• Title, Summary, Keyword: analgesic effects

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The Effects of Licorice Fraction and Glycyrrhizin on Prostaglandin Synthetase Activity of Bull Seminal Vesicle (감초의 분획과 Glycyrrhizin이 황소정랑의 Prostaglandin Synthetase활성에 미치는 효과)

  • Joe, Young-Sun;Kim, Nak-Doo;Ko, Kwang-Ho
    • Korean Journal of Pharmacognosy
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    • v.17 no.2
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    • pp.107-112
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    • 1986
  • The investigation aimed to study the effects of methanol fraction of licorice (FM 100) and glycyrrhizin on prostaglandin synthetase activity, in relation to their analgesic effects. Effects of FM 100 and glycyrrhizin on the activity of prostaglandin synthetase extracted from bull seminal vesicles were examined by the modified method of Takeguchi et al. The analgesic effect of FM 100 was tested in mice by the acetic acid writhing method. FM 100 was administered orally to mice. BSV prostaglandin synthetase activity was inhibited significantly by FM 100 in a dose-dependent manner, whereas the activity was slightly inhibited by glycyrrhizin. Statistically significant analgesic effects were also observed with FM 100. The results suggest that analgesic effect of licorice may be due to the inhibition of prostaglandin synthesis.

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Brain Uptake and the Analgesic Effect of Oxytocin - its Usefulness as an Analgesic Agent

  • Kang, Young-Sook;Park, Ji-Hyun
    • Archives of Pharmacal Research
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    • v.23 no.4
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    • pp.391-395
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    • 2000
  • To establish the usefulness of oxytocin (OT) as an analgesic for women in delivery, the pharmacokinetic parameters and blood-brain barrier (BBB) permeability of [$^3H$] OT were obtained using an intravenous injection technique or the internal carotid artery perfusion/capillary depletion (ICAP/CDM) method. Brain uptake of OT was similar to that of sucrose, plasma space marker, indicating that OT has a poor BBB permeability. Moreover, the analgesic effects of OT injected through the jugular vein on nociception were evaluated by the tail-flick method. The antinociceptive effects of OT injected at a dose of 0.2 ${m}g/kg$or 2 ${m}g/kg$ were dose-dependent. In addition, the analgesic effects of OT on the CNS were unaffected by naloxone, a m-receptor antagonist. In a similar manner to the opioid system, OT may play a modulatory role in antinociception.

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Analgesic Effects of Electroacupuncture, Warm Needling and Radio Frequency Warm Needling on Surgical Ankle Sprain Model in Rats (흰쥐의 발목염좌에 대한 전침, 온침 및 고주파온침 자극별 진통 효과의 비교)

  • Yang, Seung-Bum;Kim, Min-Su;Choi, Suck-Jun;Kim, Jae-Hyo
    • Korean Journal of Acupuncture
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    • v.32 no.1
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    • pp.20-29
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    • 2015
  • Objectives : The objectives of this study is to compare the effects of electroacupuncture(EA), warm needling(WN) and Radio Frequency warm needling(RFWN) stimulations on the acupoints at the artificially damaged ankles of Sprague-Dawley rats, which could be classified as the Grade 3. Methods : The foot weight bearing force ratio(FWBFR) of ankle sprain was measured first at 24 hours after without any other stimulations. Pain Recovery Index(PRI) represents the analgesic level, and modified Pain Recovery Index(mPRI) shows the accumulated recovery level. PRI was measured at 2 hours after each stimulus on GB34, GB39 and GB42, and mPRI was during 7 days. Results : EA stimulation of GB34 and GB39 acupoint in grade 3 ankle sprain showed a marked analgesic and recovery effect. RFWN of GB42 exhibited significant analgesic and pain recovery effect. RFWN of GB34 resulted in pain recovery effect but not analgesic effects, and RFWN of GB39 resulted in analgesic effect 2 hours after but not pain recovery. However, WN did not affect the pain recovery among three acupoints at all. Conclusions : In the Grade 3 ankle sprain model, the difference of analgesic effects were explained by the acupoints and the stimulation methods according to the accumulated recovery effects during 7 days. It is insufficient to determine that a certain acupoint has a specific analgesic effect depending on the stimulation method by the results of this study. Therefore, the effects of each stimulation on the acupoints in any other meridians at the sprained ankle should be compared and analyzed.

