• Title, Summary, Keyword: gynecologic oncology

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Clinical utility of CA-125 in the management of uterine carcinosarcoma

  • Matsuo, Koji;Ross, Malcolm S.;Yunokawa, Mayu;Johnson, Marian S.;Machida, Hiroko;Omatsu, Kohei;Klobocista, Merieme M.;Im, Dwight D.;Satoh, Shinya;Baba, Tsukasa;Ikeda, Yuji;Bush, Stephen H.;Hasegawa, Kosei;Blake, Erin A.;Takekuma, Munetaka;Shida, Masako;Nishimura, Masato;Adachi, Sosuke;Pejovic, Tanja;Takeuchi, Satoshi;Yokoyama, Takuhei;Ueda, Yutaka;Iwasaki, Keita;Miyake, Takahito M.;Yanai, Shiori;Nagano, Tadayoshi;Takano, Tadao;Shahzad, Mian MK;Ueland, Frederick R.;Kelley, Joseph L.;Roman, Lynda D.
    • Journal of Gynecologic Oncology
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    • v.29 no.6
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    • pp.88.1-88.7
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    • 2018

Palliative Care Education in Gynecologic Oncology: a Survey of Gynecologic Oncologists and Gynecologic Oncology Fellows in Thailand

  • Ratanakaaew, A;Khemapech, N;Laurujisawat, P
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.15
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    • pp.6331-6334
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    • 2015
  • Background: The main purpose of this study was to survey the education and training of certified gynecologic oncologists and fellows in Thailand. A secondary objective was to study the problems in fellowship training regarding palliative care for gynecologic cancer patients. Materials and Methods: A descriptive study was conducted by sending a questionnaire regarding palliative care education to all certified gynecologic oncologists and gynecologic oncology fellows in Thailand. The contents of the survey included fellowship training experience, caring for the dying, patient preparation, attitudes and respondent characteristics. Statistics were analyzed by percentage, mean and standard deviation and chi-square. Results: One hundred seventy completed questionnaires were returned; the response rate was 66%. Most certified gynecologic oncologists and fellows in gynecologic oncology have a positive attitude towards palliative care education, and agree that "psychological distress can result in severe physical suffering". It was found that the curriculum of gynecologic oncology fellowship training equally emphasizes three aspects, namely managing post-operative complications, managing a patient at the end of life and managing a patient with gynecologic oncology. As for experiential training during the fellowship of gynecologic oncology, education regarding breaking bad news, discussion about goals of care and procedures for symptoms control were mostly on-the-job training without explicit teaching. In addition, only 42.9 % of respondents were explicitly taught the coping skill for managing their own stress when caring for palliative patients during fellowship training. Most of respondents rated their clinical competency for palliative care in the "moderately well prepared" level, and the lowest score of the competency was the issue of spiritual care. Conclusions: Almost all certified gynecologic oncologists and fellows in gynecologic oncology have a positive attitude towards learning and teaching in palliative care. In this study, some issues were identified for improving palliative care education such as proper training under the supervision of a mentor, teaching how to deal with work stress, competency in spiritual care and attitudes on responsibility for bereavement care.

Tertiary Cytoreduction for Recurrent Epithelial Ovarian Cancer: a Multicenter Study in Turkey

  • Arvas, Macit;Salihoglu, Yavuz;Sal, Veysel;Gungor, Tayfun;Sozen, Hamdullah;Kahramanoglu, Ilker;Topuz, Samet;Demirkiran, Fuat;Iyibozkurt, Cem;Bese, Tugan;Ozgu, Burcin Salman;Vatansever, Dogan;Tokgozoglu, Nedim;Berkman, Sinan;Turan, Hasan;Bengisu, Ergin;Sofiyeva, Nigar;Demiral, Irem;Meydanli, Mutlu
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.4
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    • pp.1909-1915
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    • 2016
  • Background: The purpose of this study was to determine the benefit of tertiary cytoreductive surgery (TC) for secondary recurrent epithelial ovarian cancer (EOC), focusing on whether optimal cytoreduction has an impact on disease-free survival, and whether certain patient characteristics could identify ideal candidates for TC. Materials and Methods: Retrospective analysis of secondary recurrent EOC patients undergoing TC at three Turkish tertiary institutions from May 1997 to July 2014 was performed. All patients had previously received primary cytoreduction followed by intravenous platinum-based chemotherapy and secondary cytoreduction for first recurrence. Clinical and pathological data were obtained from the patients' medical records. Survival analysis was caried out using the Kaplan Meier method. Actuarial curves were compared by the two tailed Logrank test with a statistical significance level of 0.05. Results: Median age of the patients was 49.6 years (range, 30-67) and thirty-eight (72%) had stage III-IV disease at initial diagnosis. Twenty six (49%) had optimal and 27 (51%) suboptimal cytoreduction during tertiary debulking surgery. Optimal initial cytoreduction, time to first recurrence, optimal secondary cytoreduction, time interval between secondary cytoreduction and secondary recurrence, size of recurrence, disease status at last follow-up were found to be significant risk factors to predict optimal TC. Optimal cytoreduction in initial and tertiary surgery and serum CA-125 level prior to TC were independent prognostic factors on univariate analysis. Conclusions: Our results and a literature review clearly showed that maximal surgical effort should be made in TC, since patients undergoing optimal TC have a better survival. Thus, patients with secondary recurrent EOC in whom optimal cytoreduction can be achieved should be actively selected.

