• Title, Summary, Keyword: Uterine cervical neoplasms

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Uterine Tumor Resembling Ovarian Sex-Cord Tumor - A Case Report of the Cytologic Finding - (난소의 성끈 종양을 닮은 자궁종양 -세포학적 소견 1예 보고-)

  • Kim, In-Sun;Han, Eun-Mee;Jung, Woon-Yong;Lee, Ju-Han;Yeom, Bum-Woo
    • The Korean Journal of Cytopathology
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    • v.14 no.2
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    • pp.71-75
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    • 2003
  • Uterine stromal tumors with features of ovarian sex-cord differentiation are relatively rare. The neoplasms composed of sex cord-like components in more than 50% of the tumor are classified as group II. We report the cytologic findings of a case of uterine tumor resembling ovarian sex-cord tumor. The cervical smears of a 62-year-old woman with submucosal tumor showed loose aggregates of spindle cells as well as glandular or tubular structures of round cells with a distinct ceil membrane and a prominent small nucleolus. Because uterine stromal tumor can have sex cord differentiation, its possibility should be considered in the interpretation of cervical smears.

Estimation of Joint Risks for Developing Uterine Cervix Cancer in Korea (한국인 자궁경부암의 복합위험도 추정)

  • Yoon, Ha-Chung;Shin, Ae-Sun;Park, Sue-Kyung;Jang, Myung-Jin;Yoo, Keun-Young
    • Journal of Preventive Medicine and Public Health
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    • v.35 no.3
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    • pp.263-268
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    • 2002
  • Objective : This study was aiming at estimating the joint effects of various risk factors associated with uterine cervix cancer in Korea. Methods : Data obtained from a case-control study were analyzed with a multiplicative model. Results : After adjustment for age and husband's educational attainments, the family history of cervical cancer (OR=2.1, 95% CI=1.2-3.9), unstable marital status due to separation, by death or divorce, etc. (OR=2.8, 95% CI=1.7-4.6), and a large number of deliveries ($\geq$3 vs. nulliparous OR=6.5, 55% CI=1.4-29.0) increased the risk of uterine cervix cancer, Conversely, first sexual intercourse at an older age ($\geq$25 years vs. <19 years OR=0.4, 95% CI=0.2-0.6) and husband's circumcision (OR=0.7, 95% CI=0.5-1.0) decreased the risk. In the multiplicative model, the highest joint risk (OR=39.2, 95% CI 5.9-258.9) was observed in women with a family history of uterine cervical cancer, an unstable marital status, where the ex-husband was not circumcised, with 3 or more delivery experiences, and having her first sexual intercourse when younger than 19 years of age. However, women without a family history of uterine cervix cancer, married to a circumcised husband, having had her first sexual intercourse at 25 years or older, and nulliparous, showed the lowest joint effect (OR=0.3, 95% CI=0.1-0.5). Conclusion : As carcinogenesis is a complex action involving various factors, we consider a joint effects approach to be appropriate in an epidemiological study on risk factors for uterine cervix neoplasms cervix neoplasm.

Pancreatic Metastasis from Adenocarcinoma of the Uterine Cervix (췌장으로 전이한 자궁경부선암 1예)

  • Kim, Do Jun;Park, Jin Myung;Kim, Ji Hyun;Nam, Kilwoo;Kang, Chang Don;Lee, Sung Joon;Lee, Kyoungyul;Jeon, Yong Hwan
    • The Korean Journal of Gastroenterology
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    • v.73 no.3
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    • pp.182-185
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    • 2019
  • Pancreatic metastasis from cervical cancer is extremely rare. We report a case of metastatic adenocarcinoma of the pancreas from uterine cervical cancer. A 70-year-old woman was referred because of a pancreatic mass detected by CT. She had been diagnosed with uterine cervical adenocarcinoma 20 months previously. After concurrent chemoradiotherapy, CT showed no evidence of the cervical mass, and follow-up showed no evidence of recurrence. Endoscopic ultrasound-guided fine needle aspiration biopsy of the pancreatic mass resulted in a diagnosis of metastatic adenocarcinoma from uterine cervix.

Malignant Tumors of the Female Reproductive System

  • Weiderpass, Elisabete;Labreche, France
    • Safety and Health at Work
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    • v.3 no.3
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    • pp.166-180
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    • 2012
  • This review summarizes the epidemiology of cancer of the female reproductive system and associated lifestyle factors. It also assesses the available evidence for occupational factors associated with these cancers. Cervical, endometrial, and ovarian cancers are relatively common, and cause significant cancer morbidity and mortality worldwide, whereas vulvar, vaginal, fallopian tube cancers, and choriocarcinomas are very rare. As several lifestyle factors are known to play a major role in the etiology of these cancers, very few published studies have investigated possible relationships with occupational factors. Some occupational exposures have been associated with increased risks of these cancers, but apart from the available evidence on the relationships between asbestos fibers and ovarian cancer, and tetrachloroethylene and cervical cancer, the data is rather scarce. Given the multifactorial nature of cancers of the female reproductive system, it is of the utmost importance to conduct occupational studies that will gather detailed data on potential individual confounding factors, in particular reproductive history and other factors that influence the body's hormonal environment, together with information on socio-economic status and lifestyle factors, including physical activity from multiple sources. Studies on the mechanisms of carcinogenesis in the female reproductive organs are also needed in order to elucidate the possible role of chemical exposures in the development of these cancers.

