• Title, Summary, Keyword: hand and foot syndrome

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The Literatural Study on Acupuncture and Moxibustion Therapy of Arthalgia Syndrome (비증(痺症)의 침구치료(鍼灸治療)에 관한 문헌적(文獻的) 고찰(考察))

  • Je, Byung Sun;Lim, Lark cheol;Oh, Min Suck
    • Journal of Haehwa Medicine
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    • v.13 no.1
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    • pp.61-69
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    • 2004
  • I have come to next conclusions in consequence of documentary study about medical books of many generations regarding acupuncture and moxibustion therapy of arthalgia syndrome. 1. Jing point of regular channels is most used. Next there are extraordinary point, ashi point in the acupuncture and moxibustion therapy of arthalgia syndrome. 2. The gall baldder channel of foot-shaoyang is most used. Next there are the urinary bladder channel of foot-taiyang, the large intestine channel of hand-yangming, the stomach channel of foot-yangming, the small intestine channel of hand-taiyang, the spleen channel of foot-taiyin, the liver channel of foot-jueyin, the triple-warmer channel of hand-shaoyang, the du channel, the lung channel of hand-taiyin, the kidney channel of foot-shaoyin, the pericardium channel of hand-jueyin, the heart channel of hand-shaoyin, the ren channel in the order of frequency in used channel among the twelve channels. 3. Three yang channels of foot is most used. Next there are three yang channels of hand, three yin channels of hand, three yin channels of foot in the order of frequency in use among the twelve channels. 4. The gall baldder channel of foot-shaoyang is most used. Next there are the urinary bladder channel of foot-taiyang, the large intestine channel of hand-yangming, the triple-warmer channel of hand-shaoyang, the stomach channel of foot-yangming, the small intestine channel of hand-taiyang, the liver channel of foot-jueyin, the lung channel of hand-taiyin, the spleen channel of foot-taiyin, the kidney channel of foot-shaoyin, the du channel, the pericardium channel of hand-jueyin, the ren channel the heart channel of hand-shaoyin in the order of frequency in used point among the twelve channels. 5. Huantiao is most used. Next there are Weizhong, Quchi, Yangfu, Chize Feiyang Xiyangguan Xiguan Tianjing, Sanli Xiaoluo in the order of frequency in use. 6. Jing point in the order of frequency of use, expel wind-evil and remove wetness-evil on the Acupuncture and Moxibustion Therapy of Arthalgia Syndrome.

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Hand-Foot syndrome induced by sorafenib, a multitargeted tyrosine kinase inhibitor, in a patient with advanced renal cell carcinoma (진행된 신세포암 환아에게 sorafenib 투여시 발생한 Hand-Foot syndrome 1예)

  • Lee, Seung Hyun;Noh, Sung Hun;Kim, Sun Young;Jang, Kyu Yun;Hwang, Pyoung Han
    • Korean Journal of Pediatrics
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    • v.52 no.1
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    • pp.119-123
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    • 2009
  • Renal cell carcinoma (RCC) arising from epithelial cells of the renal tubules is a highly aggressive and malignant tumor in all ages; however, it rarely occurs in children. the standard treatment for RCC is radical nephrectomy with lymph node dissection when the tumor is localized and can be completely resected. Adjuvant chemotherapy, radiotherapy, and immunotherapy are used for pediatric patients with advanced RCC involving lymph nodes or metastatic lesions. Sorafenib is an oral, multikinase inhibitor that has recently been approved for use in metastatic RCC. Common toxicities that have been reported include dermatologic changes such as rash or desquamation and hand-foot skin reaction, diarrhea, fatigue, alopecia, and hypertension. In particular, hand-foot syndrome (HFS) an erythematous skin lesion of the palms and solesis most often caused by cytostatic chemotherapeutic agents. In this report, we have studied a 14-year-old female patient with hand-foot syndrome that occurred in association with sorafenib for the treatment of metastatic RCC. Furthermore, this case demonstrates that reversal of complications can be achieved by discontinuing the drug and intervention with topical steroids, vitamin E, and high-dose pyridoxine.

