• Title, Summary, Keyword: Sst I

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Study on Antitumor Activity and Immunomodulatory effects of Seoleosojong-tang (활어소종탕이 항종역반응에 미치는 영향)

  • Son Ki Jeong;Park Yang Chun
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.18 no.1
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    • pp.137-147
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    • 2004
  • In order to evaluate the antitumor activity and immunomodulatory effects of Seoleosojong-tang(SST), studies were done. We measured the cytotoxic activity for various kinds of cancer cells, inhibitory effect on activity of DNA topoisomerase I, cell adhesion to complex extracellular matrix, survival time in ICR bearing S-180, pulmonary colonization and histological changes of lung in C57BL/6 injected i.v. with B16-F10, CAM assay, expression of CD4/sup +/, CD8/sup +/, B220/sup +/, cytokine gene in spleen cell. The results were obtained as follows: 1. In cytotoxicity against A549, HT1080, 816-F10, NCL-H661 was showed cytotoxicity as compared with control. 2. The inhibitory effect on adhesion of A549, 816-F10 to complex extracellular matrix was over 40% at 100 ㎍/㎖ of SST. 3. In DNA topoisomerase I assay, SST has inhibitory effect. 4. The T/C% was 120.8 in SST treated group in S-180 bearing ICR mice. 5. In pulmonary colonization assay, a number of colonies were decreased significantly and histological changes were showed that infiltration area of cancer cells were inhibited effectively in SST treated group. 6. In CAM Assay, SST has antiangiogenic effect. 7. On the expression of positive cell to CD4/sup +/, CD8/sup +/ and 8220/sup +/ in spleen cells, CD4/sup +/ cells were increased significantly in SST treated group. 8. Effect of SST on IL-1β gene expression in splenic cell was significantly increased as function of whole concentration. 9. The gene expression of IL-4, IL-6, IL-10, IL-12, IFN-γ, TNF-α were increased in SST treated group. From above results SST could be usefully applied for antitumor activity and immunomodulatory effects, but further research of SST should be required.

A RAMS Atmospheric Field I Predicted by an Improved Initial Input Dataset - An Application of NOAA SST data - (초기 입력 자료의 개선에 의한 RAMS 기상장의 예측 I - NOAA SST자료의 적용 -)

  • Won, Gyeong-Mee;Jeong, Gi-Ho;Lee, Hwa-Woon;Jung, Woo-Sik;Lee, Kang-Yoel
    • Journal of Environmental Science International
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    • v.18 no.5
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    • pp.489-499
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    • 2009
  • In an effort to examine the Regional Atmospheric Modeling System (RAMS ver. 4.3) to the initial meteorological input data, detailed observational data of NOAA satellite SST (Sea Surface Temperature) was employed. The NOAA satellite SST which is currently provided daily as a seven-day mean value with resolution of 0.1 $^{\circ}$ grid spacing was used instead of the climatologically derived monthly mean SST using in RAMS. In addition, the RAMS SST data must be changed new one because it was constructed in 1993. For more realistic initial meteorological fields, the NOAA satellite SST was incorporated into the RAMS-preprocess package named ISentropic Analysis package (ISAN). When the NOAA SST data was imposed to the initial condition of prognostic RAMS model, the resultant performance of near surface atmospheric fields was discussed and compared with that of default option of SST. We got the good results that the new SST data was made in a standard RAMS format and showed the detailed variation of SST. As the modeling grid became smaller, the SST differences of the NOAA SST run and the RAMS SST43 (default) run in diurnal variation were very minor but this research can apply to further study for the realistic SST situation and the development in predicting regional atmospheric field which imply the regional circulation due to differential surface heating between sea and land or climatological phenomenon.

