• Title, Summary, Keyword: Saponin

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Effects of Ginseng saponin on Serum Cholesterol Level in Rabbits (인삼 Saponin이 가토 혈청 Cholesterol에 미치는 영향)

  • 조형원;오진섭
    • YAKHAK HOEJI
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    • v.6 no.1
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    • pp.19-20
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    • 1962
  • Ginseng saponin was tested for the anticholesterolemic property by a "three-day fasting method". The results indicate that ginseng saponin has not significant anticholesterolemic activity on rabbits. P. Griminger previously offered the postulate that saponin-cholesterol complex formation causes anticolesterolemic effect in chicks. Above results, however, suggests that the postulate is not the whole answer for the anticholesterolemic activity of saponin.f saponin.

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Toxicity and Hemolytic Activitiy of Saponin Isolated from Sapindus mukorossi (연명피 사포닌의 독성 및 용혈작용)

  • 박은희
    • YAKHAK HOEJI
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    • v.39 no.2
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    • pp.137-140
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    • 1995
  • Saponin isolated from Sapindus mukorossi Gaertn has been shown to contain a strong anti-inflammatory activity. In this study, several pharmacological properties such as acute toxicity, local irritation and hemolytic activity of Sapindus saponin and its genin component, hederagenirl, were examined. The acute toxicity of Sapindus saponin was very low. Estimated from the LD$_{50}$ values, it showed much weaker toxicity in oral administration than in intraperitoneal injection. Hederagenin gave a very high LD$_{50}$ value even in intraperitoneal injection. Sapindus saponin showed a potent local irritation after topical application, whereas hederagenin did a very weak local irritation. Sapindus saponin also gave a high hemolytic activity.

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Effect of Saponin from the Shoot of Aralia elata in Normal Rats and Steptozotocin Induced Diabetic Rats (두릅추출물이 정상쥐 및 당뇨쥐에 미치는 영향)

  • 김영희;임정교
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.28 no.4
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    • pp.912-916
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    • 1999
  • The purpose of this study was to investigate the effect of saponin in the shoot of Aralia elata on serum lipid level and glucose in streptozotocin(STZ) induced diabetic rats. Sprague Dawley normal male rats weighing 70$\pm$5g were randomly assigned to normal(control group), crude saponin(S group), and shoot of Aralia elata(D group). Experimental diets have been fed for 6 weeks. STZ induced diabetic rats were classified to diabetic control(DC group) and crude saponin(DS group). Diabetic rats were experimentally induced by intravenous injection of STZ(65mg/kg of body weight) dissolved in citrate buffer(pH 4.5). DS group has been i.p. injected with crude saponin solved in phosphate buffer(pH 7.0, 10mg/100g body weight) and DC group fed for 10 days. Body weight decreased significantly in crude saponin group. Feed intakes and feed efficiency ratio were not significantly different among C, S, and D group. The crude saponin group has indicated the lowest values of serum total cholesterol, glucose, and triglyceride. However, the values of serum glucose and triglyceride were not significant. Insulin levels among the crude saponin group, the shoot powder group, and the control group were not significantly different. When STZ induced diabetic rats have i.p. injection of crude saponin, the crude saponin has reduced the serum glucose but it is not been significant.

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Effect of Ginseng Saponin on Adrenaline-Induced Hyperglycemia and Hyperlipidemia (인삼사포닌이 Adrenaline에 의한 고혈당 및 고지방혈증에 미치는 영향)

  • 이동권;임창진;박은희;홍순근
    • YAKHAK HOEJI
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    • v.25 no.2
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    • pp.49-55
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    • 1981
  • To elucidate the effect of ginseng saponin on adrenaline-induced hyperglycemia and hyperlipidemia, ginseng saponin was administered before and after administration of adrenaline, and concentration of glucose, triglyceride(TG), and free fatty acid (FFA) as well as lipase activity in plasma was determined. 1) Glucose concentration was slightly increased by administration of ginseng saponin at 1 hour before and 10 minutes after adrenaline administration, but decreased by administration of ginseng saponin at 7 and 4 hours before adrenaline administration. TG and FFA concentration was also greatly inhibited by administration of ginseng saponin in advance. 2) When gineseng saponin 3, 10, 30mg/kg were administered 7 hours before adrenaline administration, glucose and TG concentration as well as lipase activity were inhibited in proportion to the dose of ginseng saponin, but FFA concentration was slightly inhibited. 3) It was suggested that protopanaxatriol group have potentiating effect on adrenaline induced hyperglycemia but protopanaxadiol group have inhibitory effect. And ginseng saponin seems to have strong inhibitory action on TG mobilization into blood and stimulatory effect on esterification of FFA in liver and adipose tissue.