Expression and Functional Role of ALDH1 in Cervical Carcinoma Cells

  • Rao, Qun-Xian;Yao, Ting-Ting;Zhang, Bing-Zhong;Lin, Rong-Chun;Chen, Zhi-Liao;Zhou, Hui;Wang, Li-Juan;Lu, Huai-Wu;Chen, Qin;Di, Na;Lin, Zhong-Qiu
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.4
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    • pp.1325-1331
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    • 2012
  • Tumor formation and growth is dictated by a very small number of tumor cells, called cancer stem cells, which are capable of self-renewal. The genesis of cancer stem cells and their resistance to conventional chemotherapy and radiotherapy via mechanisms such as multidrug resistance, quiescence, enhanced DNA repair abilities and anti-apoptotic mechanisms, make it imperative to develop methods to identify and use these cells as diagnostic or therapeutic targets. Aldehyde dehydrogenase 1 (ALDH1) is used as a cancer stem cell marker. In this study, we evaluated ALDH1 expression in CaSki, HeLa and SiHa cervical cancer cells using the Aldefluor method to isolate ALDH1-positive cells. We showed that higher ALDH1 expression correlated with significantly higher rates of cell proliferation, microsphere formation and migration. We also could demonstrate that SiHa-ALDH1-positive cells were significantly more tumorigenic compared to SiHa-ALDH1-negative cells. Similarly, SiHa cells overexpressing ALDH1 were significantly more tumorigenic and showed higher rates of cell proliferation and migration compared to SiHa cells where ALDH1 expression was knocked down using a lentivirus vector. Our data suggested that ALDH1 is a marker of cervical cancer stem cells and expand our understanding of its functional role.

Current landscape and future perspective of sentinel node mapping in endometrial cancer

  • Bogani, Giorgio;Raspagliesi, Francesco;Maggiore, Umberto Leone Roberti;Mariani, Andrea
    • Journal of Gynecologic Oncology
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    • v.29 no.6
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    • pp.94.1-94.10
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    • 2018
  • Endometrial cancer (EC) represents the most common gynecological neoplasm in developed countries. Surgery is the mainstay of treatment for EC. Although EC is characterized by a high prevalence several features regarding its management are still unclear. In particular the execution of lymphadenectomy is controversial. The recent introduction of sentinel node mapping represents the mid-way between the execution and omission of node dissection in EC patients. In the present review we discuss the emerging role of sentinel node mapping in EC. In addition, we discussed how type of tracers utilized and site of injection impacted on sentinel node detection rates. Future perspective regarding EC management are also discussed.

Early and Late Complications after Inguinofemoral Lymphadenectomy for Vulvar Cancer

