• Title/Summary/Keyword: drug release

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Controlled Drug Release from Polyacrylic Acid-Polyethylene Glycol Interpenetrating Networks (폴리아크릴산-폴리에칠렌글리콜 IPN공중합체 마트릭스의 팽윤 및 약물방출)

  • Kim, Youn-Jung;Kim, Kil-Soo;Lee, Seung-Jin
    • Journal of Pharmaceutical Investigation
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    • v.24 no.4
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    • pp.257-263
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    • 1994
  • The interpenetrating polymer networks (IPNs) of polyacrylic acid (PAA)-polyethylene glycol (PEG) were synthesized via crosslinking of PEG and simultaneous free radical polymerization of PAA. The equilibrium swelling of the IPNs matrices, ranged from 40% to 95%, was varied to a great extent as compared with PAA homopolymer due to the interpolymer interaction between PAA and PEG. The drug release kinetics of drug loaded matrices was significantly affected by the charge of drugs as well as interpolymer complexation.

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Drug Release from Hollow Suppository(I) - Release Rate of Indomethacin from Witepsol H-15 Suppository - (중공 좌제의 약물방출 (I) - Witepsol H-15 기제로부터의 인도메타신의 방출속도 -)

  • 이화정;구영순
    • YAKHAK HOEJI
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    • v.35 no.3
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    • pp.197-202
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    • 1991
  • In order to study drug release from the suppository, three types of hollow suppositories and one conventional suppository were prepared using indomethacin(IDM) as a model drug and Witepsol H-15 as a base. The 4 types of suppository prepared are as follows: type I, conventional suppository containing 50 mg of IDM powder, type II, hollow supository containing 50 mg of IDM powder in the cavity, type III, hollow suppository containing 25 mg of IDM powder in the base and IDM microcapsules (25 mg as IDM powder) in the cavity, and type IV, hollow suppository containing IDM microcapsules (25 mg as IDM powder) in the base and 0.5 ml of 5%(w/v) IDM-PEG 300 solution in the cavity. The drug amount released(%) from type II and I within 24 hrs was 46.7% and 66.9%, respectively. Comparing with the drug amount released from four types of suppository within initial 2 hrs and 24 hrs, that of type IV was high as 32.7% and 76.6%, respectively. IDM-ethycellulose microcapsules passed through 270 mesh sieve and the IDM content was 20.95%.

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Drug Release Characteristics of Crosslinked Poly(alkylene oxide) Hydrogels (가교된 폴리 알킬렌 옥사이드 하이드로겔의 약물방출 특성)

  • Kim, Shin-Jeong;Lee, Seung-Jin
    • Journal of Pharmaceutical Investigation
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    • v.21 no.2
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    • pp.91-95
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    • 1991
  • Polyethylene glycol, polypropylene glycol and block copolymer of ethylene glycol and propylene glycol were crosslinked by triisocyanate to form water swellable, rubbery polymer. The equilibrium swelling of the hydrogels ranged from 3% to 60% according to the hydrophobic-hydrophilic properties of the prepolymers. Model drugs, sodium salicylate and prednisolone were incorporated in the polymer matrices by swelling loading. Physical properties of the drugs affected the drug release mechanisms due to the change in the swelling behaviors of the polymeric devices. Zero order release was observed in the case of relatively hydrophobic polymer matrices.

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Controlled Release of Drugs from Silicone Rubber Matrices-Effects of Physical Properties of Drugs and Release Controlling Agents on Drug Release Mechanisms- (실리콘 마트릭스로부터의 약물조절 방출-약물 및 방출조절제의 물성이 방출기전에 미치는 영향-)

  • Jeon, So-Young;Lee, Seung-Jin
    • Journal of Pharmaceutical Investigation
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    • v.21 no.4
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    • pp.237-245
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    • 1991
  • Matrix type silicone rubber devices were designed for long-term implantable drug delivery system. Release controlling agents (RCA), i.e., polypropylene glycol, polyethylene glycol, were employed to control drug release from the devices. The release rate of drug from RCA dispersed silicone matrices was mainly dependent on hydrophilicity-hydrophobicity of drug and RCA. In the case of hydrophilic drug, the release from the RCA dispersed matrix was regulated by swelling kinetics. Especially when the relatively hydrophobic polypropylene glycol was used, swelling control mechanism induced zero-order release kinetics. Whereas, the release of hydrophobic drug was resulted from partition mechanism. The effect of RCA was to increase drug diffusivity.

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Development of Gastric Retentive Bi-layered Tablet using Floating Drug Delivery System (부유 기술을 이용한 위체류 이중정의 개발)

  • Park, Jun-Bom
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.16 no.11
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    • pp.7549-7554
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    • 2015
  • The aim of this study was to develop gastric retentive bi-layered tablet using floating drug delivery technique. Metformin was selected as a model drug due to its narrow absorption window as well as very highly water solubility. These properties of metformin led to be difficult controlling the drug release. The bi-layered tablet was prepared with bi-layered compression machine to minimize interference between floating part and controlling part. The tablet weight, appearance and hardness were evaluated after compression process. The times of 'time to floating' and 'Floating duration' were tested for floating ability and drug release study was also carried out to understand drug release behavior. Furthermore, the drug release of bi-layered tablet was compared with marketed metformin tablet with sustained release pattern (Glucopharge XR$^{(R)}$).The floating ability and drug release behaviors were well controlled by changing amounts of $NaHCO_3$ (floating substance) and hydroxypropyl methylcellulose (HPMC; release control material). Bi-layered tablet had 13s of time to float, over 10h of floating duration and very similar drug release behavior compared with Glucopharge XR$^{(R)}$($f_2$: 89.6). Consequently, the bi-layered tablet with floating ability was successfully prepared and these properties can maximize the efficacy of metformin.

