• Title, Summary, Keyword: blood donors

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The Self-efficacy and Critical Factors of Apheresis Blood-Donors (성분헌혈자의 자기효능감과 관련변인)

  • Hong Kyong Hee;Park Ho Ran;Sohng Kyeong Yae
    • Journal of Korean Public Health Nursing
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    • v.17 no.1
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    • pp.122-131
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    • 2003
  • This study was designed to provide the base of nursing intervention that could help apheresis blood-donors to promote self-efficacy effectively by analyzing critical factors that influence on this. The subjects recruited for the research were 468 persons who participated in platelet donation at a university hospital apheresis unit in Seoul. The data for this study were collected between May and June, 2002 using questionnaires. Data were analyzed by t-test, ANOVA, Scheffe test, and stepwise multiple regression. The results were as follows. 1. The mean self-efficacy score on the questions related to blood donation was $32.9\pm5.1$, indicating that blood donors have above the mean level of self-efficacy related to blood donation. 2. The self-efficacy score was significantly higher for the group of persons who have more than 5 times of experiences in blood donation than others who have only one experience. 3. The critical factors that influence self-efficacy related to donation were the marital status, educational level. and previous experiences of whole blood donation, while the critical factor that influence on general self-efficacy was previous experiences of whole blood donation. Therefore, it is necessary to establish more effective and organized nursing intervention strategies that can promote the self-efficacy of apheresis blood-donors.

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INTERPRETATION OF BACTERIAL CONTAMINATION OF ALLOGENEIC TISSUES OBTAINED FROM CADAVERIC AND LIVING DONORS (조직은행에서 채취한 동종조직의 세균 배양 평가)

  • Lee, Eun-Young
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.31 no.1
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    • pp.31-38
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    • 2005
  • Thorough screening of donors medical and social history, extensive serological and bacterial screening combined with developed processing and sterilization methods have improved the safety of the allogeneic tissues in recent decades. The risk of bacterial infection through allogenic tissue transplantation is one of the major problems facing tissue banks. The purpose study is to report the contamination rate in 358 retrieved tissues obtained strictly aseptic conditions, between 2001 and 2002 in Korea Tissue Bank. Samples from 9 donors(total 13 donors) were used in blood culture, and in 7 donors the blood culture were negative. Of the 358 tissues cultured in their entirety, 186(52%) were initially culture negative and 177(48%) were positive. Organism low pathogenicity were cultures from 20.2% of the tissues. To minimize the bacterial load, donors should be obtain in operating rooms, using aseptic techniques with only a few personnel for procurement. The procurement cultures from donors and retrieved tissues with multiple should be carefully interpreted. Blood cultures should be taken account, since these can help to find contamination not detect swab culture. A prospective cohort study is needed to determine which of the varied processing and sterilization methodologies gives the best quality.

Impact of IL-2 and IL-2R SNPs on Proliferation and Tumor-killing Activity of Lymphokine-Activated Killer Cells from Healthy Chinese Blood Donors

  • Li, Yan;Meng, Fan-Dong;Tian, Xin;Sui, Cheng-Guang;Liu, Yun-Peng;Jiang, You-Hong
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.18
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    • pp.7965-7970
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    • 2014
  • One of the goals of tumor immunotherapy is to generate immune cells with potent anti-tumor activity through in vitro techniques using peripheral blood collected from patients. However, cancer patients generally have poor immunological function. Thus using patient T cells, which have reduced in vitro proliferative capabilities and less tumor cell killing activity to generate lymphokine-activated killer (LAK) cells, fails to achieve optimal clinical efficacy. Interleukin-2 (IL-2) is a potent activating cytokine for both T cells and natural killer cells. Thus, this study aimed to identify optimal donors for allogeneic LAK cell immunotherapy based on single nucleotide polymorphisms (SNP) in the IL-2 and IL-2R genes. IL-2 and IL-2R SNPs were analyzed using HRM-PCR. LAK cells were derived from peripheral blood mononuclear cells by culturing with IL-2. The frequency and tumor-killing activity of LAK cells in each group were analyzed by flow cytometry and tumor cell killing assays, respectively. Regarding polymorphisms at IL-2-330 (rs2069762) T/G, LAK cells from GG donors had significantly greater proliferation, tumor-killing activity, and IFN-${\gamma}$ production than LAK cells from TT donors (P<0.05). Regarding polymorphisms at IL-2R rs2104286 A/G, LAK cell proliferation and tumor cell killing were significantly greater in LAK cells from AA donors than GG donors (P<0.05). These data suggest that either IL-2-330(rs2069762)T/G GG donors or IL-2R rs2104286 A/G AA donors are excellent candidates for allogeneic LAK cell immunotherapy.

