• Title, Summary, Keyword: fine needle aspiration cytology

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Fine Needle Aspiration Cytology of Liposarcoma - Report of 3 cases - (세침 흡인 세포학적 검사로 진단된 지방육종 -3 예 보고-)

  • Koh, Eun-Suk;Jin, So-Young;Kwon, Tae-Jung;Lee, Dong-Wha
    • The Korean Journal of Cytopathology
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    • v.1 no.2
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    • pp.139-146
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    • 1990
  • The application of fine needle aspiration (FNA) cytology to the soft tissue tumors had been neglected. In recent years, however, FNA has been used increasingly in the preoperative diagnosis of these tumors due to its usefulness and accuracy. We present 3 cases of liposarcoma, myxoid, myxoid with round cell, and pleomorphic, diagnosed by FNA cytology with histologic confirmation. Good correlation between histologic and FNA cytologic findings was found. Although the cytologic appearances of liposarcomas varied with histologic type, the main criterion was the presence of atypical multivacuolated lipoblast with characteristically scalloped nuclei.

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Fine Needle Aspiration Cytology of Presacral Chordoma -A Case Report- (척삭종의 세침흡인 세포학적 소견 - 1 증례 보고 -)

  • Yeon, Su-Kyeong;Jee, Mi-Kyung;Kang, Chang-Suk;Kim, Byoung-Kee;Kim, Sun-Moo;Sim, Sang-In
    • The Korean Journal of Cytopathology
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    • v.4 no.2
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    • pp.133-139
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    • 1993
  • A case of presacral chordoma in a 55-year-old male diagnosed by aspiration biopsy cytology Is reported. Cytologically, three cell types were recognized in a mucoid background. large, mononucleated or binucleated physaliphorous cells with vacuolated bubbly cytoplasm; small, uniform and rounded non-vacuolated cells; and cells with microvacuolated and plump cytoplasm. The diagnosis of chordoma was possible because typical radiological and cytomorphological features were supported by the results of special staining and immunohistochemical staining with the cell block specimen obtained from the fine needle aspiration.

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Diagnostic Pitfalls in Breast Fine Needle Aspiration Cytology: False Positive and False Negative (유방 세침흡인 세포검사의 진단적 함정: 위양성과 위음성)

  • Park, Kyeong-Mee
    • The Korean Journal of Cytopathology
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    • v.18 no.2
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    • pp.112-118
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    • 2007
  • Fine needle aspiration cytology (FNAC) has become a highly preferred, minimally invasive diagnostic tool of choice in the diagnosis of a palpable breast mass owing to its sensitivity, specificity, cost-effectiveness, and expediency. Although breast needle biopsies have been widely employed recently due to the increased detection rate of non-palpable early lesions, the importance of the use of FNAC cannot be underestimated. It comprises part of the diagnostic triad for the breast along with a physical examination and mammography, which together contribute to an increasing diagnostic accuracy. The differential diagnosis of a benign and malignant lesion is of the utmost importance in the diagnosis of breast lesions, and therefore the understanding of the possible diagnostic pitfalls is of great importance.

Fine Needle Aspiration Cytology of Sparganosis (스파르가눔증의 세침흡인 세포학적 소견)

  • Paeng, Sung-Suk;Kim, Yoon-Ju;Yang, Seong-Eun;Chang, Hee-Jin;Suh, Jung-Il;Moon, Young-Chun
    • The Korean Journal of Cytopathology
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    • v.7 no.1
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    • pp.59-63
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    • 1996
  • Human sparganosis is a rare parasitic disease in which the larval cestode proliferates in the various organs in the body. It usually presents as a subcutaneous or soft tissue mass. By fine needle aspiration this lesion can be diagnosed with its characteristic cytologic findings. We experienced 3 cases of sparganosis diagnosed by the fine needle aspiration. Aspirates were taken from subcutaneous mass in the abdomen and both thighs respect ively. The aspirates showed a portion of body of sparganum with numerous calcospherules, smooth muscles and tegmental cells. They also revealed granulomas with various inflammatory infiltration of eosinophils, neutrophils, lymphocytes and plasma cells.

