• Title, Summary, Keyword: hepatoma

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A Case of Hepatoma with Duodenal Metastasis Proved by Liver Aspiration Cytology and Gastrofiberscopic Duodenal Biopsy (십이지장 궤양으로 발현된 전이성 간세포암종 1예)

  • Kim, Sung-Jin;Park, Seok-Gun;Han, Dong-Sun;Kim, Sung-Sook
    • The Korean Journal of Cytopathology
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    • v.2 no.2
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    • pp.105-110
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    • 1991
  • We report a case of hepatoma with duodenal metastasis in a 53 year-old male patient. Hepatoma was confirmed by fine needle aspiration cytology technique, and duodenal metastasis by gastrofiberscopic biopsy. Duodenal metastasis of hepatoma is rare. We briefly review the role of fine needle aspiration cytology technique in diagnosis of hepatoma.

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The Effects of ALA-PDT on Leukemia Cells and Hepatoma Cells

  • Chen, Ji-Yao;Ren, Qing-Guang;Wu, Su-Min;Wang, Pei-Nan
    • Journal of Photoscience
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    • v.9 no.2
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    • pp.512-514
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    • 2002
  • S-aminolevulinic acid (ALA) is a new kind drug used in photodynamic therapy. ALA-PDT have successfully used in superficial malignancies and some skin diseases. Here the effects of ALA-PDT were studied on leukemia cells and hepatoma cells to explore the application on different kind cancers. It was found from the fluorescence emission spectra, that after ALA incubation the sensitizer - protoporphyrin IX (PpIX) was endogenously produced in both leukemia and hepatoma cells. The fluorescence images showed that the PpIX distribute in cytoplasm. However the efficiency of ALA photodynamic inactivation to two cell lines was different. The leukemia cells were more sensitive for ALA-PDT than hepatoma cells, revealing that the ALA-PDT effect is cell line dependent. However by using ALA-Hexyl ester (He-ALA) instead of ALA, the cell photo-inactivation was improved. The PDT efficiency of He-ALA was 10 times high than that of ALA, showing He-ALA is a very promising drug in ALA-PDT.

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A Case of Hepatoma with Hot Uptake of $^{99m}Tc$-DISIDA to Spleen (원발성 간암환자에서 관찰된 $^{99m}Tc$-DISIDA의 비장 섭취 1예)

  • Lee, Ye-Bong;Kim, Sung-Jin;Park, Eun-Hwi;Bang, In-Sook;Kim, Heung-Joo;Yun, Sung-Chul;Lee, Won-Jae
    • The Korean Journal of Nuclear Medicine
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    • v.27 no.1
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    • pp.140-143
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    • 1993
  • We report a case of hepatoma which had a suggested splenic metastasis in a 64 year-old male patient. Hepatoma proved by abdominal CT (Computed Tomography) and considerable accumulation of $^{99m}Tc$-DISIDA was noted in a enlarged spleen. We suggests the splenic uptake of the radionuclide corresponded to the diffuse metastasis of hepatoma to spleen.

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Resveratrol enhances cisplatin-induced apoptosis in human hepatoma cells via glutamine metabolism inhibition

  • Liu, Zhaoyuan;Peng, Qing;Li, Yang;Gao, Yi
    • BMB Reports
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    • v.51 no.9
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    • pp.474-479
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    • 2018
  • Cisplatin is one of the most effective chemotherapeutic drugs used in the treatment of HCC, but many patients will ultimately relapse with cisplatin-resistant disease. Used in combination with cisplatin, resveratrol has synergistic effect of increasing chemosensitivity of cisplatin in various cancer cells. However, the mechanisms of resveratrol enhancing cisplatin-induced toxicity have not been well characterized. Our study showed that resveratrol enhances cisplatin toxicity in human hepatoma cells via an apoptosis-dependent mechanism. Further studies reveal that resveratrol decreases the absorption of glutamine and glutathione content by reducing the expression of glutamine transporter ASCT2. Flow cytometric analyses demonstrate that resveratrol and cisplatin combined treatment leads to a significant increase in ROS production compared to resveratrol or cisplatin treated hepatoma cells alone. Phosphorylated H2AX (${\gamma}H2AX$) foci assay demonstrate that both resveratrol and cisplatin treatment result in a significant increase of ${\gamma}H2AX$ foci in hepatoma cells, and the resveratrol and cisplatin combined treatment results in much more ${\gamma}H2AX$ foci formation than either resveratrol or cisplatin treatment alone. Furthermore, our studies show that over-expression of ASCT2 can attenuate cisplatin-induced ROS production, ${\gamma}H2AX$ foci formation and apoptosis in human hepatoma cells. Collectively, our studies suggest resveratrol may sensitize human hepatoma cells to cisplatin chemotherapy via gluta${\gamma}H2AX$mine metabolism inhibition.

