• Title, Summary, Keyword: Skin injury

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Effect of Toluene Application to Skin on the Liver Injury in Rats

  • Chae, Soon-Nim;Lee, Sang-Hee;Yoon, Chong-Guk
    • Biomedical Science Letters
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    • v.7 no.1
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    • pp.47-51
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    • 2001
  • To investigate an effect of the topical toluene application to .at skin on the liver injury, toluene (35 mg/$cm^2$) was sequentially applied for 3 or 5 days to rat skin and then the animals were sacrificed. 5 day toluene-treated rats showed the slight increase of live. weight per body weight(%) compared with control. Serum levels of xanthine oxidase and alanine aminotransferase activity were significantly increased both in 3 days and 5 days toluene-treated animals compared with control. In the histopathological findings, cytoplasmic degeneration of hepatocytes around the central vein was noted in the liver of rats applied with toluene to the skin. These results indicate toluene application to rat skin feds to somewhat slight liver injury. On the other hand, the hepatic benzylalcohol or aldehyde dehydrogenase activities were significantly decreased by toluene application to rat skin. In conclusion, the liver min was induced by toluene application to rat skin, and it can be hypothesized that accumulation of benzaldehyde in liver cell may be responsible for liver injury.

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Knowledge, Performance, and Incidence Rate of Pressure Injury Using Skin Observation Records in Long-Term Care Hospitals (피부관찰기록지 이용여부에 따른 요양병원 간호 인력의 욕창간호 지식과 수행도 및 욕창발생률)

  • Choi, Seung Eun;Yang, Nam Young
    • Journal of Korean Academic Society of Home Health Care Nursing
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    • v.27 no.1
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    • pp.102-113
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    • 2020
  • Purpose: To demonstrate the importance of comprehensive skin observation as an effective intervention for pressure injury prevention in elderly long-term care hospital patients. Methods: The survey was conducted with 70 nursing staff members working at two long-term care hospitals with 200 beds or less in D city. Data were collected from October 16 to October 23, 2019 and analyzed using descriptive statistics, the chi-square test, and the independent t-test with the SPSS 25.0 program. Results: Nursing care knowledge for pressure injury was similar between the two groups. Conversely, nursing care performance for pressure injury degree of the nursing staff in the hospital using skin observation records performed better than those who did not (t=6.11, p<.001). Furthermore, comprehensive skin assessments in long-term care hospitals using skin observation records showed a lower incidence rate of pressure injury than that showed using general skin assessments (t=-5.28, p=.006). Conclusions: Comprehensive skin assessment is important for pressure injury prevention in elderly long-term care hospital patients. To implement this effectively, it is necessary to devise institutional regulations, guidelines, and systematic education programs.

A study on Histologically Change of the Skin and Liver in Skin Burn (피부화상에 의한 피부 및 간의 조직학적 변화에 관한 연구)

  • Kim, Han-Soo;Kim, Sang-Soo;Kim, Yong-Kwon
    • Journal of Korean Physical Therapy Science
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    • v.8 no.1
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    • pp.923-934
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    • 2001
  • In order to investigate a pathogenesis of liver damage induced by skin burn, thermal injury was induced by scald burn on entirely dorsal surface in rats (total body surface area 30%) except for inhalated injury. At 5 and 24 h after scald bum, biochemical assay and morphological changes in skin tissue, serum and liver tissue were examined. The effects of bum injury on the levels of glutathione, lipid peroxide and on the activities of oxygen free radical generating and scavenging enzymes have been determined in association with observing of histologic and ultrastructural changes, measuring the protein concentration in plasma, and counting the number of intravascular polymorphonuclear leukocytes. The activity of xanthine oxidase, an enzyme of oxygen free radical generating system. was elevated (p<0.01) in serum, but not in skin and in liver tissue. Futhermore, thermal injury decreased not only the protein concentration in plasma but also the number of leukocytes, that indicates induction of edema formation with protein exudation and inflammation by neutrophil infiltration into the internal organs. These data suggest that acute dermal scald burn injury leads to liver damage, that is related to elevation of xanthine oxidase activity in serum. Xanthine oxidase may be a key role in the pathogenesis of liver damage induced by skin burn.