Comparative Assessment of Skin and Subcutaneous Toxicity in Patients of Advanced Colorectal Carcinoma Treated with Different Schedules of FOLFOX

  • Bano, Nusrat;Najam, Rahila;Mateen, Ahmed
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.3
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    • pp.1781-1786
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    • 2013
  • Objective: The study was designed to assess the skin and subcutaneous toxicity in patients with advanced colorectal carcinoma treated with four different schedules of FOLFOX. Methods: The patients with histologically confirmed advanced colorectal carcinoma (CRC) were included in the study as per specified inclusion criteria. Toxicity was graded according to CTC v2.0. The frequency of grade 3 and 4 adverse effects were comparatively assessed in each treatment arm. Results: Very severe toxicity was attributed to the FOLFOX7 schedule. The difference between the incidence rate of grade 4 toxicity with all other grades for all parameters of skin and subcutaneous toxicity was highly significant (p=0.00<0.001). Grade 4 hand and foot syndrome was reported only in the FOLFOX7 treatment arm. The most frequent adverse symptom of skin and subcutaneous toxicity reported in the patients treated with modified schedule of FOLFOX was pruritus (grade 1). Frequency and onset of skin and subcutaneous toxic symptoms like alopecia (p=0.000), nail discoloration (p=0.021) and pruritis (p=0.000) was significantly different in each FOLFOX treatment arm. A few cases of oncholysis were also reported in the FOLFOX7 treatment arm. Hand and foot syndrome was fast progressing in patients with grade 1 toxicity. Conclusion: Higher frequency and severity of hand and foot syndrome and pruritus wasa found in the FOLFOX7 treatment arm. Skin and subcutaneous toxicity was comparatively low in the FOLFOX6 treatment arm.

A literature study on Hand-Foot-Mouth disease (수족구병에 대한 문헌적(文獻的) 고찰(考察) - 중의학(中警學) 문헌(文獻)을 중심으로 -)

  • Chang, Gyu-Tae;Kang, Mi-Sun
    • The Journal of Pediatrics of Korean Medicine
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    • v.18 no.2
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    • pp.225-232
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    • 2004
  • Objectives : Hand-Foot-Mouth disease is a highly contagious disease most often seen in children. It is caused most commonly by the coxsackievirus A16 and clinically characterized by vesicles appearing on the hands, feet and in the mouth. The purpose of this study is a approach to the oriental medical treatment of Hand-Foot-Mouth disease. Method : We studied the clinical literatures of traditional chinese medicine about Hand-Foot-Mouth disease after the year 2000. Result : Hand-Foot-Mouth disease are similar to epidemic febrile disease(溫病) dampwarm syndrome(濕溫), and epidemic disease(時疫) in Oriental Medicine. Conclusion : In oriental medical treatment is classified into the treatment of internal use, external use, and combination treatment of chinese and western medicine.

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A Case Report of Chemotherapy-Induced Hand-Foot Syndrome Treated with Modified Dohongsamul-tang (가미도홍사물탕 약욕요법 이후 호전된 항암화학요법 유발 수족증후군 1례)

  • Han, Ga-jin;Jang, Myeong-woong;Seong, Sin;Kim, Sung-su
    • The Journal of Internal Korean Medicine
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    • v.39 no.2
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    • pp.259-267
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    • 2018
  • Hand-foot syndrome (HFS) frequently occurs after receiving chemotherapy, such as sorafenib, in patients with hepatocellular carcinoma (HCC), and this impairs quality of life (QOL). The prevalence of HFS due to sorafenib is 10-28%. The effective methods to treat HFS are not established aside from temporary discontinuation of chemotherapy agents and drug dosage adjustment because the mechanism of HFS has not been elucidated. According to a previous study, modified Dohongsamul-tang was effective in the treatment of patients with HFS and improved patients' QOL. Based on these results, we administered the soaking method with modified Dohongsamul-tang to a 50-year-old male patient with HCC complaining of HFS due to sorafenib. After two weeks, the symptoms of HFS were improved despite taking sorafenib. We suggest that modified Dohongsamul-tang is a novel method for treating HFS.

