• Title, Summary, Keyword: Salicylate

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Salicylate-Selective Electrodes Based on Tripodal Tris-thiourea Derivatives

  • Lee, Chaeg-Yeong;Kim, Jung-Hwan;Kim, Dong-Wan;Lee, Shim-Sung;Kim, Jin-Eun;Kim, Jae-Sang
    • Bulletin of the Korean Chemical Society
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    • v.28 no.12
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    • pp.2466-2470
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    • 2007
  • A new highly salicylate-selective PVC membrane electrode based on tripodal tris-thiourea derivatives, L1 and L2, as neutral carriers is described. The electrodes display an excellent potentiometric response to salicylate ions and an anti-Hofmeister selectivity sequence in the following order: Salicylate? > ClO4 ? > Benzoate? > I? >NO3? > NO2? > Maleate? > Acetate? > Lactate? > Fumarate?. It also exhibited a near-Nernstian potential in a linear range of 5.0 × 10?5 - 1.0 × 10?1 M with a detection limit of 9.0 × 10?5 mol/L and a slope of ?59.9 mV/decade at a pH of 7.0 in a saline buffer solution at 25 oC. The stability constant (log KS) of the anionsionophore complex was also determined at 25 oC by a conductometric titration in DMSO solution.

PAH로 오염된 토양의 미생물 분해 가속화 연구

  • 이효진;우승한;박종문
    • Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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    • pp.195-198
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    • 2001
  • Bioremediation of hazardous hydrophobic organic compounds, such as polycyclic aromatic hydrocarbons (PAHs), is a major environmental concern due to their toxic and carcinogenic properties. Bue to their low solubility in water, the compounds are microbiologically persistent. This work investigates optimal conditions to enhance the biodegradation of phenanthrene in water and soil-slurry systems. Biodegradation tests were performed with three different types of supplements: glucose as a general carbon source, salicylate as an enzyme inducer, and Triton X-100 as a surfactant. The tests indicate that glucose and Triton X-100 were not very effective to increase biodegradation rate, even though the number of microorganisms are highly increased in the case of glucose addition. Salicylate accelerated biodegradation of phenanthrene, but the addition above optimal concentration inhibited microbial growth. Salicylate is considered to be an attractive alternative for the successful bioremediation of PAH-contaminated soil.

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A Study on the Methyl Salicylate Dispersion in the Vicinity of Obstacles by Wind Tunnel Test (아음속 풍동을 이용한 구조물 형상 변화에 따른 살리실산메틸 확산 유동 연구)

  • Hong, Chang-Ki;Uhm, Han-Sup;Choi, Seung-Ki;Kim, Youn-Jea
    • The KSFM Journal of Fluid Machinery
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    • v.17 no.6
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    • pp.69-73
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    • 2014
  • To predict flow fields and chemical agent dispersion in urban area, wind tunnel experiments was performed. The agent was adopted MS (methyl salicylate) because the real chemical agent is unsafe. The exact concentration of methyl salicylate was generated by the commercial gas generator (STI-2500) and three different obstacle shapes were applied (i.e., rectangular, cylinder and pyramid). The concentration was measured with the qualified ion mobility sensor and gas chromatography. The data necessary for virtual test method of the real chemical agent were obtained.

Effects of Balyangtongum-Tang on Cochlear Morphologic Change Induced by Sodium Salicylate Ototoxicity (발양통음탕(發陽通陰湯)이 살리실산나트륨 이독성에 대한 흰쥐 와우의 형태학적 변화에 미치는 영향)

  • Yoon, Hui-Sung;Nam, Hae-Jeong;Kim, Yoon-Bum
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.18 no.1
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    • pp.221-233
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    • 2005
  • Background and Objectives : Despite of high prevalence, Tinnitus remains obscure because the cause and mechanism is poorly understood. In the absence of a suitable animal model, past investigations tool place in humans. Recently, the animal model with sodium salicylate ototoxicity is broadly used because of its reversibility. Balyangtongum-Tang had been used clinically to treat tinnitus and other hearing problems. We investigated the effects of Balyangtongum-Tang on cochlear morphologic change induced by sodium salicylate ototoxicity and were to find out its therapeutic effects on ototoxicity in rat model. Materials and Methods : Healthy ten Sprague-Dawley rats were divided into normal(2), control(4) and sample(4) groups. The sample group was given extract of Balyangtongum - Tang(1cc/100g) once a day for 4 days. After 3 hours when last medication were given, the sample and control groups were injected intraperitoneally with sodium salicylate(500mg/kg). We observed the cochlear morphologic changes of rats every 1, 2, 3 and 5 hours after injection. Results : The electron microscopic finding of outer hair cell shows some changes in the curticular plate and cytoplasm. Some vacuoles were found in the control and sample groups. Vacuolization in the curticular plate and cytoplasm of the sample group after 3, 5 hours were similar to the control group. But the curticular plate of the sample group after 1, 2 hours did not from vacuole. On the other hand the control group after 1, 2 hours formed vacuoles in the curticular plate. Light microscopic findings of cochlear duct in control and sample groups didn't find any difference. Conclusion : The results suggest that extract of Balyangtongum-Tang reduces the morphologic changes induced by sodium salicylate ototoxicity and the effects are remarkable in frist 2 hours. However the effective times are different with previous studies, it seems to due to the difference of tolerance and sensitivity of laboratory animals.

