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Effect of Dangguisoo-san plus Yuhyangjeongtong-san (Dangguixu-san plus Ruxiangdingtong-san) in the Traffic Accidents Patients with Night Pain (당귀수산합유향정통산(當歸鬚散合乳香定痛散)이 야간통을 동반한 교통사고 환자에게 미치는 영향)

  • Park, Jung-Woo;Jeong, Su-Hyeon
    • Journal of Korean Medicine Rehabilitation
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    • v.25 no.1
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    • pp.87-93
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    • 2015
  • Objectives This study investigated the effect of korean medicine treatment with Dangguisoo-san plus Yuhyangjeongtong-san (Dangguixu-san plus Ruxiangdingtong-san) on traffic accidents patients with night pain. Methods 77 traffic accidents patients with night pain were treated with Dangguisoo-san plus Yuhyangjeongtong-san (Dangguixu-san plus Ruxiangdingtong-san), acupuncture, cupping, physical therapy. VAS (Visual Analogue Scale), NDI (Neck Disability Index), ODI (Oswestry disability index), total sleep time, the number of bed time arousal were checked to evaluate the effectiveness of the treatment. Results VAS, NDI, ODI of patients treated with Dangguisoo-san plus Yuhyangjeongtong-san (Dangguixu-san plus Ruxiangdingtong-san) were all improved and there were statistical significance (p<0.05). Total sleep time, the number of bed time arousal of patients treated with Dangguisoo-san plus Yuhyangjeongtong-san (Dangguixu-san plus Ruxiangdingtong-san) were all improved and there were statistical significance (p<0.05). Conclusions According to the study, Korean complex therapy with Dangguisoo-san plus Yuhyangjeongtong-san (Dangguixu-san plus Ruxiangdingtong-san) might effective in traffic accidents patients with night pain.

Quantitative Analyses of the Functional Constituents in SanYangSam and SanYangSanSam

  • Shin, Il-Soo;Jo, Eunbi;Jang, Ik-Soon;Yoo, Hwa-Seung
    • Journal of Pharmacopuncture
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    • v.20 no.4
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    • pp.274-279
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    • 2017
  • Objective: SanYangSam and SanYangSanSam are traditional Korea-medical herbs that are grown from Panax ginseng C.A. Meyer. In our previous studies, we found that the functional compounds in SanYangSam and SanYangSanSam were different and depended on the type and the cultivation environment of ginseng. This study aimed to profile the functional constituents in SanYangSam and SanYangSanSam. Methods: To profile the functional aspects of the many compounds that have therapeutic activities in SanYangSam and SanYangSanSam extracts, we used liquid chromatography tandem mass spectrometry and quadrupole orthogonal acceleration time-of-flight mass spectrometry. Results: A total of four major compounds were detected; two of which were the natural flavonoids kaempferol and quercetin. Among others, two polyacetylene compounds, including panaxydol and panaxynol, were detected. Conclusion: In this study, we found that panaxydol, one of the polyacetylene constituents of ginseng, is a candidate anti-cancer agent in SanYangSam and SanYangSanSam pharmacopuncture. In addition, we found that the panaxydol levels in the SanYangSanSam extract were over 30 times those in the SanYangSam extract.

Effect of Gamidojeok-san on Hypertension (가미도적산이 고혈압에 미치는 영향)

  • Sin Hwang Su;Oh Young Seon;Kim Yoon Sik;Seol In Chan
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.18 no.6
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    • pp.1710-1713
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    • 2004
  • This study was Investigated to prove the effect of Gamidojeok-san (Jiaweidaochi-san) on the hypertension. After administer Gamidojeok-san (Jiaweidaochi-san) extract to SHR(Spontaneous Hypertensive Rat) for 5 weeks, we examined changes of blood pressure, pulse rate, aldosterone and catecholamine in serum. Results : Following results were obtained; Gamidojeok-san(Jiaweidaochi-san) showed significant antihypertensive effect. Gamidojeok-san(Jiaweidaochi-san) decreased pulse rate but insignificant. Gamidojeok-san(Jiaweidaochi-san) showed a significant decrease in the aldosterone. Gamidojeok-san(Jiaweidaochi-san) was ineffective on the dopamine. Gamidojeok-san(Jiaweidaochi-san) decreased the norepinephrine but insignificant. Gamidojeok-san(Jiaweidaochi-san) showed a significant decrease in the epinephrine. These results indicate that Gamidojeok-san(Jiaweidaochi-san) can be used in hypertension. Further study will be needed about the functional mechanism and etc..

