• Title, Summary, Keyword: antitumor

Search Result 1,480, Processing Time 0.056 seconds

Synthesis of Steroidal Nitrosoureas as Antitumor Activity

  • Kim, Jack-C.;Choi, Soon-Kyu;Moon, Sung-Hwan
    • Archives of Pharmacal Research
    • /
    • v.9 no.4
    • /
    • pp.215-217
    • /
    • 1986
  • Steroidal nitrosoureas have been synthesized and their antitumor activity on L 1210 cells was evaluated, N-(2-Chloroethyl)-N-nitrosocarbamoyl-3-aza-A-homo-5$\alpha$-cholestane (5a) showed significantly low $ED_{50}$ value of 1.6 $\nu$g/ml whose activity is equivalent to that of methyl-CCNU ($ED_{50}$ = 1.7 mg/ml).

  • PDF

Synthesis and Structure of Purine Derivatives as Antitumor Effects

  • Moharram, H.H.;El-Bayouki, Khairy A.M.;Haggag, B.;Basyouni, W.M.;Osman, A.M.
    • Archives of Pharmacal Research
    • /
    • v.12 no.2
    • /
    • pp.138-142
    • /
    • 1989
  • The nucleophilic substitution reaction of 6-chloro purines (I) with malononitrile and ethyl cyanoacetate is carried out in DMSO and in the presence of an alkali. The possible tautomeric-ylidene form for the products is considered and discussed in view of IR, UV, NMR and mass spectral determinations. The derivatives were tested for their antitumor activities.

  • PDF

Novel Benzoylurea Derivatives as Potential Antitumor Agents; Synthesis, Activities and Structure-Activity Relationships

  • Hwang, Ki-Jun;Park, Kyung-Ho;Lee, Chong-Ock;Kim, Beom-Tae
    • Archives of Pharmacal Research
    • /
    • v.25 no.6
    • /
    • pp.781-785
    • /
    • 2002
  • A series of pyrazoloxyphenyl benzoyl urea derivatives was designed and synthesized for cytotoxic evaluation as potential antitumor agents. The synthetic compounds were evaluated for in vitro cytotoxicity against five human tumor cell lines, including A-549, SKOV-3, SK-MEL-2, XF-498 and HCT-15. Among others, compound 11 exhibited 50∼100 times greater antitumor activities than the commercial product, Cisplatin.

Studies on Antitumor and Immunopotentiation Activities of Polysaccharides from Trichosanthes Rhizome

  • Chung, Yeoun-Bong;Lee, Chong-Chull;Park, Soo-Wan;Lee, Chung-Kyu
    • Archives of Pharmacal Research
    • /
    • v.13 no.3
    • /
    • pp.285-288
    • /
    • 1990
  • The polysaccharide fraction from the rhizome of Trichosanthes kirilowii (Cu-curbitaceae) showed marked antitumor and cytotoxic activity with immunopotentiating activity. It was evidenced by the increase in the number of circulating leucocytes and peritoneal exudate cells and the recovery of lowered antibody forming activity in mice. The polysaccharide was mainly composed of glucose, galactose, fructose, manmose and xylose and a small amount of protein.

  • PDF

Synthesis and Antitumor Activity of Cannabigerol

  • Baek, Seung-Hwa;Han, Du-Seok;Yook, Chan-Nam;Kim, Young-Chae;Kwak, Jung-Suk
    • Archives of Pharmacal Research
    • /
    • v.19 no.3
    • /
    • pp.228-230
    • /
    • 1996
  • Cannabigerol(3) was synthesized and evaluated for its inhibitory activity against mouse skin melanoma cells. Cannabigerol displayed significant antitumor activity [inhibitory concentration $(IC_{50})=31.31\mug/mL]$ in vitro assay.

  • PDF

Practices of Antitumor Screening Tests for Natural Products (천연항종양성자원 とスクリニングの 실제)

  • 코이치
    • Korean Journal of Plant Resources
    • /
    • v.5 no.2
    • /
    • pp.95-103
    • /
    • 1992
  • Present anticancer drugs in the clinical side have not showed a conclusive effect of the chemotherapy for cancer patients. In order to find much more efficient antitumor agents fromnatural resources, various screening methods vivo and in vitro have been developed by manyresearchers. The intention of this paper is to provide an outline of some background on the tumorsystem in drug development of natural products, to review some screening programs for theevaluation of antitumor activity and to introduce the practical procedures of some antitumorscreening methods in vivo and in vitro. At the end of this paper, the current literatures related toantitumor natural products from higher plants at our laboratory are described.Key words'anticancer drugs, screening methods.

  • PDF

Antitumor Activity of some Phenolic Components in Plants

  • Ryu, Shi-Yong;Choi, Sang-Un;Lee, Chong-Ock;Lee, Seung-Ho;Ahn, Jong-Woong;Zee, Ok-Pyo
    • Archives of Pharmacal Research
    • /
    • v.17 no.1
    • /
    • pp.42-44
    • /
    • 1994
  • The activity-guided fractionation of some medicinal plants led to yield five kinds of natural stilbene compounds namely 3, 5-dihydroxy-4'-methoxystillbene(I), rhapontigenin(II), reveratrol(III), rhaponticin(IV) and piceid(V) and two common flavonoids, apigenin(VI) and luteolin(VII) as active principles of the antitumor property, in vitro, against five kinds of human tumor cell lines, A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT15.

  • PDF

Synthesis of Mannich Bases of Antineoplaston A10 and their Antitumor Activity

  • Choi, Bo-Gil;Seo, Hee-Kyoung;Chung, Byung-Ho;Choi, Sang-Un;Lee, Chong-Ock
    • Archives of Pharmacal Research
    • /
    • v.17 no.6
    • /
    • pp.467-469
    • /
    • 1994
  • Some Mannich bases of Antineoplaston A10 which is antitumor agent under chlinical investigation were synthesized and tested fro cytotoxicity. The tested compounds (2a, 2b, 2d) showed good activity comparable to that of carboplatin.

  • PDF

Studies on Immunopotentiating Activities of Antitumor Polysaccharide from Aerial Parts of Taraxacum platycarpum

  • Jeong, Jong-Yup;Chung, Yeoun-Bong;Lee, Chong-Chull;Park, Soo-Wan;Lee, Chung-Kyu
    • Archives of Pharmacal Research
    • /
    • v.14 no.1
    • /
    • pp.68-72
    • /
    • 1991
  • The polysaccharide fraction from Taraxii Herba showed potent immunopotentiating activities with antitumor activities. The fraction having small amount of protein inhibited the growth of solid tumor and increased peritoneal exudate cells and immunoorgan weights in normal mice, and also increased hypersensitivities in tumor bearing mice.

  • PDF

Antitumor Activity of the Extract of Unripe Cotton Ball (목화의 미성숙다래 추출물의 항종양활성)

  • 박정일;김왕유;이용희;문경식;김준겸;김원기;이승기
    • YAKHAK HOEJI
    • /
    • v.43 no.1
    • /
    • pp.23-27
    • /
    • 1999
  • We previously reported that the extract of unripe cotton ball of Gossypium indicum shows cytotoxic activity and induces an apoptosis in vitro. In present study, its antitumor activity was investigated in vivo. Butanol soluble extract of unripe cotton ball reduced the weight of solid tumor in sarcoma 180 transplanted mouse model. It showed stronger activity than that of Krestin.

  • PDF