A Study on the Repeated Blood-Donation and Health Promotion Behavior, Self-efficacy, and Self-esteem of Blood-donors. (헌혈자의 헌혈 반복성과 건강증진행위, 자기 효능감, 자존감과의 관계)

  • Hong Kyong Hee;Park Ho Ran
    • Journal of Korean Public Health Nursing
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    • v.17 no.2
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    • pp.333-341
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    • 2003
  • This study was designed to provide basic strategies of nursing intervention in order to keep and obtain healthy, responsible and regular donors by investigating and analyzing relationships of health promotion behavior. self-efficacy and self-esteem of blood-donors. The subjects collected for the research were four hundred and sixty-eight individuals who participated in platelet donation at a university hospital apheresis unit in Seoul. The data for this study were collected between May and June, 2002 using questionnaires. The results were as follows. 1. The proportion of subjects who have not had previous experience of whole blood-donation was $13.7\%$, while the proportion of subjects who have had two times previous experiences was $16.2\%$ and over five times was $30.6\%$. 2. Mean score of health promotion behavior was 2.7 (range 1-4), self-efficacy was 3.8 (range 1-5) and self-esteem was 3.3 (range 1-4), which showed higher than middle. 3. There was positive significant relationship between the number of blood-donation and health promotion behavior as well as the number of blood donation and self-efficacy. 4. Positive significant relationship existed between the number of whole blood-donation and the number of apheresis blood-donation. Therefore, to increase recurrence of blood-donation. it is necessary to establish more effective and organized nursing intervention strategies that can promote the health promotion behavior, self-efficacy and self-esteem of blood-donors.

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Comparison Study of Knowledge, Attitude and Motivation Between Blood Donors and Non-donors (헌혈자와 비헌혈자의 헌혈에 대한 지식, 태도 및 동기에 대한 비교)

  • Shin, Jae-Hack;SaKong, Jun;Kim, Seok-Beom;Kim, Chang-Yoon;Kang, Pock-Soo;Chung, Jong-Hak;Song, Dal-Hyo
    • Yeungnam University Journal of Medicine
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    • v.6 no.2
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    • pp.159-172
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    • 1989
  • This study was conducted to compare the date on knowledge, attitude and motivation toward blood donation between donors and nondonors. The study population included 622 donors and 322 nondonors who visited the mobile blood donation car of Taegu Red Cross Blood Center and participated the group appointed blood donation campaign managed by the center from March 1 to March 31, 1989. The donors and nondonors were questioned above mentioned items with a formulated questionnaire. Among the general characteristics of the subjects in the study, male predominace(84.1% in donors and 73.6% in nondonors) in young age group (16-24 years) was the outstanding feature. As a medium of information about blood donation, "television" was playing a dominant role(donors ; 75.2%, nondonors ; 78.9%), while "magazine"played more important roles among donors. Of the donors, 70.6% and of the nondonors, 58.1% replied that they had ever been induced to donate blood (p<0.01). Major inducers were friend and personnel of mobile blood donation vehicle. On the measuring of knowledge level, the average rates of correct answer was higher in donors (62.6%) than in nondonors (54.1%) (p<0.01). Higher the education level was presented, higher the knowledge level (p<0.05). There have been noticeable difference between donors and nondonors in blood replying the questionnaire set to measure their attitude toward blood donation. especially in the items such as "impression toward blood", "selection of transfusion blood source" and "view on the situation of blood shortage." The major motivation toward blood donation of the groups were "possible future need" and "altruism or humanitarian interest". The major reasons for not donating blood in both groups were "fear of the needle" and around to visit to mobile car or center."

