• Title, Summary, Keyword: carboxymethyl chitosan

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Preparation of Biomedical Grade Carboxyinethyl Chitin and Carboxymethyl Chitosan (의용 카르복시메틸 키틴과 카르복시메틸 키토산의 제조)

  • 김성태;김재환
    • Textile Science and Engineering
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    • v.30 no.5
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    • pp.395-402
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    • 1993
  • Carboxymethyl chitin and carboxymethyl chitosan have low oxygen permeability, so they can be used as antiseptics. Moreover, water solubility of carboxymethyl chitin and carboxymethyl chitosan make them possible to be applied in groceries and medicines. In this study, biomedical grade chitin and chitosan were extracted from chionoecetes opilio and carboxymethyl chitin anal carboxymethyl chitosan which can be applied in groceries and medicines were obtained from them. The reaction conditions of carboxymethylation such as NaOH concentration. reaction temperature and reaction time were investigated by means of monitoring of viscosity. In addition, some properties were compared with biomedical grade carboxymethyl chitin and carboxymethyl chitosan commercialized by NOVA chemical.

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Effect of Carboxymethyl Chitosan on Quality of Fermented Pan Bread (발효빵에 첨가한 Carboxymethyl Chitosan이 품질에 미치는 영향)

  • Lee, Kyoung-Hae;Lee, Young-Chun
    • Korean Journal of Food Science and Technology
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    • v.29 no.1
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    • pp.96-100
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    • 1997
  • Carboxymethyl chitosan (CMC) was added to pan bread, prepared by the straight-dough method, and its effects on shelf-life, retrogradation, antimicrobial activity, water activity, and sensory quality of pan bread were evaluated. The results of differential scanning calorimetry (DSC) and thermoconstanter analysis for retrogradation indicated that shelf-life of pan bread was significantly extended by addition of CMC. Growth of microorganisms, including bakery molds (Aspergillus, Penicillium, etc.) was significantly inhibited by adding CMC to pan bread. Sensory color, off-flavor and overall acceptability of pan bread were stable during storage. However, sensory texture of control was significantly different from that of sample with added CMC.

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Effects of carboxymethyl chitosan fabric and low molecular weight heparin on reducing adhesion formation in the rat (Rat에서 carboxymethyl chitosan fabric과 low molecular weight heparin의 유착방지 효과)

  • Kwon, Young-sam;Jang, Kwang-ho
    • Korean Journal of Veterinary Research
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    • v.43 no.4
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    • pp.703-708
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    • 2003
  • This study was carried out to compare the efficacy of carboxymethyl chitosan fabric (CMCF) with that of the combination of low molecular weight heparin (LMWH) and CMCF for the prevention of postoperative adhesions in the rat. Adhesions were induced by suturing both the ileal serosa and peritoneum scraped until petechial bleeding occurred. CMCF were sutured between two surfaces, and LMWH were instilled intraperitoneally immediately before closure of the peritoneomuscular layer. The adhesions were blindly assessed 2 weeks later by using a tensiometer. The mean tensile strength(Newton) of formed adhesions was $2.59{\pm}0.85$ in control group, $2.10{\pm}0.75$ in the CMCF group and $1.53{\pm}0.44$ in the CMCF+LMWH group. The most favorable prevention against adhesion was achieved in the CMCF+LMWH group. Therefore, we could conclude that CMCF+LMWH were effective in prevention against postoperative adhesion in the rat.

Development of Functional Textile Material by Using Chitosan 1. Preparation and Characterization of Chitosan Fiber and Chitosan Fiber Coated with S-carboxymethyl Keratein (키토산을 이용한 기능성 소재 개발 1. 키토산 섬유와 S-카르복시메틸케라틴 코팅 키토산 섬유의 제조와 특성)

  • 민경혜;신윤숙
    • Textile Coloration and Finishing
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    • v.11 no.3
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    • pp.32-40
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    • 1999
  • Chitosan fiber was prepared by wet spinning with various draw ratio. Chitosan fiber was coated with f-carboxymethyl keratein(SCMK) by extruding chitosan solution into 1 M NaOH solution containing 1% SCMK. Among three chitosan used in this study(chitosans of 5 cps, 50 cps, 100 cps), 50 cps chitosan gave the best tenacity and optimum concentration was 5%. SCMK coating increased the tenacity of chitosan fiber. Regardless of SCMK coating, tenacity and elongation of both chitosan fibers were increased with the increase of draw ratio. Chitosan fiber showed antimicrobial activity against Staphyloccus aureus showing 66∼72% of bacteria reduction rates. On the other hand, chitosan fiber coated with SCMK didn't show any antimicrobial activity.