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Skin Spread of Rhubarb Mixed with Olibanum and Myrrha Decreases KC Level in Skin and Serum Following Scald Burn Injury

  • Park, Jin-Yong;Kang, Byung-Soo
    • Biomedical Science Letters
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    • v.7 no.3
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    • pp.145-149
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    • 2001
  • The present study was conducted to determine whether local production of neutrophil chemoattractant cytokines preceded the influx of neutrophils 1311owing dermal scald burn injury. In order to inhibit the influx of neutrophils, we induced scald burn injury on dorsal skin of rats (TBSA 15%) and spread Rhubarb (R. undulatum L.) and complex (Rhubarb+Olibanum+Myrrha) on scald skin in rats. 1. Levels of dermal KC, the indicator of skin iuflammation, caused by burn gradually increased 5 hours, 24 hours (p<0.001) and 72 hours (p<0.001) after the burn occurred. After 24 hours it occurs, KC in skin was decreased by both skin spread of Rhubarb (p<0.05) and complex (p<0.05) compared to scald bum group. After 72 hours, KC by skin sp.end of Rhubarb and complex was significantly decreased (p<0.01), and the inhibition effect of KC production by complex is higher than by Rhubarb. 2. KC content in serum was increased (p<0.01) at 24 hours after burn injury and comes down back to the normal level after 72 hours. At 24 hours postbunt both Rhubarb (p<0.05) and complex (p<0.01) skin spread decreased KC in serum. The inhibition effect of KC production by complex skin spread group is higher than by Rhubarb skin spread group. The data suggest that the KC production effects by Rhubarb skin spread group and complex skin spread group are high. Especially the endurance of the effect by complex skin spread group was longer than by Rhubarb skin spread group. The inhibition effect of KC production by complex skin spread group increases more than by Rhubarb skin spread group as time passes.

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Effects of Lepidii Semen on Acute Edematous Lung Injury Induced by Skin Burn

  • Myoung-Je Cho;Hyun Gug Cho
    • Biomedical Science Letters
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    • v.9 no.1
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    • pp.37-42
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    • 2003
  • The present study was conducted to determine whether administration of heat extract of Lepidii Semen has an inhibitory effect on neutrophil-derived oxidative injury following dermal scald burn in rats. Acute lung injury was induced by scald burn (15% of TBSA) in rats. To identify acute edematous lung injury, protein concentrations and numbers of polymorphonuclear leukocytes were measured in bronchoalveolar lavage (BAL) at 5 h after skin burn. In addition, the level of lung KC (neutrophil chemoattractant cytokine) and activity of lung myeloperoxidase (MPO) were measured, and histopathological changes were observed as well. Lung weight and concentration of BAL protein, the index of lung injury, were clearly increased at 5 h postburn compared with those of sham-operated group. Administration of heat extract of Lepidii Semen after scald burn inhibited the production of KC in lung tissue and decreased the activity of lung MPO related to infiltration of neutrophils. In histopathological changes in lung tissue, infiltration of inflammatory cells and pulmonary edema induced by skin burn were decreased by administration of heat extract of Lepidii Semen after scald burn. These results suggest that Lepidii Semen may be an effective medical stuff for acute lung injury induced by skin burn.

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Reperfusion Injury after Autologous Cranioplasty in a Patient with Sinking Skin Flap Syndrome

  • Kwon, Sae-Min;Cheong, Jin-Hwan;Kim, Jae-Min;Kim, Choong-Hyun
    • Journal of Korean Neurosurgical Society
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    • v.51 no.2
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    • pp.117-119
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    • 2012
  • The sinking skin flap syndrome is a rare complication after a large craniectomy. It consists of a sunken skin above the bone defect with neurological symptoms such as severe headache, mental changes, focal deficits, or seizures. In patient with sinking skin flap syndrome, cerebral blood flow and cerebral metabolism are decreased by sinking skin flap syndrome, and it may cause the deterioration of autoregulation of brain. We report a case of a patient with sinking skin flap syndrome who suffered from reperfusion injury after cranioplasty with review of pertinent literature.

The Effect of LED Light Irradiation on Skin Injury Cure of Rat (LED 광원이 Rat의 피부 창상 치유에 미치는 영향)

  • Cheon, Min-Woo;Kim, Seong-Hwan;Park, Yong-Pil;Kim, Tae-Gon;Yu, Seong-Mi
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.20 no.12
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    • pp.1087-1092
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    • 2007
  • We developed the 4-channel Light Medical Therapy Apparatus for Skin Injury Cure using a high brightness LED. This equipment was fabricated using a micro-controller and a high brightness LED, and designed to enable us to control light irradiation time, intensity and reservation. In this paper, the designed device was used to find out how high brightness LED light affects the skin injury of SD-Rat(Sprague-Dawley Rat). In the experiment, $1\;cm^2$ wounds on the skin injury of SD-Rat(Sprague-Dawley Rat) were made. Light irradiation group and none light irradiation group divided, each group was irradiated one hour a day for 14 days. In result, compared with none light irradiation group, the lower incidence of inflammation and faster recovery was shown in light irradiation group.

