• Title, Summary, Keyword: RCT

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Numerical Analysis of the Discharge and Luminous Characteristics of a Planar Type Xe Plasma Flat Lamp (대향형 Xe 플라즈마 평판 램프의 방전 및 발광 특성에 관한 수치적 연구)

  • Kim, Hyuk-Hwan;Lee, Won-Jong
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.24 no.10
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    • pp.822-833
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    • 2011
  • A Xe plasma flat lamp, which has been noticed as a new eco-friendly LCD (liquid crystal display) backlight, requires the improvement of the luminance and the luminous efficiency although it has several advantages. To improve the performance of a lamp, it is necessary to understand the effects of discharge variables on the luminous characteristics of the lamp. Since it is difficult to diagnose a lamp discharge experimentally, the numerical analysis can be used instead. In this study, the luminous characteristics of a planar type Xe plasma flat lamp were analyzed with the variation of an input voltage and a pulse frequency. The numerical analysis of a lamp discharge was then performed using a RCT (relaxation continuum) model and a LFA (local field approximation) model. The comparison with the experimental results showed that the RCT model is valid for the numerical analysis of the flat lamp. The numerical analysis also showed that the modifications of a high frequency component and a voltage falling rate in the input voltage waveform could improve the luminous characteristics of the lamp.

Review of the Latest Oriental and Traditional Clinical Articles and Protocol about Male Sexual Dysfunction (남성 성기능장애 관련 한의학 및 전통의학 임상 연구 동향 분석과 프로토콜 분석)

  • Park, Dong-Su;Park, Sun Young;Shin, Seon Mi
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.27 no.5
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    • pp.530-539
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    • 2013
  • This study reviews the latest articles about oriental and traditional medicine treatment of male sexual dysfunction. We searched the article from 2000 to 2012 using 5 data bases. There were no restrictions on the type of publication, but articles not available in full text were excluded. The methological quality of RCT study was assessed according to Jadad scores and Cochrane's assessment of risk of bias. 18 articles were included in this study. 5 articles published in Korea, the rest were foreign articles. 9 articles were randomized controlled trial(RCT), Case-control studies were 3, case reports were 3, One group pre-post test were 3. In RCT studies, Jadad scores were generally low, and risk of selection bias and performance bias were generally high, risk of detection bias was unclear. Oriental and traditional medicine treatment is as effective as western medicine treatment for male sexual dysfunction, more rigorous oriental medicine treatment studies should be warranted.

Effects of Adipokine Retnla on the Regulation of High-Density Lipoprotein Metabolism

  • Lee, Mi-Ran
    • Journal of the Korea Society of Computer and Information
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    • v.21 no.12
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    • pp.139-145
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    • 2016
  • In this paper, we propose to evaluate the effect of Resistin-like molecule alpha (Retnla) on the expression of transporters involved in modulating concentrations of peripheral cholesterol and plasma high-density lipoprotein (HDL) cholesterol. High levels of blood cholesterol are a well-recognized risk factor for atherosclerosis and are eliminated via the process of reverse cholesterol transport (RCT). We recently showed that Retnla ameliorates hypercholesterolemia and atherosclerosis by increasing biliary cholesterol secretion, the final step of the process, in low-density lipoprotein receptor-deficient mice. However, the role of Retnla in HDL-mediated cholesterol efflux, initial step of RCT pathway, is not yet clear. To identify cholesterol transport genes regulated by Retnla, we performed an extensive microarray-based gene expression screen using livers from Retnla-overexpressing (Tg) mice and control animals. The most significant change in Retnla-Tg mice was an upregulation of ATP-binding cassette sub-family G member 4 (Abcg4) transport and was validated using quantitative RT-PCR. The validated gene was also induced by treatment of purified Retnla protein in RAW 264.7 cells incubated with acetylated low-density lipoprotein and Hepa1c1c7 cells. Taken together, these results indicates that Retnla might also accelerate initial step of RCT pathway, suggesting therapeutic value of Retnla in the treatment of hypercholesterolemia and atherosclerosis.

Regulatory innovation for expansion of indications and pediatric drug development

  • Park, Min Soo
    • Translational and Clinical Pharmacology
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    • v.26 no.4
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    • pp.155-159
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    • 2018
  • For regulatory approval of a new drug, the most preferred and reliable source of evidence would be randomized controlled trials (RCT). However, a great number of drugs, being developed as well as already marketed and being used, usually lack proper indications for children. It is imperative to develop properly evaluated drugs for children. And expanding the use of already approved drugs for other indications will benefit patients and the society. Nevertheless, to get an approval for expansion of indications, most often with off-label experiences, for drugs that have been approved or for the development of pediatric indications, either during or after completing the main drug development, conducting RCTs may not be the only, if not right, way to take. Extrapolation strategies and modelling & simulation for pediatric drug development are paving the road to the better approval scheme. Making the use of data sources other than RCT such as EHR and claims data in ways that improve the efficiency and validity of the results (e.g., randomized pragmatic trial and randomized registry trial) has been the topic of great interest all around the world. Regulatory authorities should adopt new methodologies for regulatory approval processes to adapt to the changes brought by increasing availability of big and real world data utilizing new tools of technological advancement.

Mathmatical Analysis of Water Hamer Generated in an Initially Empty Piping with a Sudden Contraction Subject to Rapid Filling (빈관의 급속한 채움에 의한 관단면의 급축소 부분에서의 수격작용)

  • 우효섭;이삼희
    • Proceedings of the Korea Water Resources Association Conference
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    • pp.133-143
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    • 1989
  • An analytical equation was formulated using the continuity, momentum, and energy equatoins for the trensients generated in an initially empty piping with a sudden contraction subject to rapid filling with liquid. Also, two mathmatical models, "MOC" and "RCT", were applied to this particular pipping to reveal that the rigid column method is less applicable than the method of characteristics to the piping.

