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A Study on the Strength Safety of an Aluminium Liner for a Hydrogen Fuel Storage Tank (수소연료 저장탱크용 알루미늄 라이너의 강도안전성에 관한 연구)

  • Kim, Chung-Kyun;Kim, Do-Hyun
    • Journal of the Korean Institute of Gas
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    • v.16 no.3
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    • pp.16-21
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    • 2012
  • In this study, the strength safety for 110 liter hydrogen fuel storage tank with 70MPa filling pressure has been analyzed using a FEM technique. The strength safety of a composite fuel tank in which is fabricated by an aluminum liner of 6061-T6 and carbon fiber wound composite layers of T800-24K and T700-12K of Toray, and MR60H-24P of Mitsubishi Ray has been investigated based on the criterion of a strength safety of US DOT-CFFC and Korean Standard. The FEM computed results on the strength safety of 70MPa hydrogen gas tank showed that the hydrogen fuel storage tank in which is fabricated by T800-24K and T700-12K of Toray, and MR60H-24P of Mitsubishi Ray is safe because those two carbon fibers have very similar material properties. But, the composite storage tank with a filling pressure of 70MPa in which is fabricated by T700-12K of Toray may not guaranty the strength safety, and thus this study recommends a composite hydrogen fuel tank under 60MPa.

Immunoenhancing Effect of Conjugated Linoleic Acids on Phagocytic Activity of Porcine Peripheral Blood Phagocytes (돼지 말초혈액 탐식세포의 탐식활성에 있어서 CLA의 면역증강효과)

  • Kang Ji-houn;Kim Ju-hyang;Chung Chung-soo;Lee Chul-young;Yang Mhan-pyo
    • Journal of Veterinary Clinics
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    • v.21 no.4
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    • pp.336-342
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    • 2004
  • The immunoenhancing effect of CLA isomers (CLA mixture, 10t-12c CLA, 9c-11c CLA, 9c-11c CLA, and 9t-11t CLA) on phagocytic activity of porcine peripheral blood leukocytes was examined. The phagocytic activities of peripheral blood mononuclear cells (PBMC) and polymorphonuclear cells (PMN) were analyzed by a flow cytometry system. The direct treatments of CLA isomers have no effect on phagocytosis of PMN as well as PBMC composed of approximately 10% monocytes and 90% lymphocytes. However, the phagocytic activities of PMN and monocyterich fraction from PBMC were remarkably enhanced by culture supernatant from PBMC treated with CLA mixture, 10t-12c CLA and 9c-11t CLA but not 9c-11c CLA and 9t-11t CLA. The phagocytic activity of PBMC was not enhanced by culture supernatant from PBMC treated with all CLA isomers. These results indicated that CLA isomers such as CLA mixture, l0t -12c CLA and 9c-11t CLA have an enhancing effect on phagocytosis of PMN and monocytes, which may be mediated through active humoral substances produced by CLA-stimulated PBMC. This study suggested that CLA stimulates PBMC to elaborate soluble factor(s), which may be an important mechanism for the enhancement of phagocytosis in non-specific immunity.

Immunostimulntory Effects of Immu-Forte at 3 Months Post-Treatment in Mice (면역기능증강성 동암 바이오스 신물질에 대한 3개월간의 마우스 투여후의 면역학적 및 혈액학적 변화)

