• Title/Summary/Keyword: collaborative research

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A Study on the Improvement of Product Management System in International Collaborative Research (국제공동연구 성과물 관리제도 개선방안)

  • Yoon, Chong-Min
    • Journal of Korea Technology Innovation Society
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    • v.12 no.3
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    • pp.499-524
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    • 2009
  • Recently the portion of international collaborative research in national R&D is being on the increase. But the management system of products from the international collaborative research is not sufficient. Not only the internal management system of public research institute, universities or government support R&D centers, are not enough, but also the legislations in government level are not established. In this paper, the problems and situations of product management system in international collaborative research are investigated and analyzed, and the methodology of improvement of them are presented.

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Bioactive Prenylated Flavonoids from the Stem Bark of Artocarpus kemando

  • Seo, Eun-Kyoung;Lee, Dong-Ho;Shin, Young-Geun;Chai, Hee-Byung;Navarro, Hernan-A.;Kardono, Leonardus B.S.;Wani, Mansukh, C.;Rahman, Ismail;Cordell, Geoffrey-A.;Farnsworth, Narman-R.;Pezzuto, John-M.;Kinghorn, A.-Douglas;Wani, Mansukh-C.;Wall, Monroe-E.
    • Archives of Pharmacal Research
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    • v.26 no.2
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    • pp.124-127
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    • 2003
  • Four known prenylated flavonoids, artonins E (1) and O (2), artobiloxanthone (3), and cycloartobiloxanthone (4), were isolated from the stem bark of Artocarpus kemando by bioassayguided fractionation using the DNA strand-scission and the KB cytotoxicity assays as monitors. Compounds 1 and 3 exhibited strong DNA strand-scission activity, and all four compounds were found to be cytotoxic.

Phenolic Compounds Obtained from Stems of Couepia ulei with the Potential to Induce Quinone Reductase

  • Jang, Dae-Sik;Park, Eun-Jung;Kang, Young-Hwa;Vigo, Jose-Schunke;James-G.Graham;Fernando-Cabieses;Harry-H.S.Fong;John-M.Pezzuto;A.Douglas-Kinghorn
    • Archives of Pharmacal Research
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    • v.27 no.2
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    • pp.169-172
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    • 2004
  • Activity-guided fractionation of the EtOAc-soluble extract of the stems of Couepia ulei, using a bioassay based on the induction of quinone reductase (QR) in cultured Hepa 1c1c7 mouse hepatoma cells led to the isolation of two active compounds, a new natural product, erythro-2,3-bis(4-hydroxy-3-methoxyphenyl)-3-ethoxypropan-1-o1 (1), and a known compound, evofolin-B (2), along with five inactive compounds all of known structure, viz., betulinic acid, oleanolic acid, pomolic acid, ($\pm$)-syringaresinol, and ursolic acid. These isolates were identified by analysis of physical and spectral data. Compounds 1 and 2 exhibited QR inducing activity, with observed CD (concentration required to double induction) values of 16.7 and 16.4 $\mu\textrm{M}$, respectively.

Analyzing the Domestic Collaborative Research Network in Industrial Engineering (국내 산업공학 공동연구 네트워크 분석)

  • Jeong, Bokwon;Lee, Hakyeon
    • Journal of Korean Institute of Industrial Engineers
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    • v.40 no.6
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    • pp.618-627
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    • 2014
  • This paper aims to construct and analyze the domestic collaborative research network in industrial engineering. Using co-authorship information contained in the papers published in the two journals of the Korean Institute of Industrial Engineers, the collaborate research network at the institutional level is constructed. The core institutions in the network are identified by means of the centrality indexes of social network analysis. In addition, the five types of roles of the institutions in industry-university-institute cooperation are examined through brokerage analysis: coordinator, consultant, gatekeeper, representative, and liaisons. The findings are expected to be fruitfully utilized in formulation of R&D strategy of relevant organizations and technology policy making for promoting collaborative research in industrial engineering.

Perspectives on the Quality Assurance of Ginseng Products in North America

  • Fitzloff, J.F.;Yat, P.;Lu, Z.Z.;Awng, D.V.C.;Arnason, J.T.;Breemen, R.B.van;Ha, T.ll;Blumenthal, M.;Fong, H.H.S.
    • Proceedings of the Ginseng society Conference
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    • 1998.06a
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    • pp.138-145
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    • 1998
  • A validated and reproducible HPLC method was developed for the profiling and quantitative analysis of ginsenosides in commercial products available in North America. Analysis of 280 Panax ginseng and Panax quinquefolius products showed profiles indicative of the presence of ginsenosides in the majority of these products. However, the quantitative contents of the products vary greatly, not only in products of different formulations, but also of products within each of the fromulations examined.

