The seismic behaviour of rotating machine-foundation systems subjected to six-component nonstationary earthquake ground accelerations is analyzed. The rotating machine-foundation system is idealized by using discs, rotating shaft, fluid-film journal bearings, pedestals, and space frame foundation. Thus, governing equations of motion for the rotating machine-foundation system are obtained by considering Gyroscopic effect, Coriolis effect, dynamic characteristics of fluid-film journal bearings, and translational and rotational motions of seismic rigid base. The influences due to Gyroscopic effects, Coriolis effects, and rotational motions of seismic base on the overall structural response are demonstrated by a numerical example. The results show that the inclusion of base rotations and Gyroscopic effects contributes significantly to the system response.