• Title, Summary, Keyword: depigmentation

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The Study on Depigmentation Effects of Salt, Acetum, Sesami Semen Nigrum (염(鹽), 초(醋), 향유(香油)의 미백효과에 관한 연구)

  • Cho, Jae-hun;Kim, Hye-jeong;Kim, Yoon-bum
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.16 no.2
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    • pp.79-95
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    • 2003
  • Objectives: This study was performed to investigate the depigmentation effects of Salt, Acetum, Sesami Semen Nigrum. Methods: Inhibition of tyrosinase activity, melanin production & cell viability in cultured B16 melanoma cells, UV screen and cytoprotective effects on PC12 cells injured by hydrogen peroxide were measured. Results: Salt, Acetum, Sesami Semen Nigrum did not show any inhibitory effects of tyrosinase activity & melanin production in melanoma cells, UV screen and cytoprotective effects on PC12 cells injured by hydrogen peroxide. Conclusions: This study shows that Salt, Acetum, Sesami Semen Nigrum which were generally used for the addition in external application do not have the depigmentation effects. Following this, the depigmentation effects of the other addition which were generally used for external application shoud be examined.

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Depigmentation activity of many herb (미백효과(美白效果)가 있는 천연물에 대한 고찰)

  • Jang, Kyung-hee;Roh, Seok-seon
    • Journal of Haehwa Medicine
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    • v.13 no.2
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    • pp.289-302
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    • 2004
  • Recently many effort focused to understand the mechanical insights of melanogenesis to develop the agent for hyper-pigmentation. So this study was performed to investigate the depigmentation of many herb. This study show that many herb which were generally used for external application have some depigmentation effects. So we should use them for whitening agents and the depigmentation effects of the other natural subjects which were generally used for external application should be examined. In the future, it is nessary more study on the manufacturing method, the time of use and the dose.

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The Study on Depigmentation Effects of Aloe, Camellia sinensis and Mel (알로에(蘆회), 녹차(綠茶), 꿀(蜂蜜)의 미백효과에 관한 연구)

  • Han, Eun-jeong;Lee, Gil-young;Kim, Hae-jeong;Kim, Yoon-bum
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.16 no.3
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    • pp.145-163
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    • 2003
  • Objectives : This study was performed to investigate the depigmentation effects of Aloe, Camellia sinensis and Mel. Methods : Inhibition of tyrosinase activity, melanin production & melanoma cell viability in cultured B16 melanoma cells, UV screen and cytoprotective effects on PC12 cells injured by hydrogen peroxide were measured. Results : Aloe has some inhibitory effects on tyrosinase activity, on the other hand Camellia sinensis and Mel do not have. They did not show any inhibitory effects on melanin production in melanoma cells and cytoprotective effects on PC12 cells injured by hydrogen peroxide. Aloe and Camellia sinensis have some inhibitory effects on UV screen. Conclusions : This study shows that Aloe and Camellia sinensis which were generally used for external application have some depigmentation effects. Following this, We should use them for whitening agents and the depigmentation effects of the other natural subjects which were generally used for external application should be examined.

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A Study on the Antioxidative and Depigmentation Activities of the Ethanol Extract of Saururus Herba (삼백초(三白草) 에탄올추출물의 항산화능 및 피부 미백작용 연구)

  • Park, Dae-Jung;Lee, Jang-Cheon
    • The Korea Journal of Herbology
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    • v.23 no.2
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    • pp.193-202
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    • 2008
  • Objectives : The purpose of this study is to investigate the etahnol extract of Saururus Herba and their dermal boiactivity properties related to cosmeceuticals such as depigmentation and radical scavenging effect. Methods : Using B16/F10 Melanin cells, we measured depigmentation effect of the etahnol extract of Saururus Herba. Antioxidant activities of the etahnol extract of Saururus Herba were determined by DPPH radical scavenging activity. Results : The etahnol extract of Saururus Herba showed considerable radical scavenging activity($SC_{50}$ : 25 ${\mu}g$/ml). Antioxidant activity is in a dose dependant manner. The etahnol extract of Saururus Herba down-regulated melanin synthesis effectively. B16 cells incubated with the etahnol extract of Saururus Herba showed reduces melanin formation and tyrosinase activity. The etahnol extract of Saururus Herba alone markedly suppressed melanin content and tyrosinase activity. Conclusions : These results suggest that the ethanol extract of Saururus Herba is a potent depigmentaion agent and it may be a candidate for antioxidant agent.

