• Title, Summary, Keyword: RCT

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Review of Intention-to-Treat Analysis in Randomized Controlled Trials (무작위 대조군 실험 연구에서 치료의향분석 (Intention-to-treat analysis)에 대한 고찰)

  • Kim, Junghun Aj
    • Therapeutic Science for Rehabilitation
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    • v.9 no.2
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    • pp.27-38
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    • 2020
  • Introduction : This review aims to introduce an intention-to-treat analysis(ITT) method and demonstrate the importance of rigorous utilization of this method to researchers in Korea. Discussion : ITT analysis includes all data as results in randomized control trials (RCT). Thereby the result of RCT is high validated to adapt in the real-world so that the result should be expected at clinical practice. Therefore, many RCT quality assessment tools include the question of the utilization of ITT analysis in individual trials. However, many researchers omit to report ITT, not utilize ITT or use ITT incorrectly. Conclusion : Through this review, more Korean researchers may understand and utilize ITT which is expected to enhance the quality of RCT papers.

Review of Randomized Controlled Clinical Trials Targeting Treatment of Diabetic Peripheral Neuropathy (당뇨병성 말초 신경병증에 대한 RCT 분석 연구)

  • Kim, Jin-Mi;Son, Chang-Gue;Cho, Chung-Sik;Kim, Chul-Jung
    • The Journal of Korean Medicine
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    • v.31 no.4
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    • pp.164-170
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    • 2010
  • Objective: This study aimed to produce an overview of RCT for treatments of diabetic peripheral neuropathy. Method: All RCT studies for treatments of diabetic peripheral neuropathy were selected via PubMed. The general trend of RCT number, subject and result, including Oriental medicine, were analyzed. Result: A total 147 RCT studies were found. The number of RCT has rapidly increased since 2003. 114 RCTs were conducted with western drugs, while RCTs with electrical stimulation and Oriental medicine were eight and ten respectively. All RCTs with acupuncture, moxibustion and herbal drugs showed positive results. Conclusion: Oriental medicine-derived RCTs for diabetic peripheral neuropathy are very rare, even their potential was sufficient. This study may provide valuable information for development of Oriental medicine against diabetic peripheral neuropathy in the future.

Systematic Review of Chuna Manipulative Treatment for Ankle Sprain

  • Kwak, Min Kyung;Kim, Min Wook;Jeong, Sang Jun;Kim, Shin Ae;Jeong, Mi Young;Kim, Jae Hong
    • Journal of Acupuncture Research
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    • v.35 no.2
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    • pp.61-68
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    • 2018
  • Background: This study was performed to review the efficacy of national and international randomized controlled trials (RCT) investigating Chuna manipulative treatment for ankle sprains. Methods: Online databases (PubMed, Cochrane, EMBASE, CNKI, NDSL, OASIS), were searched for studies where Chuna treatment was performed for ankle sprains up to October 12th, 2017. Only RCT were selected that fulfilled the inclusion/exclusion criteria. Data were analyzed using the Cochrane risk of bias tool. Results: There were 676 studies retrieved from the databases, resulting in analysis of 24 RCT. There was an average of 7 treatment visits over a 7 day period and the most frequent evaluation tool used was efficacy rate, with drug therapy being the most common control used in the trials. In 15 RCT, several Chuna methods were used in combination, amongst which, the osteopathic technique was most common. Statistically significant improvement in evaluation indices was reported in 19 RCT, and in 3 RCT, statistically significant improvement was reported, but not for all indices. In the remaining 2 RCT, there were no significant differences in any of the evaluation indices. No adverse reactions were reported in any of the RCT, although it was unknown whether all the trial protocols indicated that adverse reactions should be monitored, and for this reason, the risk of bias was unclear. Conclusion: The review of 24 studies suggest that Chuna manipulative treatment for ankle sprains was effective in most cases, although, potential bias in these studies was difficult to evaluate.

