• Title, Summary, Keyword: TPM

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Evaluation of Immunological Safety of Topiramate, an Anti-epileptic Drug, in a Murine Model

  • Han, Sang-Bae;Kim, Jee-Youn;Kwon, Soon-Woo;Kang, Jong-Soon;Kim, Hwan-Mook;Song, Suk-Gil;Hong, Jin-Tae;Kim, Young-Soo;Kim, Won-Seop
    • Biomolecules & Therapeutics
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    • v.17 no.2
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    • pp.168-174
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    • 2009
  • Epilepsy is one of the most common neurological disorders, and topiramate (TPM) is one of the most effective drugs that can render patients seizure-free. The focus of the present study was to evaluate the immunological safety of TPM in a mouse model. We examined the in vitro effect of TPM on immune functions of BV2 microglial cells, RAW 264.7 macrophages, B cells, T cells, and dendritic cells. We also examined the in vivo effect of TPM on mouse immune organs, such as lymph node, spleen, and thymus. When cells were directly treated with TPM at concentrations from 1 to $30{\mu}g/ml$, TPM did not affect nitrite production by BV2 cells and macrophages, proliferation of B cells and T cells, or maturation of dendritic cells. In addition, TPM did not change the weight and cellularity of lymph nodes, spleen, and thymus in vivo at doses from 3 to 100 mg/kg injected i.p. into mice once a day for 4 consecutive days. These data showed that TPM, which is widely used as an anti-epileptic drug, is immunologically safe.

Application of Time-Driven Activity-Based Costing(TDABC) for Total Productive Maintenance(TPM) and Cost of Quality(COQ) Processes (TPM과 COQ 프로세스에서 시간동인 ABC시스템의 활용)

  • Choi, Sungwoon
    • Journal of the Korea Safety Management and Science
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    • v.17 no.1
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    • pp.321-335
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    • 2015
  • This study introduces the methods to apply and develop the integrated Cost of Quality (COQ) and Time-Driven Activity-Based Costing (TDABC) model for seeking not only quality improvement but also reduction of overhead cost. Inefficient and uneconomical COQ activities can be identified by using time driver which also maximizes the quality improvement for Prevention-Appraisal- Failure (PAF) quality costs. In contrast, reduction of the indirect cost of unused capacity resource using Quality Cost Capacity Ratio (QCCR) of TDABC minimizes overhead cost for COQ activities. In addition, linkage between Overall Equipment Effective (OEE) and Time Driver develops the integrated system of Total Productive Maintenance (TPM) and TDABC model. Lean OEE maximizes when an Unused Time (UT) of TDABC that are TPM losses and lean wastes reduces whereas the TPM Cost Capacity Ratio (TCCR) of TDABC minimizes indirect cost for non-value added TPM activities. Numerical examples are derived to better understand the proposed COQ/TDABC model and TPM/TDABC model from this paper. From the proposed model, process mapping and time driver of TDABC are known to lessen indirect cost from general ledger of comprehensive income statement with a better quality innovation and improvement of equipment.

The Study on the Utilization of TPM program Affecting the Productivity Increase (TPM 프로그램의 활동요인이 경영성과에 미치는 효과)

  • Oh, Yon-Woo;Lee, Kee-Chai
    • Proceedings of the Korean Operations and Management Science Society Conference
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    • pp.969-974
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    • 2005
  • TPM program, which is a methodology for improving the management results through the management innovation activity of a company, has been widely introduced in the field of a service industry as well as a manufacturing industry. The main purpose of this study is to present the theoretical model by the relationship between active factors of TPM program and management results for a productivity increase, and to investigate the direct and indirect effects on the management of a company through a parametric study. A questionnaire survey of 300 companies that presently utilize the TPM program has been conducted. In order to verify the validity and the reliability of the contents of the questionnaire survey, a confirmatory factor analysis has been done. A frequency analysis has also been performed to examine the characteristics of the respondent. The factor analysis and the frequency analysis were done by using SAS Ver. 8.2, and the verification of a research model was done by using LISREL Ver. 8.52. The active factors of TPM in the research model consist of 'an independent preservation', 'an individual improvement', 'a planned reservation' and 'an education & training'. Among those active factors, the individual improvement and the education & training significantly influence on the facility efficiency and the organization and personnel management. The organization and personnel management has a greater influence on the management results. Therefore, the education and training for employes is most important for the improvement of the management results through TPM program, and the individual improvement activity is also important.

