• Title, Summary, Keyword: Small Intestine

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THE EFFECT OF DIFFERENT CARBOHYDRATE AND NITROGEN SOURCES ON THE UTILIZATION OF AMINO ACIDS IN THE SMALL INTESTINE OF SHEEP

  • Lee, N.H.;Armstrong, D.G.
    • Asian-Australasian Journal of Animal Sciences
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    • v.3 no.3
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    • pp.165-175
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    • 1990
  • This experiment was conducted to examine the effects of different carbohydrate and nitrogen source upon the utilization of amino acids in the small intestine of sheep. The results obtained are as follows: 1) For the quantities of total amino acid-N(TAA-N), essential amino acid-N(EAA-N) and nonessential amino acid-N(NEAA-N) passing at the duodenum and ileum except NEAA-N passing at the ileum were no significant differences (p>0.05) between diets. The quantities of NEAA-N passing at the ileum for the diets containing meat and bone meal were significantly higher (p>0.05) than the diets containing soybean meal. The mean values for the proportionate disappearance apparently digested TAA-N, EAA-N and NEAA-N within the small intestine for four diets were $0.692{\pm}0.0449$, $0.702{\pm}0.0132$ and $0.682{\pm}0.726$, respectively. 2) There were no significant differences (p>0.05) in duodenal individual amino acid flow between diets with the exception of aspartic acid and glycine. The amounts of each amino acid in duodenal digesta, expressed as a proportion of the amounts ingested for the four diets, were shown that there were net gains of EAA with the exception of arginine and NEAA with the exception of glutamic acid, glycine and praline prior to the small intestine. 3) Within the small intestine, there were no significant losses of each EAA (p>0.05) but significant losses of aspartic acid and glycine of NEAA between diets (p<0.01). The mean values of the proportionate losses of methionine, alanine and lysine within the small intestine were $0.816{\pm}0.04$, $0.767{\pm}0.04$ and $0.732{\pm}0.01$, respectively.

Effects of Carthami flos on pacemaker potentials of small intestinal and colonic interstitial Cells of Cajal (홍화의 생쥐 소장 및 대장 카할 간질세포의 향도잡이 전위 조절에 미치는 효능에 관한 연구)

  • Kim, Byung Joo
    • Herbal Formula Science
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    • v.27 no.4
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    • pp.237-244
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    • 2019
  • Objectives : The purpose of this study was to investigate the effects of Carthami flos on pacemaker potentials of small intestinal and colonic Interstitial Cells of Cajal (ICC). Methods : To dissociate the ICC, we used enzymatic digestions from the small intestine and colon in mice. In the ICC, the electrophysiological whole-cell patch-clamp configuration was used to record pacemaker potentials in the cultured ICC. Results : 1. The ICC generated pacemaker potentials in the murine small intestine and colon. 2. Pretreatment with a Ca2+ free solution and thapsigargin, a Ca2+-ATPase inhibitor in the endoplasmic reticulum, stopped the pacemaker potentials. In the case of Ca2+-free solutions, Carthami flos did not induce membrane depolarizations in the murine small intestine and colon. However, when thapsigargin in a bath solution was applied, Carthami flos induced membrane depolarizations only in the murine colon. 3. Pretreatment with 2-APB (transient receptor potential melastatin (TRPM) channel inhibitor) abolished the pacemaker potentials and suppressed Carthami flos-induced effects in the murine small intestine and colon. 4. However, pretreatment with T16Ainh-AO1 (Ca2+ activated Cl- channel; anoctamin 1 (ANO1) inhibitor) did not affect the pacemaker potentials and induced Carthami flos-induced effects only in the murine small intestine. Conclusions : These results suggest that Carthami flos can modulate the pacemaker activity of ICC and the mechanisms underlying pacemaking in ICC might be different in the small intestine and the colon.

Relationship between electrical stimulus strength and contraction force from the inside of small intestine (전기 자극 강도에 따른 소장 내부에서의 수축력 관계)

  • Woo, S.H.;Kim, T.W.;Lee, J.H.;Park, H.J.;Moon, Y.K.;Won, C.H.;Lee, S.H.;Park, I.Y.;Cho, Jin-Ho
    • Journal of Sensor Science and Technology
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    • v.17 no.1
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    • pp.1-8
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    • 2008
  • Recently, capsule endoscope was developed to observe small intestine in human body. However, the capsule does not have any locomotive ability, which reduces the benefit of the capsule endoscope. Many researches have done to give locomotion to the capsule, still it consumes too much power to generate the motion by small battery. One of the moving method is electrical stimulus that consumes less power than many methods. The electrical stimulus method causes contraction in the small intestine, and it moves the capsule. Some of papers showed it is possible to guide the capsule by electrical stimulus, however the relationship between electrical stimulus at the mucous and contraction force in the small intestine is not reported, yet. In this paper, the mucous in the small intestine was stimulated, and measured the contraction force in the small intestine is shown. The result shows, the relationship between electrical stimulus parameters (voltage, duration) and contraction force. Also, equation between electrical stimulus parameters and contraction force is roughly induced.

Characterization of Absorption Process of Taurine Across Rat Small Intestine

  • Kim, Kyung-Soon
    • Archives of Pharmacal Research
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    • v.6 no.2
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    • pp.109-114
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    • 1983
  • A mechanism of taurine transfer across the rat small intestine was elucidated by using the in situ recirculation perfusion or loop method. Taurine uptake was saturable, Km= 39.9 mM, and energy dependent, and required sodium. The close structural analogues, aminomethane sulfonic acid, .gamma.-amino-butyric acid, hypotaurine, and .betha.-alanine, reduced significantly taurine uptake when present in 10-fold excess. The .alpha.-amino acid, glycine, did not inhibit uptake. Hence, all of these findings lead to a conclusion that a carrier-mediated transport system for taurine exists in the small intestine.