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Salicylate Enhances Insulin Signaling by Preventing Ser731 Phosphorylation of Insulin Receptor Substrate 1 (Insulin Receptor Substrate 1의 세린731 인산화 억제를 통한 살리실산의 인슐린저항성 개선효과 기전)

  • Lee, Yong-Hee
    • YAKHAK HOEJI
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    • v.52 no.3
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    • pp.182-187
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    • 2008
  • Salicylate (SA) was shown to alleviate insulin resistance. Here, we showed that SA inhibited Ser731 phosphorylation of insulin receptor substrate 1 (IRS1) and S6 kinase activation, and enhanced tyrosine phosphorylation of IRS1 in response to insulin or amino acid. Experiments using a cJun N-terminal kinase (JNK)-deficient cell and an IRS1 JNK-binding mutant showed that JNK is not required for Ser731 phosphorylation. A two-week treatment of obese mice with SA resulted in decreased Ser731 phosphorylation and enhanced insulin signaling. These results suggest that SA enhances insulin signaling by inhibiting Ser731 phosphorylation of IRS1.

Anti-inflammatory Action of Glycyrrhetic Acid Derivatives (Glycyrrhetic acid 유도체(誘導體)의 소염작용(消炎作用))

  • Kyung, Woo-Hyun
    • The Korean Journal of Pharmacology
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    • v.5 no.1
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    • pp.39-43
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    • 1969
  • In the present investigation, the anti-inflammatory activity of glycyrrhetic acid derivatives (abbreviated as AMKOA, 28-OMKOA, 30-OMKOA) was compared with hydrocortisone and sodium salicylate by a new anti-inflammatory test, utilizing the chorio-allantoic membrane of the chick embryo, which is outstandingly suitable for large scale screening of new compounds. The anti-inflammatory activity of the glycyrrhetic acid derivatives was similar to hydrocortisone and superior to sodium salicylate.

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The Vasodilator Effect of a Cream Containing 10% Menthol and 15% Methyl Salicylate on Random-Pattern Skin Flaps in Rats

  • Dolen, Utku Can;Sungur, Nezih;Koca, Gokhan;Ertunc, Onur;Bosi, Ayse Tulay Bagci;Kocer, Ugur;Korkmaz, Meliha
    • Archives of Plastic Surgery
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    • v.42 no.6
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    • pp.695-703
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    • 2015
  • Background It is still difficult to prevent partial or full-thickness flap necrosis. In this study, the effects of a cream containing menthol and methyl salicylate on the viability of random-pattern skin flaps were studied. Methods Forty female Sprague-Dawley rats were divided into two equal groups. Caudally based dorsal random-pattern skin flaps were elevated, including the panniculus carnosus. In the study group, 1.5 mL of a cream containing menthol and methyl salicylate was applied to the skin of the flap, and saline solution (0.9%) was used in the control group. Upon completion of the experiment, flap necrosis was analyzed with imaging software and radionuclide scintigraphy. Histopathological measurements were made of the percentage of viable flaps, the number of vessels, and the width of the panniculus carnosus muscle. Results According to the photographic analysis, the mean viable flap surface area in the study group was larger than that in the control group (P=0.004). According to the scintigrams, no change in radioactivity uptake was seen in the study group (P>0.05). However, a significant decrease was observed in the control group (P=0.006). No statistically significant differences were observed between the groups in terms of the percentage of viable flaps, the number of vessels, or the width of the panniculus carnosus muscle (P>0.05). Conclusions Based on these results, it is certain that the cream did not reduce the viability of the flaps. Due to its vasodilatory effect, it can be used as a component of the dressing in reconstructive operations where skin perfusion is compromised.