Overview for pattern and results of moxibustion-derived clinical trials (뜸을 이용한 RCT임상연구의 경향에 대한 개괄)

  • Son, Chang-Gue
    • Korean Journal of Acupuncture
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    • v.26 no.1
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    • pp.41-49
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    • 2009
  • Objective : To make comprehensive picture of clinical trials using moxibustion and their results by today, then help a strategy for moxibustion-derived clinical studies in the future. Methods : Surveyed literatures containing randomized controled clinical trial (RCT) from PubMed and Korean journals. Analysis was performed according to distribution mainly by study subject, target diseases, study design, and its efficacy. Results : Fifty two literatures were selected according to inclusion criteria of randomized controled clinical study. Moxibustion-derived RCT have been rapidly increased from 2003 since the first was published in China in 1992. The main subjects of RCT are associated with immunity, cancer, arthritis, chronic colitis and urogenital disorders, which are connected to cold-elated pathogenesis. The average number of subjects was 94, and direct-moxibustion was mainly applied. The control groups were set up by giving conventional therapy, herbal medicine, acupuncture or only observation. The most of RCTs showed positive results. Conclusions : This study would be helpful for designing or conducting RCTs to develop the scientific development of moxibustion.

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Randomized Clinical Controlled Trials of a Herb Remedies in Korea - Systematic Review (한약을 이용한 한국에서의 무작위 임상시험 개괄적 검토)

  • Oh, Rai-Young;Seol, In-Chan;Son, Chang-Gue
    • The Journal of Korean Medicine
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    • v.31 no.4
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    • pp.1-8
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    • 2010
  • Objective: The study aimed to review all randomized controlled clinical trials (RCTs) performed in Korea with herbal medicine, to produce further useful information for herbal-drug development. Methods: All papers reporting RCT with herbal drugs were collected via public database of Korea Science and Technology Integration Services, and various Oriental medicine journals. Then, the clinical question, herbal medicine, result, RCT design, and its conductor were analyzed. Results: A total of 20 RCTs were finally selected, and most of them were performed after 2003. The main subjects of RCT were related to heart and blood circulation, dermatitis, respiration disorder, Sasang constitution, or psychiatric disorders. Eight RCTs were done with a single herb while 12 RCTs were with multiple herbal formulae. In particular, three RCTs for atopic dermatitis with three formulae showed positive results. The quality of RCT was considered as better than average. Conclusions: This study revealed the current status of RCT using herbal drugs. This result would provide helpful information for research and drug development using traditional herbal medicine.

Cooperative Transmission Scheme in OFDMA Uplink System (OFDMA 상향 시스템에서의 협동 전송 기법)

  • Yoon, Jae-Seon;Song, Hyoung-Kyu
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.32 no.5A
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    • pp.475-483
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    • 2007
  • Recently, consumers demand high-quality wireless multimedia services via terrestrial and satellite network. And the interest for new services to sustain its successful commercial deployment grows tremendously. So, the MIMO schemes, such as STCs, MRC, has been used for realizing high reliability. However, MIMO schemes has some limitations. MIMO scheme needs more size, cost, and hardware complexity to employ additional antennas. Moreover, sufficient spaces between antennas are required to guarantee the independence of each channel and the devices which use multiple antennas should be enlarged. A cooperative transmission technique which is detect and forward type applying virtual MIMO with STBC matrix in DVB-RCT(Digital Video Broadcasting with Return Channel via Terrestrial) system based on OFDMA is also proposed.

Recent Clinical Research on Effect of Acupuncture for Rhinitis - Within RCT, Review - (비염의 침 치료에 대한 최근 임상 연구 동향 - RCT, Review 중심으로 -)

  • Shin, Ji-Hye;Lee, Jang-Cheon;Kim, Ki-Bong
    • The Journal of Pediatrics of Korean Medicine
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    • v.26 no.1
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    • pp.46-59
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    • 2012
  • Objectives The purpose of this study is to investigate recent clinical studies on effect of acupuncture for rhinitis in other countries. We have analyzed the studies on effect of acupuncture for rhinitis within randomized controlled trial(RCT), reviewed for 11 years (from 2001 to 2011). Methods The search database includes PubMed. To narrow the search, the following key search terms were used: 'rhinitis, acupuncture'. The search was limited to the publication date from 2001 to 2011. Results Total 20 studies were selected: RCT(13), review(5), case report(1), and cost effectiveness study(1). In RCT, 9 studies used acupuncture only, and 8 studies of them have revealed that acupuncture is effective on rhinitis. In review, 3 studies are systematic review, 2 studies are no systematic review. Among systematic review, 2 studies have revealed partial effectiveness of acupuncture for rhinitis, but they suggested the necessity of further studies. Conclusions Domestic studies on effect of acupuncture for rhinitis are necessary. For more accurate results, controlled, large scale and well designed studies are recommended.