Levan acetate를 이용한 hydrocortisone의 방출 제어

  • Im, Seung;Lee, Gi-Yeong;Kim, Dong-Un;Choe, Chun-Sun
    • 한국생물공학회:학술대회논문집
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    • 2001.11a
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    • pp.849-852
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    • 2001
  • The preparation, characterization and drug release behaviour of hydrocortisone(HC) loaded levan acetate microparticles were investigated. Hydrophobic levan acetate was prepared by chemical modification of hydrophilic levan and micro particles were made by dialysis method or solvent evaporation method. The morphology of levan acetate was observed by SEM and drug release profiles were investigated at pH 7.4 and pH 1.2. Newly synthesised levan acetate can be used for carrier of drugs.

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Controlled Drug Release Using Biodegradable Polymer (체분해성 고분자를 이용한 약물의 조절방출)

  • Na, Jae Woon;Cha, Wol Suk;Kim, Sun Il
    • KSBB Journal
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    • v.5 no.4
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    • pp.377-382
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    • 1990
  • The characteristics controlled drug release have been studied for biodegradable polymer matrix. Polymer matrix was prepared from glycerine, prednisolone and dextran. Mathematical analysis of the data showed that the release behavior actually conformed to the Higuchi's diffusion controlled model. The release time was increased as drug loading doses increased, whereas decreased as glycerine concentration increased. The release rate did not change by varying molecular weight of dextran.

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Pharmaceutical Studies on Microencapsulated Etilefrine Hydrochloride (염산에틸에프린의 마이크로캅셀에 관한 약제학적 연구)

  • Kim, Johng-Kap;Choi, Soo-Il
    • Journal of Pharmaceutical Investigation
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    • v.16 no.1
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    • pp.12-17
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    • 1986
  • Etilefrine hydrochloride was microencapsulated with ethylcellulose by phase separation method to develop a sustained release dosage form. The results of dissolution test carried out with various microcapsules showed that the drug release was decreased with increasing the particle size of microcapsules at a constant core to wall ratio, and with decreasing the core to wall ratio. Also ethylcellulose 50 cps and fast stirring rate (900 rpm) was better in decreasing the drug release than ethylcellulose 22 cps and slow stirring rate (300 rpm), respectively.

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Preparation and Characterization of Biodegradable Poly($\varepsilon$-caprolactone) Microcapsules Containing Erythromycin by Emulsion Solvent Evaporation Technique (액중건조법을 이용한 항생제를 함유한 생분해성 폴리카프로락톤 마이크로캡슐의 제조 및 특성)

  • 박수진;김승학;이재락;이해방;홍성권
    • Polymer(Korea)
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    • v.26 no.3
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    • pp.326-334
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    • 2002
  • The purpose of this work was the producing of a biodegradable poly($\varepsilon$-caprolactone) (PCL) microcapsule and the analyzing of form and features for the manufacturing conditions which could be observed in a prospective drug delivery systems (DDS) through drug release. The effects of different stirring rates, stirring times and concentrations of emulsifier for the diameter and form of the microcapsules were observed using image analyzer (IA) and scanning electron microscopy (SEM). As a result, the microcapsules were made in wrinkle and spherical forms with a mean particle size of 40~300$\pm$20 $mu extrm{m}$. PCL microcapsules containing drugs were confirmed using FT-IR spectra. The role of interfacial adhesion between PCL and drug was determined by contact angle measurements. The drug release test of PCL microcapsules was characterized by UV/vis. spectra. It was found that the drug release rate of the microcapsules prepared with high concentration emulsifier was significantly fast.

Development of Specific Organ-Targeting Drug Delivery System (III)-In Vitro Study on Liver-Targeting Adriamycin Delivery System using Human Serum Albumin Microspheres- (장기표적용 약물수송체의 개발에 관한 연구(제 3보 -알부민 미립구를 이용한 Adriamycin의 간 표적용 수송체에 관한 in vitro 연구-)

  • Kim, Chong-Kook;Hwang, Sung-Joo;Yang, Ji-Sun
    • Journal of Pharmaceutical Investigation
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    • v.19 no.4
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    • pp.195-202
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    • 1989
  • In attempt to improve the chemotherapeutic activity of adriamycin, adriamycin-entrapped HSA microspheres were prepared and investigated by the various in vitro experiments. The shape, surface characteristics and size distribution of HSA microspheres are observed by scanning electron microscopy. The in vitro drug release, albumin matrix degradation by protease of HSA microspheres were studied. The shape of HSA microspheres were spherical and the surface was smooth and compact. The size of HSA microspheres ranged from 0.4 to $2.5\;{\mu}m$ and have average diameters of 0.5 to $0.7\;{\mu}m$. The size distribution of HSA microspheres prepared by ultrasonication was mainly affected by albumin concentration and heating time in the process of hardening. In in vitro, almost all adriamycin was released from HSA microspheres for 8 hr. Analysis of the resulting adriamycin release profiles demonstrated that adriamycin is released from the microspheres in two distinct steps, a fast phase (until 30 min) followed by a much slower sustained release phase. Drug release, which is due to diffusion, was depended on the rate of matrix hydration. Drug release was largely affected by albumin concentration and heating temperature during the process of hardening. Albumin matrix degradation of HSA microspheres was affected by heating temperature and albumin concentration. Higher temperature and longer times generally produce harder, less porous, and slowly degradable microspheres.

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