  • Jung Ji-Youn;Ahn Nam-Shik;Park Joon-Suk;Jo Eun-Hye;Hwang Jae-Woong;Lee Seoung-Hun;Park Jung-Ran;Kim Sun-Jung;Lee Yong-Geon;Jeong Yun-Hyeok;Chung Ji-Hye;Lee Soo-Jin;Lee Sang-Bum
    • Journal of Food Hygiene and Safety
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    • v.20 no.2
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    • pp.118-122
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    • 2005
  • Immu-Forte (Dong-Ahm Bio's. Corp., Korea) was evaluated fir its effectiveness as a nonspecific immunostimulator in mice. The effects of Immu-Forte were determined by analysis of cytokines using ELISh and phenotype of leukocyte subpopulations using monoclonal antibodies specific to mouse leukocyte differentiation antigens and flow cytometry. CD4 T cells, CD8 T cells, macrophages, IL-12 and IFN-r in Immu-Forte EX-treated middle dose group increased in 3 months posttreatment and were significantly higher (p<0.05) than that of control at 3 months posttreatment. All T cells, all B cells, macrophages, IL-2, IL-4 and IL-12 in Immu-Forte EX-treated low dose uoup increased in 3 months posttreatment and were significantly higher (p<0.05) than that of control at 3 months posttreatment. In the Immu-Forte soy-treated group, CD4 T cells, IL-2, IL-4 and IL-12 were significantly higher in high dose-treated group, and CD 4 T cell, macrophages, IL-2, IL-4 and IL-12 were significantly higher in middle dose-treated group, and all T cell, IL-2, IL-4 and IL-12 were significantly higher in low dose-treated group. In the Itnmu-Forte A-treated group, macrophages, m cells and IL-12 in high dose-treated group and all T cells, macrophages, NK cells, IL-2, IL-4 and IL-12 in middle dose-treated group and NK cells in low dose-treated group were significantly higher (p<0.05) than that of control at 3 months posttreatment. In the Immu-Forte F-treated Group, all B cells, IL-4 and IL-12 in high dose-treated group and all T cells, aBl B cells, CD 4 T cells, CD8 T cells, macrophage, IL-2, IL-4, IL-12 and IFN-r in middle dose-treated group and NK cells and IL-12 in low dose-treated group were significantly higher (p<0.05) than that of control at 3 months posttreatment. In conclusion, the study has demonstrated that Immu-Forte had an immunostimulatory effect on mice through proliferation and activation of mouse immune cells.

Spontaneous Morphological Transformation in Adenovirus Type 12 Induced Tumor Cells of Armenian and Chinese Hamsters (Adenovirus Type 12로 誘發한 Armenian Hamster 및 Chinese Hamster의 腫瘍細胞에서 보이는 形質轉換)

  • Kang, Yung-Sun;Sahsook Hahn
    • The Korean Journal of Zoology
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    • v.17 no.2
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    • pp.51-56
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    • 1974
  • Newborn Armenian and Chinese hamsters inoculated with adenovirus type 12 developed undifferentiated small cell tumors as early as 27 days after inoculation in the Chinese hamsters and within 30$\\sim$45 days in the Armenian hamsters. These tumors were transplantable and epithelial-like cell in morphology. Cultures of 6 tumors underwent spontaneous reversion to fibroblast-like morphology during the 14$\\sim$20 in vitro passages in the absence of chromosomal disturbances. While epithelial-like tumor derivatives were oncogenic and positive for the T-antigen, fibroblast-like revertants were non-oncogenic and negative for the T-antigen. Two other tumor derivatives reverted to fibroblast-like forms, immediately following exposure to SV40. These lacked the adenovirus T-antigen but were positive for the SV40 T-antigen and formed sarcomas in animals.

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Spreading Pattern of Epidurally-Administered Contrast Media in Rabbits (토끼에서 경막외강으로 투여한 조영제의 분포양상)

  • Lee, Sang-Chul
    • The Korean Journal of Pain
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    • v.10 no.2
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    • pp.231-234
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    • 1997
  • Background: The aim of this study was to examine the precise spreading pattern of contrast media in small increments in rabbits. Following pentobarbital anesthesia, the epidural puncture was done surgically with a blunt hook. Methods: The tip of epidural catheter was located at the mid-portion of T7 and T12, in the T7 group (n=7) and T12 group (n=8), respectively. Injection of the contrast media was started at 0.1 mL/kg and increased by 0.1 mL/kg up to a maximum of 0.6, mL/kg, under fluoroscopy. Results: In both groups, the extent of spread increased continuously as a Starling resistor with increasing injected volume(T7 group: $y=4.0+41.8x-28.1x^2$, T12 group: $y=0.2+57.7x-43.5x^2$) the total spread of contrast media was similar. The contrast media spread equally, both rostral and caudal, from catheter tip in T7 group; media spread approximately twice as far rostral as compared to caudal in T12 group (P<0.05). Conclusions: In rabbits, the position of epidural catheter tip should be positioned 2~3 segments below the aimed segment in lower thoracic or lumbar region, whereas in mid-thoracic region it should be positioned close to the level of aimed segment. Rabbits have relatively small epidural space therefore, the volume of injectant should be carefully determined with the suggested equations of this study.