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Simplified Triangular Partitioning Mode (TPM) in Versatile Video Coding(VVC) (VVC 의 삼각 분할 모드(TPM) 간소화 기법)

  • Park, Dohyeon;Yoon, Yong-Uk;Do, JiHoon;Jeong, Dae-Gwon;Kim, Jae-Gon
    • Proceedings of the Korean Society of Broadcast Engineers Conference
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    • pp.116-117
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    • 2019
  • 새로운 비디오 부호화 표준으로 JVET 에서 표준화 중인 VVC(Versatile Video Coding)에서는 더욱 유연한 화면간 예측을 위해 TPM(Triangular Partitioning Mode)을 채택하여 적용하고 있다. 하지만, TPM을 위한 추가적인 움직임 탐색 및 움직임 정보 저장은 VVC 부/복호화기의 복잡도를 증가시킨다. 본 논문에서는 TPM의 복잡도를 줄이기 위한 간소화 기법을 제안한다. 제안기법은 분할된 두개의 삼각 블록에 대한 움직임 정보 조합의 수를 줄여 움직임 탐색의 수를 줄이고 전송되는 데이터의 오버헤드도 함께 줄이는 TPM 간소화 기법이다. 실험결과, 제안기법은 RA(Random Access)와 LDB(Low-Delay B) 부호화 모드에서 미미한 성능 감소가 있었지만 4~6%의 두드러진 부호화 수행 시간 감소를 확인할 수 있었다.

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The Effect and Influencing Mechanism of TPM Factors to Performance

  • Park, Chae-Heung
    • Journal of the Korean Society for Quality Management
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    • v.30 no.4
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    • pp.154-163
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    • 2002
  • This study tries to analyze how TPM works in domestic manufacturing industry by estimating two-stage model. First stage tests the effects of five TPM-factor variables (TFV : (1) Small group activity & Autonomous maintenance, (2) Education & Training, (3) Planned maintenance, (4) improving effectiveness of each piece of facility (5) Safety & Environment) to two TPM-performance variables. Second stage tests how two TPVs affect the industry's productivity level. By combining these two stages, this study uses a model to explain how TPM, represented by TFVs, works to improve productivity via TPVs. Multivariate and univariate regression and correlation analyses were peformed. It is shown that five TFVs works in two different ways to improve the industry's productivity level. In the second stage, overall equipment effectiveness has relatively more significant effects to the productivity level.

An Emprical Study of TPM Application for Loading and Unloading Equipments of Incheon Port (인천항(仁川港) 항만하역장비(港灣荷役裝備)에 대한 TPM 적용을 위한 실증적 연구)

  • Park Sang-Ki;Lee Chang-Ho
    • Journal of the Korea Safety Management and Science
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    • v.8 no.2
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    • pp.169-184
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    • 2006
  • We analyzed the questionnaire survey for the current maintenance of Incheon port's loading and unloading equipments and the possibility of TPM(Total Productive Maintenance) application. Results of the survey indicated that the current maintenance of Incheon port's loading and unloading equipments was not good. So we suggest TPM as the future maintenance methodology of equipments. Using TPM to the loading and unloading equipments we will expect to improve the productivity of the loading and unloading operation and to increase the life time of equipment. And also it will raise the safety of Incheon port.

