• Title, Summary, Keyword: adverse effects

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Meta-analysis of Associations between ATM Asp1853Asn and TP53 Arg72Pro Polymorphisms and Adverse Effects of Cancer Radiotherapy

  • Su, Meng;Yin, Zhi-Hua;Wu, Wei;Li, Xue-Lian;Zhou, Bao-Sen
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.24
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    • pp.10675-10681
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    • 2015
  • Background: The ataxia telangiectasia mutated (ATM) protein and p53 play key roles in sensing and repairing radiation-induced DNA double strand breaks (DSBs). Accumulating epidemiological evidence indicates that functional genetic variants in ATM and TP53 genes may have an impact on the risk of radiotherapy-induced side effects. Here we performed a meta-analysis to investigate the potential interaction between ATM Asp1853Asn and TP53 polymorphisms and risk of radiotherapy-induced adverse effects quantitatively. Materials and Methods: Relevant articles were retrieved from PubMed, ISI Web of Science and the China National Knowledge Infrastructure (CNKI) databases. Eligible studies were selected according to specific inclusion and exclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were pooled to estimate the association between ATM Asp1853Asn and TP53 Arg72Pro polymorphisms and risk of radiotherapy adverse effects. All analyses were performed using the Stata software. Results: A total of twenty articles were included in the present analysis. In the overall analysis, no significant associations between ATM Asp1853Asn and TP53 Arg72Pro polymorphisms and the risk of radiotherapy adverse effects were found. We conducted subgroup analysis stratified by type of cancer, region and time of appearance of side effects subsequently. No significant association between ATM Asp1853Asn and risk of radiotherapy adverse effects was found in any subgroup analysis. For TP53 Arg72Pro, variant C allele was associated with decreased radiotherapy adverse effects risk among Asian cancer patients in the stratified analysis by region (OR=0.71, 95%CI: 0.54-0.93, p=0.012). No significant results were found in the subgroup analysis of tumor type and time of appearance of side effects. Conclusions: The TP53 Arg72Pro C allele might be a protective factor of radiotherapy-induced adverse effects among cancer patients from Asia. Further studies that take into consideration treatment-related factors and patient lifestyle including environmental exposures are warranted.

Is ginseng free from adverse effects?

  • Xie, Jing-Tian;Mehendale, Sangeeta R.;Maleckar, Spring A.;Yuan, Chun-Su
    • Oriental Pharmacy and Experimental Medicine
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    • v.2 no.2
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    • pp.80-86
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    • 2002
  • Ginseng is a perennial herb widely used in China, Japan, and Korea. It is also one of the most commonly used herbal medicines in the U.S. Although it is generally considered safe to use, adverse effects associated with ginseng use have been reported. Inappropriate ginseng use, such as high dose administration, may cause insomnia, headaches, diarrhea, as well as cardiovascular and endocrine disorders. Other factors that may contribute to adverse effects of ginseng include the variety of ginseng species, variability in commercial ginseng preparations, and potential ginseng-drug interactions. To minimize adverse effects of ginseng, consumers should be advised to use it appropriately, and the herbal industry should try to provide standardized ginseng preparations.

Pattern Analysis of High-caffeine Energy Drink Consumption and Adverse Effects among College Students in a University (대학생들의 고카페인 에너지음료 소비실태 및 부작용 분석)

  • Lee, Jieun;Huh, Wan;Choi, Eun Joo
    • YAKHAK HOEJI
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    • v.57 no.2
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    • pp.110-118
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    • 2013
  • High-caffeine energy drink consumption has been increasing in young adults, frequently causing the most common symptoms such as tremor, insomnia, anxiety, and nervousness and rarely leading to serious adverse effects like seizure, acute mania, and stroke due to caffeine overdose. There have been little current studies regarding analysis of high-caffeine energy drink consumption and its adverse effects in Korea. This study was to examine high-caffeine consumption patterns, associated factors, and adverse effects based on responses from 231 college students in a University through survey. About 88.3% (n=204) of total respondents reported that they had energy drinks. College students mostly consumed energy drinks to keep awake (46%) when studying and to recover fatigue (27%). Approximately 44% respondents mainly reported palpitation (73.9%) and insomnia (72.8%) regarding adverse effect questionnaire. Current reports on the risk of recreational use, co-ingestion of alcohol and energy drink as well as energy drink consumption among children and adolescents are increasing, requiring further long-term research and awareness of these issues.

