• Title, Summary, Keyword: family History

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The association of family history of prostate cancer with the diagnosis of clinically significant prostate cancer in Korean population

  • Park, Jee Soo;Koo, Kyo Chul;Chung, Byung Ha;Lee, Kwang Suk
    • Investigative and Clinical Urology
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    • v.60 no.6
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    • pp.442-446
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    • 2019
  • Purpose: The impact of family history on the diagnosis of the prostate cancer among Asian population remains controversial. We evaluated whether a positive family history of the prostate cancer in Korean men is associated with the diagnosis and aggressiveness of the prostate cancer. Materials and Methods: Patients who underwent a transrectal ultrasound-guided prostate biopsy from March 2015 to September 2017 were evaluated. Information on family history was obtained via a self-administered questionnaire. The presence of prostate cancer and clinically significant prostate cancer (Gleason score ≥7) was evaluated according to the presence of a family history. Results: Of 602 patients (median age, 68.3 years; median prostate-specific antigen level, 6.28 ng/mL), 41 (6.8%) patients had a family history of prostate cancer. Family history was a significant factor for detecting prostate cancer (odds ratio [OR], 2.99; 95% confidence interval [CI], 1.330-6.704; p=0.008). In multivariate analysis for predicting clinically significant prostate cancer, family history was a significant predictor (OR, 6.32; 95% CI; 2.790-14.298; p<0.001). Conclusions: A family history of prostate cancer in Korean men was a significant factor for predicting prostate cancer. Moreover, significant differences in the aggressive features of the disease were identified between patients with and without a family history.

Study on the Distribution and Correlation of Stroke Risk Factor according to Age with Stroke Patients - Focused on Past History and Stroke Family History (중풍 환자의 연령에 따른 중풍 위험인자의 분포 및 상관관계 연구 - 병력과 중풍 가족력 중심으로)

  • Shin, Hyun-Su;Kang, Byoung-Kab;Jo, Hyun-Kyung
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.25 no.4
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    • pp.734-742
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    • 2011
  • The purpose of this study was to investigate the distribution and correlation of stroke risk factor according to age with stroke patients. This study was based on clinical data registered in Daejeon Oriental Medical Hospital from November 2006 to December 2010. Study subjects consisted of 779 patients with stroke within 1 month and they were classified according to age and existence of past history such as hypertension, diabetes mellitus, ischemic heart diseaseand stroke family history. Stroke family history was distributed differently according to age unlike past history and in their 50's showed a particularly high rate. There was not statistically significant correlation between stroke family history and past history except for only between stroke family history and diabetes mellitus in the patients in their 80's and more. There was statistically significant correlation between hypertension and diabetes mellitus and especially in the patients in their 60's and 70's. There was statistically significant correlation between hypertension and ischemic heart disease and especially in the patients in their 80's and more. There was statistically significant correlation between diabetes mellitus and ischemic heart disease in the patients in their 60's. There was statistically significant correlation among hypertension, diabetes mellitus and ischemic heart disease, but stroke family history and past history had independence, so management and research for this subject should be required further and further.

Family History and Survival of Patients with Gastric Cancer: A Meta-Analysis

  • Oh, Myueng Guen;Kim, Jin Hwa;Han, Mi Ah;Park, Jong;Ryu, So Yeon;Choi, Seong Woo
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.8
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    • pp.3465-3470
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    • 2014
  • Background: Previous studies have generated conflicting evidence regarding associations between family history and survival after gastric cancer surgery. In this study, we investigated this question using a meta-analysis. Materials and Methods: To identify relevant studies, PubMed and Embase databases were searched up to June 2013. Two reviewers independently assessed search results and data extraction of included studies. Hazard ratios (HRs) and 95% confidence intervals (CIs) for overall survival (OS) were calculated based on fixed- or random-effects models. Homogeneity of effects across studies was assessed using $x^2$ test statistics and quantified by $I^2$. Results: A total of five studies were selected according to the inclusion criteria. The total number of patients included was 2,030, which ranged from 145 to 598 per study. There was no significant difference in OS by family history of cancer (HR=0.83, 95%CIs=0.50-1.38), but subgroup analysis of patients with a first-degree family history of cancer (HR=0.74, 95%CIs=0.60-0.93) and gastric cancer family history (HR=0.56, 95%CIs=0.41-0.76) tended to show better OS in these patients. Conclusions: This meta-analysis suggests that a first-degree family history of cancer or gastric cancer family history is associated with better survival of gastric cancer patients after surgery, after a systematic review of five previous studies. These results can be applied by clinicians when counselling patients regarding their risk of death from gastric cancer. Further study is needed to investigate the underlying mechanism between family history and survival in gastric cancer patients.