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LOCAL AND GLOBAL EXISTENCE AND BLOW-UP OF SOLUTIONS TO A POLYTROPIC FILTRATION SYSTEM WITH NONLINEAR MEMORY AND NONLINEAR BOUNDARY CONDITIONS

  • Wang, Jian;Su, Meng-Long;Fang, Zhong-Bo
    • Bulletin of the Korean Mathematical Society
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    • v.50 no.1
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    • pp.37-56
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    • 2013
  • This paper deals with the behavior of positive solutions to the following nonlocal polytropic filtration system $$\{u_t=(\mid(u^{m_1})_x{\mid}^{{p_1}^{-1}}(u^{m_1})_x)_x+u^{l_{11}}{{\int_0}^a}v^{l_{12}}({\xi},t)d{\xi},\;(x,t)\;in\;[0,a]{\times}(0,T),\\{v_t=(\mid(v^{m_2})_x{\mid}^{{p_2}^{-1}}(v^{m_2})_x)_x+v^{l_{22}}{{\int_0}^a}u^{l_{21}}({\xi},t)d{\xi},\;(x,t)\;in\;[0,a]{\times}(0,T)}$$ with nonlinear boundary conditions $u_x{\mid}{_{x=0}}=0$, $u_x{\mid}{_{x=a}}=u^{q_{11}}u^{q_{12}}{\mid}{_{x=a}}$, $v_x{\mid}{_{x=0}}=0$, $v_x|{_{x=a}}=u^{q21}v^{q22}|{_{x=a}}$ and the initial data ($u_0$, $v_0$), where $m_1$, $m_2{\geq}1$, $p_1$, $p_2$ > 1, $l_{11}$, $l_{12}$, $l_{21}$, $l_{22}$, $q_{11}$, $q_{12}$, $q_{21}$, $q_{22}$ > 0. Under appropriate hypotheses, the authors establish local theory of the solutions by a regularization method and prove that the solution either exists globally or blows up in finite time by using a comparison principle.

The Effects of Deposition Temperature on the Growth Behavior of the $BNdT(Bi_{3.25}Nd_{0.75}Ti_{3}O_{12})$ Ferroelectric Thin Films ($BNdT(Bi_{3.25}Nd_{0.75}Ti_{3}O_{12})$ 강유전 박막 성장거동에 미치는 증착온도의 영향)

  • Kwon, Hyun-Yul;Nam, Sung-Pill;Kim, Jung-Hun;Lee, Sung-Gap;Lee, Young-Hie
    • Proceedings of the KIEE Conference
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    • pp.176-178
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    • 2005
  • Ferroelectric $Bi_{3.25}Nd_{0.75}Ti_{3}O_{12}(BNdT)$ thin films were proposed for capacitor of FeRAM. The BNdT thin films were grown on Pt/Ti $SiO_2/P-Si(100)$ substrates by the RF magnetron sputtering deposition. The dielectric properties of the BNdT were investigated by varying deposition temperatures. Increasing deposition temperature, the (117) peak was increased. An increase of columnar and recrystalline structure of BNdT films with increasing deposition temperature was observed by the Field Emission Scanning Electron Microscopy(FE-SEM). The dielectric constant and dielectric loss of the BNdT thin films with deposition temperature of $600^{\circ}C$ were 319 and 0.05, respectively.

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The Behavior of Dopants During the Formation of T$TiSi_2$ in the Poly-Si/Single-Si Substrate with Implanted Impurities (불순물이 주입된 Poly-Si/Single-Si 기판에서 $TiSi_2$ 형성시 Dopants의 기동)

  • 최진성;황유상;강성건;김동원;문환구;심태언;이종길;백수현
    • Journal of the Korean Institute of Telematics and Electronics A
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    • v.28A no.12
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    • pp.24-30
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    • 1991
  • As a study to use Ti-silicides as interconnection material, the formation of Ti-silicides and the behavior of dopants were investigated for specimens where dopants are introduced on both single-Si substrate and poly-Si that was deposited on the single-Si. Result showed that stable C54 TiSiS12T formed above $700^{\circ}C$ and the formed TiSiS12T had bad surface roughness. And arsenics were chiefly redistributed in TiSiS12T while boron was accumulated near the interface between TiSiS11T and Si during RTA treatment.

