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Development of a Basic Standard Tool for Pattern Identification of Benign Prostatic Hyperplasia (BPH) (전립선비대증 변증도구 개발 기초 연구)

  • Jeong, Ho-young;Lee, Ji-yoon;Park, Yang-chun;Jung, In-chul;Cho, Chung-sik
    • The Journal of Internal Korean Medicine
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    • v.38 no.3
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    • pp.301-318
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    • 2017
  • Objective: The purpose of this study was to develop a standard tool of pattern identification, which will be applied to clinical research, for benign prostatic hyperplasia. Method: The items and structure of the instrument were based on a review of the published literature in China and Korea. The advisory committee on this study included 11 kidney-endocrine professors of the Korean Medical Colleges Division and 4 Korean medicine doctors who had a doctor's degree in the Kidney-Endocrine Division. The advisory committee was questioned regarding pattern identification importance, symptom weight, treatment importance, changes in the symptoms, rare changes in the symptoms, and frequency of prescriptions regarding benign prostatic hyperplasia. Results: The Korean instrument of pattern identification was completed; it was composed of four questions for benign prostatic hyperplasia. Conclusion: We sincerely look forward to improving the instrument through the continuous clinical studies.

Concurrent Thyroid Carcinoma and Benign Thyroid Disease (양성 갑상선질환과 함께 나타나는 갑상선암)

  • Chung So-Hwan;Yoon Jung-Han;JaeGal Young-Jong
    • Korean Journal of Head & Neck Oncology
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    • v.14 no.1
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    • pp.88-93
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    • 1998
  • In order to review the clinicopathologic characteristics of the thyroid cancer associated with benign thyroid disease, we evaluated 47 patients treated between January, 1993 and September, 1997 at the Chonnam National University Hospital. In those period, we had operated a total of 690 thyroidectomy of which 320 were diagnosed as thyroid cancer. Forty three(91.4%)occurred in women and four(8.5%)occurred in men. The mean age at operation was 46.7years(range, 15 to 76 years). Forty three of the 47 cancers(91.4%) were papillary carcinomas while 4(8.5%)were follicular. Twenty four of the 47 patients (51%) were occult thyroid carcinomas measured less than 1 cm in diameter. The concurrent benign disease were nodular goiter(n=17), Hashimoto's thyroiditis(n=16), follicular adenoma(n=10), Graves' disease(n=2) and diffuse hyperplasia(n=2). Thirty one patients were diagnosed by preoperative FNAC and they underwent total thyroidectomy. Three were diagnosed by frozen section examination at the time of operation. Among them, one underwent total thyroidectomy and two underwent subtotal thyroidectomy. Eight cases revealed lymph node metastases and 2 cases extended to surrounding muscles. In conclusion, concurrent thyroid cancers and benign thyroid disease are not uncommon and a regular ultrasonic follow-up with selective aspiration cytologic examination is recommaned to enhance their diagnostic accuracy.

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Clinicopathological Evaluation of Odontogenic Tumours in Pakistan - A Seven Years Retrospective Study

  • Naz, Iram;Mahmood, Muhammad Khurram;Akhtar, Farhan;Nagi, Abdul Hannan
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.7
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    • pp.3327-3330
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    • 2014
  • Background: The purpose of the study was to analyse the clinicopathological spectrum of benign and malignant odontogenic tumours (OT) in Pakistan. Materials and Methods: This retrospective study was carried out at the Armed Forces Institute of Pathology (AFIP) Rawalpindi. Seven years archival records of histologically diagnosed odontogenic tumours, both benign and malignant, were collected and the lesions re-diagnosed histologically in accordance with the WHO classification of head and neck tumours (2005). Clinical as well as histological data were analysed and frequency of each type of OT was calculated using computer software programme SPSS (version 17). Mean tumour size was calculated and Chi-square test was applied to find associations of age, gender and site with each histological type of tumour. Results: Only 1.7% of the odontogenic tumours diagnosed in this said period were malignant while the remaining 98.3% were benign. Amongst benign lesions, ameloblastoma was the most common (61.3%) type while primary intraosseous squamous cell carcinoma (1.7%) was the only reported malignant tumour. Mean age of the affected patients was $31.7{\pm}16.7$ years with posterior mandible as the commonest site involved. Conclusions: Our study revealed ameloblastoma and primary intraosseous squamous cell carcinoma as the commonest diagnosed benign and malignant tumours respectively. There was a significant difference in age and site of origin of different types of OT at the time of their presentation. However, all the tumours showed male predominance.