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The Study on Depigmentation of Kamikwibi-Tang (가미귀비탕의 미백효과에 관한 연구)

  • Park, Ho-Soon;Kim,Hye-Jung;Kim, Yoon-Bum
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.17 no.2
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    • pp.48-58
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    • 2004
  • Objective: This study was performed to investigate the depigmentation effects of the extracts of Kamikwibi-Tang. Methods Inhibition of tyrosinase activity, melanin production & cell viability in cultured B16 melanoma cells, UV screen and cytoprotective effects on PC12 cells injured by hydrogen peroxide were measured. Results: The extracts of Kamikwibi-Tang did not have any inhibitory effects on tyrosinase activity and did not show any inhibitory effects on melanin production in melanoma cells and also did not have any inhibitory effects on UV screen. But the extracts showed high cytoprotective effects on PC12 cells injured by hydrogen peroxide. Conclusion : These results suggest that Kamikwibi-Tang indrectly inhibits melanin biosynthesis which is involved in hyperpigmentation and could be used as a whitening agent for the skin.

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The Study on Depigmentation of Kamibangpungtongsung-San (加味防風通聖散의 美白效果에 관한 硏究)

  • Lee Seung-eun;Kim Hae-jeong;Kim Yoon-bum
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.17 no.1
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    • pp.94-103
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    • 2004
  • Objective: This study was performed to detennine the depigmenting effects of Kamibongpungtongsung-San. Methods: To determine the depigmenting effects of Kamibangpungtongsung-San. we measured the degree of tyrosinase inhibition, melanin production & cell viability in cultured B16 melanoma cells, UV screen and cytoprotective effects on PC12 cells injured by hydrogen peroxide. Results: Komibangpungtongsung-San did not show inhibitory effects on melanin production in melanoma cells, UV screen and cytoprotective effects on PC12 cells injured by hydrogen peroxide. However it showed mild inhibitory effects on tyrosinase activity. Conclusion : This study shows that Kamibangpungtongsung-San, a generally used prescription for dermatologic diseases, do not have depigmenting effects via tyrosinase inhibition. Therefore, the depigmenting effect and mechanism of depigmentation by Kamibangpungtongsung-San need to be evaluated and investigated in other directions.

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A comparison of different gingival depigmentation techniques: ablation by erbium:yttrium-aluminum-garnet laser and abrasion by rotary instruments

  • Lee, Kwang-Myung;Lee, Dong-Yeol;Shin, Seung-Il;Kwon, Young-Hyuk;Chung, Jong-Hyuk;Herr, Yeek
    • Journal of Periodontal and Implant Science
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    • v.41 no.4
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    • pp.201-207
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    • 2011
  • Purpose: The aim of this study is to compare two different gingival depigmentation techniques using an erbium:yttrium-aluminum-garnet (Er:YAG) laser and rotary instruments. Methods: Two patients with melanin pigmentation of gingiva were treated with different gingival depigmentation techniques. Ablation of the gingiva by Er:YAG laser was performed on the right side, and abrasion with a rotary round bur on the opposite side. Results: The patients were satisfied with the esthetically significant improvement with each method. However, some pigment still remained on the marginal gingival and papilla. The visual analog scale did not yield much difference between the two methods, with slightly more pain on the Er:YAG laser treated site. Conclusions: The results of these cases suggest that ablation of the gingiva by an Er:YAG laser and abrasion with a rotary round bur is good enough to achieve esthetic satisfaction and fair wound healing without infection or severe pain. Prudent care about the gingival condition, such as the gingival thickness and degree of pigmentation along with appropriate assessment is needed in ablation by the Er:YAG laser procedure.