Current Status of and Perspectives on Cervical Cancer Screening in Korea

  • Lim, Sung-Chul;Yoo, Chong Woo
    • Journal of Pathology and Translational Medicine
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    • v.53 no.4
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    • pp.210-216
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    • 2019
  • Since the introduction of the Papanicolaou (Pap) smear system in 1943, cervicovaginal cytology has been used as a standard screening test for cervical cancer. The dissemination of this test contributed to reductions of the incidence and mortality of cervical cancer worldwide. In Korea, regular health check-ups for industrial workers and their family members were introduced in 1988 and were performed as part of the National Cancer Screening Program in 1999. As a result, the incidence of cervical cancer in Korea has been steadily decreasing. However, about 800 cases of cervical cancer-related deaths are reported each year due to false-negative test results. Hence, new screening methods have been proposed. Liquid-based cytology (LBC) was introduced in 1996 to overcome the limitations of conventional Pap smears. Since then, other LBC methods have been developed and utilized, including the human papilloma virus test—a method with higher sensitivity that requires fewer screenings. In this study, we review current issues and future perspectives related to cervical cancer screening in Korea.

Prognostic implications of tumor volume response and COX-2 expression change during radiotherapy in cervical cancer patients

  • Noh, Jae Myoung;Park, Won;Huh, Seung Jae;Cho, Eun Yoon;Choi, Yoon-La;Bae, Duk Soo;Kim, Byoung-Gie
    • Radiation Oncology Journal
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    • v.30 no.4
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    • pp.218-225
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    • 2012
  • Purpose: The relationship between treatment outcomes, alteration of the expression of biological markers, and tumor volume response during radiotherapy (RT) in patients with uterine cervical cancer was analyzed. Materials and Methods: Twenty patients with cervical squamous cell carcinoma received definitive RT with (n = 17) or without (n = 3) concurrent chemotherapy. Tumor volumes were measured by three serial magnetic resonance imaging scans at pre-, mid-, and post-RT. Two serial punch biopsies were performed at pre- and mid-RT, and immunohistochemical staining for cyclooxygenase (COX)-2 and epidermal growth factor receptor was performed. The median follow-up duration was 60 months. Results: The median tumor volume response at mid-RT (V2R) was 0.396 (range, 0.136 to 0.983). At mid-RT, an interval increase in the distribution of immunoreactivity for COX-2 was observed in 8 patients, and 6 of them showed poor mid-RT tumor volume response ($V2R{\geq}0.4$). Four (20%) patients experienced disease progression after 10 to 12 months (median, 11 months). All 4 patients had poor mid-RT tumor volume response (p = 0.0867) and 3 of them had an interval increase in COX-2 expression. Overall survival (OS) and progression-free survival (PFS) decreased in patients with $V2R{\geq}0.4$ (p = 0.0291 for both). An interval increase in COX-2 expression at mid-RT was also associated with a decreased survival (p = 0.1878 and 0.1845 for OS and PFS, respectively). Conclusion: Poor tumor volume response and an interval increase in COX-2 expression at mid-RT decreased survival outcomes in patients with uterine cervical cancer.

MR Imaging Findings of Uterine Cervical Adenocarcinoma (자궁경부 선암종의 자기공명영상 소견)

  • 김종철
    • Investigative Magnetic Resonance Imaging
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    • v.2 no.1
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    • pp.113-119
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    • 1998
  • Purpose : Because adenocarcinomas of the uterine cervix have lower 5-year survival rate than squamous cell carcinomas due to early lymph node metastasis and local extension, scrutiny of lymph node metastasis and local extension by radiologic examination is necessary in case of clinically diagnosed or suspected adenocarcinomas. The purpose of this study is to evaluate whether there are specific findings of these tumors, compared with squamous cell carcinomas, through the analysis of magnetic resonance (MR) imaging findings. Materials and Methods : Of 21 pathologically proven cervical adenocarcinomas, MR imaging findings of 18 tumors (histologic staging : two Ib, four IIa, two IIb, one IIIa, and one IIIb) were retrospectively analyzed and compared with those of 40 wquamous cell carcinoma in consecutive patients as a control group. T1-wetighted and fast spin echo T2-weighted images were obtained on the axial and sagittal planes, using a 1.5-T MR scanner. The largest diameter, location, signal intensity and degree of contrast enhancement contour, shape and longitudinal extent of the tumor and associated findings on MR image were analyzed. Results : The largest diameters of cervical adenocarcinomas ranged from 0.8 to 4.1 cm(mean, 2.2 cm). Of 18 adenocarcinomas, nine were of endocervical type. All adenocarcinomas were isointense to surrounding cervical stroma on T1-weighted images and hyperintense(homogeneous in ten, inhomogeneous in eight) on fast spin echo T2-weighted images. Adenocarcinomas enhanced on contrast study in all patients (homogeneous in six, inhomogeneous in 12 with hyperintese enhnacing rim in two). Eight adenocarcinomas had smooth contours and ten had irregular ones. The shape of adenocarcinoma was irregular in eight patients, barrel shape in six, papillary/polypod in three, and nodular in one. All adenocarcinomas involved lower half of the uterine cervix and six tumors extended up to the upper half. Pelvic lymph nodes of more than 1.5cm in diameter in two adenocarcinomas pateints and no detectable small pelvic lymph nodes on MR imaging in one patient were pathologically positive. Hydrometra was associated in two adenocarcinomas patients, and hematometra in one patient. Compared with squamous cell carcinomas, more frequent MR findings of endocervical type and barrel shape in cervical adenocarcinomas were statistically significant. Conclusion : Cervical adenocarcinomas had more frequent MR findings of endocervical type and barrel shape, compared with wquamous cell carcinomas. Adenocarcinoma of the uterine cervix may be suspected on MR imaging, when a cervical carcinoma is of barrel shape along the endocervical canal and tends to involve lymth nodes in earlier stages.