  • Cirik, Derya Akdag;Karalok, Alper;Ureyen, Isin;Tasci, Tolga;Kalyoncu, Rukiye;Turkmen, Osman;Kose, M Faruk;Tulunay, Gokhan;Turan, Taner
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.13
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    • pp.5175-5179
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    • 2015
  • Background: We aimed to determine the frequency of early and late complications following groin surgery for vulvar cancer and analyze possible risk factors. Materials and Methods: This retrospective cohort study included 99 women who underwent for vulvar cancer. The early (${\leq}1$ month) complications were wound infection, breakdown and lymphocyst and late (>1 month) complications were lower limb lymphedema, incontinence and erysipelas. The risk factors for developing each of the complications were analyzed with regression analysis. Results: In the entire cohort, 29 (29.3%) women experienced early and 12 (12.1%) had late complications. Wound complications including infection and breakdown were the leading early complications (23.2%). In the multivariate analysis, both obesity (body mass index ${\geq}30kg/m^2$) and advanced age (${\geq}65years$) were found as independent predictive factors for early complications. Obese women of advanced age had 6.32 times more risk of experiencing any of the early complications, when compared to non-obese and young women (55.6% vs 8.7%). The most common late complication was lower limb lymphedema (10.1%) that was more frequently seen in young women. However, neither age nor lymph node count were significantly associated with the occurrence of lower limb lymphedema. Conclusions: More than 40% of the women suffered from postoperative complications after inguinofemoral lymphadenectomy in the current study. While advanced age and obesity were the significant predictors for any of the early complications, there was no identified risk factor for lower limb lymphedema.

Factors Influencing Posttraumatic Growth of Gynecologic Oncology Patients Undergoing Chemotherapy (항암화학요법을 받는 부인암 환자의 외상 후 성장 영향 요인)

  • Yun, Sun Jeong;Kim, Hye Young
    • Korean Journal of Women Health Nursing
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    • v.25 no.4
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    • pp.409-422
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    • 2019
  • Purpose: The purpose of this study was to investigate the factors impacting the posttraumatic growth (PTG) factors during chemotherapy in gynecologic oncology patients. Method: The data were collected at six hospitals at a university hospital, general hospital, women's hospital, and 3 oncology hospitals in D metropolitan city. The participants of the study were 135 female patients undergoing chemotherapy for their gynecologic oncology. To identify the factors that influence PTG, we used the questionnaires for the family support, sexual distress, health promoting behavior, and PTG. Results: There was a significant positive correlation between family support and health promoting behavior and PTG. There was significant negative correlation between sexual distress and PTG. Factors impacting the PTG of gynecologic oncology women undergoing chemotherapy were age, recurrence, family support, sexual distress, and health promoting behavior. These factors accounted for 47.0% of PTG. Conclusion: It is necessary to develop and apply programs that include sexual distress management education, and health promotion with families. PTG programs for gynecologic oncology patients undergoing chemotherapy should be approached considering these results.

Is Target Oriented Surgery Sufficient with Borderline Ovarian Tumors? - Role of Accompanying Pathologies

  • Gungor, Tayfun;Cetinkaya, Nilufer;Yalcin, Hakan;Ozdal, Bulent;Ozgu, Emre;Baser, Eralp;Yilmaz, Nafiye;Caglar, Mete;Zergeroglu, Sema;Erkaya, Salim
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.16
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    • pp.6749-6754
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    • 2014
  • Background: There are limited data in the literature related to concomitant genital or extra-genital organ pathologies in patients with borderline ovarian tumors (BOTs). The aim of this study was to evaluate our experience with 183 patients to draw attention to the accompanying organ pathologies with BOTs. Materials and Methods: One hundred eighty-three patients with BOTs, diagnosed and/or treated in our center between January of 2000 and March of 2013 were evaluated retrospectively. Data related to age, tumor histology, lesion side, disease stage, accompanying incidental ipsilateral and/or contralateral ovarian pathologies, treatment approaches, and follow-up periods were investigated. Incidental gynecologic and non-gynecologic concomitant organ pathologies were also recorded. Results: The mean age at diagnosis was 40.6 years (range: 17-78). Ninety-five patients (51%) were ${\leq}40$ years. A hundred and forty-seven patients (80%) were at stage IA of the disease. The most common type of BOT was serous in histology. Non-invasive tumor implants were diagnosed in 4% and uterine involvement was found 2% among patients who underwent hysterectomies. There were 12 patients with positive peritoneal washings. Only 17 and 84 patients respectively had concomitant ipsilateral and concomitant contralateral incidental ovarian pathologies. The most common type of uterine, appendicular and omental pathologies were chronic cervicitis, lymphoid hyperplasia and chronic inflammatory reaction. Conclusions: According to our findings most of accompanying pathologies for BOT are benign in nature. Nevertheless, there were additional malignant diseases necessitating further therapy. We emphasize the importance of the evaluation of all abdominal organs during surgery.