The $Sst$ I Restriction Fragment Length Polymorphism of the Apolipoprotein C-III Gene in Korean Subjects

  • Youk, Hyei-Soo;Kim, In-Sik;Kang, Sang-Sun;Kang, Hee-Gyoo;Hyun, Sung-Hee
    • Biomedical Science Letters
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    • v.17 no.4
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    • pp.347-353
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    • 2011
  • The definite mechanism in the control of triglyceride metabolism is not well understood. Nowadays, it has been known that the polymorphism of apolipoprotein C-III $Sst$ I was an important candidate for contributing to the control of triglyceride metabolism. In 298 Korean women aged 30 years or more, the genotypes of apolipoprotein C-III $Sst$ I were statistically compared with total blood cholesterol, triglyceride, high density lipoprotein, fasting blood sugar and hemoglobin A1c. Multiple logistic regression analysis was carried out to compare the odd-ratios of hypertriglyceridemia, hypercholesterolemia and diabetes mellitus with them. The differences among the polymorphic types ($S_1S_1$, $S_1S_2$, and $S_2S_2$) were not statistically significant in the distribution of triglyceride, total cholesterol, high density lipoprotein, fasting blood sugar, and hemoglobin A1c. There were not statistically significant in the odds ratios of the hypertriglyceridemia, hypercholesterolemia, and diabetes mellitus, neither. Those were not statistically significant. This study did not show that there was any association between the polymorphism of apolipoprotein C-III $Sst$ I and various laboratory values-total blood cholesterol, triglyceride, high density lipoprotein, fasting blood sugar and hemoglobin A1c.

DIURNAL HEATING IN THE OKHOTSK SEA UNDER ANTICYCLONIC CONDITIONS: MULTISENSOR STUDY

  • Mitnik, Leonid;Alexanin, Anatoly;Mitnik, Maia;Alexanina, Marina
    • Proceedings of the KSRS Conference
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    • v.2
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    • pp.1027-1030
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    • 2006
  • Development of diurnal warming in the open Okhotsk Sea during the daytime and calm conditions was studied using sea surface temperature (SST) fields retrieved from NOAA AVHRR, Terra and Aqua MODIS, Aqua AMSR-E and ADEOS-II AMSR data. Sea surface wind fields were estimated from AMSR-E/AMSR measurements as well as were obtained from QuikSCAT scatterometer. Weak winds and cloudless conditions were observed in the central area of anticyclone, which moved slowly on 28-30 June 2003 east off Sakhalin. The area where the amplitude of the diurnal SST signal ${\Delta}T$ was significant also shifted slowly and had or circular or elongated shape. The ${\Delta}T$ was estimated relative to the SST values in the areas surrounding the centre of anticyclone where wind speed W exceeded 5- 6 m/s. The diurnal variations of SST, day-night differences were computed using NOAA-12 and NOAA-16 AVHRRderived data. Analysis of simultaneous SST and W fields showed that the increase of W from 0 to 5-6 m/s causes the decrease of ${\Delta}T$ to zero. Maximum warming exceeded $8^{\circ}C$ and was observed in the centre of anticyclone where W = 0 m/s. So strong heating was likely due to the increased chlorophyll a concentration in the area under study that follows from analysis of satellite ocean colour data.

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Variability of Surface Water Properties in the Japan/East Sea on Different Time Scales

  • Ponomarev, Vladimir;Rudykh, Natalya;Dmitrieva, Elena;Ishida, Hajime
    • Ocean and Polar Research
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    • v.31 no.2
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    • pp.177-187
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    • 2009
  • This study examined the multi-scale variabilities of sea surface temperature (SST) and salinity in the Japan/East Sea (JES) based on statistical analyses of observational data, with a focus on the northwestern part of the sea. The regionality of JES SST variability was estimated for different frequency ranges on semimonthly (11-17 days), monthly to seasonal (30-90 days), quasi-semiannual (157-220 days), and quasi-biennial (1.5-3 years) time scales using cluster analyses of daily gridded SST data for 1996 to 2007 from the Japan Meteorological Agency (JMA). Several significant peaks and regional cores were found in each frequency range of the SST anomaly (SSTA) oscillations. Quasi-semiannual SSTA oscillations with high amplitude were found in the south-southwestern part of the Japan Basin ($41-43^{\circ}N$) and were amplified in the area adjacent to Peter the Great Bay. Oscillations with periods of 79 and 55 days also prevailed over the southwest Japan Basin between the Yamato Rise and the continental slope. A similar method was applied to classify SST and the annual cycle of surface salinity using Generalized Digital Environmental Model (GDEM) gridded data. The Tatarskii Strait and adjacent area showed the most specific annual cycles and variability in salinity on interannual to interdecadal time scales. The most significant inverse relationship between surface salinity in the Tatarskii Strait and southern JES areas was found on the interdecadal time scale. Linkages of sea water salinity in the Tatarskii Strait with Amur River discharge and wind velocity over Amurskii Liman were also revealed.