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Optimization of Saponin Extraction Conditions in Ginseng Milk using Response Surface Methodology (반응표면분석 법을 이용한 인삼우유 중 사포닌 추출조건의 최적화)

  • 이승수;박종면
    • Journal of Ginseng Research
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    • v.18 no.1
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    • pp.53-59
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    • 1994
  • To develop the methodology of the quantitative analysis of saponin in ginseng milk, conditions of the saponin extraction were optimized using the fractional factorial design with 3 variables and 3 levels by a RSM computer program. The extraction of saponin increased with an increase in extraction temperature up to $90^{\circ}C$ and then decreased significantly at $100^{\circ}C$. Extraction time affected the saponin yield in a similar trend. On the other hand, decreasing cooling temperature increased the amount of the saponin extracted. Recovery yield of the saponin from ginseng milk varied from 70.0% to 92.9%. The optimum extraction temperature, time and cooling temperature determined by partial differentiation of the model equation were $86^{\circ}C$, 2.83 hrs and $4^{\circ}C$, respectively. Key words Ginseng milk, saponin, response surface methodology.

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Effect of Ginseng Saponins on Phagocytosis of Feline Peripheral Blood Phagocytes (고양이 말초혈액 탐식세포의 탐식능에 있어서 인삼 사포닌의 효과)

  • 양만표;박세형;윤영원
    • Journal of Veterinary Clinics
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    • v.15 no.1
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    • pp.116-123
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    • 1998
  • 고양이 말초혈액 탐식세포(단핵구세포(MNC) 및 다형핵백혈구(PMNC))의 탐식능 에 있어서 인삼 saponin(ginseng total saponin(G75), ginseng PT saponin(GPT) 및 ginseng PD saponin(GPD))의 면역증강 효과를 flow cytometry를 이용하여 분석하였다. 인삼 ssponins을 직접 첨가하여 배양한 MNC 및 PMNC에서는 탐식중강 효과가 나타나지 않았다. 각각의 인삼 saponin을 첨가하여 배양한 PMNC 및 MNC 배양상충액의 존재하에 PMNC 및 MNC의 탐식능을 겅토한 결과, MNC의 탐식능은 Gff 첨가 PMNC 배양상충액과 GTS 및 GPT 첨가 MNC 배양상충액의 존재하에서 약간의 탐식증강 효과를 보였다. PMNC 탐식능의 경우에는 GPD 첨가 PMNC 배양상충액에서 미약한 탐식증강 효과가 나타났으나, 각각의 인 삼 saponin 첨가 MNC 배양상충액 존재하에서는 모두 현저한 탐식중강 효과를 나타내었다. 이상의 결과로부터 고양이 말초혈액 탐식세포의 탐식증강 효과는 인삼 saponin의 직접적인 작용보다는 인삼 saponin에 의해 활성화된 단핵구세포에서 분비되는 가용성물질에 의해 단 핵구세포보다는 다형핵백혈구에서 현저하게 탐식효과가 증강되는 것으로 판단되었다.

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Removal Conditions of Cholesterol from Cream by Saponin Treatment (Saponin을 이용한 크림 중의 Cholesterol 제거조건)

  • 오훈일;장은정;곽해수
    • Food Science of Animal Resources
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    • v.18 no.3
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    • pp.224-231
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    • 1998
  • In order to prepare low cholesterol cream by treatment with saponin, the optimal conditions of saponin conc., pH of saponin solution, temperature and amount of celite addition were investigated. The results revealed that the optimal conc. and pH of saponin solution were 5% and 5.5 removing 71.67% and 73.40% of cholesterol, respectively. The temperature of reaction with saponin was best at 60$^{\circ}C$, removing 74.34% of cholesterol in this condition. The addition of celite was more effective than non-addition in the removal of cholesterol from cream. The results of this study indicate that saponin is effective on cholesterol removal from cream.

