• Title/Summary/Keyword: combination treatment

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Analysis of the Effect on Korean Medicine Alone and Korean-Western Medicine Combination Treatment for Herpes Zoster through Domestic Case Report (국내 증례 보고를 통해 본 대상포진의 한방 단독 치료와 한·양방 협진 치료의 효과 분석)

  • Kim, Hea-Ju;Kang, Ha-Ram;Seo, Hyung-Sik
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.34 no.1
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    • pp.44-55
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    • 2021
  • Objectives : The aim of this article is to compare the effect of the korean medicine alone with korean-western combination treatment to herpes zoster. Methods : Domestic databases(OASIS, NDSL, RISS, KISS, KTKP, KMBASE, DBPIA, KoreaMed, National Assembly Library) were used to search case study papers related to herpes zoster and korean medicine treatment. We searched them using the term 'Herpes zoster' or 'Ramsey Hunt' combinated with 'Acupuntcure', 'Herbal medicine' or 'Korean medicine'. Results : A total of 36 studies were selected and analyzed. 25 studies treated with korean medicine and 11 studies treated with korean-western combination treatment which include any western medication. Of these 36 papers, there were a total of 24 cases in which a VAS test was undertaken. According to 36 published papers, no statistically significant difference in the periods of treatment with korean medicine alone from those of korean-western combination treatment was found. Also, no statistical difference in the VAS changes per period with korean medicine alone from those with korean-western combination treatment was found. Conclusions : According to the results, These findings suggest that korean medicine treatment can be effective for the herpes zoster the same as korean-western combination treatment.

Combination Treatment of Korean Medicine with Ohrim-san for Lower Urinary Tract Symptoms (LUTS) after Laparoscopic Myomectomy Patient : A Case Report (복강경하 근종적출술 후 발생한 하부요로증상에 대한 오림산을 포함하는 복합한의진료의 경과 : 증례보고)

  • Jeong, So-Mi;Jo, Hee-Geun
    • The Journal of Korean Obstetrics and Gynecology
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    • v.33 no.3
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    • pp.187-197
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    • 2020
  • Objectives: This case report aims to report the clinical effectiveness of the combination treatment of Korean medicine on a post-laparoscopic myomectomy patient's lower urinary symptoms (LUTS). Methods: The patient who diagnosed with uterine myoma had Laparoscopic myomectomy. After the operation, the patient complained of dysuria, nocturia, frequent urination, urgent urination and urinary retention. The patient received combination treatment of Korean medicine during 14 days of hospitalization. The treatment included Ohrim-san, acupuncture, moxibustion, and pharmacoacupuncture. The effects were evaluated through the Numeric Rating Scale (NRS), Overactive Bladder Symptom Score (OABSS), Frequency-Volume chart, and 5-Level version of EuroQol-Five Dimension (EQ-5D-5L). Results: After the treatment, the clinical symptoms such as dysuria, nocturia, frequent urination, urgent urination, urinary retention were improved. Also, the quality of life was enhanced. Conclusions: This case report shows that the combination treatment of Korean Medicine with Ohrim-san may be effective for treating lower urinary tract symptoms (LUTS) after laparoscopic myomectomy.

Clinical Study of Combination Treatment of Oriental Medicine on Thalamic Pain Syndrome (시상증후군(Thalamic Pain Syndrome) 환자의 한방 병합치료에 관한 임상적 고찰)

  • Woo, Young-Min;Song, Kyung-Sup;Lee, Jin-Hun
    • The Journal of Internal Korean Medicine
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    • v.21 no.5
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    • pp.765-771
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    • 2000
  • Objectives : To evaluate the pain control effect of combination treatment of Oriental Medicine on patients who suffered from thalamic pain syndrome caused by thalamic stroke. Methods : We reviewed the medical records and brain imaging data of all patients with thalamic stroke from September 1998 to August 2000 who visited to Department of Oriental Internal Medicine, National Medical Center. We evaluated clinical features of thalamic pain syndrome, including incidence, onset interval from stroke, nature, pain distribution, and assessed the pain control effect of combination treatment by Visual Analog Scale(VAS). Results : 64 cases were selected under the inclusion criteria, and 17 patients(26.5%) with thalamic pain syndrome were identified from 64 thalamic strokes. VAS proved combination treatment effective to control pain of thalamic pain syndrome. In 12 cases(70.5%), pain onset was within the first week poststroke. The patients with allodynia were 6(35.3%). In 12 cases(70.5%), the lesion was mainly located in the posterolateral areas of thalamus. Conclusion : We conclude that combination treatment of the Oriental Medicine modalities have pain control effectiveness on thalamic pain syndrome.(t=-5.47, p=0.0001)

