• Title, Summary, Keyword: Scale-up

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A Study on the Domestic Scale-up Policy Direction through the Analysis of Scale-up Support Policy for Global Startups (글로벌 창업기업 스케일업(Scale-up) 지원 정책 분석을 통한 국내 스케일업 정책 방향에 관한 연구)

  • Hong, Dae Ung;Jun, Byung Hoon
    • Asia-Pacific Journal of Business Venturing and Entrepreneurship
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    • v.14 no.6
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    • pp.11-27
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    • 2019
  • The second venture "boom" diffusion strategy can be confirmed to be focused only on financing investment and finance, including achieving 5 trillion won annually in new venture investments, creating 20 unicorns, activating M&As and creating dynamic recovery markets. Of course, existing studies show that the fund is a very important policy for corporate growth, but various policy support will be needed to effectively scale up. To overcome these limitations, the scale-up support policies already in operation are analyzed by introducing scale-up policies in advanced countries such as the U.S. and Britain. It also aims to analyze domestic scale-up policies to draw up implications for establishing more effective scale-up policies. Academically, we are very lacking in research on scale-up at home and abroad, and we propose suggestions through this comparative study of policy cases to contribute to the promotion of various studies related to the scalability aspects of future research topics related to scale-up.

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Scale-up의 원리와 응용

  • 김익환
    • The Microorganisms and Industry
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    • v.16 no.2
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    • pp.49-52
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    • 1990
  • 발효공업이 발달되면서 발효조의 scale-up에 대한 문제는 꾸준하게 연구되어져 왔다. 이 scale-up은 미생물 뿐만 아니라 최근에는 동물이나 식물 그리고 곤충세포의 대량배양을 위해서도 계속적으로 연구되고 있는 분야이다. 수많은 생물반응기가 개발되었고 또 개발중에 있는데, 각 반응기에 대한 scale-up의 방법은 서로 상이할 수 있기 때문에 본 고에서는 현재 산업계에서 가장 많이 사용되고 있는 전통적인 교반조 발효기에 대한 scale-up의 원리와 응용을 다루고자 한다.

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Dynamic Behavior of an Internal Loop Reactor during Scale-up (내부순환반응기의 Scale-up에 따른 동력학적 특성의 변화)

  • 최윤찬;박영식
    • Journal of Environmental Science International
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    • v.6 no.1
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    • pp.25-31
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    • 1997
  • The variations of gas hold-up, overall volumetric oxygen mass transfer coefficients and liquid circulation velocity in an internal loop reactor were investigated to manifest scale-up effect. The relationship between superficial gas velocity and gas hold-up were found as Ugr = 0.045 $\varepsilon$r in the pilot-scale and Ugr = 0.056 $\varepsilon$r in the bench-scale reactor. The overall volumetric oxygen mass tractsfer coefficient, KLa was slightly increased in the pilot-scale than in the bench-scale reactor. Flow regime was changed from the bubble flow to the churn-turbulent flow when the superficial gas velocity reached to 3.5 - 4 cm/sec in the pilot-scale.

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The Correlations among the Dynamic Gait Index the Berg Balance Scale and Timed Up & Go Test in people with stroke (뇌졸중 환자에서 Dynamic Gait Index와 Berg Balance Scale 및 Timed Up & Go 검사간의 상관관계)

  • Lee, Sang-Ho;Hwang, Byoung-Yong
    • Journal of Korean Physical Therapy Science
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    • v.15 no.3
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    • pp.1-8
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    • 2008
  • The purpose of this study was to compare the relationship among the Dynamic Gait Index(DGI), Berg Balance Scale(BBS) scores, Timed Up & Go Test(TUG), and subject characteristics. The subjects were fifteen stroke with hemiplegia were chosen in the Konyang University Hospital. Dynamic balance was measured Dynamic Gait Index(DGI), and balance was measured using Berg Balance Scale(BBS). Timed Up & Go Test(TUG) was used to evaluate functional mobility. Data were analyzed using Spearman correlation. There was significant correlated among Dynamic Gait Index(DGI), Berg Balance Scale(BBS) and Timed Up & Go Test(TUG)(p<.01). The correlation among subject characteristics and Dynamic Gait Index(DGI), Berg Balance Scale(BBS), Timed Up & Go Test(TUG) score was significant result in r = -.527 from Dynamic Gait Index(DGI) and pathogenesis(p<.05). There were no significant statistical differences among the types of spasticity and Dynamic Gait Index(DGI), Berg Balance Scale(BBS), Timed Up & Go Test(TUG). The comparison among the sex, type of hemiplegia, pain, pathogenesis and Dynamic Gait Index(DGI), Berg Balance Scale(BBS), Timed Up & Go Test(TUG) score was significant result in pathogenesis(p<.05). The results of this study showed that there was high correlations among the Dynamic Gait Index(DGI) and balance test of people with stroke.

