• Title, Summary, Keyword: dBG

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Effect of water extract and distillate from the mixture of black goat meat and medicinal herb on osteoblast proliferation and osteoclast formation (흑염소와 약용식물 복합 증탕추출액 및 증류액이 조골세포 증식과 파골세포 형성에 미치는 영향)

  • Song, Hyo-Nam;Leem, Kang-Hyun;Kwun, In-Sook
    • Journal of Nutrition and Health
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    • v.48 no.2
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    • pp.157-166
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    • 2015
  • Purpose: The effects of water extract and distillate from the mixture of black goat meat and medicinal herb on MG-63 osteoblast proliferation and mouse bone marrow derived osteoclast formation were investigated. Methods: Proximate composition, volatile basic nitrogen (VBN), mineral content, free amino acid composition and free fatty acid composition in black goat meat were determined. Water extract and distillate were prepared with three groups; goat meat only (BG-E, BG-D), six herbs added group (BG-E6, BG-D6), and eight herbs added group (BG-E8, BG-D8). Osteoblast proliferation, mineralization and calcium uptake activity of MG-63 cells were measured and tartrate resistant acid phosphatase activity of osteoclasts was analyzed. Results: Black goat meat had remarkably low fat and high level of calcium. Glutamic acid was the most abundant amino acid. Herbs added extract groups (BG-E6 and BG-E8) showed increased MG-63 cell proliferation in a concentration dependent manner, while all the distillates did not show the effect. All extracts and distillates showed significantly increased osteoblast mineralization depending on the concentration. In particular, herb added extract, BG-E6, increased 170.3% of control and the distillate of BG-D and BG-D6 increased up to 168.5% and 159.8%, respectively. Calcium uptake activities of all water extracts showed remarkable increase of BG-E6 and BG-E8 up to 615.5% and 628.1% of control, respectively. Ditillates had no effect except BG-D6. All water extracts significantly reduced the activity of tartrate-resistant acid phosphatase (TRAP) in osteoclasts derived from mouse bone marrow. Conclusion: Combination of black goat meat and medicinal herb increased the MG-63 cell proliferation and effectively inhibited osteoclast differentiation in both water extracts and distillate of them, which implies that they could be used as potent functional food materials for bone health.

Fault free Shortest Path routing on the de Bruijin network (드브르젼 네트워크에서 고장 노드를 포함하지 않는 최단 경로 라우팅)

  • Ngoc Nguyen Chi;Nhat Vo Dinh Minh;Zhung Yonil;Lee Sungyoung
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.29 no.11B
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    • pp.946-955
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    • 2004
  • It is shown that the do Bruijn graph (dBG) can be used as an architecture for interconnection network and a suitable structure for parallel computation. Recent works have classified dBG based routing algorithms into shortest path routing and fault tolerant routing but investigation into fault free shortest path (FFSP) on dBG has been non-existent. In addition, as the size of the network increase, more faults are to be expected and therefore shortest path dBG algorithms in fault free mode may not be suitable routing algorithms for real interconnection networks, which contain several failures. Furthermore, long fault free path may lead to high traffic, high delay time and low throughput. In this paper we investigate routing algorithms in the condition of existing failure, based on the Bidirectional do Bruijn graph (BdBG). Two FFSP routing algorithms are proposed. Then, the performances of the two algorithms are analyzed in terms of mean path lengths and discrete set mean sizes. Our study shows that the proposed algorithms can be one of the candidates for routing in real interconnection networks based on dBG.

The Protective Effect of Black Ginseng Against Transient Focal Ischemia-induced Neuronal Damage in Rats

  • Park, Hyun-Jung;Shim, Hyun-Soo;Kim, Kyung-Soo;Shim, In-Sop
    • The Korean Journal of Physiology and Pharmacology
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    • v.15 no.6
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    • pp.333-338
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    • 2011
  • Black ginseng (BG) has been widely used as herbal treatment for improving physiological function. In order to investigate the neuroprotective action of this herbal medicine, we examined the influence of BG on the learning and memory of rats using the Morris water maze, and we studied the effects of BG on the central cholinergic system and neural nitric oxide synthesis in the hippocampus of rats with neuronal and cognitive impairment. After middle cerebral artery occlusion was applied for 2h, the rats were administered BG (100 or 400 $mgkg^{-1}$, p.o.) daily for 2 weeks, followed by training and performance of the Morris water maze test. The rats with ischemic insults showed impaired learning and memory on the tasks. Treatment with BG produced improvement in the escape latency to find the platform. Further, the BG groups showed a reduced loss of cholinergic immunoreactivity and nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d)-positive neurons in the hippocampus compared to that of the ISC group. These results demonstrated that BG has a protective effect against ischemia-induced neuronal and cognitive impairment. Our results suggest that BG might be useful for the treatment of vascular dementia.