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Effects of Sayeoksanhap-Pyeongweisan-Gamibang(SPG) on Hepatological Changes in Animals Damaged by $CCl_4$ (사역산합평위산가미방(四逆散合平胃散加味方)의 경구투여와 약침의 병용이 백서의 간손상에 미치는 영향)

  • Kim, Sung-Wook;Kim, Hyung-Woo;Cho, Su-In;Yun, Yeo-Choong
    • Journal of Acupuncture Research
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    • v.24 no.4
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    • pp.197-207
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    • 2007
  • Objectives: This study was designed to investigate protective effects of Sayeoksanhap-Pyeongweisan-Gamibang(SPG) on hepatological changes in rats damaged by $CCl_4$. Methods : We investigated the effects of SPG on hepatological changes in terms of AST/ALT levels, Total cholesterol, HDL-cholesterol and triglyceride in serum and lipid peroxidation in rat liver. Results : Combination treatment with acupuncture and oral administration of SPG decreased AST and ALT in serum. Combination treatment also decreased lipid peroxidation in liver and triglyceride in serum. In addition, HDL-cholesterol in serum was increased significantly by combination treatment. Contrary, level of total cholesterol was not changed by combination treatment. Conclusion : These results suggest that Combination treatment with acupuncture and oral administration of SPG was useful to protect liver against $CCl_4$ by its antioxidant action in liver tissues.

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Clinical Study on East-West Combination Treatment in Joint Disorders (관절.류마티스 질환의 한.양방 협진에 관한 임상적 고찰)

  • Shin, Ye-Jji;Kim, Chan-Young;Kwon, Na-Hyoun;Kwon, Sin-Ae;Lee, Jung-Woo;Koh, Hyung-Kyun;Woo, Hyun-Su;Park, Dong-Suk;Baek, Yong-Hyeon
    • Journal of Acupuncture Research
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    • v.26 no.6
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    • pp.121-132
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    • 2009
  • Objectives : To evaluate the current status of East-West combination treatment in joint disorders. Methods : The medical records of patients who visited the Joints & Rheumatism Center at the Kyung Hee East-West Neo Medical Center from April 2006 to June 2009 were evaluated. The general characteristics of patients who underwent combination treatment, trend in number of cross-system referrals, and disorders and involved body regions of patients referred to the Eastern medical hospital from the Western medical hospital were initially assessed. 6 major disorders were found from the initial scanning. The trend in number of cross-hospital referrals, number of visits to the Eastern medical hospital, current status of combination treatment, treatment modality, and reason for cross-system referral was evaluated. Results : 1. 1510 patients were referred from the Eastern medical hospital to the Western medical hospital, and 1065 patients were referred from the Western medical hospital to the Eastern medical hospital. First visit patients reached a peak at the second quarter of 2007 and fourth quarter of 2006 respectively, and have steadily decreased from then on. Referrals of female patients were twice as common as male patient referrals. Patients in their sixth or seventh decade of life were most commonly referred, and more outpatients were referred compared to inpatients. 2. Patients with knee joint disorders were most commonly referred from the Western medical hospital to the Eastern medical hospital, followed by hip, shoulder, ankle, wrist, and elbow joint disorders. The most common disorders for each of the above regions in referred patients were knee osteoarthritis, avascular necrosis of the hip, adhesive capsulitis, and ankle strain and sprain. The generalized disorders rheumatoid arthritis and ankylosing spondylitis followed. 3. Patients referred to the Eastern hospital received approximately 3 to 10 Eastern medical treatment sessions. 45 percent remained on constant combination treatment, and 98 percent of referred patients received acupuncture treatment. Conclusions : In regard to the number of patients and duration of combination treatment, combination treatment was successfully performed for knee osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, while it was not so for avascular necrosis of the hip, adhesive capsulitis, and ankle strain and sprain. Further research on this subject is required.

