• Title, Summary, Keyword: gastritis

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A Study on the degree and Types of Gastritis and Gastrointestinal Symptoms (사상체질(四象體質)과 성별(性別)에 따른 위염(胃炎)의 정도, 종류 및 소화기(消化器) 증상(症狀)에 관한 연구)

  • Lee, Tae-Gyu;Hwang, Min-Woo;Lim, Jinny;Kim, Sang-Bok;Lee, Soo-Kyung;Koh, Byung-Hee;Song, Il-Byung
    • Journal of Sasang Constitutional Medicine
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    • v.16 no.2
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    • pp.58-64
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    • 2004
  • 1. Objectives However there was a report that dyspepsia occurs more frequently in Soeumin, there has not been any clinical research if structural changes such as gastritis occurs differently according to Sasang Constitution. So in this research, we investigated to find out if there are differences in the degree and types of gastritis and gastrointestinal symptoms according to Sasang Constitution and gender difference. 2. Methods Subjects were 30 men and 38 women, who had visited Kyung-Hee Medical Center for physical examination and took gastroscopy and differential diagnosis of Sasang Constitution in March, 2003. We investigated the degree and types of gastritis and gastrointestinal symptoms. 3. Results and conclusions Gender difference han no relation with types of gastritis, but had significant relation with the degree of gastritis and gastrointestinal symptoms. But Sasang Constitution had no significant relation with the degree and types of gastritis and gastrointestinal symptoms.

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A Review of Recent Clinical Research about Banhasasim-tang Combined with Conventional Therapy on Atrophic Gastritis (위축성 위염에 대한 반하사심탕과 표준치료 병용요법의 최신 연구 동향)

  • Lee, Ga-young;Ahn, Su-bin;Jeong, Min-jeong;Jang, In-soo
    • The Journal of Internal Korean Medicine
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    • v.40 no.6
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    • pp.1169-1178
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    • 2019
  • Objective: The purpose of this study was to investigate the effect of combined therapy with Banhasasim-tang and conventional treatment for atrophic Gastritis. Methods: The study collected data of clinical studies of combined therapy with Banhasasim-tang and conventional treatment for atrophic gastritis. Electronic databases were used, including PubMed, Cochrane, CNKI, Wanfang, CINII, J-stage, NDSL, and OASIS. The main search terms included such as "Atrophic Gastritis", "Banhasasim-tang", "BanXia Xiexin Tang". This study only included randomized controlled trials (RCTs) that adopted combined therapy with Banhasasim-tang and conventional treatment for atrophic gastritis. Results: A total of 18 RCTs were selected. They all adopted combined therapy with Banhasasim-tang and conventional treatment for atrophic gastritis. In all the studies, the intervention group significantly improved the score of effective rate, and in the 8 studies, Hp negative conversion rate was significantly improved when Banhasasim-tang was taken. Conclusion: Through the analysis of 18 RCTs, we found Banhasasim-tang combined with conventional therapy were more effective in the positive performance of atrophic gastritis than conventional therapy single contribution. However, due to the low quality of the selected studies and the lack of endoscopy, biopsy, follow-up observation, so there is a slight insufficient to prove its conclusion. Therefore, we hope that more systematic and diverse clinical studies will be conducted.

The Inhibitory Effect of Quercetin-3-O-${\beta}$-D-Glucuronopyranoside on Gastritis and Reflux Esophagitis in Rats

  • Min, Young-Sil;Lee, Se-Eun;Hong, Seung-Tae;Kim, Hyun-Sik;Choi, Byung-Chul;Sim, Sang-Soo;Whang, Wan-Kyun;Sohn, Uy-Dong
    • The Korean Journal of Physiology and Pharmacology
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    • v.13 no.4
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    • pp.295-300
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    • 2009
  • It was evaluated the inhibitory action of quercetin-3-O-${\beta}$-D-glucuronopyranoside (QGC) on reflux esophagitis and gastritis in rats. QGC was isolated from the herba of Rumex Aquaticus. Reflux esophagitis or gastritis was induced surgically or by administering indomethacin, respectively. Oral QGC decreased ulcer index, injury area, gastric volume, and acid output and increased gastric pH as compared with quercetin. Furthermore, QGC significantly decreased gastric lesion sizes induced by exposing the gastric mucosa to indomethacin. Malondialdehyde levels were found to increase significantly after inducing reflux esophagitis, and were reduced by QGC, but not by quercetin or omeprazole. These results show that QGC can inhibit reflux esophagitis and gastritis in rats.

