• Title, Summary, Keyword: dysplasia

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Evidence for Enhanced Telomerase Activity in Barrett's Esophagus with Dysplasia and Adenocarcinoma

  • Merchant, Nipun B.;Dutta, Sudhir K.;Girotra, Mohit;Arora, Manish;Meltzer, Stephen J.
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.2
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    • pp.679-683
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    • 2013
  • Background: Dysplasia and adenocarcinoma developing in Barrett's esophagus (BE) are not always endoscopically identifiable. Molecular markers are needed for early recognition of these focal lesions and to identify patients at increased risk of developing adenocarcinoma. The aim of the current study was to correlate increased telomerase activity (TA) with dysplasia and adenocarcinoma occurring in the setting of BE. Materials and Methods: Esophageal mucosal biopsies were obtained from patients (N=62) who had pathologically verified BE at esophagogastroduodenoscopy (EGD). Mucosal biopsies were also obtained from the gastric fundus as controls. Based on histopathology, patients were divided into three groups: 1) BE without dysplasia (n=24); 2) BE with dysplasia (both high grade and low grade, n=13); and 3) BE with adenocarcinoma (n=25). TA was measured by a PCR-based assay (TRAPeze$^{(R)}$ ELISA Telomerase Detection Kit). Statistical analyses were performed using one-way ANOVA and post-hoc Bonferroni testing. Results: TA was significantly higher in biopsies of BE with dyplasia and BE with adenocarcinoma than in BE without dysplasia. Subgroup analyses did not reveal any significant correlations between TA and patient age, length of BE, or presence of gastritis. Conclusions: Telomerase activity in esophageal mucosal biopsies of BE may constitute a useful biomarker for the early detection of esophageal dysplasia and adenocarcinoma.

Septo-optic dysplasia plus diagnosed in a middle-aged woman

  • Oh, Seung Tae;Kang, Mi-Ri;Oh, Seong-il;Kim, Eung Gyu;Kim, Sang Jin;Seo, Jung Hwa;Chung, Eun Joo;Ji, Ki-Hwan
    • Annals of Clinical Neurophysiology
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    • v.20 no.2
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    • pp.85-88
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    • 2018
  • Septo-optic dysplasia is a congenital anomaly with diverse phenotypes from normal to mixtures of visual abnormality, endocrine dysfunction, psychomotor retardations and epileptic seizures. It is characterized by optic atrophy, pituitary dysfunction and midline structure abnormalities in corpus callosum or septum pellucidum. Diagnosis of septo-optic dysplasia plus is made when cortical malformations accompanied. Here we report a middle-aged woman with septo-optic dysplasia plus having unilateral optic atrophy, agenesis of septum pellucidum and cortical malformations.

Treatment including orthognathic surgery of a patient with Hypohidrotic ectodermal dysplasia with cleft palate: A Clinical report (구개열을동반한저한성외배엽형성이상환자의 악교정수술을포함한치료: A Clinical report)

  • Kim, Jwa-Young;Park, In-Young;Song, Yun-Jung
    • The journal of the Korean dental association
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    • v.57 no.2
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    • pp.93-99
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    • 2019
  • Ectodermal dysplasia is a genetic disorder in which various clinical manifestations involve two or more of the differentiated tissues of the ectoderm. Facial deformity, which is frequently associated with ectodermal dysplasia, appears in the form of cleft lip or cleft palate, especially in the middle facial area.Cleft and tooth defects result in decreased alveolar bone development.This leads to severe skeletal incongruity. Facial features include frontal protrusion, malar bone hypoplasia, flat nose, mandibular prominence and long lower facial height. This clinical report presents treatment including orthognathic surgery of a patient with Hypohidrotic Ectodermal dysplasia with cleft palate.

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POLYOSTOTIC FIBROUS DYSPLASIA (다골성 섬유성 이형성증)

  • Lee Kang-Sook;Park Sang-Eok;Choi Karp-Shik
    • The Journal of Korean Academy of Maxillofacial Radiology
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    • v.24 no.1
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    • pp.189-193
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    • 1994
  • Fibrous dysplasia is a benign fibro-osseous condition that is replacement of normal bone and marrow tissues by cellular fibrous tissue and immature bone, and it is divided into monostotic type and polyostotic type. Polyostotic fibrous dysplasia involves multiple bones, such as skull, jaw bones, femur and tibia. And it is also divided into two forms: the less severe Jaffe's type and the more severe Albright's syndrome. Clinically, it frequently occurs in the 2nd decade, and occurs more frequently in maxilla than in mandible. And the lesions of fibrous dysplasia tend to become static as skeletal maturity is reached. The authors experienced three cases of polyostosic fibrous dysplasia in the craniofacial area with the complaints of facial asymmetry due to painless swelling. And we discussed the clinical, radiological, and histopathological features of these cases with a brief review of the literatures.