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Combined Treatment with 5-Fluorouracil and Capsaicin Induces Apoptosis in HT-29 Human Colon Cancer Cells (5-Fluorouracil과 Capsaicin의 병용에 의한 HT-29 대장암세포 사멸 증진 효과)

  • Lee, Yun-Seok;Lee, Jong-Suk;Kim, Jung-Ae
    • YAKHAK HOEJI
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    • v.53 no.4
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    • pp.184-188
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    • 2009
  • Fluorouracil (5-FU) is one of the most widely used chemotherapeutic drugs in the treatment of advanced colorectal cancer patients. Capsaicin (N-vanillyl-8-methyl-alpha-nonenamide), a spicy component of hot pepper, is a homovanillic acid derivative that preferentially induces cancer cells to undergo apoptosis. The purpose of the present study is to examine whether capsaicin enhances the anticancer effect of 5-fluorouracil in HT-29 human colon cancer cells by inducing apoptosis, and whether PPARgamma is involved in the capsaicin action in combination treatment with 5-FU. Treatment of the cells with either 5-FU or capsaicin alone for 48 h had little effect on the cell viability up to $50{\mu}M$ concentration, whereas co-treatment of the cells with capsaicin in the presence of 5-FU for 48 h significantly decreased the cell viability in a concentration-dependent manner. In addition, caspase-3 activity, a marker enzyme for apoptosis, was significantly increased by the combined treatment with 5-FU and capsaicin compared to the 5-FU or capsaicin alone treatment. Also, treatment with troglitazone, a peroxisome proliferator-activated receptor gamma ($PPAR{\gamma}$) agonist, further enhanced the effect of the combination treatment on the cell viability and caspase-3 activity, and bisphenol A diglycidyl ether (BADGE), a $PPAR{\gamma}$ antagonist, blocked the effect of the combination treatment. These results suggest that the combination treatment of HT-29 cells with 5-FU and capsaicin induces apoptotic cell death at relatively low concentration than each drug alone, and the combination treatment may be associated with the $PPAR{\gamma}$ pathway activation.

Induction of Apoptosis by Combination Treatment with Luteolin and TRAIL in T24 Human Bladder Cancer Cells (T24 방광암세포에서 Luteolin과 TRAIL의 복합 처리에 따른 Apoptosis 유도)

  • Park, Hyun Soo;Choi, Yung Hyun
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.42 no.9
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    • pp.1363-1369
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    • 2013
  • Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can selectively induce apoptosis by targeting cancer cells. However, some cancer cells are resistant to TRAIL-induced cytotoxicity. One method of overcoming TRAIL resistance is combination treatment with reagents to sensitize cells to TRAIL. Luteolin, a flavonoid, has been shown to have anti-cancer effects by inducing apoptosis and cell cycle arrest in various cancer cell lines in vitro. In this study, we investigated the effects of combination treatment with non-toxic concentration of TRAIL and luteolin in T24 human bladder cancer cells. Combined treatment with luteolin and TRAIL significantly inhibits cell proliferation via activation of caspases by inducing Bid truncation, up-regulation of Bax and down-regulation of X-linked inhibitor of apoptosis protein (XIAP). However, the apoptotic effects of combination treatment with luteolin and TRAIL were significantly inhibited by specific caspases inhibitors. Taken together, these results indicate that combination treatment with TRAIL and luteolin can induce apoptosis in TRAIL-resistant cancer cells through down-regulation of XIAP and modulation of tBid and Bax expression.