Levels of Serum 25-Hydroxy-Vitamin D in Benign and Malignant Breast Masses

  • Alipour, Sadaf;Hadji, Maryam;Hosseini, Ladan;Omranipour, Ramesh;Saberi, Azin;Seifollahi, Akram;Bayani, Leila;Shirzad, Nooshin
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.1
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    • pp.129-132
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    • 2014
  • Background: The true association between breast cancer and vitamin D is currently under investigation. We compared serum 25-hydroxy-vitamin D levels in women with benign and malignant breast masses and controls. Materials and Methods: Levels of vitamin D were measured by electrochemiluminescense. Serum levels >35 ng/ml, 25-35 ng/ml, 12.5-25 ng/ml and <12.5 ng/ml were considered as normal, mild, moderate and severe vitamin D deficiency, respectively. Results: Overall, 364 women were included in the control, 172 in the benign and 136 in the malignant groups. The median serum vitamin D level was significantly lower in breast cancers than controls. Levels were also lower in malignant than benign cases and in benign cases than controls although statistically non-significant. Conclusions: Multinomial logistic regression analysis showed that severe vitamin D deficiency causes a three-fold increase in the risk of breast cancer while this was not the case for moderate and mild deficiency.

Improved Diagnostic Accuracy in Characterization of Adnexal Masses by Detection of Choline Peak Using 1H MR Spectroscopy in Comparison to Internal Reference at 3 Tesla

  • Malek, Mahrooz;Pourashraf, Maryam;Gilani, Mitra Modares;Gity, Masoumeh
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.12
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    • pp.5085-5088
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    • 2015
  • Background: The aim of this study was to assess the role of the presence of a choline peak in 3 Tesla 1H magnetic resonance spectroscopy (MRS) for differentiating benign from malignant adnexal masses. Materials and Methods: A total of 46 adnexal masses (23 malignant and 23 benign) underwent 1H MRS study prior to surgery to assess the presence of choline peak. Results: A choline peak was detected in 16 malignant masses (69.5%) and was absent in the other 7 (30.5%). A choline peak was only detected in 6 (26%) of the benign adnexal masses. The presence of an MRS choline peak had a sensitivity of 69.5%, a specificity of 74%, a positive predictive value (PPV) of 72.7%, and a negative predictive value (NPV) of 71% for diagnosing malignant adnexal masses. A significant difference between the frequency of mean choline peaks in benign and malignant adnexal masses was observed (P value < 0.01). Conclusions: A 1H MRS choline peak is seen in malignant adnexal masses more frequently than the benign masses, and may be helpful for diagnosing malignant adnexal masses.

Knowledge of Human Papillomavirus and its Association with Head and Neck Benign and Malignant Lesions in a Group of Dental Patients in Pakistan

  • Gichki, Abdul Samad;Buajeeb, Waranun;Doungudomdacha, Sombhun;Khovidhunkit, Siribang-On Pibooniyom
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.4
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    • pp.1581-1585
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    • 2015
  • Human papillomaviruses (HPVs) remain a serious world health problem due to their association with cervical and head and neck cancers. While over 100 HPV types have been identified, only a few subtypes are associated with malignancies. HPV 16 and 18 are the most prevalent oncogenic types in head and neck cancers. Although it has been proven that some subsets of benign and malignant head and neck lesions are associated with HPV, the general population have very little awareness and knowledge of their association with HPV. Therefore, the purpose of this study was to determine the knowledge of HPV and its links with head and neck benign and malignant lesions in a group of Pakistani dental patients who attended the Dental Department of the Sandeman provincial hospital in Quetta, Pakistan. One hundred and ninety-two patients were recruited and requested to answer a questionnaire. It was revealed that there was a low level of knowledge about HPV and its association with head and neck benign and malignant lesions among the participants. This result suggested that more education regarding the relationship of HPV in inducing head and neck benign and malignant lesions is required in this group of patients.

