• 제목, 요약, 키워드: RCT

검색결과 337건 처리시간 0.044초

무작위 대조군 실험 연구에서 치료의향분석 (Intention-to-treat analysis)에 대한 고찰 (Review of Intention-to-Treat Analysis in Randomized Controlled Trials)

  • 김정헌
    • 재활치료과학
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    • v.9 no.2
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    • pp.27-38
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    • 2020
  • 서론 : 본 연구는 무작위 대조군 실험(Randomized control trial: 이하 RCT) 연구에서 치료의향분석(Intention-to-treat analysis)의 올바른 활용에 대해서 고찰하고자 한다. 본론 : 치료의향분석은 RCT 연구에서 무작위 분배 이후에 모든 대상자의 데이터를 결과에 포함하는 분석방법이다. RCT 연구의 결과는 일반화에 있어서 매우 높은 타당성을 갖는다. 이런 측면에서 중도 탈락을 포함한 모든 대상자의 데이터를 결과 분석에 포함하여야 그 결과를 실제 임상에 적용했을 때 중재의 효과가 예측 가능하기 때문이다. 이런 이유로 RCT 연구에 대한 질평가 도구들은 치료의향분석 실시여부를 확인하고 있다. 그럼에도 많은 연구자들은 치료의향분석의 이해도가 낮아 잘못 활용하고 있거나 활용하지 않는 경우가 많다. 결론 : 본 고찰 연구를 통해 국내 많은 연구자들이 치료의향분석방법을 정확하게 이해하고 올바르게 활용하여 RCT 연구에 반영할 것을 기대한다.

당뇨병성 말초 신경병증에 대한 RCT 분석 연구 (Review of Randomized Controlled Clinical Trials Targeting Treatment of Diabetic Peripheral Neuropathy)

  • 김진미;손창규;조충식;김철중
    • 대한한의학회지
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    • v.31 no.4
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    • pp.164-170
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    • 2010
  • Objective: This study aimed to produce an overview of RCT for treatments of diabetic peripheral neuropathy. Method: All RCT studies for treatments of diabetic peripheral neuropathy were selected via PubMed. The general trend of RCT number, subject and result, including Oriental medicine, were analyzed. Result: A total 147 RCT studies were found. The number of RCT has rapidly increased since 2003. 114 RCTs were conducted with western drugs, while RCTs with electrical stimulation and Oriental medicine were eight and ten respectively. All RCTs with acupuncture, moxibustion and herbal drugs showed positive results. Conclusion: Oriental medicine-derived RCTs for diabetic peripheral neuropathy are very rare, even their potential was sufficient. This study may provide valuable information for development of Oriental medicine against diabetic peripheral neuropathy in the future.

Systematic Review of Chuna Manipulative Treatment for Ankle Sprain

  • Kwak, Min Kyung;Kim, Min Wook;Jeong, Sang Jun;Kim, Shin Ae;Jeong, Mi Young;Kim, Jae Hong
    • Journal of Acupuncture Research
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    • v.35 no.2
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    • pp.61-68
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    • 2018
  • Background: This study was performed to review the efficacy of national and international randomized controlled trials (RCT) investigating Chuna manipulative treatment for ankle sprains. Methods: Online databases (PubMed, Cochrane, EMBASE, CNKI, NDSL, OASIS), were searched for studies where Chuna treatment was performed for ankle sprains up to October 12th, 2017. Only RCT were selected that fulfilled the inclusion/exclusion criteria. Data were analyzed using the Cochrane risk of bias tool. Results: There were 676 studies retrieved from the databases, resulting in analysis of 24 RCT. There was an average of 7 treatment visits over a 7 day period and the most frequent evaluation tool used was efficacy rate, with drug therapy being the most common control used in the trials. In 15 RCT, several Chuna methods were used in combination, amongst which, the osteopathic technique was most common. Statistically significant improvement in evaluation indices was reported in 19 RCT, and in 3 RCT, statistically significant improvement was reported, but not for all indices. In the remaining 2 RCT, there were no significant differences in any of the evaluation indices. No adverse reactions were reported in any of the RCT, although it was unknown whether all the trial protocols indicated that adverse reactions should be monitored, and for this reason, the risk of bias was unclear. Conclusion: The review of 24 studies suggest that Chuna manipulative treatment for ankle sprains was effective in most cases, although, potential bias in these studies was difficult to evaluate.