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A non-model based robot manipulator control using neural networks (무모형 로봇을 위한 신경 회로망 제어 방식)

  • Jung, Seul
    • 제어로봇시스템학회:학술대회논문집
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    • pp.698-701
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    • 1996
  • A novel neural network control scheme is proposed to identify the inverse dynamic model of robot manipulator and to compensate for uncertainties in robot dynamics. The proposed controller is called reference compensation technique(RCT) by compensating at reference input trajectory. The proposed RCT scheme has many benefits due to the differences in compensating position and learning algorithm. Since the compensation is done outside the plant it can be applied to many control systems without modifying the inside controller. It performs well with low controller gain because the operating range of input values is small and the output of the neural network controller is amplified through the controller gain. The back-propagation algorithm is used to train and simulations of three link robot manipulator are carried out to prove the proposed controller's performances.

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Mathematical Analysis of Water Hammer Generated in an Initially Empty Piping witha Sudden Contraction Subhect to Rapid Filling (빈관의 급속한 채움에 의한 관단명의 급축소 부분에서의 수격작용)

  • 우효섭;이삼희
    • Water for future
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    • v.22 no.4
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    • pp.435-440
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    • 1989
  • An analytical equation was formulated using the continuity, momentum, and energy equations for the trensients generated in an initially empty piping with a sudden contraction subject to rapid filling with liquid. Also, two mathematical models, MOC and RCT were applied to this particular piping to reveal that the rigid column method is less applicable than the method of characteristics to the piping.

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Analysis of Rotatory Equilibrium Sense using Rotating Stimulator (회전 자극기를 이용한 회전평형 분석)

  • 기호성;김종윤;양길태;김동욱;송철규;김남균
    • Proceedings of the Korean Society for Emotion and Sensibility Conference
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    • pp.202-206
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    • 2000
  • 본 연구에서는 회전 자극기를 이용하여 성별에 따른 회전 평형감각 특성을 분석하였다. 피검자는 정상성인 남녀 각각 10명에 대해, 두부회전과 rotatory chair test(RCT)에 의한 회전자극 전과 후의 변화정도를 살펴보았고, COP, Flicker Test, 적외선 카메라를 이용한 체열 측정 등을 통해 전정자극 특성을 평가하였다. 그 결과 COP를 통한 신체동요도 측정 결과 회전자극 제시 후 두부회전의 경우 총 누적거리가 1.47배, RCT의 경우 1.78배까지 증가했고, 플리커 치는 여성(8.6%)이 남성(5%)보다 높게 나타났고, 여성이 남성보다 회전자극에 민감함을 알 수 있었다. 또한, 남녀 모두 회전 자극 후 눈 주위의 온도상승이 미소하게 일어남을 알 수 있었다.

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TTA 2.3GHz 휴대인터넷 프로젝트그룹(PG302)

  • Hong, Dae-Hyeong
    • TTA Journal
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    • pp.41-45
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    • 2006
  • 2.3GHz 휴대인터넷 프로젝트그룹(PG302)에서는 차세대 성장동력으로 각광을 받고 있는 휴대인터넷 (WiBro) 기술의 상용 서비스에 대비하여 표준화를 성공적으로 추진해왔다. 국내 표준화를 위하여 2단계의 제정및 개정과정을 거쳐 2005년 말에 휴대인터넷 표준을 완성하였다. 또 국제 표준화를 위하여 광대역 무선 접속에 대한 표준화를 추진해온 국제표준화 기구인 IEEE 802.16 WG과 협력관계를 구축하여 WiBro 표준의 국제화를 성공적으로 달성했다. 현재는 WiBro 서비스를 경제적으로 제공하기 위해 요구되는 상호호환성 및 적합성 시험(IOT/RCT) 규격의 표준화를 활발히 진행하고 있다. 또 휴대인터넷과 다른 망과의 연동을 위한 표준, USIM 기반의 휴대인터넷 상호 인증 표준의 제정을 추진하고있다. 2006년부터는 관련 국제 표준화 움직임과 행보를 같이 하여, 시험 표준인 IOT/RCT 규격에 대한 국제 표준화도 추진할 예정이다. 또 향후 성능이 향상된 차세대 휴대인터넷 서비스의 제공을 위한 3단계 표준화도 함께 진행하여 ITU-R 등을 중심으로 국제적으로 이루어질 IMT-Advanced 표준화에 대응할 예정이다.

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Review on the Efficacy and Safety of Mahuang and Ephedrine in the Treatment of Obesity -Focused on RCT- (비만 치료에서 마황 및 에페드린의 유효성, 안전성에 대한 고찰 - RCT 연구를 중심으로 -)

  • Jo, Ga-Won;Ok, Ji-Myung;Kim, Seo-Young;Lim, Young-Woo
    • The Journal of Korean Medicine
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    • v.38 no.3
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    • pp.170-184
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    • 2017
  • Objectives: The objective of this study was to summarize randomized clinical trials (RCTs) that have assessed efficacy and safety of mahuang and ephedrine on treatment of obesity and to propose better process of study. Methods: NLM Medline (pubmed), the Cochrane library, Scopus, Science Direct, RISS, KISS were systemically searched for clinical trials investigating the efficacy, safety of mahuang and ephedrine on treatment of obesity from 2000 to 2017. Results: 16 RCTs met all the inclusion criteria. In most reports, mahuang and ephedrine significantly reduced body weight, body fat mass. There were no serious adverse events associated with mahuang and ephedrine in all studies. Conclusions: In appropriate dose of mahuang and ephedrine for healthy adult was safe, and weight loss effect of mahuang and ephedrine was better than control group. Improved clinical practice guidelines should be developed for safe use of mahuang and ephedrine.