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Development of a Natural Surfactant from Extracts of Saponaria officinalis L. (비누풀 잎 추출물로부터 천연 계면활성제 개발)

  • Jang, A Reum;Kim, Hyo Jeong;Kim, Kwang Soo;Park, Eun Kyung
    • KSBB Journal
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    • v.28 no.3
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    • pp.202-207
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    • 2013
  • In this study, saponin content of extract from modified preconditioning process was investigated in Saponaria officinalis L. for cosmetic natural surfactant. Saponin content in steamed leaves from S. officinalis L. was about three times more than that in dried leaves (tea saponin and quillaja saponin). And saponin extracts from steamed leaves was excellently shown in both forming force and forming stability. In emulsion activity, saponin extracts from steamed leaves had a similar level to quillaja saponin and tea saponin. Saponin extracts from steamed leaves in S. officinalis L. showed nontoxic effect below in $1,000{\mu}g/mL$ of concentration and dose-dependent inhibition of NO production. From the experiment, the extracts of S. officinalis L. showed good cosmetic agent.

Effects of a Ginseng Saponin Fraction on the Tumoricidal Activity of Murine Macrophage Against K562 Cells (생쥐 대식세포의 K562 종양세포치사 활성에 미치는 인삼 분획물의 영향)

  • Kim, Woong;Jung, Noh-Pal
    • Journal of Ginseng Research
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    • v.13 no.1
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    • pp.24-29
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    • 1989
  • The tumoricidal activity of marine macrophage against K562 tumor cells was studied in the presence of lipopolysaccharide(LPS) and ginseng saponin. 1 The tumoricidal activity was increased more by LPS treatment with ginseng saponin (44% in 24 hours) than by LPS only (22% in 24 hours). In the case of diol saponin, the tumoricidal activity was increased as much as 35% at concentrations of 10-3 to 1034%. Triol saponin increased the tumoricidal activity more than LPS only treatment at each concentration . 2. When total, dial and triol saponin were added to K.562 tumor cell in various concentration without macrophage, it was found that the ginseng saponin hall no tumoricidal effect. This result suggests that ginseng saponin increases the tumoricidal activity of K562 tumor celts through the tumoricidal activity of the macrophage.

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THE EFFECT OF KOREAN RED GINSENG SAPONIN ON THE ALKALINE PHOSPHATASE ACTIVITY OF RAT OSTEOBLASTIC CELL(ROS17/2.8) IN CULTURE (한국 홍삼사포닌이 배양중인 쥐 조골세포의 염기성 인산분해효소 활성도에 미치는 영향)

  • Jung, Jin-Kwang;Kim, Jung-Keun;Lee, Jae-Hyoun
    • Journal of Periodontal and Implant Science
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    • v.25 no.3
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    • pp.694-702
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    • 1995
  • Using the Korean red ginseng saponin, which is known to world-wide and thd effects of it have been investigated by many reserachers for years. Ginseng saponin, one of the major components of Korea ginseng root, has many various biologic effects, such as cytotoxic effect, tumorcidal activity, protein biosynthesis and membrane modifying effect. The purpose of this study was to evaluate effects of ginseng saponin on the alkaline phosphatase activity of ROS cells in culture. After ROS cells were seeded into a 96-well plate, 96-well plate cultured until confluence was obtained. To evaluate cytotoxic effect of total saponin in cultured ROS cells, the plates were added to each total saponin concentration (0-1mg/ml). After 48hr., cells were counted by stain with 0.2% trypan blue at randomly selected field microscopically. Also, to evaluate alkaline phosphatase(ALP) activity of total saponin in cultured ROS cell, the plate was added to each total saponin concentration (0-1mg/ml) and ALP activity was assayed. To evaluate time-course of ALP activity, $31.25{\mu}g/ml$ of saponin added to 96-well plate. After culture of 6, 12, 24 and 48hr., ALP activity test was performed. To evaluate effect of cycloheximide in ALP activity, 96-well plate was added to saponin and cycloheximide. In control group, the plate was added saponin only. The results were as follows. 1. After the various concentration of total saponin was added in the medium, 500 and $1000{\mu}g/ml$ of total saponin showed cytotoxic effect of ROS(P<0.005). 2. In contrast to control group, 7.6, 15.6, 31.25, 62.5 and $250{\mu}g/ml$ of total saponin increased ALP activity significantly. 3. Otherwise, 500 and $1000{\mu}g/ml$ of total saponin decreased ALP activity significantly(P<0.005). 4. As the time span increases, $31.25{\mu}g/ml$ of total saponin increased ALP activity. 5. Cycloheximide decreased saponin-indueced ALP actitity in ROS(P<0.005). These results suggest that Ginseng total saponin stimulates the ALP activity of rat osteoblastic cells.

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