• Title, Summary, Keyword: acute toxicity

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Studies on Acute Toxicity and general Pharmacology of Fluorosilicic acid (불화규산의 급성독성 및 일반약리연구)

  • 김성진;김유영;최부병
    • Biomolecules & Therapeutics
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    • v.8 no.2
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    • pp.179-183
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    • 2000
  • To determine biosafety of fluorosilicic acid as a source of fluoride, we carried out acute toxicity and general pharmacological studies using mouse. Fluorosilicic acid had little effects on general behavior, pain response, convulsion, skeletal muscle function and intestinal mobility as compared to controls. It had either little adverse effects on alkaline phosphatase and collagen levels in osteoblast cells. This study supports the safety of fluorosilicic acid in animals.

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ACUTE MAMMALIAN TOXICITY OF O-CHLOROBENZYLIDENE MALONONITRILE(CS)

  • Rim, Byung-Moo;Rim, Chae-Woong
    • Toxicological Research
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    • v.5 no.1
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    • pp.49-52
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    • 1989
  • Acute inhalation intoxication of CS (O-chlorobenzylidene malononitrile) occurred among the 192 animals in confined animal cages of farm as the result of prolonged exposure. A total of 8 animals (3 silver foxes, 3 fitches and 2 minks) died in 15 hours after the exposure. Distinct evidences of pulmonary atelectasis were observed as with hepatorenal damages. The lethal toxicity of CS was considered to be due to early severelung damages leading to asphyxia, accompanying acute toxic hepatitis and nephritis.

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Acute Toxicity of HRccine (HFRS virus vaccine) in Rats and Rabbits (HRccine(HFRS-virus vaccine)의 급성독성)

  • 임동문;백영옥;김달현;박관하;조정식;이영순
    • Toxicological Research
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    • v.11 no.1
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    • pp.133-136
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    • 1995
  • HRccine(HFRS-virus vaccine) was administered subcutaneously or intragastrically to Spargue Dawley rats and subcutaneously to Japanese white rabbits to investigate the acute toxicity. $LD_50$ values were above 600 times the expected clinical dose in both animals. There were no differences in body weight changes, clinical signs and autopsy findings between all treated groups and control group in both animals. Therefore, it was concluded that HRccine is a very safe substance.

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Acute Oral Toxicity of AG-OS, Water Treatment Agent, in Rats and Mice (렛드와 마우스에서 Ag-Os(수처리제)의 급성 독성)

  • 이용규;신춘환
    • Toxicological Research
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    • v.13 no.4
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    • pp.323-325
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    • 1997
  • Ag-Os, water treatment agent, was administered orally to ICR mice and Sprague-Dawley rats to investigate the acute oral toxicity. $LD_{50}$ values were above 5 g/kg, 2,000 fold higher than the expected concentration in water, in both species with oral administration. There were also no differences in body weight changes, clinical signs and atopsy findings between all treated groups and control group. Therefore, it was concluded that Ag-Os is a very safe compound.

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Effect of Cynanchi wilfordii Radix Extract on the Acute Toxicity in Mice and Subacute Toxicity in Rats (백수오(白首烏) 엑스의 마우스 급성독성(急性毒性) 및 흰쥐 아급성독성(亞急性毒性)에 미치는 영향(影響))

  • Chung, Eun-Jin;Lee, Byung-Joo;Chung, Myung- Hyun
    • Korean Journal of Pharmacognosy
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    • v.24 no.2
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    • pp.166-176
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    • 1993
  • This study was attempted to investigate the acute toxicity in mice, the subacute toxicity in rats of Cynanchi wilfordii Radix extract, the effect on transaminase activities, hematological parameters, leukocyte parameters in serum of subacute-toxicated rats. In acute toxicity test, the death rate was not observed in 50, 100, 200, 300 mg/kg(i.p.), one tenths to two tenths in 300, 500, 1000, 1500 mg/kg(p.o.) for two weeks. In subacute test, rats were all died in 300 mg/kg(p.o.) during 4 weeks, in 500, 1000 mg/kg(p.o.) during three weeks. The cause of death believed to be stomach ulcer. The activities of S-GOT and S-GPT were significantly increased in all sample-treated groups, when compared with the normal groups. A number of WBC and neutrophil belong to hematological parameter were significantly increased, lymphocyte was decreased in all sample-treated group, when compared with normal group. The hemolytic action on water extract, saponin and alcohol extract showed very low activities.

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Acute and Subacute Toxicity of New Woohwangchungsimwon in Rats (랫드에서 신우황청심원의 급성 및 아급성독성시험)

  • 오승민;남혜윤;김준수;연제덕;신대희;이진영;박대규;조명행;정규혁
    • Toxicological Research
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    • v.14 no.2
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    • pp.237-248
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    • 1998
  • The acute and subacute toxicity of New Woohwangchungsimwon(NWCH) which was used l-muscone as substitutive material of musk were investigated in S.D. rats. In intraperitoneal acute toxicity test. rats(Sprague-Dawley, SPF) were injected intraperitoneally with dosages of 0, 540, 750, 1,070, 1.500 and 3,000 mg/kg. Body weights were significantly decreased at 540 mg/kg dose group in both sexes and abnormal autopsy findings were founded in both sexes at all treated groups. Intraperitoneal $LD_{50}$ of NWCH was 812.3 mg/kg in male and 872.3 mg/kg in female rats. In the subacute toxicity study, NWCH was administrated orally to both sexes of rats for 4 weeks as several doses(0, 320, 800 and 2, 000 mg/kg). There were neither dead animals nor significant changes of body weights during the experimental period. In addition, no differences were found between control and treated groups in clinical signs, urinalysis, hematology, serum biochemical analysis, and other findings. Above data strongly suggest that no observed adverse effect level of NWCH might be over 2,000 mg/kg/day in this study.