A Study on Prevention of Disasters through TPM for Loading and Unloading Equipments of Incheon Port (인천항(仁川港) 항만하역장비(港灣荷役裝備)에 대한 TPM 적용으로 재해예방에 관한 연구)

  • Park Sang-Ki;Lee Chang-Ho
    • Journal of the Korea Safety Management and Science
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    • v.8 no.1
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    • pp.1-16
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    • 2006
  • We applied the TPM to loading and unloading equipments of Incheon port and compared with the current maintenance of Incheon port's equipments. Also we analyzed the death disaster causes of equipments and work tools and suggested TPM techniques as a plan of disaster prevention. Using TPM to the loading and unloading equipments we expect to obtain the breakdown zero, defective zero, and disaster zero. And then it should raise the productivity of harbor loading and unloading equipments.

A study of 6 Sigma Method Type On The Base Of The TPM (연구개발 부문 TPM을 기반으로 한 6시그마 운영방안에 관한 연구)

  • Yang, Soung-Yeun;Lee, Kang-Koon
    • Proceedings of the Korean Society for Quality Management Conference
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    • pp.389-395
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    • 2006
  • 6 시그마는 현재 모든 비즈니스에서 경영혁신의 일반 단어가 되었다. 연구개발 분야에서 선 개발 활동을 통한 부가가치 창출과 시장 선점 활동을 하기 위해서는 초기관리와 불량관리 활동 및 TPM의 공통 필수 지주에 대해서 철저히 하지 않으면 안 된다. 이에 여러 가지 경영혁신 기법들이 제시되고 있지만 장점을 충분히 살리지 못하고 있다. TPM 활동을 극대화하기 위한 방법으로 6 시그마에서 사용하는 기법들과 사상을 TPM활동에 도입하여 TPM이 내포하고 있는 단점들을 해결하여 보다 높은 효과를 얻을 수 있는 새로운 통합 모형을 제시하고자 한다.

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A Study on the TPM for Performance Management of Weapon System R&D Program (무기체계 연구개발 사업의 성능관리를 위한 기술성과측정에 관한 연구)

  • Hur, Jang-Wook;Noh, Hyun-Il
    • Journal of the Korea Institute of Military Science and Technology
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    • v.13 no.4
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    • pp.612-618
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    • 2010
  • In order to successfully manage of the state-of-the-art weapon system R&D program which are under the limited budget and schedule but also has a high level of technical risks, it is gaining weights to use such a scientific program management tool as TPM. Therefore, the purpose of this research is to review the concept of the TPM and its relation among MOE, MOP and TPM, and introduce an application method of TPM mainly focusing on helicopter development program. It has the organized structure, detailed procedure and 282 parameters for performance management through the TPM.

연구개발부문의 성과창출을 위한 TPM R&D(Research & Development)보전과 Lean DFSS 프로세스의 핵심요인 연계에 관한 연구;H사 TPM R&D를 중심으로

  • Yang, Soung-Yeun;Lee, Kang-Koon
    • Proceedings of the Korean Society for Quality Management Conference
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    • pp.18-32
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    • 2007
  • 최적의 혁신기법이란 각사의 핵심역량을 명확히 한 후 꾸준히 그리고 지속적으로 자사에 맞게 시스템(SYSTEM)을 변형해 나가는 과정에서 완성된다고 볼 수 있다. 반도체 제조사인 H사는 지난 IMF 때 경영적인 어려움을 극복하고 최근 각 부문(제조, 연구개발, 영업 등)의 탁월한 경영성과를 올리고 있다. 이러한 성과를 뒷받침하는 것은 경영혁신 활동이 일환으로 TPM을 2001년부터 꾸준하게 적용을 해 오고 있다는 것이다. 일반적으로 TPM은 제조중심의 활동이 대부분이나, H사는 R&D부문 경영혁신 활동에 TPM활동을 접목해 활동을 하고 있다. 본 연구는 H사의 R&D부문 TPM R&D보전의 10대 지주 활동과 연구개발 부문에서 활발하게 연구되고 있는 Lean DFSS의 두 방법론에의 장 ${\cdot}$ 단점을 분석하여 좀 더 바람직한 방법론을 연구해 볼 필요가 있다.

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