• Title, Summary, Keyword: arthritis

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The Effect of Chungpyesagantang on Lipopolysaccharide induced Arthritis in Mice (청폐사간탕(淸肺瀉肝湯)이 생쥐의 Lipopolysaccharide 유발 관절염(關節炎)에 미치는 영향(影響))

  • Park, Seong-Sik;Kim, Ju-Hee
    • Journal of Sasang Constitutional Medicine
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    • v.14 no.3
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    • pp.114-131
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    • 2002
  • 1. PURPOSE : The purpose of this study is to investigate the effect of Chungpyesagantang on LPS induced Arthritis in Mice. 2. METHOD : All the BALB/C Mice used in this study were 4wks of age at the start of the experiment. The experimental model of Arthritis was induced by injectection of $300{\mu}g/kg$ LPS in mice knee joint. The experiment was compare daily CS treatment group after Arthritis elicitation with Arthritis elicitated group at day 4, 7, 14 after Arthritis elicitation. 3. RESULTS 1) The hyperplasia of synoviocytes of CS treatment group after Arthritis elicitation is soften than Arthritis elicitated group. 2) The aggregation of collagen fibers CS treatment group after Arthritis elicitation is decreased than Arthritis elicitated group. 3) The distribution of TUNEL positive cells(apoptotic cell) of CS treatment group was remarkably increased than Arthritis elicitated group. 4) The distribution of $TNF-{\alpha}$, $NF-{\kappa}B\;p50$, COX-2 positive cells of CS treatment group after Arthritis elicitation in synovial membrane was decreased than Arthritis elicitated group. 5) The distribution of $IL-2R-{\alpha}$, ICAM-1 positive cells of CS treatment group after Arthritis elicitation in apical surface of synovial membrane was decreased than Arthritis elicitated group. 6) The distribution of $NF-{\kappa}B\;p50$, $IL-2R-{\alpha}$ in common iliac lymph node of CS treatment group after Arthritis elicitation positive cells was decreased than Arthritis elicitated group. 4. CONCLUSION : As a result of these experimental results, it may be concluded that Chungpyesagantang used for treatment of LPS induced Arthritis in Mice. Inflamation activity in CS treatment group after Arthritis elicitation was decreased than Arthritis elicitated group.

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The Effects of Far-Infrared on Rheumatoid Arthritis Induced Rats (원적외선 전신조사가 류마티스 관절염 유발 흰쥐에 미치는 영향)

  • Kim Gye Yeop;Cho Kyoung Oh;Kim Myung Hee;Cheong Hyun Woo
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.18 no.5
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    • pp.1301-1308
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    • 2004
  • The purpose of this study was to observe the effects of far-infrared on rheumatoid arthritis induced rats by type ⅡI collagen with the change of arthritis index, hind paw volume, TNF-α and histopathologic findings. Thirty-six Sprauge-Dawley rats which were divided into four group. Group Ⅰ : Normal group, Group Ⅱ : Collagen-Induced Arthritis group, Group Ⅲ : Far-Infrared 25㎝ radiation group, Group Ⅳ : Far-Infrared 35㎝ radiation group. The results of this study were as follows: In arthritis index, far-infrared radiation group(Ⅲ, Ⅳ) are more decreased than collagen-induced arthritis group(Ⅱ). Group Ⅲ and Ⅳ showed the most significant effect at 14 day(p<0.05). In hind paw, far-infrared 25㎝ radiation group(Ⅲ) significantly decreased more than only collagen-induced arthritis group on day 14(p<0.05). Far-infrared 35㎝ radiation group(Ⅳ) significantly decreased more than collagen-induced arthritis group on day 3, 7 and 14(p<0.05). In the ELISA study of TNF-α concentration, collagen-induced arthritis group significantly increased in the concentration more than normal group. Far-infrared radiation group(Ⅲ, Ⅳ) decreased in TNF-α concentration more than collagen-induced arthritis group(Ⅱ) on day 14. In histopathologic findings, collagen-induced arthritis(Ⅱ) and far-infrared 25㎝ radiation group(Ⅲ) increased in synovial membrane thickness on 3 day. Far-infrared 35 em radiation group(Ⅳ) decreased in the concentration more than collagen-induced arthritis group on day 14. The above results suggest that far-infrared radiation effectively reduced in rheumatoid arthritis. It would be considered that far-infrared has an effects on relieving rheumatoid arthritis.