The Adverse Effects of Education Using Smart Devices on Students (스마트 기기 활용교육이 학생에게 미치는 역기능)

  • Han, Kyujung
    • Journal of The Korean Association of Information Education
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    • v.18 no.4
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    • pp.471-482
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    • 2014
  • It is known that the smart education has a positive impact of critical thinking skills and problem solving, communication and collaboration, creativity and innovation in the 21st century. However, some people concern about the adverse effects of smart education such as smart devices addiction and health problems. In this study, we conducted the adverse effects of education using smart devices on students. The questionnaire survey was conducted and analyzed for students in 9 schools at A city(four elementary schools, three middle schools, two high schools) that are receiving smart education. The types of adverse effects of smart education includes smartphone addiction, lack of information ethics, health problems, and lack of social and learning ability. We showed the differences each item compared among elementary school, middle school and high school about adverse effects of smart education. The result of survey didn't have any adverse affect of smart education such as internet addiction or smartphone addiction. However in order to protect the copyright, the school needs to fight against indiscriminated downloads and perform the information ethics education. Plus we surely need to be more open-minded in reading and exercise at school and home.

A Review of Combination Effects and Adverse Effects of Yerba Mate (Ilex paraguariensis) on the Treatment of Obesity (비만치료를 목적으로 마테(Yerba Mate, Ilex paraguariensis)를 함유한 복합투여물의 효과 및 부작용에 대한 고찰)

  • Ahn, Jae Hyun;Lee, Min Ho;Lee, Seung Hoon;Choi, Do Young;Lee, Jae Dong
    • Journal of Acupuncture Research
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    • v.33 no.2
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    • pp.135-150
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    • 2016
  • Objectives : The aim of this study is to review the combination effects and adverse effects of Yerba Mate (Ilex paraguariensis) on the treatment of obesity. Methods : Four databases were searched, including Pubmed, National assembly library, RISS4u, and NDSL, for studies published before March 31, 2016 using the keywords 'yerba mate', 'Ilex paraguariensis', and those related to 'obesity'. Clinical trials, and both in vivo and in vitro studies were classified according to the following categories: publication year, nationality, types and composition of test compounds, combination effects, adverse effects, and safety. Results : A total of 16 articles (14 clinical trials, one in vivo, one in vitro) were included in the analysis. Combination effects were reported from six YGD (Yerba Mate, Guarana, Damiana, Zotrim), five Meltdown, one Shred-matrix, one DBX (DymaBurn Xtreme), one XSIII research study, and adverse effects were reported from two YGD (Zotrim), four Meltdown, one Shred-matrix and one MetEF research study. YGD and Shred-matrix increased satiety while YGD and MetEF had adverse gastrointestinal effects potentially due to guarana. Meltdown and Shred-matrix increased energy expenditure and fat oxidation and had the adverse effects of increased heart rate and blood pressure due to the thermogenic effect of caffeine and yohimbine. DBX increased resting energy expenditure but no difference was observed in respiratory exchange ratio. XSIII reduced body weight gain and food intake more than each of the extracts did on their own. Conclusion : Taken together, the combination effects and adverse effects differed according to the composition of test compounds and the ratio of ingredients. Multicomponent approaches should be used for treating multifactorial diseases such as obesity. As a general conclusion, there is a place for a combination of herbal components including yerba mate, based on the principle of Kun-Shin-Choa-Sa for the treatment of obesity.

Consumption Status, Risk Awareness and Experience of Adverse Effects of High-Caffeine Energy Drink among University Students (대학생의 고카페인 에너지음료 섭취실태, 위험 인식 및 부작용 경험)

  • Park, Jeong Sook;Lee, Eun Joo;Lee, Chae Young;Jung, Hyun Sun
    • Journal of Korean Public Health Nursing
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    • v.29 no.1
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    • pp.102-114
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    • 2015
  • Purpose: This study was conducted in order to identify consumption status, risk awareness and experience of adverse effects of high caffeine energy drink among university students. Methods: This study was a descriptive survey including 270 students in 2 universities and 7 colleges in D metropolitan city. Consumption Status, Risk Awareness and Experience of Adverse Effects of High-Caffeine Energy Drink tools were developed by literature review. Data analyzed using descriptive statistics and $x^2$-test. Results: In the results, 86.7% of the students had previous experience of energy drink consumption and male students and smokers had more experience of energy drink consumption than female students and nonsmokers. The reason of energy drink consumption was increasing alertness for studying. 45.7% of the students were aware of the risk of high caffeine energy drink and the first risk was sleep disturbance. 51.1% of students were experienced adverse effects, mainly palpitation and sleeplessness. Conclusion: The results suggest a need to increase awareness of adverse effects and potential risks of high caffeine energy drink consumption in university students. In addition, university and government should provide education and campaigns to prevent excessive high caffeine energy drink consumption.