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Bioequivalence Evaluation of Senafen Tablet and Airtal Tablet Containing Aceclofenac 100 mg (아세클로페낙(100mg) 제제인 세나펜 정과 에어할 정의 생물학적동등성 평가)

  • 박은우;송우헌;차영주;최영욱
    • Biomolecules & Therapeutics
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    • v.6 no.4
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    • pp.423-428
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    • 1998
  • Aceclofenac is an orally effective non-steroidal anti-inflammatory agent of the phenylacetic acid derivative. Bioequivalence study of two aceclofenac preparations, the test drug (Senafe $n_{R}$: Daewon Phar-maceutical Company) and the reference drug (Airta $l_{R}$: Daewoong Pharmaceutical Company), was conducted according to the guidelines of Korea Food and Drug Administration (KFDA). Sixteen healthy male volunteers, 24$\pm$4 years old and 63.9$\pm$6.9 kg of body weight in average, were divided randomly into two groups and administered the drug orally at the dose of 100 mg as aceclofenac in a 2$\times$2 crossover study. Plasma concentrations of aceclofenac were monitored by HPLC method for 12 hr after administration. AU $Co_{-12h}$ (area under the plasma concentration-time curve from initial to 12 hr) was calculated by the linear trapezoidal method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{msx}$) were compiled directly from the plasma drug concentration-time data. Student's t-test indicated no significant differences between the formulations in these parameters. Analysis of variance (ANOVA) revealed that there are no differences in AU $Co_{12h}$, $C_{max}$ and $T_{max}$ between the formulations. The apparent differences between the formulations were far less than 20% (e.g., 0.25, 0.01 and 7.32 for AU $Co_{-12h}$, $C_{max}$. and $T_{max}$, respectively). Minimum detectable differences (%) between the formulations at $\alpha$=0.05 and 1-$\beta$=0.8 were less than 20% (e.g., 14.65, 12.47 and 15.46 for AU $Co_{-l2h}$, $C_{max}$ and $T_{max}$, respectively). The 90% confidence intervals for these parameters were also within $\pm$ 20% (e.g.,-10.19~10.68, -8.87~8.89 and -3.69~ 18.33 for AU $Co_{-12h}$, $C_{msx}$ and $T_{max}$, respectively). These results satisfy the bioequivalence criteria of KFDA guidelines, indicating that two formulations of aceclofenac are bioequivalent.quivalent.ivalent.ent.t.ent.

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Composition of a Medium for Serum-free Culture of an Adipose-derived Stem Cell Line Established with a Simian Virus 40 T Antigen (Simian virus 40의 T항원 도입으로 수립한 지방유래줄기세포주의 효율적인 무혈청 배양법 및 무혈청 배지조성)

  • Kim, Gyu Bin;Joo, Woo Hong;Kim, Dong Wan
    • Journal of Life Science
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    • v.24 no.12
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    • pp.1301-1307
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    • 2014
  • Adipose-derived stem cells (ADSCs) are considered promising tools for tissue regeneration. However, ADSCs have very poor proliferation capacity. Therefore, fetal bovine serum (FBS) is generally added to the culture media of ADSCs. As FBS contains many uncharacterized components that may affect cellular functions, methods for serum-free cultures of ADSCs have been widely investigated. In this study, to develop an efficient method for a serum-free culture of ADSC-T, we used an ADSC line established by introducing the simian virus 40 (SV40) T gene into primary ADSCs. We then investigated the effect of amino acids, vitamins, and other components on the growth of ADSC-T. When the ADSC-T cells were plated with DMEM/F12 serum-free medium, the cells did not proliferate, and the mixture of amino acids, vitamins, and B27 supplement did not increase the growth of the cells. However, when the ADSC-T cells were provided with serum-free DMEM/F12 after they had been cultured with serum-supplemented DMEM for 24 h, the cells proliferated, and the vitamins and B27 supplement increased the cell growth. Stem-Pro serum-free medium also appeared to be useful as a suspension culture for the ADSC-T cells. The ADSC-T cells secreted large amounts of proteins of around 70 kDa. Insulin-like growth factor (IGF) and fibroblast growth factor basic (FGF basic) were secreted by ADSC-T in larger amounts in the serum-free culture than in the serum-supplemented culture.