Risk Factors of Arthritis in Middle-aged Women in Korea (중년여성의 관절염 발생 영향요인 분석)

  • Yang, Kyung-Mi;Lee, Jong-Eun;Jung, Hye-Sun;Kim, Sook-In;Lee, So-Young;Lee, Yoon-Jung;Kim, Soon-Lae
    • Journal of Korean Academy of Community Health Nursing
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    • v.17 no.4
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    • pp.512-520
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    • 2006
  • Purpose: To investigate the risk factors of arthritis, this study was carried out with 1,829 Korean women aged between 40-64 who responded to a health behavior survey. Methods: Data were extracted from the results of the 2001 National Survey on Health and Nutrition conducted by the Ministry of Health and Welfare. Results: 1 Financial difficulty and continuous anxiety about health were directly associated with arthritis. The odd ratios of these two factors of arthritis were 1.43 and 1.82 respectively. 2. With regard to the presence or absence of arthritis according to demographic characteristic, the incidence of arthritis was higher in the age between 50-64, in the group whose education level was middle school or lower, and in those who experienced the death of spouse, divorce or separation. Nevertheless, it was not significantly different according to financial status and employment status. 3. Concerning the presence or absence of arthritis according to psychological characteristic, the incidence of arthritis was found to be higher in those who were not healthy by subjective health assessment, in those who were always anxious about their health, in those who were always depressed and sad, and in those who felt heavy stress. 4. With regard to the presence or absence of arthritis according to the health behavior, the incidence of arthritis was higher in postmenopausal cases and cases who were having hormone therapy, and the incidence of arthritis was higher in those who did not drink alcohol, those with BMI higher than 25, and those who slept shorter than 7 hours a day. Conclusion: Based on the above results, it is required to provide a means applicable to communities by developing preventive education that can prevent the incidence of arthritis in middle-aged women as well as intervention programs.

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The effect of medicinal herb administration to arthritis induced rabbit arthritistreatment (생약복합제제가 토끼의 퇴행성관절염 개선에 미치는 영향)

  • Kwon, Tae Dong;Kim, Ki Hoon
    • Journal of Nutrition and Health
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    • v.45 no.5
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    • pp.437-442
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    • 2012
  • The purpose of this study was is to investigate the arthritis treatment and prevention of the effects the herbral administration to experimental animals induces arthritis 4 weeks for medicinal herbs (Scutellaria baicalensis Georgi, Acanthopanacis cortex, Achyranthis Radix). To investigate the prevention of histopathological examination and molecular biological examinations for arthritis improvement in vivo New Zealand, white rabbits were divided into a normal (Normal, n = 7), or a collagen-induced arthritis (CIA, n = 7), or a collagenase injection and medicinal herbs (SAA, n = 7). It was confirmed that induced arthritis was treated with Gross examination, and the measurement of average arthritis index (MAI) and improved arthritis by medicinal herbs. TNF-${\alpha}$ and IL-$1{\beta}$ were significantly increased in the CIA and SAA groups, compared to the normal group (p < 0.05). MMP-1 and TIMP-2 were significantly increased in the CIA, compared to the other groups (p < 0.05). MMP-1 and TIMP-2 were significantly decreased in the SAA group, compared to the CIA group (p < 0.05). As a result, Herbal administration used in this study might be able to help in the treatment of arthritis induced by inflammatory and immunosuppressive effects, that which can be expected.