Vasodilatory Effects of Samhwangsasim-tang on Vascular Smooth Muscle (삼황사심탕의 혈관이완 효능과 기전)

  • Kim Jong Bong;Kwon Oh Kui;Son Chang Woo;Shin Heung Mook
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.18 no.5
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    • pp.1382-1386
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    • 2004
  • This study was performed for the investigation of vasodilatory efficacy and its underlying mechanisms of Samhwangsasim-tang(SST), herbal remedy. SST relaxed vascular strips precontracted with phenylephrine or KCI(51 mM), but the magnitude of relaxation was greater in phenylephrine(PE) induced contraction. The relaxation effects of SST was endothelium-independent. L-NAME, iNOS inhibitor, and methyl en blue(MB), cGMP inhibitor, did not attenuate the relaxation responses of SST. In the absence of extracellular Ca2+, pre-incubation of the aortic rings with SST significantly reduced the contraction by PE, suggesting that the relaxant action of the SST includes inhibition of Ca/sup 2+/ influx and release of Ca/sup 2+/ from intracellular stores (SR). In addition, the cell death was induced by SST in human aortic smooth muscle cells but not that of human umbilical vein endothelial cells. We conclude that in rat thoracic aorta, SST may induce in part vasodilation through inhibition of Ca/sup 2+/ influx and release of Ca/sup 2+/ from intracellular stores.

Numerical Simulation of Square Cylinder Near a Wall with the ε -SST Turbulence Model (ε -SST 난류 모델을 적용한 벽면 근처 정사각주 유동장의 수치 해석)

  • Lee,Bo-Seong;Kim,Tae-Yun;Park,Yeong-Hui;Lee,Dong-Ho
    • Journal of the Korean Society for Aeronautical & Space Sciences
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    • v.31 no.8
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    • pp.1-7
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    • 2003
  • The numerical simulation of flow-filed around a square cylinder near a wall with $\varepsilon$-SST turbulence model is carried out in this study. The newly suggested $\varepsilon$-SST turbulence model that modifies the original SST turbulence model is proved to yield more accurate results than the other 2-equation turbulence models in large separation region around a bluff body. Therefore, $\varepsilon$-SST turbulence model can be effectively applied for predicting the flow-fields with large separation. And it is found that vortex shedding is suppressed below the critical gap height, the Strouhal number is affected by the gap height and the wall boundary layer thickness.

Dynamically Induced Anomalies of the Japan/East Sea Surface Temperature

  • Trusenkova, Olga;Lobanov, Vyacheslav;Kaplunenko, Dmitry
    • Ocean and Polar Research
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    • v.31 no.1
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    • pp.11-29
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    • 2009
  • Variability of sea surface temperature (SST) in the Japan/East Sea (JES) was studied using complex empirical orthogonal function (CEOF) analysis. Two daily data sets were analyzed: (1) New Generation 0.05o-gridded SST from Tohoku University, Japan (July 2002-July 2006), and (2) 0.25o-gridded SST from the Japan Meteorological Agency (October 1993-November 2006). Linkages with wind stress curl were revealed using 6-h 1o-gridded surface zonal and meridional winds from ancillary data of the Sea- WiFS Project, a special National Centers for Environmental Prediction/National Center for Atmospheric Research (NCEP/NCAR) product (1998-2005). SST anomalies (SSTA) were obtained by removing the seasonal signal, estimated as the leading mode of the CEOF decomposition of the original SST. Leading CEOF modes of residual SSTA obtained from both data sets were consistent with each other and were characterized by annual, semiannual, and quasi-biennial time scales estimated with 95% statistical significance. The Semiannual Mode lagged 2 months behind the increased occurrence of the anticyclonic (AC) wind stress curl over the JES. Links to dynamic processes were investigated by numerical simulations using an oceanic model. The suggested dynamic forcings of SSTA are the inflow of subtropical water into the JES through the Korea Strait, divergence in the surface layer induced by Ekman suction, meridional shifts of the Subarctic Front in the western JES, AC eddy formation, and wind-driven strengthening/weakening of large-scale currents. Events of west-east SSTA movement were identified in July-September. The SSTA moved from the northeastern JES towards the continental coast along the path of the westward branch of the Tsushima Current at a speed consistent with the advective scale.