An Effect of Infrared Therapy on Acupoints ; Randomized Controlled Trials Review (경피적외선요법의 경혈(經穴) 조사(照射) 치료법에 대한 고찰)

  • Hwang, Eui-Hyoung;Shin, Byung-Cheul;Shin, Mi-Suk;Cho, Hyun-Woo;Jung, Yeo-Leum;Sul, Jae-Uk
    • Journal of Korean Medicine Rehabilitation
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    • v.21 no.2
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    • pp.203-210
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    • 2011
  • Objectives : The aim of this study is to establish evidence-based guideline on infrared therapy on acupoints. Methods : We investigated all the articles in websites including Pubmed, China national knowledge Infrastructure(CNKI) and medical journals authorized by national research foundation of Korea. The key words are acupoints and infrared. For the first time, we withdrew some papers no relationship to key words by reading titles and abstracts. In the second, we only selected randomized clinical trials(RCT) published from 2000 to 2010. Results : Out of 62 papers, only 2 RCT were analyzed. One (RCT 1) was about depression patients with insomnia(jadad score: 1). The other(RCT 2) was about urimic pruritus patients(jadad score: 5). In RCT 1, experimental group was significantly better than control group. In RCT 2, there was not statistical signification between two groups. Conclusions : In reality, there were not many papers on infrared therapy applications. Further study just like RCTs may be needed to establish evidenced-based guideline on infrared.

A Real-time Traffic Control Scheme for ATM network:RCT (ATM망을 위한 실시간 트래픽 제어 기법:RCT)

  • Lee, Jun-Yeon;Lee, Hae-Wan;Kwon, Hyeog-In
    • The Transactions of the Korea Information Processing Society
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    • v.4 no.11
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    • pp.2822-2831
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    • 1997
  • A B-ISDN network based on ATM must support several kinds of transport services with different traffic characteristics and service requirements. There is neither link-by-link flow control nor error control in the ATM layer. For different services, different flow/error controls could be performed at the AAL layer or at a higher Iayer(e.g. transport layer). In traditional data networks, the window now control mechanism combined with error control was used prevalently. But, the window flow control mechanism might be useless in ATM networks because the propagation delay is too large compared with the transmission rate. In this paper, we propose a simple flow control mechanism, called RCT(Rate Control for end-to-end Transport), for end-to-end data transport. The RCT shows acceptable performance when the average overload period is bounded by a certain time.

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Effect of Height Variation of Recirculating Casing Treatment on the Performance of a Turbocharger Compressor (재순환케이싱처리 높이변화가 터보차저 압축기의 성능에 미치는 영향)

  • Nguyen, Van Hap;Zhou, Tianjun;Lee, Geun Sik
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.39 no.8
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    • pp.669-675
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    • 2015
  • In this study, we investigate the performance variations of an automotive turbocharger compressor with respect to the height variation of the recirculating casing treatment (RCT). We use three RCT heights, namely 1.2 mm, 1.5 mm, and 1.8 mm. We vary the compressor speed from 90,000 to 150,000 rpm, and the flow rate from 0.015 kg/s to 0.08 kg/s. The calculation results of the total pressure ratio and isentropic efficiency showed good agreement with the performance data provided by the manufacturer within a 0.7 percent error. The results showed that the RCT heights of 1.2 mm, 1.8 mm, and 1.5 mm, in that order, exhibited a more uniform pressure distribution, higher pressure ratio, and wider operational range. As the number of revolutions per minute increased, we obtained typical characteristics of a compressor map having a narrower operational range in the region of higher pressure ratio.