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Factors Predicting HPV Vaccination Practices among Female College Students (여대생의 인유두종바이러스 예방접종실천 예측요인)

  • Kim, Sun-Hee
    • Korean Parent-Child Health Journal
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    • v.20 no.1
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    • pp.39-47
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    • 2017
  • Purpose: This study was conducted to investigate the factors predicting HPV (Human Papilloma Virus) vaccination practices among female college students. Methods: A convenience sample of 207 female students attending four universities in one metropolitan city participated. Self-report questionnaires consisted of general characteristics, characteristics related prevention of cervical cancer, knowledge of HPV, knowledge of cervical cancer vaccination, and health beliefs related to HPV vaccination. Data were analyzed by $x^2$ test, independent t-test, and bivariate logistic regression. Results: Factors predicting HPV vaccination practices were information about HPV (OR=3.37), experience of HPV test (OR=12.71), and health beliefs related to HPV vaccination (OR=1.13). Conclusion: In order to increase the practice rate of HPV vaccination, it is necessary to provide simple key information that is easy to understand, rather than expert knowledge about HPV. Therefore, it is necessary to provide a way for college students to get information about virus easily. It is necessary to intervene integrally with the facilitation factor and obstacle factor of vaccination practice.

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Management for locally advanced cervical cancer: new trends and controversial issues

  • Cho, Oyeon;Chun, Mison
    • Radiation Oncology Journal
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    • v.36 no.4
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    • pp.254-264
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    • 2018
  • This article reviewed new trends and controversial issues, including the intensification of chemotherapy and recent brachytherapy (BT) advances, and also reviewed recent consensuses from different societies on the management of locally advanced cervical cancer (LACC). Intensive chemotherapy during and after radiation therapy (RT) was not recommended as a standard treatment due to severe toxicities reported by several studies. The use of positron emission tomography-computed tomography (PET-CT) and magnetic resonance imaging (MRI) for pelvic RT planning has increased the clinical utilization of intensity-modulated radiation therapy (IMRT) for the evaluation of pelvic lymph node metastasis and pelvic bone marrow. Recent RT techniques for LACC patients mainly aim to minimize toxicities by sparing the normal bladder and rectum tissues and shortening the overall treatment time by administering a simultaneous integrated boost for metastatic pelvic lymph node in pelvic IMRT followed by MRI-based image guided adaptive BT.

Knowledge regarding Cervical Cancer, Human Papillomavirus (HPV) and Intention for Vaccination among the Personnel in Korean Military Service (병사들의 자궁경부암, 인유두종 바이러스(HPV)에 대한 지식 및 백신 접종 의향)

  • Shin, Hyunkyung;Park, Hyojung
    • Journal of Korean Academy of Fundamentals of Nursing
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    • v.22 no.2
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    • pp.158-168
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    • 2015
  • Purpose: The purpose of this study was to investigate knowledge of cervical cancer, HPV and intention for vaccination in Korean soldiers on active duty. Methods: Participants were 494 army men aged 18 to 26 serving in D area. Knowledge of cervical cancer was measured using the 8 item scale developed by Han et al. (2007) and knowledge of HPV was measured using the 13 item scale developed by Pitts et al. (2009). Collected data were analyzed with t-test, $x^2$-test, and ANOVA. Results: Mean scores for cervical cancer and HPV knowledge were $6.03{\pm}1.52$ and $8.15{\pm}1.75$ respectively and vaccination intention was 75.6%. HPV vaccination intention had significant differences depending on knowledge about cervical cancer (${\chi}^2=12.76$, p=.001), and HPV (${\chi}^2=9.00$, p=.003), education (${\chi}^2=12.24$, p=.002), sexual intercourse after first meeting (${\chi}^2=11.79$, p=.003), and sexual education in the military service (${\chi}^2=12.27$, p=.001). Conclusion: When planning education program for men in military service, it is necessary to consider include content to increase knowledge of cervical cancer and HPV.