal of Korean Medical History
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    • v.28 no.2
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    • pp.1-13
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    • 2015
  • Purpose : Local medicinal herb festivals present the history of the Korean medicine and cultural resources in the regions to play an important role in attracting tourists, vitalizing local economy, and improving the local image. Therefore, it is important to understand the origin of the festival and grasp historical and cultural meaning of local medicinal herb festivals. Methods : I compared the books and articles presented in the reference list. Results & Conclusions : Local medicinal herb festivals originates from traditional yangnyeongsi. Since the $17^{th}$ century, yangnyeongsi has grown up as a special market. Implementation of the Daedong Act promoted commodity and monetary economy that helped commerce and industry develop and market grow up. It also made changes in the social status system and yangnyeongsi has been such a historical phenomenon appeared in this social background. The growth of yangnyeongsi contributed to the progress in the private medicine that triggered the gradual transfer of power in the medicine to the private sector which has long been held by the government. In yangnyeongsi, there were many cultural events to attract visitors. It's the same case in China that preserves stages that were used for cultural events in the medicine market to pass down the historic sites while those in Korea are disappearing as yangnyeongsis are being pulled out of the city areas to the suburban areas due to the redevelopment projects. For this reason, restoration of the place for traditional yangnyeongsi should be taken into account through local medicinal herb festivals.

The medical stuffs of Buddhist medicine and their usage as indicated in 『Tianjinyaofang』 (불교의학의 약물과 『천금요방(千金要方)』에서의 사용례)

  • Kim, Beom Jun;Ahn, Sang Woo;Kim, Nam Il
    • The Journal of Korean Medical History
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    • v.20 no.2
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    • pp.18-33
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    • 2007
  • Buddist Medicine has greatly influenced Chinese medicine, a medicine centered around East Asian traditional medicine. Buddhist medicine, however, was replaced when Chinese medicine became centered around Confucianism in the 12th century. According to "Tianjinyaofang" a document of the 8th century, however, traces of Buddhist medicine can be found. This study has found and organized the traces of Buddhist medicine in both Korean and Chinese medicine today.

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The association of family history of prostate cancer with the diagnosis of clinically significant prostate cancer in Korean population

  • Park, Jee Soo;Koo, Kyo Chul;Chung, Byung Ha;Lee, Kwang Suk
    • Investigative and Clinical Urology
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    • v.60 no.6
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    • pp.442-446
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    • 2019
  • Purpose: The impact of family history on the diagnosis of the prostate cancer among Asian population remains controversial. We evaluated whether a positive family history of the prostate cancer in Korean men is associated with the diagnosis and aggressiveness of the prostate cancer. Materials and Methods: Patients who underwent a transrectal ultrasound-guided prostate biopsy from March 2015 to September 2017 were evaluated. Information on family history was obtained via a self-administered questionnaire. The presence of prostate cancer and clinically significant prostate cancer (Gleason score ≥7) was evaluated according to the presence of a family history. Results: Of 602 patients (median age, 68.3 years; median prostate-specific antigen level, 6.28 ng/mL), 41 (6.8%) patients had a family history of prostate cancer. Family history was a significant factor for detecting prostate cancer (odds ratio [OR], 2.99; 95% confidence interval [CI], 1.330-6.704; p=0.008). In multivariate analysis for predicting clinically significant prostate cancer, family history was a significant predictor (OR, 6.32; 95% CI; 2.790-14.298; p<0.001). Conclusions: A family history of prostate cancer in Korean men was a significant factor for predicting prostate cancer. Moreover, significant differences in the aggressive features of the disease were identified between patients with and without a family history.

Chinese "External Medicine" and Its Views of the Body: A Case Study of the Manuscript "A Treatise on Seeking the Roots of Ulcer Medicine" (Yangyi Tan Yuan Lun (瘍醫探源論)) (中醫外科?什?不動手術? - ?代手抄本 ≪瘍醫探源論≫ 的身體物質觀)

  • Li, Jianmin
    • The Journal of Korean Medical History
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    • v.28 no.2
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    • pp.121-138
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    • 2015
  • This paper primarily discusses the materiality of the body in Chinese "external medicine". Chinese external medicine views the body as something consisting of sinew and flesh. Furthermore, there are times when Chinese surgical techniques must be applied to the body in order to manage rotting flesh and other abnormal manifestations. The materiality of the Chinese body of external medicine encompasses the way in which Chinese doctors manufactured surgical implements, the sick person's bodily experience of pus and pain associated with external diseases, and the details of the process by which doctors evaluated whether or not to carry out surgical interventions. This essay will use the Qing manuscript "A Treatise on Seeking the Roots of Ulcer Medicine" as a central case study for discussing these issues, while also showing the connections between it and other external medicine texts of the Ming and Qing era. Its author, Zhu Feiyuan, was a doctor who lived during the 18th to 19th century in Qingpu (today's Shanghai). My essay will thus discuss Chinese external medicine from a historical perspective. The way in external medicine treated illness differed from the prescriptions and pulse signs that "internal medicine" employed, and its view of the body likewise differed from that of internal medicine. I hope that this essay can provide new viewpoints on the history of the body in Chinese medicine.

Examining Distinctive Points of Introduction to Medicine(醫學入門, Yixuerumen) through the Clinical Window (임상학습서로서의 『의학입문(醫學入門)』의 가치)

  • Hong, Saeyoung;Lee, Mangoon;Cha, Wungseok;Kim, Namil
    • Journal of Korean Medical classics
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    • v.29 no.1
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    • pp.125-137
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    • 2016
  • Objectives : Introduction to Medicine(醫學入門, Yixuerumen) is one of the basic clinical texts in Korean medical history. This study is designed to prove clinical value of Introduction to Medicine for practitioners in their early stage of clinical practice. Methods : Introduction to Medicine is closely reviewed in various aspects in order to examine broad outlines of specificity as well as its distinctive constructional feature. Results : Since Introduction to Medicine showed peculiar intention of developing practitioner's clinical ability, it has been a preferential choice for Korean medicine practitioners to enhance their qualification at the early stage of one's career in Korean history. It is still valid for modern practitioners because composite medical texts are needed in order to systematize one's fragmental knowledge acquired from institutional education. Conclusions : Introduction to Medicine shows a large potential as a clinical textbook in the course of maximizing one's clinical ability with its aid. Through understanding multilateral aspects of clinical guidelines and directions engraved in Introduction to Medicine, learners will be able to derive full capacity from the text.