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Analysis of Collaborative Research Trends in Library and Information Science in Korea (국내 문헌정보학 분야의 공동연구 동향 분석)

  • Lee, HyeKyung;Yang, Kiduk;Kim, SeonWook
    • Journal of Korean Library and Information Science Society
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    • v.50 no.2
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    • pp.191-214
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    • 2019
  • In order to understand the trends of collaborative research in the field of Library and Information Science (LIS) in Korea, this study analyzed bibliometric data and keywords of 5,383 Journal papers by 195 Korean LIS professors from 2000 to 2017 as well as the author credit allocation formulas of 26 Korean university research evaluation criteria. Examination of university research evaluation criteria revealed co-authors' credit level to be generally much lower than that of single authors, which in turn reduces the relative value of collaborative research. As a result, recent journals publish more co-authored papers than single author papers both domestically and internationally. The study also found collaborative research to be less prevalent in private universities than national universities and least prevalent in associate professors among professors. Furthermore, keyword analysis of study data revealed the emerging topics of both domestic and international collaborative research to be those that reflect social phenomena as well as those that relate to information science employing new technologies.

Compounds Obtained from Sida acuta with the Potential to Induce Quinone Reductase and to Inhibit 7,12-Dimethylbenz-[a]anthracene-Induced Preneoplastic Lesions in a Mouse Mammary Organ Culture Model

  • Jang, Dae-Sik;Park, Eun-Jung;Kang, Young-Hwa;Su, Bao-Ning;Hawthorne, Michael-E.;Vigo, Jose-Schunke;Graham, James-G.;Cabieses, Fernando;Fong, Harry H.S.;Mehta, Rajendra-G.;Pezzuto, John-M.;Kinghorn, A.-Douglas
    • Archives of Pharmacal Research
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    • v.26 no.8
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    • pp.585-590
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    • 2003
  • Activity-guided fractionation of the EtOAc-soluble extract of the whole plants of Sida acuta using a bioassay based on the induction of quinone reductase (OR) in cultured Hepa 1c1c7 mouse hepatoma cells, led to the isolation of ten active compounds of previously known structure, quindolinone (1), cryptolepinone (2), 11-methoxyquindoline (3), N-trans-feruloyltyramine (4), vomifoliol (5), loliolide (6), 4-ketopinoresinol (7), scopoletin (8), evofolin-A (9), and evofolin-B (10), along with five inactive compounds of known structure, ferulic acid, sinapic acid, syringic acid, ($\pm$)-syringaresinol, and vanillic acid. These isolates were identified by physical and spectral data measurement. A new derivative of quindolinone, 5,10-dimethylquindolin-11-one (1a) was synthesized and characterized spectroscopically. Of the active substances, compounds 1-3 and 1a exhibited the most potent QR activity, with observed CD (concentration required to double induction) values ranging from 0.01 to 0.12 $\mu$ g/mL. Six compounds were then evaluated in a mouse mammary organ culture assay, with cryptolepinone (2), N-trans-feruloyltyramine (4), and 5,10-dimethylquindolin-11-one (1a) found to exhibit 83.3, 75.0, and 66.7% inhibition of 7,12-dimethylbenz[a]anthracene-induced preneoplastic lesions, respectively, at a dose of 10 $\mu\textrm{g}$/mL.

An International Collaborative Program To Discover New Drugs from Tropical Biodiversity of Vietnam and Laos