Medical adhesive related skin injury after dental surgery

  • Kim, Tae-Heung;Lee, Jun-Sang;Ahn, Ji-Hye;Kim, Cheul-Hong;Yoon, Ji-Uk;Kim, Eun-Jung
    • Journal of Dental Anesthesia and Pain Medicine
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    • v.18 no.5
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    • pp.305-308
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    • 2018
  • An 87-year-old woman was referred for the extraction of residual teeth and removal of tori prior to prosthetic treatment. After surgery under general anesthesia, the surgical tape was removed to detach the bispectral index sensor and the hair cover. After the surgical tape was removed, skin injury occurred on the left side of her face. After epidermis repositioning and ointment application, a dressing was placed over the injury. Her wound was found to have healed completely on follow-up examination. Medical adhesive related skin injury (MARSI) is a complication that can occur after surgery and subjects at the extremes of age with fragile skin are at a higher risk for such injuries. Careful assessment of the risk factors associated with MARSI is an absolute necessity.

Comparison of Skin Injury Induced by β- and γ-irradiation in the Minipig Model

  • Kim, Joong-Sun;Jang, Hyosun;Bae, Min-Ji;Shim, Sehwan;Jang, Won-Seok;Lee, Sun-Joo;Park, Sunhoo;Lee, Seung-Sook
    • Journal of Radiation Protection and Research
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    • v.42 no.4
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    • pp.189-196
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    • 2017
  • Background: The effects of radiation on tissues vary depending on the radiation type. In this study, a minipig model was used to compare the effects of ${\beta}$-rays from $^{166}Ho$ and ${\gamma}$-rays from $^{60}Co$ on the skin. Materials and Methods: In this study, the detrimental effects of ${\beta}$- and ${\gamma}$-irradiation on the skin were assessed in minipigs. The histopathological changes in the skin from 1 to 12 weeks after exposure to 50 Gy of either ${\beta}$- (using $^{166}Ho$ patches) or ${\gamma}$- (using $^{60}Co$) irradiation were assessed. Results and Discussion: The skin irradiated by ${\beta}$-rays was shown to exhibit more severe skin injury than that irradiated by ${\gamma}$-rays at 1-3 weeks post-exposure; however, while the skin lesions caused by ${\beta}$-rays recovered after 8 weeks, the ${\gamma}$-irradiated skin lesions were not repaired after this time. The observed histopathological changes corresponded with gross appearance scores. Seven days post-irradiation, apoptotic cells in the basal layer were detected more frequently in ${\beta}$-irradiated skin than in ${\gamma}$-irradiated skin. The basal cell density and skin thickness gradually decreased until 4 weeks after ${\gamma}$- and ${\beta}$- irradiation. In ${\beta}$-irradiated skin lesions, and the density and thickness increased sharply back to control levels by 6-9 weeks. However, this was not the case in ${\gamma}$-irradiated skin lesions. In ${\gamma}$-irradiated skin, cyclooxygenase-2 (COX-2) was shown to be expressed in the epidermis, endothelial cells of vessels, and fibroblasts, while ${\beta}$-irradiated lesions exhibited COX-2 expression that was mostly limited to the epidermis. Conclusion: In this study, ${\beta}$-rays were shown to induce more severe skin injury than ${\gamma}$-rays; however, the ${\beta}$-rays-induced injury was largely repaired over time, while the ${\gamma}$-rays-induced injury was not repaired and instead progressed to necrosis. These findings reveal the differential effects of ${\gamma}$- and ${\beta}$-irradiation on skin and demonstrate the use of minipigs as a beneficial experimental model for studying irradiation-induced skin damage.

The Effects of Simultaneous Hand Washing by Nurse and Child Before IV Injection (아동과 간호사의 손씻기 프로그램이 정맥주사와 관련한 아동의 불안, 동통과 피부손상에 미치는 효과)

  • Lee, Ae-Ran;Park, Min-Im;Lee, Hyo-Soon;Kim, So-Hyun;Park, Jin-Kyong;Kim, Ji-Soo
    • Child Health Nursing Research
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    • v.14 no.2
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    • pp.129-137
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    • 2008
  • Purpose: To examine the effects on skin injury, pain, and anxiety when nurses and children simultaneous wash their hands before IV injections. Method: A nonequivalent control group, non-synchronized design study was used with 61 children. For a month and a half, children in the experimental group(30) following hand-washing guidelines, washed their hands with nurses before IV insertion. Anxiety and pain were observed and recorded during IV insertion using the Anxiety Reaction Scale and FACES pain scale. After 48-72 hours on IV therapy with an arm-board, skin condition was checked by a research assistant according to guidelines for assessing skin injury developed by the researcher. t-test, ${\chi}^2$-test, Pearson correlation, and Kendall's tau b were used to analyze data with the SPSS program. Results: Children who washed their hands with the nurse before IV insertion showed less pain (p =.021) and skin injury (p <.001) compared to the control group. Conclusion: This finding suggests that simultaneous hand washing by nurse and child before IV injection has a strong effect on skin injury caused by arm-boards used to maintain IV therapy as well as on pain during IV insertion. This program demonstrates an effective intervention to prevent skin injuries in children on IV therapy.

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