The Inhibitory effect of omeprazole-cholestyramine resin in gastric secretion of rat (Omeprazole-cholestyramine resin 제제의 위산분비에 대한 억제효과)

  • 이영욱;김일웅;정지훈;라현오;최경범;이남인;손의동;허인회
    • Biomolecules & Therapeutics
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    • v.8 no.4
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    • pp.318-324
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    • 2000
  • We have examined inhibitory erects on gasritis using omeprazole-cholestyramine resinate, which has been developed to increase the stability of omeprazole, the well-known proton pump inhibitor, in an acidic condition. To test the pharmacological action of this, we investigated the effect of omeprazole-cholestyramine resinate on indomethacin-induced gastritis in rats. Omeprazole was used as a reference drug. Orally administered omeprazole-cholestyramine resinate inhibited the indomethacin-induced gastritis in a dose-dependent manner. The inhibitory effect of omeprazole-cholestyramine resinate on the gastritis was similar to that of reference drug. In addition, rectal adminstration of the omeprazole-cholestyramine resinate inhibited the indomethacin-induced gastritis in a dose-dependent manner. The inhibitory effect of omeprazole-cholestyramine resinate was equipotent to reference drug. The basal gastric acid secretion was decreased when it was administered either orally or rectally. This inhibition of omfprazole-cholestyramine resinate was similar to that of omeprazole. These data suggest that omeprazole-cholestyramine resinate inhibit the gastritis in rats, and are comparable to omeprazole available in market.

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Acute Gastritis and Splenic Infarction Caused by Epstein-Barr Virus

  • Jeong, Ji Eun;Kim, Kyung Moon;Jung, Hye Lim;Shim, Jae Won;Kim, Deok Soo;Shim, Jung Yeon;Park, Moon Soo;Park, Soo Kyung
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.21 no.2
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    • pp.147-153
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    • 2018
  • Epstein-Barr virus (EBV) infection can be presented with various clinical manifestations and different levels of severity when infected. Infectious mononucleosis, which is most commonly caused by EBV infection in children and adolescents, is a clinical syndrome characterized by fatigue, malaise, fever, sore throat, and generalized lymphadenopathy. But rarely, patients with infectious mononucleosis may present with gastrointestinal symptoms and complicated by gastritis, splenic infarction, and splenic rupture. We encountered a 16-year-old girl who presented with fever, fatigue, and epigastric pain. Splenic infarction and EBV-associated gastritis were diagnosed by using esophagogastroduodenoscopy and abdominal computed tomography. Endoscopy revealed a generalized hyperemic nodular lesion in the stomach, and the biopsy findings were chronic gastritis with erosion and positive in situ hybridization for EBV. As splenic infarction and acute gastritis are rare in infectious mononucleosis and are prone to be overlooked, we must consider these complications when an infectious mononucleosis patient presents with gastrointestinal symptom.

Gastroprotective Effect of the Three Glucuronopyranoside Flavonoids in Rats

  • Im, Wi Joon;Nam, Yoonjin;Park, Sun Young;Sohn, Uy Dong
    • The Korean Journal of Physiology and Pharmacology
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    • v.17 no.5
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    • pp.411-415
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    • 2013
  • In this study, we investigated the protective action of glucuronopyranoside flavonoids (QGC, AGC, LGC) on gastritis in rats. QGC, AGC and omeprazole decreased the gastric volume significantly, and each $ID_{50}$ was 0.75, 0.54 and 8.5 mg/kg, respectively, thus the order of potency was AGC, QGC and omeprazole. They also decreased acid output, and each $ID_{50}$ was 7.81, 0.58 and 6.71 mg/kg, respectively, thus the order of potency was AGC, omeprazole and QGC. They inhibited gastritis induced by indomethacin, and it recovered significantly by increasing the GSH levels in gastritis. The gastric MPO activity in the gastritis group increased more than in the normal group. QGC, LGC, or AGC administration reduced moderately the MPO activity in a dose-dependent manner. This study demonstrated that AGC, QGC, or LGC showed potent efficacy on the gastritis, by preventing oxidative stress. These results suggest that QGC, AGC, or LGC have gastroprotective effect in rats.

Guideline for the Clinical Trials Evaluation for Gastritis (위염치료제의 임상시험평가지침 연구)

  • Song, Yun-Kyoung;Jin, Sun-Kyung;Han, Eui-Sik;Ahn, Mee-Ryung;Jung, Ju-Yeon;Lee, Rhee-Da;Cho, Il-Yong;Kim, Dong-Sub;Ji, Eun-Hee;Park, Hyo-Young;Oh, Jung-Mi;Shin, Won;Lee, Sun-Hee;Kim, In-Kyu
    • YAKHAK HOEJI
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    • v.55 no.4
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    • pp.345-351
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    • 2011
  • Gastritis is the most common disease among Korean. The demand for the development of gastritis drugs has been increasing. Currently, however, there is no guideline available for the clinical evaluation of gastritis drugs worldwide. As a consequence, domestic and international pharmaceutical companies make errors in the drug development processes, and it becomes difficult for them to establish the scientific validity and objectivity of newly developed drugs. The objective of this study was to develop the Guideline for Clinical Trials Evaluation of Gastritis which can be used in improving the quality and consistency of clinical trials. First, we collected and reviewed the clinical trials on gastritis drugs that were available from Japan Pharmaceuticals and Medical Devices Agency and Korea Food and Drug Administration (KFDA), and investigated the recent research trends on clinical trials of gastritis drugs. Reviewers from KFDA and National Institute of Food and Drug Safety Evaluation and scientific experts from the pharmaceutical industries developed the guidelines through regularly scheduled meetings. Opinions and consultation from academic fields and industry experts were also obtained. This project will provide the clinical trial practitioners, investigator and reviewers the scientific and rational guidelines for performance and evaluation of clinical trials for gastritis drugs. Furthermore, we hope this guideline contributes to establishing the national competitiveness, improving the quality of clinical trial, and encouraging researches on drug development for gastritis.