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Fine Needle Aspiration Cytology of the Breast (유방의 세침 흡인 세포학)

  • Cho, Kyung-Ja;Koh, Jae-Soo;Ha, Chang-Won;Jang, Ja-June
    • The Korean Journal of Cytopathology
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    • v.3 no.2
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    • pp.52-59
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    • 1992
  • A number of studies have shown the value of fine needle aspiration cytology for the diagnosis of breast lesions, but reports on the comparison of cytologic and histologic variations of breast cancers are few. We reviewed histologically proven 106 breast aspirates with an emphasis on the cytology of ductal carcinomas and of an area of uncertain atypia. Positive and negative predictive values of breast aspiration cytology were 100% On review of the cases originally diagnosed as atypia of uncertain nature (19 %), features more suggestive of malignancy or benignancy were recognizable in most underdiagnosed cases and a half of overdiagnosed cases, respectively. However, indistinguishable atypism also remained. Thirty seven cases out of 53 infiltrating duct carcinomas revealed malignant cytology, with variations in background, cellularity, morphology of cell groups, and extent of isolated tumor cells. When classifying the infiltrating duct carcinomas into scirrhous, solid-tubular, and papillotubular types, scirrhous type frequently appeared as irregularly shaped tight or loose cell clusters, and solid-tubular type as round-margined cell balls.

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Fine Needle Aspiration Cytology of Osteoclastic Giant Cell Tumor of the Pancreas (췌장의 파골성 거대세포종양의 세침흡인세포학적 소견)

  • Sung, Sun-Hee;Han, Woon-Sup
    • The Korean Journal of Cytopathology
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    • v.9 no.1
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    • pp.89-94
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    • 1998
  • A case of fine needle aspiration cytology of an osteoclastic giant cell tumor of pancreas, which is an uncommon variant of ductal adenocarcinoma, is described. Aspirated tumor cells were characterized by three populations: (1) bland osteoclast like giant cells with multiple small, round nuclei with distinct nucleoli, and abundant cytoplasm, (2) Individually scattered or loosely clustered medium sized mononuclear tumor cells, having fine chromatin, smooth nuclear membrane, often prominent nucleoli, and high N/C ratio, (3) bland or atypical spindle shaped cells. Osteoid like lacy material was also seen on cell block section. The immunohistochemical studies using paraffin embedded cell block section showed positivities for vimentin and lysozyme in both giant and mononuclear turner cells. However, they were negative for cytokeratin, epithelial membrane antigen, S-100 protein, carcinoembryonic antigen, and p53.

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Fine Needle Aspiration Cytology in Bone and Soft Tissue Tumor (골 및 연부 조직 종양에서의 미세 침 흡입 세포 검사)

  • Lee, Soo-Yong;Jeon, Dae-Geun;Lee, Jong-Seok;Kim, Sug-Jun;Cho, Kyung-Ja;Oh, Hyung-Ho;Park, Min-Hyo;Park, Hyun-Soo;Jang, Jin-Dae
    • The Journal of the Korean bone and joint tumor society
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    • v.2 no.1
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    • pp.33-37
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    • 1996
  • From January 1994 to August 1995 we performed 270 cases of fine needle aspiration cytology for bone and soft tissue lesions. Among them 137 cases were diagnosed histologically. Sixty-seven cases were benign and 70 cases were malignant. We analysed these on the aspect of sensitivity, specifity, positive predictive value, negative predictive value of the cytologic examination. Malignant cases consisted of bone tumor 29 cases; soft tissue tumor 25 cases; and metastatic tumor 16 cases. The sensitivity and specifity of the aspiration cytology for malignant tumor were 67.8% and 97%, respectively. The positive and negative predictive value of aspiration cytology were 97.4% and 72.7%, respectively. Among them 40 cases were primary bony lesions; 14 benign lesions, 26 malignamt bone tumors. Sensitivity of aspiration cytology for these primary bony lesion was 90%(18/20) and its specifity was 100%(13/13). Three cases showed atypical cells in cytology but with biopsy we could find them as one benign and two malignancies. Two cases of manignancy showed negative result in cytology; one was parosteal sarcoma of proximal femur and the other was osteosarcoma of proximal tibia which was biopsied already at other hospital. Although the overall sensitivity and specifity for malignant bone and soft tissue tumors were relatively low and not so predictable, the fine needle aspiration cytology for primary bony lesion was useful in the differential diagnosis of benign or malignancy.