Dental anesthesia for patients with allergic reactions to lidocaine: two case reports

  • Lee, Jiseon;Lee, Ju-Young;Kim, Hyun Jeong;Seo, Kwang-Suk
    • Journal of Dental Anesthesia and Pain Medicine
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    • v.16 no.3
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    • pp.209-212
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    • 2016
  • Lidocaine, a local anesthetic commonly used in dental treatments, is capable of causing allergies or adverse effects similar to allergic reactions. However, the frequency of such occurrences in actual clinical settings is very rare, and even clinical tests on patients with known allergies to local anesthetics may often show negative results. When adverse effects, such as allergy to lidocaine, are involved, patients can be treated by testing other local anesthetics and choosing a local anesthetic without any adverse effects, or by performing dental treatment under general anesthesia in cases in which no local anesthetic without adverse effects is available. Along with a literature review, the authors of the present study report on two cases of patients who tested positive on allergy skin tests for lidocaine and bupivacaine and subsequently underwent successful dental treatments with either general anesthesia or a different local anesthetic.

Promotion of Adverse Drug Reactions Report through Expansion of Drug Utilization Review (의약품 사용평가(DUR) 확대를 통한 의약품 부작용 보고 활성화 방안)

  • Jeong, Su-Cheol
    • The Journal of the Korea Contents Association
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    • v.19 no.1
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    • pp.234-241
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    • 2019
  • The side effects of using drugs can greatly threaten the health of the public. The reality is that there are very few reports of current side effects. This can be activated by linking adverse drug reactions reporting to the Drug Utilization Review (DUR) currently used by pharmacies. A study of the U.S. medication management system, where drug use assessment is activated, can find ways to activate adverse drug reactions reporting. In 'Pharm IT 3000', which is used as a medication management program in pharmacies, we examined how to enable reporting of adverse drug reactions. The literature study and research on actual program operation have found a convenient way to report side effects by linking the Pharm IT 3000 prescription preparation assessment to the item.

Social Relief Scheme for Serious Adverse Drug Reactions - Lessons from other countries for Korea (외국의 의약품 부작용 피해구제제도 현황과 국내 실시 방안)

  • Park, Sylvia;Chae, Su-Mi
    • Korean Journal of Clinical Pharmacy
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    • v.18 no.1
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    • pp.18-27
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    • 2008
  • This study investigated social relief schemes for serious adverse drug reactions in foreign countries and deduced lessons and implications for Korea to implement the scheme. A social relief scheme for serious adverse drug reactions provides reliefs for diseases and such health effects as disabilities or deaths that were caused by adverse reactions to pharmaceuticals prescribed at hospitals and clinics as well as those purchased at pharmacies notwithstanding their proper use. The US and the UK do not have specific relief schemes for adverse drug reactions but apply rules of strict liability or negligence. New Zealand and Nordic countries provide no-fault compensation schemes for health effects or injuries caused by medical treatments or medicinal products. Japan and Taiwan have operated the schemes since 1980 and 2000, respectively. In designing the scheme in Korea, we suggested that cases eligible for relief be confined to serious adverse reactions such as death or disability and then extended to diseases. It is desirable to encourage the reporting system of adverse drug reactions and quality use of medicines for the relief scheme to work efficiently.

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Incidence of Adverse Effects and Discontinuation Rate between Patients Receiving 250 Micrograms and 500 Micrograms of Roflumilast: A Comparative Study

  • Joo, Hyonsoo;Han, Deokjae;Lee, Jae Ha;Rhee, Chin Kook
    • Tuberculosis and Respiratory Diseases
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    • v.81 no.4
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    • pp.299-304
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    • 2018
  • Background: Roflumilast is the only approved oral phosphodiesterase-4 inhibitor for the treatment of severe chronic obstructive pulmonary disease (COPD) in patients with chronic bronchitis and a history of frequent exacerbations. The purpose of this study was to examine the incidence of adverse effects associated with roflumilast treatment in a real-world setting. Further, we compared the incidence of adverse effects and the discontinuation rate among patients receiving different doses. Methods: We identified all outpatients diagnosed with COPD at Seoul St. Mary's Hospital between May 2011 and September 2016 and retrospectively reviewed their medical records. Roflumilast was prescribed to patients in doses of $500{\mu}g$ and $250{\mu}g$. Results: A total of 269 COPD patients were prescribed roflumilast in our hospital during the study period. Among them, 178 patients were treated with $500{\mu}g$ and 91 patients were treated with $250{\mu}g$. The incidence of adverse effects was 38.2% in the $500{\mu}g$ group and 25.3% in the $250{\mu}g$ group (p=0.034). The discontinuation rate of roflumilast was 41.6% (n=74) in the $500{\mu}g$ group and 23.1% (n=21) in the $250{\mu}g$ group (p=0.003). When adjusted by age, sex, smoking status, and lung function, $500{\mu}g$ dose was significantly associated with the discontinuation of roflumilast (odds ratio, 2.87; p<0.001). Conclusion: There was a lower incidence of adverse effects and discontinuation among patients treated with $250{\mu}g$ compared with $500{\mu}g$ dose. Further studies regarding the optimal dose of roflumilast are required.