뜸을 이용한 RCT임상연구의 경향에 대한 개괄 (Overview for pattern and results of moxibustion-derived clinical trials)

  • 손창규
    • 경락경혈학회지
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    • v.26 no.1
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    • pp.41-49
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    • 2009
  • Objective : To make comprehensive picture of clinical trials using moxibustion and their results by today, then help a strategy for moxibustion-derived clinical studies in the future. Methods : Surveyed literatures containing randomized controled clinical trial (RCT) from PubMed and Korean journals. Analysis was performed according to distribution mainly by study subject, target diseases, study design, and its efficacy. Results : Fifty two literatures were selected according to inclusion criteria of randomized controled clinical study. Moxibustion-derived RCT have been rapidly increased from 2003 since the first was published in China in 1992. The main subjects of RCT are associated with immunity, cancer, arthritis, chronic colitis and urogenital disorders, which are connected to cold-elated pathogenesis. The average number of subjects was 94, and direct-moxibustion was mainly applied. The control groups were set up by giving conventional therapy, herbal medicine, acupuncture or only observation. The most of RCTs showed positive results. Conclusions : This study would be helpful for designing or conducting RCTs to develop the scientific development of moxibustion.

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한약을 이용한 한국에서의 무작위 임상시험 개괄적 검토 (Randomized Clinical Controlled Trials of a Herb Remedies in Korea - Systematic Review)

  • 오래영;설인찬;손창규
    • 대한한의학회지
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    • v.31 no.4
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    • pp.1-8
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    • 2010
  • Objective: The study aimed to review all randomized controlled clinical trials (RCTs) performed in Korea with herbal medicine, to produce further useful information for herbal-drug development. Methods: All papers reporting RCT with herbal drugs were collected via public database of Korea Science and Technology Integration Services, and various Oriental medicine journals. Then, the clinical question, herbal medicine, result, RCT design, and its conductor were analyzed. Results: A total of 20 RCTs were finally selected, and most of them were performed after 2003. The main subjects of RCT were related to heart and blood circulation, dermatitis, respiration disorder, Sasang constitution, or psychiatric disorders. Eight RCTs were done with a single herb while 12 RCTs were with multiple herbal formulae. In particular, three RCTs for atopic dermatitis with three formulae showed positive results. The quality of RCT was considered as better than average. Conclusions: This study revealed the current status of RCT using herbal drugs. This result would provide helpful information for research and drug development using traditional herbal medicine.

OFDMA 상향 시스템에서의 협동 전송 기법 (Cooperative Transmission Scheme in OFDMA Uplink System)

  • 윤재선;송형규
    • 한국통신학회논문지
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    • v.32 no.5A
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    • pp.475-483
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    • 2007
  • OFDMA 상향 시스템은 DVB-RCT를 위해 채택되었는데, OFDM과 동일하게 다중 경로 페이딩 영향에 강하고 성능 열화 없이 수신 가능하다는 이점을 갖는다. 이 시스템의 QoS를 향상시키기 위해 기존의 MIMO시스템이 많이 연구되었으나 다중송수신 안테나를 이용하는 이들 STC, MRC 등은 다중안테나를 사용하는 데에 따른 하드웨어 복잡도 증가, 고비용, 공간상의 제약 등 여러 가지 문제점을 안고 있다. 따라서 이들을 극복하면서 QoS도 만족시킬 수 있는 새로운 기법이 필요하다. 따라서 이 논문에서는 단일 안테나를 사용하는 OFDMA 기반의 DVB-RCT 시스템을 위하여 기존의 다중 송수신 기법들의 단점을 극복하고 현존 시스템을 이용할 수 있는 협동 전송 기법을 제안한다. OFDMA 상향 시스템 기반의 단일 안테나 DVB-RCT 시스템에 제안된 협동 전송 기법을 적용함으로써, 위에서 언급한 기존 기법들의 단점들을 극복하고 MIMO 시스템과 같이 성능을 향상 시킬 수 있다.

비염의 침 치료에 대한 최근 임상 연구 동향 - RCT, Review 중심으로 - (Recent Clinical Research on Effect of Acupuncture for Rhinitis - Within RCT, Review -)

  • 신지혜;이장천;김기봉
    • 대한한방소아과학회지
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    • v.26 no.1
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    • pp.46-59
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    • 2012
  • Objectives The purpose of this study is to investigate recent clinical studies on effect of acupuncture for rhinitis in other countries. We have analyzed the studies on effect of acupuncture for rhinitis within randomized controlled trial(RCT), reviewed for 11 years (from 2001 to 2011). Methods The search database includes PubMed. To narrow the search, the following key search terms were used: 'rhinitis, acupuncture'. The search was limited to the publication date from 2001 to 2011. Results Total 20 studies were selected: RCT(13), review(5), case report(1), and cost effectiveness study(1). In RCT, 9 studies used acupuncture only, and 8 studies of them have revealed that acupuncture is effective on rhinitis. In review, 3 studies are systematic review, 2 studies are no systematic review. Among systematic review, 2 studies have revealed partial effectiveness of acupuncture for rhinitis, but they suggested the necessity of further studies. Conclusions Domestic studies on effect of acupuncture for rhinitis are necessary. For more accurate results, controlled, large scale and well designed studies are recommended.