Effect of Arthritis and Comorbid Chronic Conditions on Health-related Quality of Life in Korean Elderly (우리나라 노인에서 관절염과 동반 만성질환에 의한 건강관련 삶의 질 감소 효과)

  • No, Ji-Young;Kim, Soon-Young;Kweon, In-Sun;Nam, Hae-Sung
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.15 no.6
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    • pp.3751-3758
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    • 2014
  • This study was designed to evaluate the effects of arthritis and comorbid chronic conditions on the health-related quality of life (HRQoL) in the Korean older population. The study subjects were 2,708 Korean adults aged 65 and older from the $3^{rd}$ Korea National Health and Nutrition Examination Surveys data: 1,357 persons with a single chronic condition, such as arthritis, herniations of the intervertebral disc, osteoporosis, asthma, peptic ulcers, stroke, or cataract; 886 persons with arthritis and a second chronic condition described above; and 465 persons with no chronic condition. An analysis of covariance was performed to compare the EQ-5D index among the groups. The effects of arthritis, second chronic condition and their interactions were analyzed by multiple linear regression analysis. The results are as follows. Compared to men with arthritis only, men with stroke only, stroke and arthritis, or cataract and arthritis had a lower age adjusted EQ-5D index. Women with a stroke only, asthma only, cataract only, osteoporosis and arthritis, peptic ulcer and arthritis, stroke and arthritis, or cataract and arthritis had a lower age adjusted EQ-5D index than women with arthritis only. Arthritis and comorbid conditions had additive effects on the HRQol in both genders except for arthritis and stroke in women. In conclusion, comorbid chronic medical conditions in older people with arthritis may reduce the HRQoL in an additive manner.

A Comparative Study on Symptoms, Living Activities, Self-efficacy and Family Support between Rheumatoid Arthritis Patients and Fibromyalgia Patients (류마티스관절염과 섬유조직염환자의 증상, 일상생활, 자기효능 및 가족지지 비교 연구)

  • Kang, Hyun-Sook;Han, Sang-Sook
    • Journal of muscle and joint health
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    • v.7 no.1
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    • pp.25-39
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    • 2000
  • This study was conducted to compare symptoms, living activities, self-efficacy and family support between rheumatoid arthritis patients and fibromyalgia patients. The subjects were consisted of 150 rheumatoid arthritis patients and 125 fibromyalgia patients at H Rheumatism Clinic. Data were collected by means of structured interview with questionnaires. The results were as follows: 1. Fibromyalgia patients have more symptoms than rheumatoid arthritis patients have. But the latter has more difficulties concerning living activities. 2. Self-efficacy score of fibromyalgia arthritis patients was higher than that of rheumatoid arthritis patients, but both the scores were at moderate level. 3. The level of family support of rheumatoid arthritis patients was moderate, similar as that of fibromyalgia patients. As self-efficacy and family support are important factors to relieve symptoms of both diseases, their promotion holds a key post.

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Development of a New Herbal Anti-arthritis Drug, \textrm{Joins}^{TM}$ (SKI 306X)

  • Cho, Yong-Baik
    • Proceedings of the Korean Society of Applied Pharmacology
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    • pp.7-13
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    • 2001
  • Arthritis may be broadly classified as degenerative - related to defects in cartilage and other joint constituents, often age-associated - or inflammatory disease. Inflammatory arthritis called as rheumatoid arthritis (RA) is a chronic inflammatory arthropathy and characterized by a destructive arthritis. RA encompasses infectious arthritis, arthritis caused by intra-articular deposits of crystalline material (gout), syndromes associated with genetic defects (familial Mediterranean fever), and the immune-mediated inflammatory arthropathy. Degenerative arthritis called as osteoarthritis (OA), which is most frequently occurring, causes degenerative figures of knee, waist and knuckle, and accompanies severe pain around the cartilage. Also, it may cause morning stiffness, gelling effect, tenderness, bone swelling, crepitus, and motion disorders.

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Health-related quality of life among home-dwelling people with arthritis in Korea: Comparative study of osteoarthritis and rheumatoid arthritis

  • Joung, Kyoung-Hwa;Chung, Sung-Suk
    • Journal of the Korean Data and Information Science Society
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    • v.22 no.3
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    • pp.555-563
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    • 2011
  • Osteoarthritis (OA) and rheumatoid arthritis (RA) are most popular types of arthritis in Korea. This study compared health-related quality of life (HRQoL) of homedwelling people with OA and RA in Korea. Data were drawn from the Korean nationwide representative survey. Subjects were 3,352 people with arthritis over 19 years of age (2,953 OA respondents and 399 RA respondents). Good HRQoL in OA respondents was dierentiated with limitation of mobility, perceived health status, age, economic status, presence of arthralgia, gender, medical coverage, and educational level. Good HRQoL in RA respondents was dierentiated with limitation of mobility, perceived health status, economic status, educational status, and presence of arthralgia. In conclusion, HRQoL and predictors of good HRQoL among people with arthritis diers for OA or RA. These results can be of use in development of health programs and clinical interventions for community-dwelling people with arthritis.