Detection and Analysis of the Liver Area and Liver Tumors in CT Scans (CT 영상에서의 간 영역과 간 종양 추출 및 분석)

  • Kim, Kwang-Baek
    • Journal of Intelligence and Information Systems
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    • v.13 no.1
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    • pp.15-27
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    • 2007
  • In Korea, hepatoma is the thirdly frequent cause of death from cancer occupying 17.2% among the whole deaths from cancer and the rate of death from hepatoma comes to about 21's persons per one-hundred thousand ones. This paper proposes an automatic method for the extraction of areas being suspicious as hepatoma from a CT scan and evaluates the availability as an auxiliary tool for the diagnosis of hepatoma. For detecting tumors in the internal of the liver from CT scans, first, an area of the liver is extracted from about $45{\sim}50's$ CT scans obtained by scanning in 2.5-mm intervals starting from the lower part of the chest. In the extraction of an area of the liver, after unconcerned areas outside of the ribs being removed, areas of the internal organs are separated and enlarged by using intensity information of the CT scan. The area of the liver is extracted among separated areas by using information on position and morphology of the liver. Since hepatoma is a hypervascular turner, the area corresponding to hepatoma appears more brightly than the surroundings in contrast-enhancement CT scans, and when hepatoma shows expansile growth, the area has a spherical shape. So, for the extraction of areas of hepatoma, areas being brighter than the surroundings and globe-shaped are selected as candidate ones in an area of the liver, and then, areas appearing at the same position in successive CT scans among the candidates are discriminated as hepatoma. For the performance evaluation of the proposed method, experiment results obtained by applying the proposed method to CT scans were compared with the diagnoses by radiologists. The evaluation results showed that all areas of the liver and liver tumors were extracted exactly and the proposed method has a high availability as an auxiliary diagnosis tools for the discrimination of liver tumors.

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Relationship between Nutritional Status and Clinical Outcome in 120 Hepatoma Patients (간암환자의 영양상태와 치료결과와의 관련성)

  • Han, Bu;Kim, Young-ok
    • The Korean Journal of Food And Nutrition
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    • v.13 no.5
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    • pp.434-439
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    • 2000
  • This study was conducted to investigate the association between initial nutritional status and treatment outcome of hepatoma patients. Initial nutritional status was measured based on weight, serum albumin and total lymphocyte counts. Treatment outcome was measured in the three categories such as complication, treatment status at discharge and mortality. The study subjects were 120 patients with hepatoma cancer admitted at a university hospital in Seoul. The information about initial nutritional status and treatment outcome was collected from medical records. Chi-square test was used to test the association between initial nutritional status and treatment outcome As a result. 76.6% of the subjects were classified as the nutritional risk group based on initial nutritional states. Prevalence of complication was higher in nutritional risk group I and II than that in non-risk group(p<0.05). Death rare of the nutritional risk group was significantly higher than that of non-risk group(p<0.001). The findings suggest the strong association between the initial nutritional status and treatment outcome of hepatoma cancer.

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Radiogold Study in Primary Hepatoma and Amebic Liver Abscess: Is Their Distinction Possible? (원발성간암(肝癌)과 아메바성간농양(肝膿瘍)의 진단에 관한 핵의학(核醫學)적 고찰)

  • Bahk, Yong-Whee;Kim, Dong-Jip
    • The Korean Journal of Nuclear Medicine
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    • v.2 no.1
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    • pp.53-58
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    • 1968
  • Both primary hepatoma and amebic liver abscess are probably the most common space-occupying disease of the liver in Korea, and the importance of their accurate distinction can not be overemphasized. Radiogold hepatoscanning has been widely used at St. Mary's Hospital, and recently blood disappearance rate of colloidal $^{198}Au$ has been introduced in the study of hepatic ailments. A review of the literature revealed few previous publications concerning the differential features of the two conditions although some characteristic scan findings of each condition have been described. The present study is aimed at a critical review and analysis of various photoscan findings and blood disappearance rate determinations of colloidal $^{198}Au$ of 34 cases of primary hepatoma and 30 cases of amebic liver abscess. Among many scan manifestations, prominence of the uninvolved liver tissue, "hemispherical cold area," and splenic uptake are much more commonly encountered in primary hepatoma and the blood disappearance rate tends to be far more frequently delayed in primary hepatoma than in abscess providing at least a statistically useful basis of distinction of the two diseases.