The Safety and Analgesic Effect of Datura Flos Pharmacopuncture in Sprague-Dawley Rats

  • Jun, Seungah;Lee, Yun Kyu;Lee, Bong Hyo;Kim, Jae Soo;Lee, Hyun-Jong
    • Journal of Acupuncture Research
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    • v.36 no.3
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    • pp.147-153
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    • 2019
  • Background: The aim of this study was to investigate the safety and analgesic effects of Datura Flos pharmacopuncture (DFP). Methods: The analgesic effects of DFP were assessed using mechanical (hot plate), chemical (formalin test), and thermal (von Frey filament test) pain tests. Forty male Sprague Dawley rats were assigned randomly into DFP (75 mg/kg, 150 mg/kg), lidocaine 0.5%, or normal saline group for treatment on Kl3. Gross pathology, histopathology, biochemistry and hematology were performed. Results: In the hot plate test, DFP at a high dose (HDDFP; 150 mg/kg) produced a significant analgesic effect, at 10 and 20-minutes post injection (p < 0.01). Low dose DFP (LDDFP; 75 mg/kg) also showed an analgesic effect at 10 minutes post injection (p < 0.01). In the formalin test, HDDFP produced an analgesic effect, for 0-10 and 10-20 minutes (p < 0.01) post treatment, whereas LDDFP showed analgesic effects between 10-20 minutes (p < 0.05). In the von Frey filament test, DF-H produced an analgesic effect, 10 (p < 0.01) and 20 minutes post treatment (p < 0.05). LDDFP showed analgesic effect at 10 minutes (p < 0.05). In the acupuncture response test, HDDFP produced an analgesic effect at 10 minutes post treatment (p < 0.05). DF-H did not cause any anatomical changes to the liver or kidney and there were no abnormalities in biochemistry or hematology. Conclusion: DF-H was not toxic and provided short term analgesia, suggesting it may be useful in the management of pain.

Comparison of Pharmacological Effects of Magnoliae officinalis, Magnolia and Machilus Barks (후박(厚朴)의 약효(藥效)에 관한 연구(硏究))

  • Lee, Soung-Ro;Lee, Sagn-In
    • Korean Journal of Pharmacognosy
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    • v.17 no.3
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    • pp.199-205
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    • 1986
  • It has been known that Magnolia officinalis, Magnolia and Machilus Barks are reputed to be effective in 'Hagi', 'Sanman' and to be analgesic but there was differences of efficacy of these crude drugs against the kinds and habitates. For this reason, this study was conducted to compare the acute toxicities, analgesic effects and motilities of isolated intestine. This results obtained in this work were summarized as follow: 1. In the test of acute toxicies, Machilus bark was found to be more toxic than the others. 2. Both these was found to have analgesic effect. 3. In the effects against the motility of isolated intestine, Magnolia officinalis and Magnolia barks were found to be relaxant, Machilus bark was found to be contractive. From these results, Magnolia officinalis and Magnolia barks might have analgesic effect and relaxant effect of intestine.

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Analgesic and Anticonvulsionary Effects of 'Ssanghwa-Tang' (쌍화탕(雙和湯)의 진통(鎭痛) 및 항경련효과(沆痙攣效果)에 관한 연구(硏究))

  • Han, Dae-Suk;Lee, Hyeong-Kyu;Cho, Hee-Jae
    • Korean Journal of Pharmacognosy
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    • v.14 no.2
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    • pp.60-63
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    • 1983
  • Two prescriptions of 'Ssanghwa-Tang', Korean traditional medicine, and their individual crude drugs were studied on the analgesic and the anticonvulsionary effects. Two prescriptions showed very significant analgesic effects and the prescription B was more effective. Individual crude drugs had decreasing effects on the convulsion-start-time, but two prescriptions did not show significant activities.