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Studies on the digestive gland structures of domestic and experimental animals II. The renewal cycle of the cells in the intestinal mocosa of sucking mouse (가축(家畜) 및 실험동물(實驗動物) 소화관선(消化管腺)의 구조(構造)에 관한 연구 II. 포유(哺乳) mouse 장점막(腸粘膜)의 세포재생주기(細胞再生週期)에 대하여)

  • Kwak, Soo-dong
    • Korean Journal of Veterinary Research
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    • v.32 no.1
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    • pp.1-6
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    • 1992
  • The turnover time of the mucosal epithelium in the small intestine(jejunum and ilium) and large interstine(cecum), and the cells in the lamina propria of the small intestine was investigated with the radioautography in mice at various times after single injection of $^3H$-thymidine. Twenty suckling mice were sacrified at each of the following time intervals after injection ; 2 hrs, 1, 3, 5. 7, 14 and 17 days. 1. The labeled index of the epithelial cells in the crypt and the villus of the small intestine averaged 98.7% and 1.3% at 2 hrs, 982% and 1.8% at 1 day, 18.7% and 81.3% at 3 days, 6.3% and 93.7% at 5 days, respectively. The labeled index of the epithelial cells of the crypt-base, the upper-crypt and the mucosal surface in the large intestine averaged 71.8%, 28.2% and 0% at 2 hrs, 45%. 54.2% and 0% at 1 day, 17.2%, 54.5% and 28.2% at 3 days, 10.2%, 32.4% and 57.4% at 5 days, respectively. This result suggested that the turnover time of all the epithelial cells migrating from crypts to villi in the direction of the villus tips was calculated to be less than 5 days, and also the longest turnover time was calculated to be no longer than 7 day. 2. The labeled index of the total cells in the lamina propria of the small intestine averaged 6.2-7% at 2 hrs to 5 days, 4.7% at 7 days 2.6% at 17 days and this index is tend to be decreased moderately at 7 days and severely at 17 days. So this result suggested that the turnover time of the cells with the shorter cycle duration in the lamina propria of the small intestine were less than 5 days and that of the cells with the longer cycle duration more than 17 days.

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Synergic Effect of Trimebutine Combined with Mosapride on Gastrointestinal Dysfunction and Visceral Pain Induced in Stress Models

  • Park, Young-Joon;Park, Yong-Sul;Chung, Zoo-Chul;Nam, Yun-Sung;Chung, Yoon-Hee;Cho, Kwan-Hyung;Choi, Sung-Up;Sohn, Uy-Dong;Park, Eon-Sub;Je, Hyun-Dong;Lee, Choong-Ho;Lee, Moo-Yeol;Jeong, Ji-Hoon
    • Biomolecules & Therapeutics
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    • v.19 no.1
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    • pp.84-89
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    • 2011
  • The present study was undertaken to determine whether combined treatment with prokinetic trimebutine and mosapride has a synergic effect on gastrointestinal motility and visceral pain associated with gastrointestinal dysfunction. To develop effective gastroprokinetic agents with greater potencies than trimebutine or mosapride for the treatment of gastrointestinal tract disease, a mixture of trimebutine and mosapride was designed and prepared. In the present study, treatment with trimebutine alone showed a dose-dependent effect on propelling movements of normal small and large intestine in mice, whereas mosapride effected only small intestine motility. Co-administration of trimebutine with mosapride, a well-established prokinetic drug, produced a synergistic influence on normal small intestine motility, but demonstrated an unclear effect on large intestine motility, with a slight tendency to reduce the propelling time. In a stress model, the small and large intestine motilities were significantly decreased. The reduction of intestine motility was restored to a normal level and the restoring effect was more pronounced in the combined treatment with trimebutine plus mosapride than treatment with trimebutine or mosapride alone. Furthermore, treatment with trimebutine plus mosapride significantly decreased acute visceral pain which was not controlled by trimebutine or mosapride alone. These data suggest that combination therapy with trimebutine plus mosapride has a synergic effect on small and large intestine motility and visceral pain control in gastrointestinal disorders.

The study of muscular system about small intestine channel of hand taiyang muscle (수태양소장경근(手太陽小腸經筋)에 대한 근육학적(筋肉學的) 고찰(考察))

  • Kim, Ji-Nam;Kim, Young-Il;Hong, Kwon-Eui;Yim, Yun-Kyoung;Lee, Hyun
    • Journal of Haehwa Medicine
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    • v.14 no.1
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    • pp.67-81
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    • 2005
  • We have conclusions after the study of muscular system about small intestine channel of hand taiyang muscle. Judging from many studies of interrelation between Meridian muscle and muscle, it is considered that Meridian muscle theory has some similarities with modern anatomical muscular system. It is considered that Small intestine channel of hand taiyang muscle contains Flexor digitorum profundus muscle, Extensor digiti minimi muscle, Abductor digiti minimi muscle, Extensor carpi ulnaris muscle, Flexor carpi ulnaris muscle, Triceps brachii muscle, Infraspinatus muscle, Levator scapulae muscle, Sternocleidomastoid muscle, Masseter muscle, Temporalis muscle. The symptoms of small intestine channel of hand taiyang muscle is similar to referred pain of modern Myofascial Pain Syndrome, and the medical treatment of "I Tong Wi Su(以痛爲輸)" is also similar to that of Myofascial Pain Syndrome. Small intestine channel of hand taiyang muscle is one of the three yang channels of hand muscle, and it has unity in extension of upper limb and trunk in the movement. And it is thought that weakness of small intestine channel of hand taiyang muscle is related with muscular system causing Round Shoulder and Head Forward Position.

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