  • Soejarto, Djaja D.;Pezzuto, John M.;Fong, Harry H.S.;Tan, Ghee Teng;Zhang, Hong Jie;Tamez, Pamela;Aydogmus, Zeynep;Chien, Nguyen Quyet;Franzblau, Scott G.;Gyllenhaal, Charlotte;Regalado, Jacinto C.;Hung, Nguyen Van;Hoang, Vu Dinh;Hiep, Nguyen Tien;Xuan, Le Thi;Hai, Nong Van;Cuong, Nguyen Manh;Bich, Truong Quang;Loc, Phan Ke;Vu, Bui Minh;Southavong, Boun Hoong
    • Natural Product Sciences
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    • v.8 no.1
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    • pp.1-15
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    • 2002
  • An International Cooperative Biodiversity Group (ICBG) program based at the University of Illinois at Chicago initiated its activities in 1998, with the following specific objectives: (a) inventory and conservation of of plants of Cuc Phuong National Park in Vietnam and of medicinal plants of Laos; (b) drug discovery (and development) based on plants of Vietnam and Laos; and (c) economic development of communities participating in the ICBG project both in Vietnam and Laos. Member-institutions and an industrial partner of this ICBG are bound by a Memorandum of Agreement that recognizes property and intellectual property rights, prior informed consent for access to genetic resources and to indigenous knowledge, the sharing of benefits that may arise from the drug discovery effort, and the provision of short-term and long-term benefits to host country institutions and communities. The drug discovery effort is targeted to the search for agents for therapies against malaria (antimalarial assay of plant extracts, using Plasmodium falciparum clones), AIDS (anti-HIV-l activity using HOG.R5 reporter cell line (through transactivation of the green fluorescent protein/GFP gene), cancer (screening of plant extracts in 6 human tumor cell lines - KB, Col-2, LU-l, LNCaP, HUVEC, hTert-RPEl), tuberculosis (screening of extracts in the microplate Alamar Blue assay against Mycobacterium tuberculosis $H_{37}Ra\;and\;H_{37}Rv),$ all performed at UIC, and CNS-related diseases (with special focus on Alzheimer's disease, pain and rheumatoid arthritis, and asthma), peformed at Glaxo Smith Kline (UK). Source plants were selected based on two approaches: biodiversity-based (plants of Cuc Phuong National Park) and ethnobotany-based (medicinal plants of Cuc Phuong National Park in Vietnam and medicinal plants of Laos). At mc, as of July, 2001, active leads had been identified in the anti-HIV, anticancer, antimalarial, and anti- TB assay, after the screening of more than 800 extracts. At least 25 biologically active compounds have been isolated, 13 of which are new with anti-HIV activity, and 3 also new with antimalarial activity. At GSK of 21 plant samples with a history of use to treat CNS-related diseases tested to date, a number showed activity against one or more of the CNS assay targets used, but no new compounds have been isolated. The results of the drug discovery effort to date indicate that tropical plant diversity of Vietnam and Laos unquestionably harbors biologically active chemical entities, which, through further research, may eventually yield candidates for drug development. Although the substantial monetary benefit of the drug discovery process (royalties) is a long way off, the UIC ICBG program provides direct and real-term benefits to host country institutions and communities.

The Influence of Authors' Centrality on Research Performance in a Large-Scale Collaborative Research Network (대규모 공동연구 네트워크에서 저자의 중심성이 연구성과에 미치는 영향)

  • Moon, Seonggu;Kim, Injai
    • Journal of Information Technology Services
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    • v.17 no.2
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    • pp.179-190
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    • 2018
  • This study is about the influence of authors' centrality on research outcomes in a large-scale collaborative research network. Using the social network analysis method, five types of centralities were derived. Six research outcomes of individual researchers were also derived through bibliographic information of the social science field for the last 10 years. A multivariate regression analysis was conducted to examine the causal relationship between the centrality and research outcome, and the effect of centrality on research outcomes was found to be statistically significant. The result of this study shows that the revised citation and H-index significantly influenced the authors' centrality. This result can imply that the centrality of the researcher can expect a considerable influence of the thesis as well as a certain level of productivity. The meaning of this study is to analyze the effect of centrality on the research outcomes of the large-scale collaborative research network in the past decade, and is carefully to suggest a guideline in order to support new research information services for active researchers and the advancement of collaborative research. This study has its limitation for interpreting the diverse academic fields of the social sciences in a uniform way. In future study, it is necessary to conduct studies using various weighted indices for network centrality in order to measure the influence of research.

Predicting Co-Authorship based on Link analytics and learning (링크 분석 및 학습을 통한 공동연구성과 기반 공저자 관계 예측)

  • Jeon, HyeonJu;Kim, YunHu;Jung, Jason J.;Kim, Kono
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2019.05a
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    • pp.83-86
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    • 2019
  • This study proposes a methodology for predicting co-authorship of contributors to a highly anticipated paper through link analysis and learning, taking into account the result of collaborative research. Previous studies predict the co-authorship with high accuracy, but this shows limitations in that the quality of the predicted relationship is not considered. Therefore, to solve the above problem, we propose three steps to predict the co-authorship that will help with the expected performance: (1) Construct a heterogeneous graph to measure results of collaborative research. (2) Analyze and learn links based on results of collaborative research. (3) Predict links that are anticipated to have high expectation. It is expected to be useful for increasing confidence in the predicted co-authorship.

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