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Effect of Chitosan and N, O-Carboxymethyl Chitosan of Different Sources and Molecular Weights on Cadmium Toxicity (급원과 분자량이 다른 Chitosan 과 N, O-Carboxymethyl Chitosan이 Cadmium 중독에 미치는 영향)

  • 배계현
    • Journal of Nutrition and Health
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    • v.30 no.7
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    • pp.751-769
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    • 1997
  • This study was performed to investigate the effect of chitosan and NOCC from different sources and of different molecular weights on cadmium toxicity. Sprague-Dawley rats were blocked into 26 groups according to body weight, and were raised for 4 weeks. Cadmium chloride was given at the level of 0 or 400 ppm in diet. Various forms of chitosan and NOCC were given at the level of 0 or 4%(w/w) of diet. Cd toxicity was alleviated by various chitosan and NOCC supplements. However, the alleviating effects were different with fiber source(crab and shrimp), type(chitosan and NOCC), and molecular weight (low, medium, and high). Molecular weight had no significant effect. Compared with shrimp-source-fiber-fed groups, crab-source-fiber-fed groups showed lower Cd concentrations in blood and kidney, lower kidney metallothionein concentration, and lower liver and kidney MT-Cd contents. Compared with NOCC -fed groups, chitosan-fed groups showed lower intestine and liver Cd concentrations, lower liver and kidney MT concentrations and MT-Cd content, and higher fecal Cd excretion. Among cadmium-exposed group, low molecular weight shrimp chitosan group showed low Cd concentrations of liver and kidney, high fecal Cd excretions, and the lowest intestine and liver MT concentrations and liver MT-Cd content. In summary, a crab source fiber was more effective than shrimp source fiber, chitosan was more effective than NOCC, and the most effective one in alleviating Cd toxicity was low molecular weight shrimp chitosan.

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Effect of Chitosan and N. O-Carboxymethyl Chitosan of Different Sources and Molecular Weights on Lipid Metabolism (급원과 분자량이 다른 Chitosan 과 N, O-Carboxymethyl Chitosan이 지방대사에 미치는 영향)

  • 배계원
    • Journal of Nutrition and Health
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    • v.30 no.7
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    • pp.770-780
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    • 1997
  • This study was performed to investigate the effect of chitosan and NOCC from different sources and of different molecular weights on lipid metabolism. Sprague-Dawley rats were blocked into 26 groups according to body weight, and were raised for 4 weeks. Cadmium chloride was given at the level of 0 or 400 ppm in diet. Various chitosan and NOCC sources were given at the level of 0%(w/w) of diet. Total serum cholesterol and serum triglyceride concentrations were little affected by chitosan and NOCC supplements. However, HDL-cholesterol concentration and HDL : total cholesterol ratio were increased , and liver lipid, cholesterol , and triglyceride concentration were decreased by chitosan and NOCC supplements. The cholesterol and lipid lowering activity depends on fiber sources(crab and shrimp); type (chitosan and NOCC); and molecular weight(low , medium , and high). Among cadmium-free groups, chitosan-fed groups showed greater activity than NOCC -fed groups in lowering cholesterol and lipid levels, and greater fecal excretion of lipids and bile acids. Crab chitosans were more effective in cholesterol and lipid lowering activity than shrimp chitosans. The group fed high molecular weight crab chitosan showed the highest fecal excretion of lipids and bile acids. This indicated that high molecular weight crab chitosan was most effective in interfering with cholesterol and lipid absorption.

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Adsorption of Nucleotides on ${\beta}$-Cyclodextrin Derivative Grafted Chitosan

  • Xiao Jian-Bo;Yu Hong-Zhu;Xu Ming;Chen Xiao-Qing
    • Macromolecular research
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    • v.14 no.4
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    • pp.443-448
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    • 2006
  • A novel ${\beta}$-cyclodextrin derivative (CCD-C) was synthesized with chitosan and carboxymethyl-${\beta}$-cyclodextrin. Its structure was characterized by elemental analysis, infrared spectra analysis, and X-ray diffraction analysis. The adsorption properties for guanosine 5'-monophosphate, cytidine 5'-monophosphate and uridine 5'-monophosphate were studied. Experimental results demonstrated that CCD-C had higher adsorption capability for guanosine 5'-monophosphate, and that the adsorption capacity for guanosine 5'-monophosphate was 74.20mg/g. The adsorption capacity was greatly influenced by pH, time and temperature. The introduction of chitosan enhanced the adsorption ability and adsorption selectivity of ${\beta}$-cyclodextrin for guanosine 5'-monophosphate. This novel derivative of chitosan is expected to have wide applications in the separation, concentration and analysis of nucleotides in biological samples.