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Analysis of Reentry Test for the Donors Showing Reactivity or Grey Zone in a HBV Surface Antigen Assay by a Chemiluminescent Immunoassay (화학발광면역법에 의한 HBV 항원선별검사에서 양성 및 Grey Zone 결과를 보인 헌혈자의 헌혈 보류 해제 검사 결과 분석)

  • Shin, Sunmi;Kang, Jungwon;Lee, Kyeong Rak;Shin, Geon Sik;Kang, Jae-won;Seo, Young Ik;Min, Hyukki
    • The Korean Journal of Blood Transfusion
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    • v.29 no.3
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    • pp.301-309
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    • 2018
  • Background: If donors who were deferred due to the reactivity or grey zone in HBV surface antigen (HBsAg) assay want to donate blood again, they need to pass reentry tests. On the other hand, approximately half of the donors who are subject to the reentry tests cannot be reentered. This study examined the association between the sample to cutoff (S/Co) value of the HBsAg assay and the final results of the reentry test. Methods: This study analyzed the S/Co values of the HBsAg assay and the final results of the reentry tests for the 3,947 donors from January 2008 to December 2017 using the database of Blood Information Management System of the Korean Red Cross. Results: 1,767 donors (44.8%) were not reentered among 3,947 deferred donors. Among 1,585 donors showing ${\geq}10$ of the S/Co value in the HBsAg screening test, 1,542 donors (97.3%) were not reentered. The additional reentry tests were performed on 120 donors who were not reentered in the first reentry test; 98 donors (81.7%) were still not reentered. Overall, 4.6% of the donors showing a grey zone in the HBsAg assay were not reentered. Conclusion: The reentry test needs to be restricted for the deferred donors showing a more than 10 S/Co value. The application of the grey zone of current HBsAg assay will need to be continued to enhance the HBV-related blood safety.

Epidemiology of Hepatitis C Virus Genotypes in Northeastern Thai Blood Samples

  • Barusrux, Sahapat;Sengthong, Chatchawan;Urwijitaroon, Yupa
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.20
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    • pp.8837-8842
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    • 2014
  • Background: Hepatitis C virus (HCV) infection is an important cause of liver cancer in Thailand. The highest prevalence of anti-HCV positive among Thai blood donors is found in the northeastern region. The present analysis of the genotype distribution among anti-HCV positive northeastern-Thai blood donors was conducted to provide a base for the epidemiological pattern of HCV infection in this region. Materials and Methods: A total of 112 HCV seropositive healthy blood donors were randomly selected and tested for the presence of HCV-RNA by RT-PCR. HCV-RNA positive samples were genotyped by direct sequencing at core region genomes and confirmed by phylogenetic analysis. Results: HCV viremia was found in 94.6% (106/112) of HCV seropositive blood donors. There were 3 major genotypes distributed among this population. HCV genotype 3a was the most prevalent (71.7%) followed by genotypes 1a (7.5%), 1b (7.5%), 6i (3.8%), 6f (2.8%) and 6n (1.9%). Conclusions: HCV genotype 3a in asymptomatic infections in northeastern Thailand is significantly higher than other previous reports. Subgenotype 6 prevalence is less than in neighboring countries and distribution patterns differ. The findings are relevant as predictors for using interferon therapy in this population.

Incidence of Active HCV infection amongst Blood Donors of Mardan District, Pakistan

  • Karim, Fawad;Nasar, Abu;Alam, Ibrar;Alam, Iftikhar;Hassan, Said;Gul, Rahmat;Ullah, Sana;Rizwan, Muhammad
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.1
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    • pp.235-238
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    • 2016
  • Hepatitis C is an ailment of liver caused by hepatitis C virus (HCV) infection. About 3% of the world population is infected by this virus. HCV infection is a leading reason for liver cirrhosis and therefore a major source of hepatocellular carcinoma. The study focused on the incidence of active HCV infection in blood donors of Mardan district of KPK, Pakistan. A total of 5318 blood donors were inspected for the presence of anti-HCV antibodies and HCV-RNA using ICT (immune-chromatographic test), ELISA and RT-PCR at Mardan Medical Complex (MMC), Mardan. Out of these, 157 (2.95%) were positive by ICT, 60 (1.12%) by ELISA and 56 (1.05%) for HCV-RNA. The frequency of active HCV infectivity amongst the blood donors from district Mardan, KPK Pakistan was 1.05 %. Application of strict measures during blood donor selection and use of proper screening assays such as ELISA in place of ICT devices can give a more accurate picture so that the incidence of this viral infection in HCV negative blood recipients can be reduced.