Analysis of Dermatologic Diseases in Patients Receiving Anticancer Treatments: A Retrospective Study of 140 Cases (항암제와 관련된 피부이상반응에 대한 고찰)

  • Kang, Jeong Nan;Kim, Do Hyeong;Seol, Jung Eun;Jung, So Young;Wang, Han Young;Kim, Hyojin
    • Korean journal of dermatology
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    • v.55 no.2
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    • pp.89-95
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    • 2017
  • Background: A number of anticancer agents are known to induce many adverse reactions in the skin. Related cutaneous adverse drug reactions influence the morbidity, mortality, and anti-cancer regimen of the patients. A multidisciplinary approach to cancer management has been emphasized. Objective: To identify the causative anticancer agents and frequency of adverse reactions in the skin. Methods: We retrospectively reviewed the medical records of patients who consulted at the Dermatology Department of Busan Paik Hospital and Haeundae Paik Hospital from January 2013 to February 2015. Results: A total of 140 patients were enrolled. Among the 45 patients treated with antimetabolite analogs (30 cytarabine, 7 gemcitabine, 3 methotrexate, 2 fludarabine, 2 doxifluridine, and 1 decitabine), exanthematous drug eruption (49.1%) was the most common reaction, followed by hand-foot syndrome (28.3%). Among the 35 patients treated with fluorouracil (22 5-fluorouracil and 13 capecitabine), hand-foot syndrome (47.2%) was the most common, followed by acneiform eruption (25.0%). Among the 24 patients treated with epidermal grow factor receptor inhibitors (10 erlotinib, 10 cetuximab, and 4 gefitinib), acneiform eruption (54.8%) was the most common, followed by xerosis (19.4%). Among the 11 patients treated with anthracyclines (9 doxorubicin, 1 daunorubicin, and 1 idarubicin), acneiform eruption (45.5%) was the most common, followed by hand-foot syndrome (36.4%). Among the 7 patients treated with taxanes (4 docetaxel and 3 paclitaxel), hand-foot syndrome (42.8%) was the most common. Among the 6 patients treated with angiogenesis-inducing inhibitors (3 sorafenib, 2 pazopanib, and 1 sunitinib), hand-foot skin reaction (66.7%) was the most common. Only 2 patients (1.4%) changed treatments due to intolerable skin reactions. Conclusion: Clinicians should be aware of the various skin reactions of anticancer agents and predict their clinical course effectively.

Differences in Electric Potential of Meridian System (2) -Comparing Electrical Potentials between Healthy Volunteers and Patients with Cerebral Infarction- (12 경맥 전위측정 실험에 대한 연구(2) -정상인과 뇌경색환자의 측정전위 비교-)

  • Nam, Bong-Hyun;Choi, Hwan-Soo
    • Journal of Acupuncture Research
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    • v.17 no.3
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    • pp.25-35
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    • 2000
  • Objectives : The characteristic of meridian system has been similar to this of electric potentials in human body. Therefore to measure the electric potentials in healthy volunteers and patients, and to find out the characteristic of meridian system and also to do that of differences between them. Methods : Twenty-nine healthy volunteers, thirty patients diagnosed as a cerebral infarction and wind-syndrome caused by hyperactivity of the liver-yang(肝陽化風) were examined into electric potential of well(井穴) and sea(合穴) points in branches of the twelve meridians by physiograph. Results : Measurements were analyzed by factor analysis, then we obtained that both the right and the left electric potential of well and sea points in branches of the twelves meridians in healthy volunteers were divided into two factors, hand meridian and foot meridian. Where as the left electric potential of those in patients with cerebral infarction were divided into three factors, one is foot meridian, another is hand meridian with the exception of large intestine meridian, and the other is large intestine meridian and also the right electric potential were divided into three factors, foot meridian, hand meridian with the exception of large intestine and lung meridian, and large intestine and lung meridian. Conclusions : In the results, healthy volunteers differ from patients in characteristic of electrical potentials, which means that we are able to catch the characteristic of meridian system by electrical potentials of well and sea points.

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Concurrent SHORT syndrome and 3q duplication syndrome

  • Boaz, Alexander M.;Grasso, Salvatore A.;DeRogatis, Michael J.;Beesley, Ellis N.
    • Journal of Genetic Medicine
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    • v.16 no.1
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    • pp.15-18
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    • 2019
  • SHORT syndrome is an extremely rare congenital condition due to a chromosomal mutation of the PIK3R1 gene found at 5q13.1. SHORT is a mnemonic representing six manifestations of the syndrome: (S) short stature, (H) hyperextensibility of joints and/or inguinal hernia, (O) ocular depression, (R) Rieger anomaly, and (T) teething delay. Other key aspects of this syndrome not found in the mnemonic include lipodystrophy, triangular face with dimpled chin (progeroid facies, commonly referred to as facial gestalt), hearing loss, vision loss, insulin resistance, and intrauterine growth restriction (IUGR). 3q duplication syndrome is rare syndrome that occurs due to a gain of function mutation found at 3q25.31-33 that presents with a wide array of manifestations including internal organ defects, genitourinary malformations, hand and foot deformities, and mental disability. We present a case of a 2 year and 3 month old male with SHORT syndrome and concurrent 3q duplication syndrome. The patient presented at birth with many of the common manifestations of SHORT syndrome such as bossing of frontal bone of skull, triangular shaped face, lipodystrophy, micrognathia, sunken eyes, and thin, wrinkled skin (progeroid appearance). Additionally, he presented with findings associated with 3q duplication syndrome such as cleft palate and cryptorchidism. Although there is no specific treatment for these conditions, pediatricians should focus on referring patients to various specialists in order to treat each individual manifestation.