Study of the Relationship between the East Asian Marginal SST and the Two Different Types of El Niño (서로 다른 두 유형의 엘니뇨와 동아시아 인근 해역 표층 온도 상관성 연구)

  • Yoon, Jin-Hee;Yeh, Sang-Wook
    • Ocean and Polar Research
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    • v.31 no.1
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    • pp.51-61
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    • 2009
  • In this study we define the two different types of El $Ni{\tilde{n}}o$, i.e., the eastern Pacific El $Ni{\tilde{n}}o$ (i.e., EP-El $Ni{\tilde{n}}o$) versus the central Pacific El $Ni{\tilde{n}}o$ (i.e., CP-El $Ni{\tilde{n}}o$), during the boreal summer (June-July-August, JJA) and winter (December-January-February, DJF) using the two NINO indices in the tropical Pacific. The two different types of El $Ni{\tilde{n}}o$ significantly differ in terms of the location of the maximum anomalous sea surface temperature (SST) in the tropical Pacific. The CP-El $Ni{\tilde{n}}o$ has been observed more frequently during recent decades compared to the EP-El $Ni{\tilde{n}}o$. In addition, our analysis indicates that the statistics of CP-El $Ni{\tilde{n}}o$ during JJA is closely associated with the warming trend in the central equatorial Pacific. We also examine the different responses of the East Asian marginal SST to the two types of El $Ni{\tilde{n}}o$ during JJA and DJF. The CP-El $Ni{\tilde{n}}o$ during both JJA and DJF is concurrent with warm SST anomalies around the Korean Peninsula including the East China Sea, which is in contrast to the EP-El $Ni{\tilde{n}}o$. Such different responses are associated with the difference in tropics/mid-latitude teleconnections via atmosphere between the two types of El $Ni{\tilde{n}}o$. Furthermore, our results indicate that atmospheric diabatic forcing in relation to the precipitation variability is different in the tropical Pacific between the EP-El $Ni{\tilde{n}}o$ and the CP-El $Ni{\tilde{n}}o$.

Distribution von Pronomina in A.cI.-Konstruktionen (A.c.I.-구문에서의 대명사 분포에 관한 연구)

  • Kim Youn-Chan
    • Koreanishche Zeitschrift fur Deutsche Sprachwissenschaft
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    • v.7
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    • pp.105-125
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    • 2003
  • Personal- und Reflexivpronomen stehen in einer komplementaren Beziehung zueinander. Die vorliegende Arbeit zeigt, welches von beiden Pronomen verschiedenen AcI-Konstruktionen jeweils richtig ist Vor allem stelle ich hier die These auf, dass Grammatik in erster Linie ein Regelwerk ist und dass dernzufolge $S\"{a}tze$ mit gleicher Struktur immer einheitlich und konsistent mit denselben Regeln $erkl\"{a}rt$ werden sollten: (1) a. Der Gefangen $l\"{a}sst$ den Polizisten auf ${\ast}sich_i/ihn_i$ achten. b. $Hans_i{\;}l\"{a}sst$ Maria zu $sich_i/{\ast}ihm_i$ kommen. (2) a. $Peter_i$ sieht Hans von ${\ast}sich_i/ihm_i$ betrogen. b. $Hans_i{\;}f\"{u}hlt$ die Freundin von $sich_i/{\ast}ihm_i$ weggezogen. Bei diesen Beispielen liegt der Verteilungsunterschied der Pronomina nicht an Grammatikregeln sondern am individuellen Sprachgebrauch. Ferner wird hier darauf hingewiesen, dass die AcI-Verben mit Ausnahme des Verbs lassen a1s 3-wertige Verben so wie die $S\"{a}tze$ in Beispiel (3) zu behandein sind D.h., die Struktur $f\"{u}r$ AcI-Konstruktionen sieht so aus wie (4b), nicht wie (4a). Betrachten wir dies noch einmal an einem Beispiel: (3) a. Ich sehe mich $m\"{u}de$ b. Ich $f\"{u}hle$ mich viel besser.

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