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Fine Needle Aspiration Cytology of Clear Cell Sarcoma - A Case Report - (투명세포육종의 세침흡인 세포학적 소견 - 1예 보고 -)

  • Lim, Sung-Chul;Chung, You-Kyung;Kim, Dong-Chool;Lee, Yoon-Kyung;Shin, Eun-Taik
    • The Korean Journal of Cytopathology
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    • v.9 no.2
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    • pp.233-239
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    • 1998
  • Clear ceil sarcoma(CCS) is an uncommon soft tissue sarcoma that occurs in tendons and aponeuroses, usually of the lower extremities and is believed to be of neural crest origin that have a capability to produce melanin. These tumors commonly metastasize and have a very poor prognosis. The fine needle aspiration cytologic finding of CCS is not well documented. We recently experienced a case of CCS. The patient was a 54-year-old male with painful swelling of the right inguinal area. Fine needle aspiration cytology revealed polygonal or fusiform tumor cells with clear or granular cytoplasm and vesicular nuclei containing one or two nucleoli. Immunohistochemical staining for S-100 protein and HMB-45 revealed strong positivity and variable developing stages of premelanosomes were observed by electron microscopy in the excised specimen.

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Fine Needle Aspiration Cytology of Pulmonary Lesions in Wegener's Granulomatosis - A Case Report - (Wegener's Granulomatosis 폐병변의 세침흡인 세포학적 소견 - 1예 보고 -)

  • Seo, Eun-Joo;Kwon, Hi-Jeong;Min, Ki-Ouk
    • The Korean Journal of Cytopathology
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    • v.9 no.1
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    • pp.85-88
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    • 1998
  • We described the findings of fine needle aspiration cytology of the lung from a patient with Wegener's granulomatosis. Early diagnosis and prompt treatment of the patients with Wegener's granulomatosis is essential for a better prognosis. However, the variety of clinical presentations and nonspecific radiologic infiltrates of Wegener's granulomatosis frequently make the diagnosis difficult. Although an open lung biopsy is required for a firm diagnosis, fine needle aspiration cytology & biopsy preparation can also provide an adequate tissue sample, when the findings of fine needle aspiration are considered with clinical manifestations and ANCA value in the serum. The cytologic smears showed scattered necrotic tissue fragments entrapping many neutrophils and occasional epithelioid cells. Multinucleated giant cells were infrequently observed. Ziehl-Neelsen stain for acid fast bacilli was negative. All the cytologic features recapitulated the histopathologic findings of purulent and necrotizing granulomatous inflammation seen in Wegener's granulomatosis.

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Fine Needle Aspiration Cytology of Ganglioneuroma - A Case Report - (신경절신경종의 세침흡인 세포학적 소견 - 1예 보고 -)

  • Kim, Hee-Kyung;Jin, So-Young;Lee, Dong-Wha
    • The Korean Journal of Cytopathology
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    • v.14 no.1
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    • pp.12-16
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    • 2003
  • Ganglioneuroma is a well-differentiated, benign tumor of the sympathetic nervous system. These tumors belong to a family of neoplasm that exhibit a wide range of differentiation, with neuroblastoma at one end and ganglioneuroma at the other. Because it share morphologic features with other both benign and malignant neural tumors, accurate preoperative diagnosis is often difficult. Nonetheless, it is critical for proper management. Fine needle aspiration cytology (FNAC) in the diagnosis of the ganglioneuroma has been a little documented. We describe a case of mediastinal ganglioneuroma in a 33-month-old girl. The diagnosis was suggested on FNAC and was confirmed by histopathologic examination later.