Skin-Related Toxicity of Tyrosine Kinase Inhibitor in Thyroid Cancer (갑상선암에서 표적치료항암제의 피부 관련 부작용)

  • Lim, Dong-Jun
    • International journal of thyroidology
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    • v.11 no.2
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    • pp.82-87
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    • 2018
  • Skin-related toxicity is one of the most important adverse events from multi-target tyrosine kinase inhibitor (MTKI) to treat radioiodine refractory thyroid cancer. As hand foot skin reaction can limit quality of life and therapeutic effectiveness, it is essential to cope with a variety of severity of skin-related toxicity induced by MTKI. Herein, we will discuss two representative cases of skin-related toxicities which were managed by discontinuation/reduction of therapeutic doses of MTKI and were treated by proper medication in thyroid cancer patients with distant metastasis.

The Literature Study on Venesection therapy (자락요법(刺絡療法)의 문헌적(文獻的) 고찰(考察))

  • Min, Boo-Ki;Yoon, II-Ji;Choi, Seung-Hoon;Oh, Min-Suck
    • Journal of Haehwa Medicine
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    • v.13 no.2
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    • pp.277-287
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    • 2004
  • I have come to next conclusions in consequence of documentary study about medical books of many generations regarding venesection therapy. 1. Venesection therapy is much used for five sensory organ disease. Besides that internal disease, pain paralysis disease of muscle and joints, sugical disease, disease of woman and children, fever sunstroke CVA emergency case follow that in the order of frequency of use. 2. It is used for swollen tongue, eye pain, pharyngitis, swelling and pain in the throat, bleeding from the eye ear nose mouth or subcutaneous tissue, tonsillitis, aphthae and so on in the five sensory organ disease. Focus, sosang, jinjin yuye, taiyang, baihui are used for five sensory organ disease in the order of frequency of use. 3. It is used for malaria, headache, precordial pain, head-wind, abdominal colic, diseases characterized by acute diarrhea and vomiting, and so on in the Internal disease. Superficial venules and lymph vessesls, taiyang, quze are used for Internal disease in the order of frequency of use. 4. It is used for low back pain, hypochondriac pain, numbness, knee pain, tinea pedis, red swelling pain of hand and arm, flaccidity-syndrome, and so on in the pain paralysis disease of muscle and joints. Weizhong, superficial venules and lymph vessesls, Ashi point, zhigou are used for pain paralysis disease of muscle and joints in the order of frequency of use. 5. It is used for furuncle, tinea capitis, and so on in the sugical disease. Focus, weizhong are used for sugical disease in the order of frequency of use. 6. It is used for inflammatory disease with redness of skin, and so on in the disease of woman and children. Focus, weizhong, yanglingquan, yaoshu, sanyinjiao are used for disease of woman and children in the order of frequency of use. 7. It is used for fever, CVA, sunstroke, cadaverous coma, common cold, and so on in the fever sunstroke CVA emergency case. Sosang, weizhong, chize are used for fever sunstroke CVA emergency case in the order of frequency of use. 8. The urinary bladder channel of foot-taiyang is most used. Next there are the du channel, the stomach channel of foot-yangming, the lung channel of hand-taiyin, the gall baldder channel of foot-shaoyang, the triple-warmer channel of hand-shaoyang, the large intestine channel of hand-yangming, the spleen channel of foot-taiyin, the kidney channel of foot-shaoyin the pericardium channel of hand-jueyin the liver channel of foot-jueyin, the ren channel, the heart channel of hand-shaoyin, the small intestine channel of hand-taiyang in the order of frequency in use. 9. Superficial venules and lymph vessesls, focus, five shu points, extra-point, back point are used in the venesection therapy, those are characteristic of locating an acupuncture point.

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