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Jinan red ginseng extract inhibits triglyceride synthesis via the regulation of LXR-SCD expression in hepatoma cells

  • Hwang, Seung-mi;Park, Chung-berm
    • Korean Journal of Food Science and Technology
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    • v.51 no.6
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    • pp.558-564
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    • 2019
  • Hypertriglyceridemia is one of the metabolic syndrome that is often observed as a result of lipid abnormalities. It is associated with other lipids, metabolic disorders, cardiovascular disease and liver disease. Korean red ginseng is known to affect obesity, dyslipidemia, liver disease and liver function, but the mechanism of its effect is not clear. This study examined the beneficial effects of hypertriglyceridemia and the mechanism of action of Jinan red ginseng extract (JRG) in hepatoma cells. To measure the levels of triglyceride accumulation, we studied the expression of proteins and mRNAs related to lipidogenesis in hepatoma cells (Huh7 and HepG2). JRG decreases the lipidogenic markers, peroxisome proliferator-activated receptor γ (PPARγ), CCAAT-enhancer-binding proteins α (C/EBPα) and C/EBPβ which are major regulators of triglyceride synthesis in hepatoma cells. We also found that JRG reduced sterol regulatory element binding proteins 1c (SREBP-1c), C/EBPα and C/EBPβ by regulating liver X receptor (LXR) and stearoyl CoA desaturase (SCD) expressions. In addition, the first-limited step of synthesis triglyceride (TG), glycerol-3-phosphate (G3P) is decreased by JRG. These results suggest that the anti-hypertriglyceride effect of JRG in hepatoma cells could be accompanied with the inhibition of lipidogenic transcription factors by regulating LXR and SCD expression.

Analysis of Mitochondrial DNA Mutation in hepatoma

  • Chung, Ku-Sun;Lee, Kyo-Young;Shim, Sang-In;Kim, Jin-Sun;Song, Eun-Sook
    • BMB Reports
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    • v.33 no.5
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    • pp.417-421
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    • 2000
  • Mitochondrial DNA (mtDNA) mutation was investigated in a hepatoma patient using a polymerase chain reaction (PCR) and an in situ hybridization technique. Biotin-labeled probes for the subunit m of cytochrome c oxidase revealed differences in the in situ hybridization. A PCR assay using biopsied and microdissected tissues showed that common deletion (4,977 bp) was more pronounced in the cancer region than in the normal parts of the same patient. These results suggest that mtDNA deletion might be associated with tumorigenesis in hepatoma.

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Anti-proliferating Effects of Some Plants on the Hepatoma Cell (수종 식물들의 Hepatoma cell 증식 저해작용)

  • Chung, Yong Za;Lee, Un Joo
    • Korean Journal of Clinical Pharmacy
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    • v.9 no.2
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    • pp.103-108
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    • 1999
  • The anti-proliferating effects of some plants on hepatoma cell lines were studied by the 3-[4,5-dim-ethylthiazol-2yl]-2,5-diphenyl-tetrazolium bromide (MTT assay), to investigate the anticancer effect with some plants around here. As the result, we saw that the anti-prolferating effect to the plants. Among the plants, Equisetum arvense L. and Lactuca dentata Makino. var, flaviflora Makino of them relatively showed a good ant-proliferating effect. Capsicum annuum L. var. angulosum Mill (Leaf) was the best among them. We also examined morphological changes on the hepatoma cells in this process. In case of Capxicum annuum L. var. angulosum Mill, the tells become vague after 2 days, and then destroyed faster than others. We can fee also the condensated chromosome on the treated cells with Capxicum annuum L. var. angulosum Mill. And we also observed condensation through using a fluorescent microscope by PI staining, and observed DNA fragmentation.

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