Case of Combined Eastern-Western Medicine Treatment on a Patient Diagnosed with Benign Paroxysmal Positional Vertigo after Acute Vestibular Neuritis (양성 돌발성 체위 현훈으로 이행된 급성 전정신경염 환자의 한양방 협진 치료 1례)

  • Park, Young-hwa;Lim, Bo-ra;Ok, Hyo-joon;Sun, Jong-joo;Park, Joon-ha
    • The Journal of Internal Korean Medicine
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    • v.37 no.2
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    • pp.273-282
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    • 2016
  • Objective: This clinical study was performed with a female patient to evaluate the effects of combined Eastern-Western medicine treatment on benign paroxysmal positional vertigo after acute vestibular neuritis.Method: We used acupuncture, herbal medication, Western medication, fluid therapy, and the canalith repositioning maneuver to treat a female patient suffering from dizzy spells. The vertigo scale was checked to assess any improvement in symptoms.Results: The patient had originally recovered from acute vestibular neuritis, but after the first discharge, she came down with benign paroxysmal positional vertigo and had to be rehospitalized. She eventually got better, however, and her score on the vertigo scale improved.Conclusion: This study demonstrates that combined Eastern-Western medicine treatment may be an effective option for treating benign paroxysmal positional vertigo after acute vestibular neuritis, despite the difficulty of the treatment in this case.

Two Cases of Benign Monomelic Amyotrophy of the Lower Extremities (하지에 생긴 양성 일지성 근위축 2예)

  • Lee, Dong Kuck
    • Annals of Clinical Neurophysiology
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    • v.2 no.2
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    • pp.125-129
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    • 2000
  • Benign monomelic amyotrophy(BMA) is an uncommon cause of progressive mildly disabling atrophy and weakness of a limb. It predominantly affects the distal upper limb of young men. I present two men with BMA of the lower extremities. Although the disorder seemed clinically confined to a arm or leg, I confirmed by electromyography evidence of denervation in the other extremities. I reviewed the literatures and discuss the differential diagnosis. BMA is a diagnosis of exclusion that requires consideration in men with unilateral arm or leg atrophy and weakness.

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Primary Benign Rib Tumors: 3 cases (늑골에 발생한 원발성 양성 종양[3 치험예])

  • Lee, Nam-Soo;Baek, In-Gi;Sohn, Kwang-Hyun
    • The Korean Journal of Thoracic and Cardiovascular Surgery
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    • v.14 no.4
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    • pp.359-363
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    • 1981
  • From Aug. 1975 to Aug. 1981,3 patients with primary benign rib tumors have been treated at the department of thoracic surgery, Paik Hospital, Seoul, Korea. Of these, one was aneurysmal bone cyst and two were fibrous dysplasia. Complete excision of the benign tumor including rib resection was performed in all patients and resulted in long term cure.

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Surgical treatment of benign tumors of the lung (폐양성종양의 수술요법에 대한 연구)

  • 김주현
    • The Korean Journal of Thoracic and Cardiovascular Surgery
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    • v.17 no.3
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    • pp.475-483
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    • 1984
  • Here presented six cases of benign tumors of the lung treated surgically between Dec. 1957 and Dec. 1983 in the Department of Thoracic Surgery, Seoul National University Hospital. They include four cases of hamartoma, one case of benign mesothelioma, and one case of Castlemans disease. The operative procedures are three cases of lobectomy, one case of segmentectomy, and two cases of mass excision. The operative results are excellent without complication.

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