Effects of Sunghyangjungki-san(Xingxiangzhengqi-san) on Bax and Bcl-2 Expressions in the MCAO Rats (성향정기산(星香正氣散)이 중대뇌동맥폐쇄 흰쥐의 Bax 및 Bcl-2 발현에 미치는 영향)

  • Jeong, Beoul;Lee, Jong-Soo
    • Journal of Korean Medicine Rehabilitation
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    • v.18 no.2
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    • pp.33-43
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    • 2008
  • Objectives : Sunghyangjungki-san(Xingxiangzhengqi-san) is a herb decoction prescribed frequently for stroke patients. The present study investigated neuroprotective effects of Sunghyangjungki-san(Xingxiangzhengqi-san) against the ischemic damage of the rat brain. Neuronal cell death under the cerebral ischemia is distinguished with the delayed cell death through apoptosis. Consequently, the effects of Sunghyangjungki-san(Xingxiangzhengqi-san) was evaluated with Bax and Bcl-2 expressions as apoptosis related factors in the brain tissues. Methods : The ischemic damage was induced by the middle cerebral artery occlusion(MCAO) method in Sprague-Dawley rats. Water extract of Sunghyangjungki-san(Xingxiangzhengqi-san) was treated for 5 days after the MCAO. Neurological scores and infarct size with TTC were measured. Bax and Bcl-2 expressions in the brain tissues were observed with immunohistochemistry. Results : Sunghyangjungki-san(Xingxiangzhengqi-san) treatment improved neurological score significantly at 5 days after the MCAO. Sunghyangjungki-san(Xingxiangzhengqi-san) treatment decreased infarct size by the MCAO, but it was not significant statistically. Sunghyangjungki-san(Xingxiangzhengqi-san) treatment attenuated Bax positive neurons significantly in the cerebral penumbra and the caudate putamen. Bcl-2 positive neurons were increased, but not significant. Sunghyangjungki-san(Xingxiangzhengqi-san) treatment increased Bcl-2/Bax expression ratios significantly in the cerebral penumbra and the caudate putamen. Conclusions : These results suggest that Sunghyangjungki-san(Xingxiangzhengqi-san) has a neuroprotective effect on the stroke with modulation of apoptosis related factors.

Study on the Analgesic and Anti-inflammatory Effects of ‘Bingso-San’ and ‘Kamibingso-San’ (빈소산(檳蘇散)과 가미빈소산(加味檳蘇散)이 진통(鎭痛) 및 소염작용(消炎作用)에 미치는 영향(影響))

  • Park, Woong-Dug;Ahn, Dug-Kyung
    • Korean Journal of Pharmacognosy
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    • v.14 no.1
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    • pp.24-29
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    • 1983
  • The results of the comparison among the effect of 'Bingso-San' extract powder, 'Kamibingso-San' extract powder, separately extracted 'Bingso-San' extract powder and separately extracted 'Kamibingso-San" extract powder are as follows: 1) All prescriptions were tested for analgesic effects in mouse, having pain caused by acetic acid, and their voluntarinesses were recognized. And separately extracted 'Kamibingso-San' extract powder has the most effective analgesic function, then 'Kamibingso-San' extract powder, then 'Bingso-San' extract powder, then separately extracted 'Bingso-San' extract powder. 2) The anti-inflammatory effects of 'Bingso-San' extract powder and 'Kamibingso-San' extract powder on the edema at the rat paw showed significantly statistical value than those of the other prescriptions. 3) According to the above mentioned results it was concluded that the addition of Olibanum and Clematidis Radix strengthen the algesic effect of 'Bingso-San' and there is addition in the anti-inflammatory effect of the 'Bingso-San' extract powder.

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Effect of SMA on the Interfacial Shear Strength for Single Glass Fiber and PC/SAN Blends (SMA가 PC/SAN 블렌드와 유리섬유간의 계면결합력에 미치는 영향)

  • Lee, Ui-Hwan;Nam, Gi-Jun;Lee, Jae-Uk
    • Polymer(Korea)
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    • v.25 no.4
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    • pp.512-520
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    • 2001
  • One of the most important factors which affect the mechanical properties of fiber-reinforced composite materials is the interfacial shear strength (IFSS). The IFSS of glass fiber and polycarbonate (PC)/styrene-co-acrylonitrile (SAN) blend system has been measured by the single fiber fragmentation test (SFFT). SAN contents were varied up to 30 wt% and the IFSS increased with the SAN contents. Styrene-co-maleic anhydride (SMA) was used as the compatibilizer and the glass fiber was surface treated with organosilane coupling agents. Addition of small amount of SMA in PC/SAN blend improved the IFSS by chemical bonding between maleic anhydride and silanol. The optimum MA content was 0.4 wt% of total matrix contents. Also, IFSS was greatly affected by the miscibility condition of SAN/SMA blends, which depended on the copolymer composition of SAN and SMA. It was found out that, higher IFSS could be obtained when the SAN/SMA blend was in miscible pairs. In case of SAN/SMA miscible pairs, the IFSS depended on the MA content in total matrix, not on the MA content in SMA.