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Analgesic and Antipyretic Effects of Acupucture in Ruminant (반추동물에 있어서 침술의 진통 및 해열효과)

  • Nam Tchi-Chou;Kweon Oh-Kyeong;Seo Kang-Moon
    • Journal of Veterinary Clinics
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    • v.11 no.1
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    • pp.393-399
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    • 1994
  • This study was carried out to investigate the analgesic and antipyretic effects of acupuncture in goat suffered from pain and fever induced experimentally : electroacupuncture and laser acupuncture for the relief of pain and traditional needing for the of fever. Pain was induced by intraperitoneal injection of 0.7% acetic acid solution and it's extent was estimated with the number of writhing syndrom as indicator of pain. When lipopolysaccharide was given into the vein in goat, fever with biphasic type was produced. In the goats with pain the superior analgesic effects of electroacupuncture to aminopyrine and sulpyrine were found, but the effects of laser acupuncture were not satisfactory. The high body temperature of goats was gradually decreased with the lapse of time following traditional needling(venesection by needle) and showed a tendency to return to normal body temperature. Serum GOT, GPT:, BUN, creatinine values and acetylcholinesterase activity following electroacupuncture were not altered. It is considered that electroacupuncture combined with medicament can sucure exellent analgesic and antipyretic effects in animal practice.

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Analgesic Effects of Intramuscular Stimulation Therapy on Pain in the Elderly (근육내 전기자극에 의한 노인성 통증조절 효과)

  • Lee, Jeong-Weon
    • Physical Therapy Korea
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    • v.9 no.2
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    • pp.51-59
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    • 2002
  • The purpose of this study was to determine the effect of intramuscular stimulation (IMS) therapy in older persons with musculoskeletal pain. The subjects were 181 older persons (54 males, 127 females) with musculoskeletal pain. Intramuscular stimulation unit with needles (size $.3{\times}30$ mm) was applied for the treatment. The analgesic effects were measured by visual analog scale (VAS). Results showed that the post-treatment VAS score was significantly decreased after IMS therapy for fifteen minutes compared to pre-treatment score. In addition, the post-treatment VAS score was significantly decreased in patients with chronic pain (pain duration of one year after onset) compared to the post-treatment VAS score in patients with subacute pain (pain duration less than three months after onset). There was no significant difference in analgesic effects according to gender and age groups. It is determined from this study that IMS therapy can be beneficial for patients with chronic musculoskeletal pain in clinical setting. Further study is needed to identify whether the IMS therapy can change the pain threshold in patients with neurologic pain.

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Studies on the Anti-Inflammatory and Analgesic Effects of Extracts from Marine Sponges

  • Fakhr, Issa M.I.;Hamdy, Nehal A.;Radwan, Mohamed A.A.;El-Batran, Seham A.;Shabrawy, Osama A. El
    • Natural Product Sciences
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    • v.12 no.2
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    • pp.74-78
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    • 2006
  • Two specimens of sponges collected from Red Sea, Egypt, were investigated for their contents of secondary metabolites. The crude extracts of the sponges were tested for their anti-inflammatory and analgesic effects. The toxic effects of the extracts of the two marine sponges were studied. $LD_{50}$ determination revealed that the investigated extracts of 'Igernella and Ircinia spp' were 4.69 and 134.7 mg/l00 g b.wt., respectively, when injected intraperitoneally in mice. The toxic signs were recorded within the first 24 hrs after injection. Also the two marine sponges extracts showed significant anti-inflammatory and analgesic effects.

Effects of Jakyakgamchotang extract on the Analgesic effect in Mice (작약감초탕(芍藥甘草湯) 및 구성약물(構成藥物)이 진통(鎭痛)에 미치는 영향(影響))

  • Lee Ki-Ok;Kuk Yun-Beum;Yun Young-Gab
    • Herbal Formula Science
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    • v.11 no.1
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    • pp.161-170
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    • 2003
  • This study was designed to elucidate the analgesic effects of Jakyakgamchotang and Radix paeinia, Radix Glycyrrhiziae which are the component of Jakyakgamchotang in mice. The analgesic effects were measured by the Whittle's method and hot plate method. The results were as follows ; After the administration of Jakyakgamchotang extrace, the frequency of writhing syndrome was significantly inhibited. After the administration of Radix paeinia extract, the frequency of writhing syndrome was significantly inhibited. After the administration of Radix Glycyrrhiziae extract, the frequency of writhing syndrome was significantly inhibited. After the administration of Jakyakgamchotang extrace, paw licking time and escape time were significantly prolonged. After the administration of Radix paeinia extract, paw licking time was significantly prolonged. After the administration of Radix Glycyrrhiziae extract, paw licking time was significantly prolonged. It is concluded that the analgesic effects of Jakyakgamchotang were found to be more effective than Radix paeinia and Radix Glycyrrhiziae.

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