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Acute and Subacute Toxicity Studies of New Wonbangwoohwangchungsimwon in Rats (랫드에서 신원방우황청심원의 급성 및 아급성독성시험)

  • 오승민;연제덕;남혜윤;김준수;신대희;이진영;박대규;조명행;정규혁
    • Toxicological Research
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    • v.14 no.2
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    • pp.261-271
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    • 1998
  • The acute and subacute toxicity of New Wonbangwoohwangchungsimwon (NSCH) which was used l-muscone as substitutive material of musk were investigated in S.D. rats. In intraperitoneal acute toxicity test, rats were injected intraperitoneally with five dosages of 0, 500, 710, 1,000, 1,410 and 2,000 mg/kg. Body weights were significantly decreased at 500 and 710 mg/kg dose group in male and abnormal autopsy findings were founded in both sexes at all dose. Intraperitoneal $LD_{50}$ of NSCH was 1,088.3 mg/kg in male and 1159.3 mg/kg in female rats. In the subacute toxicity study, NSCH was administrated orally to both sexes of rats for 4 weeks as several doses(0, 320, 800, and 2,000 mg/kg). There were neither dead animals nor significant changes of body weights during the experimental period. In addition, no differences were found between control and treated groups in clinical signs, urinalysis, hematology, serum biochemical analysis, and other findings. Above data strongly suggest that no observed adverse effect level of NSCH might be over 2,000 mg/kg/day in this study.

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Acute Toxicity Study on Taeeumjowi-tang in Mice (태음조위탕(太陰調胃湯) 추출액이 ICR mouse에서의 경구 투여 급성독성에 미치는 영향)

  • Ma, Jin-Yeul;Huang, Dae-Sun;Seo, Chang-Seob;Lee, Si-Woo;Kim, Jong-Yeol;Shin, Hyeun-Kyoo
    • Journal of Sasang Constitutional Medicine
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    • v.22 no.2
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    • pp.101-107
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    • 2010
  • 1. Objectives: The aim of this study is to investigate the acute toxicity and safety of Taeeumjowi-tang. 2. Methods: We investigated the acute toxicity for water-extracted Taeeumjowi-tang. 25 male and 25 female mice were observed for 14 days after one day oral administration of Taeeumjowi-tang at the respective doses of 0(control group), 2560, 3200, 4000 and 5000 mg/kg. 3. Results: We observed survival rates, general toxicity, change of body weight and autopsy. 4. Conclusions: The data confirmed that Taeeumjowi-tang is free from the toxicity and safety problems in oral route respectively. Compared with the control group, we could not find any toxic alteration in all treated groups(2560, 3200, 4000 and 5000 mg/kg). In conclusion, LD50 of Taeeumjowi-tang was over 5000 mg/kg and it is very safe to mice.

Oral Acute and Subacute Toxicity Studies of Decursin and Decursinol Angelate of Angelica gigas Nakai

  • Kim, Kang-Min;Lee, Young-Jeon;Hong, Yong-Geun;Kang, Jae-Seon
    • Molecular & Cellular Toxicology
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    • v.5 no.2
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    • pp.153-159
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    • 2009
  • In this study, we assessed the acute and subacute toxicity of Angelica gigas Nakai (A. gigas Nakai) extracts, which are comprised of decursin and decursinol angelate (D/DA) in rats. For the oral acute toxicity test, Sprague-Dawley (SD) male and female rats were gavaged with two doses of D/DA (200 and 2,000 mg/kg body weight) and then observed for any toxic symptoms for 2 weeks. The LD$_{50}$ value for the rats was greater than 2,000 mg/kg body weight for both male and female rats, which indicates that there were no toxic symptoms induced by doses of up to 2,000 mg/kg body weight. For the subacute toxicity study, rats were treated with D/DA at doses of 2 and 20 mg/kg body weight once a day for 30 days. There were no significant changes in body weight and food intake observed during the subacute toxicity study. In addition, no differences were observed between the control and treated groups when urinalysis was conducted or when hematology and biochemical parameters were evaluated. Finally, histopathological examination of the organs did not reveal any lesions in the control or treated groups. Taken together, these findings indicate that D/DA is safe and non-toxic.

Acute Toxicity Study on Yangkyuksanhwa-tang in Mice (양격산화탕(凉膈散火湯) 추출액이 ICR mouse에서의경구 투여 급성독성에 미치는 영향)

  • Ma, Jin-Yeul;Huang, Dae-Sun;Seo, Chang-Seob;Lee, Si-Woo;Kim, Jong-Yeol;Shin, Hyeun-Kyoo
    • Journal of Sasang Constitutional Medicine
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    • v.21 no.3
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    • pp.131-137
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    • 2009
  • 1. Objectives: The aim of this study is data analysis for acute toxicity and safety of Yangkyuksanhwa-tang. 2. Methods: We investigated the acute toxicity for water-extracted Yangkyuksanhwa-tang. 25 male and 25 female mice were observed for 14 days after one day oral administration of Yangkyuksanhwa-tang at the respective doses of 0(control group), 2560, 3200, 4000 and 5000 mg/kg. 3. Results: We observed survival rates, general toxicity, change of body weight and autopsy. 4. Conclusions: The data confirmed that Yangkyuksanhwa-tang is free from the toxicity and safety problems in oral route respectively. Compared with the control group, we could not find any toxic alteration in all treated groups(2560, 3200, 4000 and 5000 mg/kg). In conclusion, LD50 of Yangkyuksanhwa-tang was over 5000 mg/kg and it is very safe to mice.

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