경피적외선요법의 경혈(經穴) 조사(照射) 치료법에 대한 고찰 (An Effect of Infrared Therapy on Acupoints ; Randomized Controlled Trials Review)

  • 황의형;신병철;신미숙;조현우;정여름;설재욱
    • 한방재활의학과학회지
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    • v.21 no.2
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    • pp.203-210
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    • 2011
  • Objectives : The aim of this study is to establish evidence-based guideline on infrared therapy on acupoints. Methods : We investigated all the articles in websites including Pubmed, China national knowledge Infrastructure(CNKI) and medical journals authorized by national research foundation of Korea. The key words are acupoints and infrared. For the first time, we withdrew some papers no relationship to key words by reading titles and abstracts. In the second, we only selected randomized clinical trials(RCT) published from 2000 to 2010. Results : Out of 62 papers, only 2 RCT were analyzed. One (RCT 1) was about depression patients with insomnia(jadad score: 1). The other(RCT 2) was about urimic pruritus patients(jadad score: 5). In RCT 1, experimental group was significantly better than control group. In RCT 2, there was not statistical signification between two groups. Conclusions : In reality, there were not many papers on infrared therapy applications. Further study just like RCTs may be needed to establish evidenced-based guideline on infrared.

ATM망을 위한 실시간 트래픽 제어 기법:RCT (A Real-time Traffic Control Scheme for ATM network:RCT)

  • 이준연;이재완;권혁인
    • 한국정보처리학회논문지
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    • v.4 no.11
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    • pp.2822-2831
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    • 1997
  • ATM을 기반으로 하는 B-ISDN 망은 다양한 트래픽 특성과 서비스 요구사항을 가진 여러가지 종류의 서비스를 지원해야한다. ATM 계층에는 link 계층간의 흐름 제어나 에러 제어가 없다. 그러나 다양한 종류의 각종 서비스를 위해 각기 다른 다른 흐름/에러 제어 기법이 AAL 계층이나 상위 계층(예를 들어 OSI 7 계층의 4번 전송 계층)에서 수행될 수 있다. 전통적인 데이타망에서는 에러 제어 기법이 결합된 윈도우 흐름 제어 기법이 널리 사용되었다. 그러나 윈도우 흐름 제어 기법은 전파 전달 지연(Propagation delay)이 전송률(Transmission rate)에 비해 상대적으로 너무 크기 때문에 ATM 망에서 유용하지 않을 수 있다. 본 논문에서는 양단간(end-to-end) 자료 전송을 위한 매우 간단한 흐름제어 기법인 RCT (Rate Control for end-to-end Transport)를 제안한다. RCT는 평균 과부하(Overload) 기간의 분포가 특정 시간대에 편중되어 있을 때에 높은 성능을 보인다.

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재순환케이싱처리 높이변화가 터보차저 압축기의 성능에 미치는 영향 (Effect of Height Variation of Recirculating Casing Treatment on the Performance of a Turbocharger Compressor)

  • ;;이근식
    • 대한기계학회논문집B
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    • v.39 no.8
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    • pp.669-675
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    • 2015
  • 자동차용 터보차저 원심압축기의 재순환케이싱처리(RCT)부의 높이변화가 압축기의 성능에 미치는 영향이 조사되었다. 연구대상 RCT 부의 높이는 1.2mm, 1.5mm, 1.8mm 의 세가지이며, 회전수 범위는 90,000 - 150,000 rpm, 유량 범위는 0.015 kg/s - 0.08 kg/s 이다. 전압력비와 등엔트로피 효율 비교 결과, 본 수치계산은 실제압축기의 성능 제원과 최대오차 0.7%의 범위 내에서 잘 일치하였다. 해석결과, RCT 부 높이 1.2mm, 1.8mm, 1.5mm 순서로 균일 압력분포, 높은 압력비, 넓은 작동범위를 얻었다. 이들 세가지 경우 모두, 회전수가 증가할수록 이들의 압력비는 높아지나 운전범위는 좁아지는 전형적인 압축기 맵의 특성을 보여주었다.