The Study of Pain, Depression and Quality of Life According to the Coping Strategy in Chronic Arthritis Patients (만성 관절염 환자의 대응양상에 따른 통증, 우울 및 삶의 질)

  • Yang, Hae-Ju;Park, Jeong-Sook
    • Korean Journal of Adult Nursing
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    • v.14 no.2
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    • pp.213-221
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    • 2002
  • Purpose: The aim of this study was to investigate the difference of in the level of pain, depression, and quality of life by coping strategy in the chronic arthritis patients. Method: These data were collected by means of a self-reported questionnaire from 90 chronic arthritis patients undergoing treatment at a university hospital in Daegu city from June 10, 2000 to July 15, 2000. The instruments of study were coping strategy scale by Jeon(1985), pain scale by Lee and Song(1987), depression scale by Radloff(1977) and quality of life scale by Cho(1987). Data analysis was done by SPSS Win 10.0 program and Pearson correlation, t-test, Cronbach's-${\alpha}$ were used. Result: The results of this study were as follows: 1. The item mean score of pain for chronic arthritis patient was 6.54. The item mean score of depression for chronic arthritis patient was 2.18. The item mean score of quality of life for chronic arthritis patient was 5.69. 2. The chronic arthritis patients with problem-focused coping experienced pain higher than those with emotion-focused coping(t=o.400, p=o.o45). The chronic arthritis patients with emotion-focused coping experienced depression higher than those with problem-focused coping(t=-2.564, p=0.012). The chronic arthritis patients with problem-focused coping experienced quality of life higher than emotion-focused coping(t=-1.682, p=0.046). Conclusion: In conclusion this study showed that any coping strategy can control the arthritis patient's problem. Therfore, The development of a coping strategy to reduce pain and depression and improve the quality of life in the chronic arthritis patient will be needed.

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Arthritis Patients' Knowledge Level and It's Related Factors (관절염 환자의 관절염 관련 지식수준과 관련요인)

  • 정승기;남철현;김상수;전봉천;김기열;하은필;문기내
    • Korean Journal of Health Education and Promotion
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    • v.19 no.1
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    • pp.31-44
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    • 2002
  • This study was conducted to examine arthritis patients' knowledge level and its related factors. Data were collected from 100 people who suffered from arthritis in Seoul, Busan, Daegu, Daejun, Junjoo, and Pohang from June 1, 2000 to August 31, 2000. The results of this study are summarized as follows. 1. 61.0% of the subjects was female. The incidence rate of arthritis was higher in the higher age group, lower educated group, and thinner group. In the case of male, the incidence rate was higher in the groups of single, residents in big cities, and technicians. In the case of female, it was higher in the groups of the married, residents in towns or villages, and housewives. 2. Among the sources of obtaining the knowledge related to arthritis, 38.0% of the respondents obtained the knowledge from physicians and 24.1 % got it from TV or Radio. 14.6% of them obtained it from family members, neighbors, and friends and 14.3% got it from newspapers, magazines, and pamphlets. Only 5.8% of them obtained the knowledge from pharmacists. The sources showed significant difference in the variables of age, occupation, marital status, religion, place of residence, and education level. 3. 47.2% of them thought that education related to arthritis was needed without fail, while 12.5% thought that it was not necessary. In the question related to concern about arthritis, ‘no concern’ was 31.2%, while ‘concern’ was 7.8% and ‘a little concern’ was 45.1 %. 4. The knowledge level of arthritis was 7.35 ± 1.51 points on the basis of 11 points. It showed significant difference in the variables of age, occupation, education level, and economic status. 5. The knowledge was influenced by the variables of economic status, necessity of publicity, treatment period, occupation, education level, and age. The arthritis patients did not have enough knowledge of arthritis because the education was not provided well for them. Therefore, related professionals and organizations must develop education program of arthritis in order to educate them.