Decolorization of Dyeing Wastewater with Use of Chitosan Materials

  • Xin, Chen;Sun, Hui-Li;Pan, Jia-Hui
    • Ocean Science Journal
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    • v.41 no.4
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    • pp.221-226
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    • 2006
  • More attention has been paid to the research on decolorization of dyeing wastewater nowadays. In this study, an investigation into the decolorization of dyeing wastewater was conducted using a combination of coagulant, carboxymethyl chitosan (NOCC) and coagulant aid, polyscrylamide (PAM). The factors influencing the decolorization efficiency, such as pH value, coagulant and the dosages of coagulant, were discussed. The results showed that using PAM as coagulant aid could reach a high decolorization efficiency compared with using NOCC alone. The optimal conditions were pH 2.3, 480 mg/L for NOCC, and 4-8 mg/L for PAM. Under the optimum conditions, the rate of decolorization could achieve 99%, and the removal of chemical oxygen demand (COD) could achieve 90%. In addition, the membrane processes with chitosan/rare-earth-metals could enhance the decolorization rate of Direct Black FF to 94.7%, and Indanthren Red F3B to 98.2%, respectively.

Effects of Carboxymethyl Chitosan on Yield and Whey Protein Loss in Cottage Cheese

  • Kim, Kyung-Tae;Kang, Ok-Ju
    • Preventive Nutrition and Food Science
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    • v.10 no.3
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    • pp.231-238
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    • 2005
  • A standard $1\%$ w/v solution of CM-chitosan made from squid pen was added to milk at levels of $0.5\sim3\%$ (v/v) to improve the yield and rheological properties of cottage cheese by whey protein retention. Cheese curd did not form at levels higher than $3\%$ (v/v) CM-chitosan standard solution. Yield and total protein of cottage cheese increased up to $2\%\;by\;11\;to\;42\%\;and\;17\;to\;38\%$ respectively, compared to control cheese. Whey protein losses were decreased by 11 to $42\%$ and thus accounted for all of the increase in yield. Anomalous results were obtained at the $0.8\%$ level, which neither improved yield or whey protein retention nor stabilized rheological parameters, and at the $0.5\%$ level, which improved yield and total protein without increasing whey protein retention. Elasticity and cohesiveness of CM-chitosan-containing cheese were generally improved and stabilized during storage. Monitoring of cheese chromaticity values for four weeks revealed a delay in the onset of yellowing in cheeses with CM-chitosan compared to the controls, while the concentration of added CM-chitosan had little influence on cheese chromaticity. The addition of CM-chitosan solution could be applied directly to industrial scale cottage cheese-making without the need for any modification of the production process.

Effect of carboxymethyl chitosan on postoperative intraperitoneal adhesion formation in the rat (Rat에서 carboxymethyl chitosan의 복강수술후 유착형성에 미치는 효과)

  • Jang, Kwang-ho;Kwon, Yong-sam;Kim, Jung-eun;Kwon, Eun-ju;Oh, Tae-ho;Lee, Keun-woo;Jang, In-ho
    • Korean Journal of Veterinary Research
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    • v.40 no.3
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    • pp.635-643
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    • 2000
  • The aim of this study was to determine the effectiveness of carboxymethyl chitosan(CMC) solution on preventing intraperitoneal adhesions. In this study, 44 rats were divided into four groups ; an untreated control group and three experimental groups that were treated with 3 ml of 1, 2 or 3% CMC solution, respectively. The anti-mesenteric serosa of the ileum was exteriorized and then abraded in a standard manner by scraping with a scalpel blade to create homogenous petechial hemorrhagic surface over a $0.5{\times}1cm$ area. The adhesions were blindly assessed 2 weeks later by using a computerized tensiometer. The mean tensile strength(Newton) of formed adhesions was $2.48{\pm}0.88$ in control group, $1.86{\pm}0.56$ in the 1% CMC-treated group, $1.75{\pm}0.71$ in the 2% CMC-treated group and $1.55{\pm}0.60$ in the 3% CMC-treated group. The most favorable prevention against adhesion was achieved in the 3% CMC-treated group(p<0.01). We could conclude that CMC was effective on preventing the formation of postoperative small intestinal adhesions in the rat.

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