BIOLOGICAL ACTIVITES OF PLANT LEAF EXTRACTS; AVAILABILITY OF STAR FRUIT LEAF EXTRACT AGAINST SKIN AGING

  • Yoshihito Kawashima;Zhou, Yan-Yang;Naoko Kishida;Nobuaki Ohto;Daisuke Araho;Yoko Ito;Toshimitsu Kambara;Zhou, Wan-Hua
    • Proceedings of the SCSK Conference
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    • pp.645-658
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    • 2003
  • We evaluated activities of various plant leaf extracts and found the availability against skin aging in the leaf extract of star fruit (Averrhoa carambola L), and developed Star Fruit Leaf Extract BG30 as an ingredient of cosmetics. Star Fruit Leaf Extract BG30 was found to show scavenging activities of reactive oxygen species and an inhibitory effect on the activity of matrix metalloproteinase-1. It showed increasing activity of type I collagen and recovery effect from damage of UV-B irradiation in human fibroblast. We performed the separation of the active principal from Star Fruit Leaf Extract BG30 to give isofurcatin 2"-Ο-$\alpha$-L-rhamnopyranoside, which showed increasing activity of type I collagen. To examine the anti-wrinkle effect of Star Fruit Leaf Extract BG30, seven volunteers applied a Star Fruit Leaf Extract BG30 1 % cream in double blind manner to one-side of the corner of their eye and the placebo cream to the opposite side. Clinical evaluation of wrinkling was performed every week for 5 weeks using a silicone rubber replica. A statistically significant improvement of Star Fruit Leaf Extract BG30-treated site was seen in decreased wrinkles. Star Fruit Leaf Extract BG30 results in clinically visible improvement in wrinkling when used topically for 5 weeks.

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Existence of subpolynomial algebras in $H^*(BG,Z/p)$

  • Lee, Hyang-Sook;Shin, Dong-Sun
    • Bulletin of the Korean Mathematical Society
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    • v.34 no.1
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    • pp.1-8
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    • 1997
  • Let G be a finiteg oroup. We denote BG a classifying space of G, which a contractible universal principal G bundle EG. The stable type of BG does not determine G up to isomorphism. A simple example [due to N. Minami]is given by $Q_{4p} \times Z/2$ and $D_{2p} \times Z/4$ where ps is an odd prime, $Q_{4p} is the generalized quarternion group of order 4p and $D_{2p}$ is the dihedral group of order 2p. However the paper [6] gives us a necessary and sufficient condition for $BG_1$ and $BG_2$ to be stably equivalent localized et pp. The local stable type of BG depends on the conjegacy classes of homomorphisms from the p-groups Q into G. This classification theorem simplifies if G has a normal sylow p-subgroup. Then the stable homotopy type depends on the Weyl group of the sylow p-subgroup.

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Tropical plant supplementation effects on the performance and parasite burden of goats

  • Romero, Juan J.;Zarate, Miguel A.;Ogunade, Ibukun M.;Arriola, Kathy G.;Adesogan, Adegbola T.
    • Asian-Australasian Journal of Animal Sciences
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    • v.31 no.2
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    • pp.208-217
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    • 2018
  • Objective: Examine the effects of supplementing bahiagrass hay (BG) with potentially anthelmintic quantities of hays of perennial peanut (PEA) or sericea lespedeza (LES) or seeds of velvet bean (Mucuna pruriens L.; MUC) or papaya (PAP) on the intake and nutritive value (Experiment 1), and the performance and parasite burden (Experiment 2) of goats. Methods: In Experiment 1, 38 male goats ($27.4{\pm}5.7kg$ body weight) were randomly assigned to each of 5 treatments: i) BG alone and BG plus; ii) PEA; iii) LES; iv) MUC; and v) PAP. Goats were fed for ad libitum consumption and adapted to the diets for 14 d followed by 7 d of measurement. The PEA, LES, MUC (50%, 50%, and 10% of the diet dry matter [DM], respectively), and PAP (forced-fed at 10 g/d) were fed at rates that would elicit anthelmintic effects. In Experiment 2, goats remained in the same treatments but were allocated to 15 pens (3 pens per treatment) from d 22 to 63. All goats were infected with parasites by grazing an infected bahiagrass pasture from 0800 to 1500 h daily and then returned to the pens. Results: Dry matter intake tended to be greater in goats fed PEA and LES than those fed BG (757 and 745 vs 612 g/d, respectively). Digestibility of DM (59.5% vs 54.9%) and organic matter (60.8% vs 56.0%) were greater in goats fed MUC vs BG, respectively. In Experiment 2, feeding PAP, LES, and PEA to goats reduced nematode fecal egg counts by 72%, 52%, and 32%, reduced abomasal adult worm counts by 78%, 52%, and 42%, and decreased plasma haptoglobin concentrations by 42%, 40%, and 45% relative to feeding BG alone, respectively. Conclusion: Supplementation with PEA, LES, and PAP decreased the parasite burden of goats but did not increase their performance. PAP was the most effective anthelmintic supplement.