Evidence for Volatile Memory in Plants: Boosting Defence Priming through the Recurrent Application of Plant Volatiles

  • Song, Geun Cheol;Ryu, Choong-Min
    • Molecules and Cells
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    • v.41 no.8
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    • pp.724-732
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    • 2018
  • Plant defence responses to various biotic stresses via systemic acquired resistance (SAR) are induced by avirulent pathogens and chemical compounds, including certain plant hormones in volatile form, such as methyl salicylate and methyl jasmonate. SAR refers to the observation that, when a local part of a plant is exposed to elicitors, the entire plant exhibits a resistance response. In the natural environment, plants are continuously exposed to avirulent pathogens that induce SAR and volatile emissions affecting neighbouring plants as well as the plant itself. However, the underlying mechanism has not been intensively studied. In this study, we evaluated whether plants "memorise" the previous activation of plant immunity when exposed repeatedly to plant defensive volatiles such as methyl salicylate and methyl jasmonate. We hypothesised that stronger SAR responses would occur in plants treated with repeated applications of the volatile plant defence compound MeSA than in those exposed to a single or no treatment. Nicotiana benthamiana seedlings subjected to repeated applications of MeSA exhibited greater protection against Pseudomonas syringae pv. tabaci and Pectobacterium carotovorum subsp. carotovorum than the control. The increase in SAR capacity in response to repeated MeSA treatment was confirmed by analysing the defence priming of the expression of N. benthamiana Pathogenesis-Related 1a (NbPR1a) and NbPR2 by quantitative reverse-transcription PCR compared with the control. We propose the concept of plant memory of plant defence volatiles and suggest that SAR is strengthened by the repeated perception of volatile compounds in plants.

Protective Effect of an Aged Garlic-bamboo Salt Mixture on the Rat with the Alcohol-salicylate Induced Gastropathy (마늘-죽염 제제가 위장 장애 유발 흰쥐의 항산화 효소활성에 미치는 영향)

  • Huh, Keun;Kim, Young-Hee;Jin, Da-Qing
    • YAKHAK HOEJI
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    • v.45 no.3
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    • pp.258-268
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    • 2001
  • Garlic has been known to be effective against the gastrointestinal diseases which can be induced by production of oxygen-derived free radical. It has been shown that bamboo salt is effective on the treatment and prevention of various gastrointestinal disorders. Bamboo salt is a processed salt invented by a Korean, ll-Hoon Kim. It has been reported that garlic and bamboo-salt are useful to the treatment of gastric disorders in Korea. To clarify the protective mechanism of the garlic-bamboo salt mixture, the gas-tropathy was induced in rats with alcohol-salicylate and the activities of the free radical scavenging enzymes were examined. In this study, we found that the garlic-bamboo salt mixture reduced the severity of hemorrhagic lesion in gastric mucosa in the rats. In addition, the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) were significnatly increased and the total content of GSH was recovered. From those results, we concluded that the protective effect of the garlic-bamboo salt mixture on gastropathy in rats is its ability to recover the level of GSH and to increase the activities of the free radical scavenging enzymes (SOD, GPx, GR).

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Design and Evaluation of Biphenyl Dimethyl Dicarboxylate Injections (비페닐디메칠디카르복실레이트 주사제의 설계 및 평가)

  • 김혜진;전인구
    • YAKHAK HOEJI
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    • v.44 no.3
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    • pp.263-271
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    • 2000
  • In an attempt to develop an injectable form of practically insoluble biphenyl dimethyl dicarboxylate (DDB), the effect of various vehicles, cosolvents and hydrotropic agents was investigated. It was found that polyethylene glycol (PEG) 400 revealed the best solvency toward DDB (17.7 mg/ml at $37^{\circ}C$), and decreasing order of the solubility was as follows: PEG 400>PEG 300>diethylene glycol monoethyl ether (DGME)>PEG-8 glyceryl caprylate/caprate. Among the hydrotropes used, sodium salicylate, sodium benzoate and nicotinamide were effective in increasing the solubility in water. The solubility of DDB in 2 M sodium salicylate, sodium benzoate and nicotinamide solutions was increased 44.3, 23.5 and 44.0 times than that in water, respectively. The addition of sodium salicylate and sodium benzoate to PEG 300-water PEG 400-water and DGME-water cosolvents remarkably increased the solubility of DDB, and significantly retarded precipitate formation when mixed with water Hemolytic properties of DDB injections (2 mg/4~10 ml) in PEG 300-water or DGME-water (60:40 v/v) cosolvents containing sodium benzoate (0.14~0.35 M) were very low. It was concluded from the results that these solutions would be applied to the design of new DDB injections.

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