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Scale- Up of Water-Oil Hydrolysis System

  • Hur, Byung-Ki;Kim, Eun-Ki
    • Journal of Microbiology and Biotechnology
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    • v.9 no.6
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    • pp.773-777
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    • 1999
  • Scale-up experiments for hydrolysis of beef tallow, fat, and palm kernel with lipase derived from Candida cylindracea were carried out in 1-1, 100-1, and 10,000-1 reactors. The optimum agitation speed for the hydrolysis of the 1-1 reactor was investigated and found to be 350rpm, and this was a basis for the scale-up of agitation speed. The hydrolysis system in this work was the oil-water system in which the hydrolysis seems to process a heterogeneous reaction. An emulsion condition was the most important factor for determining the reaction rate of hydrolysis. Therefore, the scale-up of agitation speed was performed by using the power n = 1/3 in an equation of the rules of thumb method. The geometrical similarity for scaling-up turned out to be unsatisfactory in this study. Thus, the working volume per one agitator was used for the scale-up. In the case of scale-up from a 1-1 reactor to a 100-1 reactor, the hydrolysis of palm kernel was very much scaled-up by initiating the rules of thumb method. However, the hydrolysis of fat and beef tallow in a 100-1 reactor was a little higher than that of the 1-1 reactor because of the difference of geometrical similarity. The scale-up of hydrolysis from the 100-1 reactor to the 10,000-1 reactor was improved compared to that of the 1-1 to 100-1 reactor. The present results indicated that the scale-up of hydrolysis in the oil-water system by the rules of thumb method was more satisfactory under the condition of geometrical similarity. Even in the case where geometrical similarity was not satisfactory, the working volume per one agitator could be used for the scale-up of a heterogeneous enzyme reaction.

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A Study on the Scale-Up of Fluidized Bed Combustors for Low-Calorific Value Wastes (저발열량 폐기물 소각용 유동층 소각로의 Scale-Up에 관한 연구)

  • Park, S.H.;Kim, J.E.;Park, B.S.
    • Journal of the Korean Society of Combustion
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    • v.1 no.1
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    • pp.1-10
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    • 1996
  • An effective scale-up methodology of fluidized bed incinerators for low calorific value industrial wastes such as paper sludge and sewage sludge has been developed based on the similarity rules. Conventional scale-up theories are briefly reviewed and a new simple theory defining the diffusion Fourier number is established taking account of the lateral mixing of fuels in the fluidized bed. From the design and the operating conditions of the pilot FBC plant at Inchon, important design data for the full-scale incinerators are calculated and discussed.

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Scale-up of Optimized Chemical Processes for Micron and Submicron Products (마이크론 이하 단위의 제품생산 최적화를 위한 화학공정의 스케일업)

  • Chung, Young Mi
    • Applied Chemistry for Engineering
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    • v.28 no.1
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    • pp.17-22
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    • 2017
  • This review deals with scale-up strategies for optimized chemical processes particularly for micron and submicron products. The method of finding scale-up factors was also introduced for two systems, a system with chemical reaction and a system without chemical reaction. This review is expected to serve as an initial guideline for process engineers who are to scale up their current chemical processes for small products of micron or submicron size.

Effects of Stireed Tank Bioreactor Scale-up on Cell Growth and Alkaloids Production in Cell Cultures of Eschscholtzia californica (탱크 교반형 생물반응기의 scale-up이 Eschscholtzia californica 세포생장 및 알칼로이드 생성에 미치는 영향)

  • 유병삼;변상요
    • KSBB Journal
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    • v.13 no.6
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    • pp.700-705
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    • 1998
  • Studies were made to investigate effects of the scale-up of stirred tank bioreactors on cell growth and alkaloids production for suspension cultures of Eschscholtzia californica. In the 1.5 L STR, cell lysis was observed at 110 rpm or higher agitation speed. The agitation speed of 30 L STR was 43.7 rpm to maintain the same shear stress developed in 1.5 L STR of 100 rpm. As a result of scale-up from 1.5 L to 30 L STR, the specific growth rate was decreased from 0.12 to 0.07 day-1. The alkaloids productivity was also decreased from 0.24 to 0.14 mg/L-day. Changes of mixing performance and oxygen transfer were studied to explain the decrease of cell growth and alkaloids production. Decreased oxygen transfer rate coefficient(KLa) and increased mixing time by the scale-up was observed at various aeration rates.

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Scale-up of Flat Panel Photobioreactor considering Hydrodynamics (수력학을 고려한 평판형 광생물 반응기의 스케일업에 관한 연구)

  • Kim, Gwang-Ho;Lee, Dong-Woon;Jeong, Sang-Hwa
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.17 no.1
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    • pp.48-56
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    • 2018
  • Due to the growing concerns of energy resource depletion and environmental destruction, the mass production of microalgae has been studied. The scale-up of a photobioreactor (PBR) is required for the mass production of biomass. In this paper, the geometric parameters and oxygen transfer rate (OTR) are considered, to scale up a flat panel photobioreactor (FP PBR). The PBR is designed using the goal-driven optimization (GDO) method to accomplish the scale-up. The local sensitivity of each output parameter with respect to the input parameter is analyzed through the design of experiment (DOE), and the design candidates are evaluated with the screening sampling method. The volumetric mass transfer coefficient is measured by the dynamic method.