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Acute Toxicity Study on Ojeok-san(Wuji-san) in Mice (ICR 마우스를 이용한 오적산의 급성독성 실험)

  • Um, Young-Ran;Lee, Jae-Hoon;Moon, Hyun-Jung;Park, Hwa-Yong;Ma, Jin-Yeul
    • The Journal of Korean Obstetrics and Gynecology
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    • v.22 no.3
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    • pp.135-142
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    • 2009
  • Purpose: Ojeok-san(Wuji-san) is one of the most frequently prescribed traditional medicine. To evaluate acute toxicity, ICR mice were treated with Ojeok-san(Wuji-san) administration. Methods: In this study, we investigated the acute toxicity of water-extracted Ojeok-san(Wuji-san). 0(control group), 1250, 2500, and 5000 mg/kg of Ojeok-san(Wuji-san) were orally administered to 20 male and 20 female for 14 days. We observed survival rates, general toxicity, change of body weight, and autopsy. Results: Compared with the control group, we could not find any toxic alteration in all treated groups (1250, 2500 and 5000 mg/kg). Conclusions: $LD_{50}$ of Ojeok-san(Wuji-san) might be over 5000 mg/kg and it is very safe to ICR mice.

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Analysis of studies on Bangpungtongseong-san (Fangfengtongsheng-san) to establish the fundament for Evidence Based Medicine (EBM) (EBM 기반구축을 위한 방풍통성산 실험 연구 분석)

  • Kim, Jung-Hoon;Lee, Jun-Kyoung;Shin, Hyeun-Kyoo
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.24 no.1
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    • pp.1-15
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    • 2011
  • Objective : To establish the fundament for EBM of Traditional Korean Medicine, the papers on Bangpungtongseong-san (Fangfengtongsheng-san) frequently used in medical institutions of Traditional Korean Medicine were analyzed through researching domestic and international papers. Methods : The papers were classified by the registration of domestic or international journals, the year of publishment, experimental fields and the kinds of studies on biological activities. Results : Among 324 volumes of papers on Bangpungtongseong-san (Fangfengtongsheng-san), 38 volumes were selected according to selective criteria. 18 volumes were published in domestic journals, 20 volumes were in Japanese journal. The papers on instrumental analyses reported the quantification of standard compounds of herbal medicines in Bangpungtongseong-san (Fangfengtongsheng-san) using HPLC method. The papers on biological activities of Bangpungtongseong-san (Fangfengtongsheng-san) showed inhibitory effect to obesity, arteriosclerosis, allergic response, inflammation, pain, hyperlipidemia, hypertension, atopy, diabete mallatus and improvement of gastrointestinal activity and cerebral blood circulation. Among biological activities, papers on anti-obesity effect were reported mostly. Conclusions : Further studies including anti-obesity activity need to be preceeded to establish the fundament for EBM of Bangpungtongseong-san (Fangfengtongsheng-san).

Control of morphology and interfacial tension of PC/SAN blends with compatibilizer

  • Kim, J.H.;Kim, M.J.;Kim, C.K.;Lee, J.W.
    • Korea-Australia Rheology Journal
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    • v.13 no.3
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    • pp.125-130
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    • 2001
  • Block copolymers of PC-b-PMMA (polycarbonate-b-polymethylmethacrylate) and PC -b-SAN (polycarbonate-b-(styrene-c-acrylonitrile)), were examined as compatibilizers for blonds of PC with SAN copolymer. The average diameter of the dispersed particles was measured with an image analyser, and the interfacial properties of the blonds were analysed with an imbedded fiber retraction (IFR) technique. The average diameter of dispersed particles and interfacial tension of the PC/SAN blends reached a minimum value when the SAN copolymer contained about 24 wt% AN. Interfacial tension and particle size were further reduced by adding compatibilizer to the PC/SAN blends. PC-b-PMMA was more effective than PC-b-SAN as a compatibilizer in reducing the average diameter of the dispersed particles and interfacial tension of PC/SAN blend. A direct proportionality between the particle diameter and interfacial tension was also observed. The interfacial properties of the PC/SAN blends were optimized by adding a block copolymer and using an SAN copolymer that had minimum interaction energy with PC.

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Adsorption Characteristics of Lithium Ions from Aqueous Solution using a Novel Adsorbent SAN-LMO Beads (수중의 리튬 이온 회수를 위한 새로운 흡착제인 SAN-LMO 비드의 제조)

  • Kam, Sang-Kyu;Park, Jeong-Min;Lee, Min-Gyu
    • Journal of Environmental Science International
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    • v.24 no.5
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    • pp.641-646
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    • 2015
  • In order to recover lithium ions from aqueous solution, a novel SAN-LMO beads were prepared by immobilizing lithium manganese oxide (LMO) with styrene acrylonitrile copolymers (SAN). The optimum condition for synthesis of SAN-LMO beads was 5 g of LMO and 3 g of SAN content. The characterization of the prepared SAN-LMO beads by SEM and XRD were confirmed that LMO was immobilized in SAN-LMO beads. The removal and the distribution coefficient of lithium ions decreased with increasing lithium ion concentration and solution pH. Even when the prepared SAN-LMO beads were reused 5 times, the leakage of LMO and the damage of SAN-LMO beads was not observed.