Depigmentation Activity of Barley, Unpolished Rice, Job's-tear (보리·현미·율무의 미백효과에 관한 연구)

  • Lee, Tae-huen;Kim, Hye-jeong;Kim, Yoon-bum
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.16 no.2
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    • pp.57-77
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    • 2003
  • Objectives: The aim of this study was to investigate the depigmentation effects of Barley, Unpolished rice, Job's-tear. Metbods: We investigated that the extracts of Barley, Unpolished rice, Job's-tear inhibit activity of tyrosinase, the enzyme which convert ts 3-(3,4-dihydroxyphenyl) alanine to dopachrom in the biosynthetic process of melanin, the UV absorbance of the extracts in the UV-A region and UV-B region was measured by UV scanning, the effect of extracts on cell viability and melanin production in cultured B16 mouse melanoma cells were measured, and cytoprotective effects of extracts on PC12 cells injured by hydrogen peroxide measured by MTT assay. Results: The extracts of Barley, Unpolished rice, Job's-tear inhibited activity of tyrosinase in low density. The Barley, Job's-tear extracts not only showed inhibitory effects on melanin production in cultured B16 mouse melanoma cells, but also exhibited cytoprotective effects on PC12 cells injured by hydrogen peroxide in low density. Unpolished rice extract showed inhibitory effect on melanin production in cultured B16 mouse melanoma cells, but did not showed cytoprotective effect Barley, Unpolished rice, Job's-tear extracts did not showed an absorbance effect in the UV-A region and UV-8 region. Conclusions: These results suggest that Barley, Unpolished rice, Job's-tear inhibit melanin biosynthesis which is involved in hyperpigmentation and could be used as a whitening agent.

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A Study on the Whitening Effects of Pueraria thomsonii Extract and its Three Tectorigenin Derivatives (분갈화 추출물과 분갈화 유래 Tectorigenin류 3종의 미백 효능에 대한 연구)

  • Ahn, Young Je;Chang, Yun Hee;Lee, So Young;Jin, Mu Hyun
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.45 no.1
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    • pp.49-56
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    • 2019
  • Pueraria thomsonii Benth. as a medicinal ingredient, has been traditionally used in Chinese medicine to treat fever, acute dysentery, diarrhea, diabetes, and cardiovascular disease. The effects of P. thomsonii flower on skin have not been reported yet. In this study, the whitening effect of P. thomsonii flower was verified using B16F1 melanoma cells and HS68 fibroblasts. P. thomsonii flower extract reduced melanin contents of B16F1 cells in a dose-dependent manner. To identify its active components, we analyzed P. thomsonii flower extract using high performance liquid chromatography (HPLC). As a result, we identified three major isoflavones of tectorigenin, tectoridin, and tectorigenin 7-O-xylosylglucoside. At a non-cytotoxic concentration, the three components also reduced melanin contents of B16F1 cells in a dose-dependent manner. The depigmentation effects were attributed to the reduced gene expression of tyrosinase and microphthalmia-associated transcription factor (MITF). In order to elucidate another depigmentation mechanism, their effects on DKK-1, a fibroblast-derived depigmentation factor, was determined in HS68 cells. As a result, P. thomsonii flower extracts, tectoridin and tectorigenin 7-O-xylosylglucoside, reduced DKK-1 gene expression, while tectorigenin increased DKK-1 gene expression in a dose-dependent manner. These results suggest that tectorigenin can be used as an effective whitening agent that inhibit melanin synthesis in melanocytes and promote the secretion of depigmentation factor from fibroblasts.