Effects of Neutralization by Soluble ABH Antigens Produced by Transplanted Kidneys From ABO-Incompatible Secretor Donors

  • Kim, Jieun;Kim, Sinyoung;Hwang, In Sik;Choi, Jong Rak;Lee, Jae Geun;Kim, Yu Seun;Kim, Myoung Soo;Kim, Hyun Ok
    • Annals of Laboratory Medicine
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    • v.37 no.3
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    • pp.254-260
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    • 2017
  • Background: Grafts survive despite blood group antigens on the transplant being continuously exposed to antibodies in the blood of recipients in ABO-incompatible kidney transplantation (ABOi KT), owing to the mechanism of accommodation. We analyzed the immunodynamics of soluble ABH antigens in allografts from secretor donors and the influence of such immunodynamics on accommodation and subsequent graft survival in ABOi KT. Methods: The genotype of a known human ${\beta}$-galactoside ${\alpha}$-1,2-fucosyltransferase gene (FUT2), which determines soluble ABH antigen secretor status, was established in 32 donors for ABOi KT at the Severance Hospital, from June 2010 to July 2015. Clinical outcomes of recipients, such as anti-A/B antibody titer change, renal function, and graft survival, were evaluated. Results: Twenty-five donors were secretors (78.1%), and seven were nonsecretors (21.9%). The frequency of anti-A/B IgG or IgM antibody titer elevation or reduction post-transplantation was not significantly related to donor secretor status. However, IgM titer was rapidly reduced in recipients transplanted from nonsecretor donors (P =0.01), which could be explained by the lack of absorption effect of soluble antigens, enhancing the binding of antibodies to antigens in the allografts. Interestingly, soluble ABH antigens did not affect rejection-free graft survival, which may be due to the nature of ${\beta}$-galactoside ${\alpha}$-1,2-fucosyltransferase. Conclusions: Soluble ABH antigens produced by transplanted kidneys from secretor donors played a role in inducing accommodation within three months of KT through neutralization; however, major graft outcomes were not affected.

Factors Affecting Health Promotion Behavior of Apheresis Blood-Donors (성분헌혈자의 건강증진행위에 영향을 미치는 요인)

  • Hong Kyong Hee;Park Ho Ran
    • Journal of Korean Public Health Nursing
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    • v.19 no.1
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    • pp.41-52
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    • 2005
  • This study was designed to provide a base for nursing intervention to help apheresis blood-donors to perform health promotion behavior effectively by surveying their health promotion behavior and by analyzing the critical factors. The study subjects were 468 participants in platelet donation at a university hospital apheresis unit in Seoul. The data for this study were collected between May and June. 2002. by questionnaire. Data were analyzed by t-test, ANOVA. Scheffe test, Pearson correlation coefficient. and stepwise multiple regression. The results were as follows. 1. The degree of performance of health promotion behavior of the subjects was a total average score of $152.9\pm21.5$ points and a mean score of 2.7 points. The highest score was 'I have a good relationship with others' in the factor of self-actualization and interpersonal support. The lowest score was 'I have my blood pressure checked regularly' in the factor of health responsibility. 2. Considering the classification according to the subjects' general characteristics. the health promotion behavior score was significantly higher for soldiers than high school students, for religious believers than atheists. and for high class economic status than mid and low class economic status. Also the health promotion behavior score was higher for those who had made more than five blood donations than those who had made zero or one donation. and for those who had made more than four blood donations than for those who had made less than four blood donations in the previous times of apheresis blood donation. The score was also higher for those not having a relationship with recipient than those having a relationship. 3. The self-efficacy related to donation. general self-efficacy and self-esteem had a significant correlation with the performance in health promotion behavior. 4. The critical factors that influenced the health promotion behavior were explained by $35.6\%$ of the general self-efficacy and by $40.2\%$ of the total of self-efficacy related to donation, and previous times of apheresis blood donation. The health promotion behavior score of apheresis blood-donors differed according to job, religion, economic status, previous times of whole blood donation, previous times of apheresis blood donation, and relationship with recipient. The health promotion behavior and self-efficacy related to donation, general self-efficacy, and self-esteem showed significant positive correlation with one another. The general self-efficacy, self-efficacy related to donation, and previous times of apheresis blood donation appeared to be the significant predictive factors of health promotion behavior. Therefore, from these study results, it is necessary to establish more effective and organized nursing intervention strategies for the health promotion behavior of apheresis blood-donors.

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