Praziquantel Treatment of Eosinophilic Gastritis Suspected to Be Due to Cerebral Sparganosis (뇌 스파르가눔증으로 인한 호산구성 위염 환자에서의 프라지콴텔 치료)

  • Lee, Sang-Hoon;Nam, Seung-Joo;Lee, Sung Joon;Kang, Chang Don;Choi, Dae Hee;Choi, Jang Won;Lee, SeungKoo
    • The Korean Journal of Medicine
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    • v.93 no.5
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    • pp.473-476
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    • 2018
  • Eosinophilic gastritis is characterized by eosinophilic infiltration of the gastrointestinal tract, which is associated with abdominal pain, diarrhea, nausea, and vomiting. The possible etiologies of secondary eosinophilic gastritis, including drug reactions, parasitic infestation, and malignancy, must be evaluated. Herein we report the case of a 65-year-old North Korean defector who presented with nausea and vomiting for 1 year. Secondary (reactive) eosinophilic gastritis caused by cerebral sparganosis was suspected after a workup that included brain magnetic resonance imaging, cerebrospinal fluid tapping, and gastric mucosal biopsy. The patient showed dramatic clinical improvement with high-dose praziquantel treatment. Even though secondary (reactive) eosinophilic gastritis caused by parasites is very rare, this case shows the importance of considering parasitic infection in eosinophilic gastritis.

The Related Factors to Perceived gastritis or Perceived enteritis in High school seniors -the 2009 Korea Youth Risk Behavior Web-based Survey- (고등학교 3학년 학생들이 인지한 위염 및 장염 관련요인 -2009년 청소년 건강행태 온라인 조사 자료를 중심으로-)

  • Bea, Sang-Sook
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.13 no.2
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    • pp.668-677
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    • 2012
  • This study analyzed the related factors affecting to perceived gastritis or perceived enteritis for 11,753 Korean high school seniors who participated in the 2009 Korea Youth Risk Behavior Web-based Survey (KYHRBWS). Of the subjects, 5,685 (47.6%)were male and 6,068(52.4%) were female and 8.7% of the students responded that they had suffered from gastritis or enteritis for a long time and the females had a slightly higher attack rate of gastritis or enteritis. Survey logistic regression models and decision tree analysis were used to calculate odd ratios and 95% confidence intervals. As a result, there was affecting to their stress and health behaviors in the risk of gastritis and enteritis, and that their lower level perceived health, smoking, heavy drinking or starting drinking before they were 13 years old and a higher level of perceived stress significantly affected the risk of gastritis or enteritis in the subjects(p<.001).

Detection of p53 Common Intron Polymorphisms in Patients with Gastritis Lesions from Iran

  • Sadeghi, Rouhallah Najjar;Damavand, Behzad;Vahedi, Mohsen;Mohebbi, Seyed Reza;Zojazi, Homayon;Molaei, Mahsa;Zali, Mohamad Reza
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.1
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    • pp.91-96
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    • 2013
  • Background: p53 alterations have been implicated in the development of many cancers, such as gastric cancer, but there is no evidence of p53 intron alterations in gastritis lesions. The aim of this study was to investigate the p53 intron alterations in gastritis along with p53 and mismatch repair protein expression and microsatellite status. Materials and Methods: PCR-sequencing was conducted for introns 2-7 on DNA extracted from 97 paired samples of gastritis lesions and normal adjacent tissue. Abnormal accumulation of p53 and mismatch repair proteins was investigated using immunohistochemistry. In addition, microsatellite status was evaluated with reference to five mononucleotide markers. Results: Gastritis cases included 41 males and 56 females in the age range of 15-83 years, 87.6% being H.pylori positive. IVS2+38, IVS3ins16 and IVS7+72 were the most polymorphic sites. Their minor allele frequency values were as follows: 0.38, 0.21 and 0.06, respectively. Samples with GG genotype at IVS2+38 and CT at IVS7+72 had no insertion. Moreover, most of the stable samples (91.9 %) had a G allele at IVS2+38. All of the samples were IHC negative for p53 protein, microsatellite stable and expressed mismatch repair proteins. p53 alterations were prominent in the H. Pylori+ group, but without statistical significance. Conclusions: According to our results, some p53 polymorphisms such as IVS2+38, IVS3ins16 and IVS7+72, because of their correlations together or with microsatellite status may contribute to gastritis development. However, so far effects on p53 expression and function remain unclear. Therefore, a comprehensive survey is needed to delineate their biological significance.