Synergistic Effects of Chios Gum Mastic Extract and Low Level Laser Therapy on Osteoblast Differentiation

  • Lee, Ki-Hyun;Kim, Young-Seok;Yu, Su-Bin;Kang, Hae-Mi;Kwak, Hyun-Ho;Kim, In-Ryoung;Park, Bong-Soo
    • International Journal of Oral Biology
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    • v.41 no.2
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    • pp.53-62
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    • 2016
  • In the present study, we evaluated the effect of CGM on osteogenic differentiation of cultured osteoblasts, and determined whether combination treatment with LLLT had synergistic effects on osteogenic differentiation. The results indicated that CGM promoted proliferation, differentiation, and mineralization of osteoblasts at the threshold concentration of $10{\mu}g/ml$; whereas, CGM showed cytotoxic properties at concentrations above $100{\mu}g/ml$. ALP activity and mineralization were increased at concentrations above $10{\mu}g/ml$. CGM in concentrations up to $10{\mu}g/ml$ also increased the expression of osteoblast-activated factors including type I collagen, BMP-2, RUNX2, and Osterix. The CGM ($50{\mu}g/ml$) and LLLT (80 mW for 15 sec) combination treatment group showed the highest proliferation levels, ALP activity, and mineralization ratios. The combination treatment also increased the levels of phosphorylated forms of p38, ATF2, PKD, ERK, and JNK. In addition, the osteoblast differentiation factors including type I collagen, BMP-2, RUNX2, and Osterix protein levels were clearly increased in the combination treatment group. These results suggested that the combination treatment of CGM and LLLT has synergistic effects on the differentiation and mineralization of osteoblastic cells.

Combination Treatment of Korean Medicine with Guibiondamtang-gamibang for Hwa-Byung Patients: 2 Cases Report (귀비온담탕 가미방을 포함한 한방치료로 호전된 화병 환자 2례 : 증례 보고)

  • Jeong, So-Mi;Hwang, Deok-Sang;Lee, Jin-Moo;Lee, Chang-Hoon;Jang, Jun-Bock;Cho, Seong-Hee
    • The Journal of Korean Obstetrics and Gynecology
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    • v.34 no.3
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    • pp.157-174
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    • 2021
  • Objectives: This case report aims to report the clinical effectiveness of the combination treatment of Korean medicine with Guibiondamtang-gamibang on Hwa-byung patients. Methods: Case 1 experienced stress at work and complained of chest discomfort, nausea, dizziness, insomnia. Case 2 experienced huge stress about money, and complained of palpitation, chest discomfort, dizziness and insomnia. They received combination treatment of Korean medicine during hospitalization. The treatment included Guibiondamtang-gamibang, acupuncture, moxibustion, pharmacoacupuncture, and fumigation. The effects were evaluated through Hwa-byung scale, instrument of oriental medical evaluation for Hwa-byung, insomnia severity index (ISI) and heart rate variability (HRV) test. Results: After the treatment, the clinical symptoms such as chest discomfort, palpitation, dizziness, nausea and insomnia were improved. Conclusions: This case report shows that the combination treatment of Korean medicine with Guibiondamtang-gamibang may be effective for treating Hwa-byung patients.

Protective Effect of Brazilin on Cisplatin Nephrotoxicity

  • Kong, Jae-Myeong;Seo, Kyung-Won;Choung, Se-Young
    • Biomolecules & Therapeutics
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    • v.2 no.2
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    • pp.103-107
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    • 1994
  • Cisplatin is one of the most effective antitumor agents currently available for cancer therapy. However, its clinical use has been limited by its severe side effects, especially nephrotoxicity. Therefore, brazilin, which has a radical scavenging effect, was given intraperitoneally to evaluate the effect on cisplatin nephrotoxicity in rats. Remarkable protective effects against nephrotoxicity of cisplatin were observed when brazilin was administered to rats simultaneously with cisplatin. Hepatotoxicity induced by combination treatment of cisplatin and brazilin was evaluated by measuring serum glutamic pyruvate transaminase and serum glutamic oxalate transaminase. Combination treatment did not affect the levels of sGPT and SGOT, and any combination treatment did not induce metallothionein in kidney. Brazilin which has radical scavenging effect directly reduced nephrotoxicity of wisplatin in vivo. Thus, it seems that nephrotoxicity of cisplatin was caused by free radicals. The present results Indicate that brazilin, when it is given with cisplatin, may provide protection against cisplatin nephrotoxicity in rats.

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