Reliability of Covariates in Baseline Survey of a Cohort Study: Epidemiological Investigation on Cancer Risk Among Residents Who Reside Near the Nuclear Power Plants in Korea (코호트 기반 조사 공변수 자료의 신뢰도 평가 연구: 원전주변지역주민 역학조사연구)

  • Bae, Sang-Hyuk;Park, Bo-Young;Li, Zhong-Min;Ahn, Yoon-Ok
    • Journal of Preventive Medicine and Public Health
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    • v.43 no.2
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    • pp.159-165
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    • 2010
  • Objectives: We evaluated the reliability of the possible covariates of the baseline survey data collected for the Epidemiological Investigation on Cancer Risk Among Residents Who Reside Near the Nuclear Power Plants in Korea. Methods: Follow-up surveys were conducted for 477 participants of the cohort at less than 1 year after the initial survey. The mean interval between the initial and follow-up surveys was 282.5 days. Possible covariates were identified by analyzing the correlations with the exposure variable and associations with the outcome variables for all the variables. Logistic regression analysis with stepwise selection was further conducted among the possible covariates to select variables that have covariance with other variables. We considered that these variables can be representing other variables. Seven variables for the males and 3 variables for the females, which had covariance with other possible covariates, were selected as representative variables. The Kappa index of each variable was calculated. Results: For the males, the Kappa indexes were as follow; family history of cancer was 0.64, family history of liver diseases in parents and siblings was 0.56, family history of hypertension in parents and siblings was 0.51, family history of liver diseases was 0.50, family history of hypertension was 0.44, a history of chronic liver diseases was 0.53 and history of pulmonary tuberculosis was 0.36. For females, the Kappa indexes were as follow; family history of cancer was 0.58, family history of hypertension in parents and siblings was 0.56 and family history of hypertension was 0.47. Conclusions: Most of the possible covariates showed good to moderate agreement.

Case-Control Study on the Relationships between Stroke and Stroke Risk Factors in Korea - Focused on Family History and Past History - (중풍발병과 중풍발병 위험요인들간의 관계에 대한 환자.대조군 연구 - 가족력과 병력을 중심으로 -)

  • Chang, Mun-Won;Ko, Mi-Mi;An, Joung-Jo;Yoo, Ho-Rhyong;Kim, Yoon-Sik;Seol, In-Chan;Jo, Hyun-Kyung
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.26 no.2
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    • pp.234-240
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    • 2012
  • The purpose of this case-control study is to investigate the relationship between storke and stroke risk factors, such as family history and past history. The case-control study over clinical data registered from Daejeon Oriental Medical Hospital in the period of November 2006 to July 2010. Study subjects consisted of 108 patients with acute stroke within 1 month as the case group (Cases) and 108 people who visited hospital for health care as the genreral control group (Controls). The participants had been interviewed by residents to find out their family history and past history. Their blood was taken to check the blood lipid level and liver function. 1. The people whose family history included cerebrovascular accident had more probability of stroke than the people who did not have cerebral vascular accident as their family history. 2. The people who suffered from hypertension had more probability of stroke than the people who did not suffer from hypertension. 3. The people who suffered from diabetes mellitus had more probability of stroke than the people who did not suffer from diabetes mellitus. Based on this study, the people who had cerebral vascular accident as their family history should thoroughly treat their blood pressure and blood sugar level to prevent the cerebral vascular accident.

Interactions of Family History of Breast Cancer with Radiotherapy in Relation to the Risk of Breast Cancer Recurrence

  • Li, Danmeng;Mai, Volker;Gerke, Travis;Pinney, Susan Mengel;Yaghjyan, Lusine
    • Journal of Breast Cancer
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    • v.20 no.4
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    • pp.333-339
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    • 2017
  • Purpose: We examined associations between a family history of breast cancer and the risk of breast cancer recurrence in women who received or did not receive radiotherapy. Methods: Our study included 2,440 women enrolled in the Breast Cancer Registry of Greater Cincinnati. Information on breast cancer risk factors, including detailed family history of breast cancer, characteristics of the primary tumor, treatment received, and recurrence status was collected at baseline and via updates. Associations between a family history of breast cancer and the risk of breast cancer recurrence were examined separately in women treated with and without radiotherapy using survival analysis. Results: Over an average follow-up time of 8.78 years, we found no associations between a family history of breast cancer and the risk of breast cancer recurrence among women with a history of radiotherapy (hazard ratio [HR], 0.96; 95% confidence interval [CI], 0.75-1.23). Among women who did not receive radiotherapy, the total number of relatives with breast cancer was positively associated with the risk of breast cancer recurrence (HR, 1.21; 95% CI, 1.00-1.47). We found no interactions of radiotherapy with family history (p-interaction >0.05). Conclusion: Radiotherapy for a primary breast cancer in women with a family history of breast cancer does not increase risk of breast cancer recurrence. If these findings are replicated in future studies, the results may translate into an important health message for breast cancer survivors with a family history of breast cancer.