Development of intermediate roll which has a long life for cold rolling mills (냉간압연용 장수명 중간롤 개발)

  • Park Y. C.;Kim B. H.;Kim I. B.;Kim J. T.;KIM H. M.;Lee W. D.
    • Proceedings of the Korean Society for Technology of Plasticity Conference
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    • pp.207-215
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    • 2004
  • There are various characteristics called for in work roll and intermediate rolls for cold rolling mills. Among these characteristics, the two main requirements are to ensure the quality of the rolled products and to reduce roll cost. To achieve these needs, resistance to wear, to thermal shock and to contact fatigue are especially important. This paper describes that new material(named DSR1) for intermediate rolls which greatly increases rolling campaign and improves resistance to wear has been developed. DSR1 was successfully manufactured and has been used in the cold rolling mill. It showed that Trial product was homogenous in hardness distribution and sufficient usable diameter. Also in service test, trial product is much more excellent rolling performance than conventional $5\%Cr$.

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Thermal cycle test for water-cooled stator bar (수냉각 고정자 권선용 바의 열 사이클 시험)

  • Kim, Tae-Hee;Oh, Se-Wook;Lee, Jai-Kwun;Son, Sam-Yong
    • Proceedings of the KIEE Conference
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    • pp.1722-1725
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    • 2003
  • 절연물에 가해지는 열화 중에서 열 사이클(Thermal cycle) 열화를 모사하기 위하여, 대형 터빈 발전기 수냉각 고정자 권선용 바를 대상으로 IEEE Std 1310 규격에 따라 200 사이클의 열 사이클 열화 시험을 수행하였다. 바에 대한 절연 특성을 분석하기 위하여 시험 수행 전후의 Tan ${\delta}$ 및 Tip-up(%, ${\Delta}$ Tan ${\delta}$), 부분방전의 최대 방전량 등을 측정하였고 또한 바를 절단하여 절연물 내의 박리와 도체와 절연물 간의 분리 등을 점검하였다. 최종적으로는 절연파괴 시험을 수행하여 절연파괴 강도를 측정하였다. 시험 결과 초기 절연 특성상의 현저한 변화는 없었으며 양호한 특성을 보였다.

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Research article Black ginseng activates Akt signaling, thereby enhancing myoblast differentiation and myotube growth

  • Lee, Soo-Yeon;Go, Ga-Yeon;Vuong, Tuan Anh;Kim, Jee Won;Lee, Sullim;Jo, Ayoung;An, Jun Min;Kim, Su-Nam;Seo, Dong-Wan;Kim, Jin-Seok;Kim, Yong Kee;Kang, Jong-Sun;Lee, Sang-Jin;Bae, Gyu-Un
    • Journal of Ginseng Research
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    • v.42 no.1
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    • pp.116-121
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    • 2018
  • Background: Black ginseng (BG) has greatly enhanced pharmacological activities relative to white or red ginseng. However, the effect and molecular mechanism of BG on muscle growth has not yet been examined. In this study, we investigated whether BG could regulate myoblast differentiation and myotube hypertrophy. Methods: BG-treated C2C12 myoblasts were differentiated, followed by immunoblotting for myogenic regulators, immunostaining for a muscle marker, myosin heavy chain or immunoprecipitation analysis for myogenic transcription factors. Results: BG treatment of C2C12 cells resulted in the activation of Akt, thereby enhancing hetero-dimerization of MyoD and E proteins, which in turn promoted muscle-specific gene expression and myoblast differentiation. BG-treated myoblasts formed larger multinucleated myotubes with increased diameter and thickness, accompanied by enhanced Akt/mTOR/p70S6K activation. Furthermore, the BG treatment of human rhabdomyosarcoma cells restored myogenic differentiation. Conclusion: BG enhances myoblast differentiation and myotube hypertrophy by activating Akt/mTOR/p70S6k axis. Thus, our study demonstrates that BG has promising potential to treat or prevent muscle loss related to aging or other pathological conditions, such as diabetes.

Mechanical characteristics of class-F groundwall insulation tapes for stator windings (고정자 권선용 F종 주절연테이프의 기계적 특성)

  • Kim, Tae-Hee;Kang, Myung-Guk;Lee, Jai-Kwun;Son, Sam-Young
    • Proceedings of the KIEE Conference
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    • pp.1676-1678
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    • 2004
  • Class-F resin-rich type insulating tapes are generally used for the groundwall insulations of the large turbine generators with air-cooled and hydrogen-cooled stator windings. In this paper, mechanical strength properties degraded over aging time in higher temperature than designed one in normal condition were experimentally investigated and the results of comparative tests were presented on the existing class-F resin-rich type tape and a developed one after curing. The resin-rich insulating tapes with composite material of Mica/Epoxy/support currently were used in this test. The tests for tensile and flexural strength properties were conducted with the specimens which were composed of unaged and the aged specimens accelerated for one, two, and three thousand hours at 180 $^{\circ}C$. The tensional strength was only measured for the unaged specimens and the results are also presented to make a comparative test for their initial mechanical characteristics.

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