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Treatment of Deformity in Polyostotic Fibrous Dysplasia Using Interlocking Intramedullary Nailing (다발성 섬유성 골이형성증 변형에 대한 나사못 맞물림 골수정을 이용한 치료)

  • Lee, Kwang-Suk;Oh, Jong-Keon;Koo, Ja-Seong
    • The Journal of the Korean bone and joint tumor society
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    • v.1 no.2
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    • pp.249-253
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    • 1995
  • The fibrous dysplasia is a progressive and disabling condition that lead to deformity, especially weight bearing bones. The morbidity that is associated with the polyostotic fibrous dysplasia is the recurrent fracture and deformity. Various methods of treatment had been failed to control this problem. We used osteotomy and reconstruction nailing for polyostotic fibrous dysplasia occured in the proximal part of right femur with varus deformity and reconstruction nailing in left femur without osteotomy, and interlocking intramedullary nailing in right tibia to prevent pathologic fracture. These methods brought a good result of bone union and full weight bearing ambulation after 1 year and 6 month follow up. We think these methods are useful methods to control refracture and deformity, so we reported this case with bibliographic reviews.

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The Diagnostic importance of clinical and radiologic features of the Multiple Cemento-osseous dysplasia (다발성 백악질공이형성증 조직병리검사시 임상, 방사선양상의 중요성)

  • Han Mi-Ra;Kim Young-Hee;Kang Byung-Cheol
    • The Journal of Korean Academy of Maxillofacial Radiology
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    • v.28 no.1
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    • pp.299-309
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    • 1998
  • This case was diagnosed as multiple cementoosseous dysplasia on the basis of clinical & radiological features but was diagnosed as ossifying fibroma on the basis of histopathological feature. The histopathologic features of the multiple cementoosseous dysplasia and cementoossifying fibroma have common features of cementum, fibrous network and bone. Multiple cementoosseous dysplasia is reactive lesion and shows restricted lesion size, occurred on anterior and posterior tooth of the mandible and needs no treatement except periodic follow up. But Cementoossifying fibroma is the true neoplasm and grows continuously and needs surgical removal. The final diagnosis of the multiple cementoosseous dysplasia requires good correlation of the clinical, histopathological, and radiological features.

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Monostotic Fibrous Dysplasia in the Metacarpal Bone: A Case Report (중수골에 발생한 단골성 섬유성 이형성증: 1예 보고)

  • Cho, Han-Il;Park, Sung-Hoon;Juhng, Seon-Kwan
    • Investigative Magnetic Resonance Imaging
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    • v.13 no.2
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    • pp.203-206
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    • 2009
  • Fibrous dysplasia is a slowly progressive, benign disorder characterized by fibrous tissue replacement of skeleton and may affect solitary or multiple bones. Monostotic fibrous dysplasia mainly occurrs in the rib, femur and tibia, however, rarely in the hand. We report a case of monostotic fibrous dysplasia confined to the 2nd metacarpal bone with findings of plain radiographs and MR imaging.

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Correction of Fibrous Dysplasia through Malarplasty without Internal Fixation

  • Oh, Young-Il;Yoon, Kyu-Ho;Park, Kwan-Soo;Cheong, Jeong-Kwon;Bae, Jung-Ho;Lee, Kwon-Woo;Han, Jung-Gil;Shin, Jae-Myung;Baik, Jee-Seon
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.35 no.5
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    • pp.337-341
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    • 2013
  • Fibrous dysplasia is a chronic developmental disease of the skeleton involving formation of immature bone. Involvement of facial bones can result in deformation of facial contour. Prominent cheek area is often treated with malarplasty, which has a variety of modifications, depending on the surgeon's preference. The authors report on a case of polyostotic fibrous dysplasia in which the patient's right cheek had a prominent appearance. The prominence was corrected with malarplasty without internal fixation. The soft nature of bone involved in fibrous dysplasia could provide greater flexibility for modification of the traditional surgery.

Frontonasal dysplasia: A case report

  • Lee, Se Il;Lee, Seung Je;Joo, Hong Sil
    • Archives of Craniofacial Surgery
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    • v.20 no.6
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    • pp.397-400
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    • 2019
  • Frontonasal dysplasia is an uncommon congenital anomaly with diverse clinical phenotypes and highly variable clinical characteristics, including hypertelorism, a broad nasal root, median facial cleft, a missing or underdeveloped nasal tip, and a widow's peak hairline. Frontonasal dysplasia is mostly inherited and caused by the ALX genes (ALX1, ALX3, and ALX4). We report a rare case of a frontonasal dysplasia patient with mild hypertelorism, a broad nasal root, an underdeveloped nasal tip, an accessory nasal tag, and a widow's peak. We used soft tissue re-draping to achieve aesthetic improvements.

A Case of Craniofrontonasal Dysplasia Diagnosed at Birth (출생시 진단된 Craniofrontonasal Dysplasia 1례)

  • Rho, Jeong A;Rho, Young Il;Moon, Kyung Rye;Park, Young Bong;Park, Sang Kee;Kim, Eun Young
    • Clinical and Experimental Pediatrics
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    • v.46 no.10
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    • pp.1044-1046
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    • 2003
  • Craniofrontonasal dysplasia(CFND), a rare congenital syndrome, is characterized by varying degrees of frontonasal dysplasia, craniosynostosis, and variable extracranial abnormalities. It was first reported by Cohen in 1979. The inheritance pattern is not straightforward. Although all modes of Mendelian inheritance have been suggested, the most plausible explanation is that this is an X-linked condition with the unusual situation of complete expression in females, and minimal to no expression in males. In our case, CFND was diagnosed in a female neonate who had unilateral coronal craniosynostosis, frontal bossing, orbital hypertelorism, broad nasal root, clefting nasal tip, corpus callosum agenesis and mild extremity abnormalities.