Early Diagnosis Behavior in Turkish Women with and without a Family History of Cervical Cancer

  • Gunaydin, Cansu;Gencturk, Nuran
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.2
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    • pp.401-406
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    • 2015
  • Background: This study was planned as comparative and descriptive in order to measure and evaluate the knowledge and attitudes regarding early diagnosis of women with and without a family history of cervical cancer. Materials and Methods: The study sample consisted of the relatives of female patients (N=253) who were admitted to Istanbul University of Medicine. Women with a family history of cervical cancer formed the case group, while those without family history of cervical cancer constituted the control group. Two distinct data collection tools, a questionnaire and the Miller Behavioral Style Scale (MBSS), were used in order to obtain data for evaluation with SPSS for Windows 20.0 statistics package program. Results: It was found that 61.0% of the case group with family history of cervical cancer and 19.0% of the control group without family history of cervical cancer were using early diagnostic methods. Thus the presence of an individual with cervical cancer in the family affected the attitudes towards early diagnosis. It was further found that the level of knowledge on cervical cancer and PAP smear test was higher in the case group, which was more sensitive with regard to being informed about cervical cancer as compared to general society. However, the average MBSS scores were not significantly different compared to the control group. Conclusions: It was noted that, women participating this study knowledgeable, but this did not necessarily transform into better behavior.

Effects of Obstetric Complications and Genetic Risk on Brain Structures in Schizophrenic Patients (산과적 합병증과 유전적 위험도가 정신분열증 환자의 뇌구조에 미치는 영향 : 전산화단층촬영 소견에 의한 연구)

  • Chung, Young Ki;Kim, Jung Hoon
    • Korean Journal of Biological Psychiatry
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    • v.3 no.2
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    • pp.211-215
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    • 1996
  • The present study investigated the associations between CT measures and obstetric complications and family history of major mental illnesses. We had the hypothesis of diosthesis-stress model in the etiology of schizophrenia. We had the following findings. 1) Family history of major mental illnesses is inversely related to obstetric complications. 2) Prefrontal sulcal widening and family history of schizophrenia. are inversely related. 3) In female but not in male patients those with family history of schizophrenia tended to have less prefrontal sulcal widening and ventricular brain ratio. These results suggest that more genetic factors contribute to structural brain abnormalities in female than in male patients.

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A Study on Sexual Life Space of the Head Family Housing in Andong based on Women's Oral Life History (여성의 구술에 기반한 안동지역 종택의 부부생활 공간에 관한 연구)

  • Kang, Miseon;Lee, Ye-Ju
    • Journal of the Architectural Institute of Korea Planning & Design
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    • v.34 no.12
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    • pp.123-134
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    • 2018
  • The purpose of this study was to analyze the space of upper class housing in Andong through the oral life history of women in terms of sexual life. Even though the living was centered on women, the women of Joseon were alienated from the history. For this reason, the life history of head family housing was not recorded in the language of women, and often passed on orally. Also sexual life is a important part in daily life, but it is hard to be recorded or mentioned in Confucian society, and there is not much space research related to sexual life. Now there is not a lot of head family housing left, and the number of people who can tell the life history which is not recorded and the storyteller is also decreasing. From now on, I will record what I have experienced or passed through interviews of the residents living in head family housing and then analyze the characteristics of the sexual life.

Relationship between Cancer Worries and Breast Cancer Screening with and without Family History among Korean Women (암가족력 유무에 따른 부정적 심리요인과 유방암 검진과의 관련성: 우리나라 여성을 중심으로)

  • Kim, Bokmi;Choi, Kui Son;Lee, Yoon Noh;Min, In Soon;Hahm, Myung-Il
    • Health Policy and Management
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    • v.27 no.2
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    • pp.157-166
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    • 2017
  • Background: Women with family history of breast cancer are more likely to be worried about having cancer and participate in breast cancer screening. However, few studies have examined relationship between family history, cancer worries, and participating in breast cancer screening in Korea. This study is to identify relationship between family history, cancer worries, and participating in breast cancer screening among women with and without family history of cancer. Methods: Respondents were 2,364 women who based on the 2013 Korean National Cancer Screening Survey which is done by National Cancer Center in Korea. Chi-square tests were performed to determine differences of cancer worries, undergoing of breast cancer screening and methods such as mammogram and ultrasonogram with and without cancer family history. Univariate and multiple logistic regression were performed to identify if family history and cancer worries are related factors on participating in breast cancer screening and methods. Stratified analysis was performed to confirm the effect of ultrasonogram on the dense breast by age. Results: Women with cancer family history frequently checked condition for conscious of having cancer (p=0.0299) and had highly perception of risk about having cancer in the future ($p{\leq}0.0001$). Women aged 30-49 did not perform significantly more ultrasonogram than women aged over 50 years old. Checking condition (moderate odds ratio [OR], 1.38; 95% confidence interval [CI], 1.20-2.08; frequently OR, 1.58; 95% CI, 1.08-1.76) and perception of risk (moderate OR, 3.12; 95% CI, 1.06-7.06; high OR, 2.74; 95% CI, 1.20-8.08) were related to participate in mammogram and ultrasonogram. A positive family history was related to 1.35 higher odds of performing only breast ultrasonogram (95% CI, 1.04-1.75). Conclusion: This study requires national education and publicity to reduce the unnecessary cost of screening, to be possible cost effective screening and to encourage women to receive more mammogram, especially women aged over 50 years old and with socioeconomic factors related to opportunistic screening.